Reactive Oxygen Species(活性氧)

Reactive oxygen species (ROS), such as superoxide anion (O₂^-), hydrogen peroxide (H₂O₂), and hydroxyl radical (HO•), consist of radical and non-radical oxygen species formed by the partial reduction of oxygen. Cellular ROS are generated endogenously during mitochondrial oxidative metabolism as well as in cellular response to xenobiotics, cytokines, and bacterial invasion.

ROS also activates MAPK pathways by the direct inhibition of MAPK phosphatases. Through PTEN, the PI3K pathway is subject to reversible redox regulation by ROS generated by growth factor stimulation. The activation of autophagy may be a cellular defense mechanism in response to ROS.

Products for Reactive Oxygen Species

Cat.No. 产品名称 Information
GC41397 BMPO
BocMPO
BMPO是一种环状硝酮自旋捕集剂，它是一种水溶性白色固体，比其他自旋捕集剂更容易提纯BMPO。
GC16921 Bromhexine HCl
盐酸溴己新
Bromhexine HCl 是一种有效且特异性的 TMPRSS2 蛋白酶抑制剂，IC50 为 0.75 μM。
GC33134 Bufotalin
蟾蜍他灵
A bufadienolide with cytotoxic and immunomodulatory activities
GC46960 Buprofezin
噻嗪酮
An insecticide
GC30067 Butylhydroxyanisole (Butylated hydroxyanisole)
丁基羟基茴香醚; Butylated hydroxyanisole; BHA; E320
丁基羟基茴香醚（Butylated hydroxyanisole）（Butylated hydroxyanisole）是一种抗氧化剂，用作食品添加剂防腐剂。
GN10356 Calycosin-7-glucoside
毛蕊异黄酮苷
An isoflavone glycoside with diverse biological activities
GC18922 Camalexin A plant defense alkaloid
GC30495 Canthaxanthin (E 161g)
斑蝥黄; E 161g; all-trans-Canthaxanthin
角黄素 (E 161g) 是一种橙红色的类胡萝卜素，具有多种生物活性，例如抗氧化、抗肿瘤特性。
GC65429 Capillarisin
茵陈色原酮
Capillarisin 作为蒿属植物蒿的一种成分，具有抗炎和抗氧化作用。Capillarisin 可为哮喘介导并发症的研究，并且可以作为一种潜在的神经保护剂来对抗布比卡因引起的神经毒性。
GC43139 Capsanthin
辣椒红
A carotenoid with diverse biological activities
GC19762 Capsanthin (75%)
辣椒红
A carotenoid with diverse biological activities
GC72610 Cartap hydrochloride Cartap hydrochloride一种有机氮杀虫剂，可在分离的小鼠和兔膈神经膈肌中引起明显的不可逆钙依赖性挛缩。
GC60674 Catalase from Aspergillus niger(≥100000U/g)
过氧化氢酶

Catalase是重要的抗氧化酶,在清除ROS。在维持氧化还原状态的平衡方面发挥着重要作用。Catalase与肿瘤的发生,发展关系密切。有潜力用于肿瘤的预防研究。
GC64933 Catalase from bovine liver(2000-5000u/mg)
过氧化氢酶

Catalase是重要的抗氧化酶,在清除ROS。在维持氧化还原状态的平衡方面发挥着重要作用。Catalase与肿瘤的发生,发展关系密切。有潜力用于肿瘤的预防研究。
GC61865 Cearoin
2,5-二羟基-4-甲氧基二苯甲酮
Cearoin 通过促进 ROS 产生和激活 ERK 来增强自噬 (autophagy) 和诱导细胞凋亡(apoptosis)。
GC52081 Chamazulene
母菊薁
A terpene with anti-inflammatory and antioxidant activities
GC64993 Chicoric acid
菊苣酸; Cichoric acid; Dicaffeoyltartaric acid
A dicaffeoyl ester with diverse biological activities
GC60693 Chitoheptaose heptahydrochloride
壳七糖七盐酸盐
Chitoheptaoseheptahydrochloride是一种具有抗氧化，抗炎，抗凋亡和心脏保护作用的壳聚糖寡糖。Chitoheptaoseheptahydrochloride显着增强了小麦幼苗的生长和光合作用参数。
GN10518 Chitosamine hydrochloride
盐酸氨基葡萄糖; D-(+)-Glucosamine hydrochloride; Chitosamine hydrochloride
An amino monosaccharide
GC68039 Chlorin e6 trimethyl ester
二氢卟吩 e6 三甲酯
Chlorin e6 trimethyl ester，是甲基脱镁叶绿酸-a 的衍生物，是一种可用于光动力疗法 (PDT) 的光敏剂。
GN10308 Chlorogenic acid
绿原酸; 3-O-Caffeoylquinic acid; Heriguard; NSC-407296
Chlorogenic acid是一种有效的神经保护剂，同时具有抗病毒、抗真菌、抗氧化和抗肿瘤作用。Chlorogenic acid还参与调节葡萄糖和脂质代谢，改善胰岛素敏感性。
GN10662 Cichoric Acid
菊苣酸,Dicaffeoyltartaric acid
Extracted from Cichorium intybus L;Suitability:Methanol,DMSO;Store the product in sealed,cool and dry condition
GC47096 Citrinin-13C13
(–)-Citrinin-13C13, CTN-13C13
A neuropeptide with diverse biological activities
GC38680 Citronellol
香茅醇; (±)-Citronellol; (±)-β-Citronellol
A monoterpene
GC65124 CL097 hydrochloride CL097 是一种有效的 TLR7 和 TLR8 激动剂，可在巨噬细胞中诱导促炎细胞因子。CL097 诱导 NADPH 氧化酶启动活性，导致 fMLF 刺激的 ROS 产生增加。
GC71777 CM-H2DCFDA CM-H2DCFDA是H2DCFDA的衍生物。
GC40632 CMS121 A substituted quinoline with diverse biological activities
GN10668 Coenzyme Q10
辅酶Q10; CoQ10; Ubiquinone-10
A cofactor in the electron transport chain
GC47116 Coenzyme Q10-d6
辅酶Q10-D6,CoQ10-d6; Ubiquinone-10-d6
An internal standard for the quantification of CoQ₁₀
GC43297 Coenzyme Q2
辅酶Q2
A biosynthetic precursor to CoQ₁₀ and an inhibitor of mitochondrial complex I
GC43316 Coumarin Boronic Acid
CBA
A fluorescent probe for direct detection of peroxynitrite
GC43317 Coumarin Boronic Acid pinacolate ester
CBA pinacolate ester, CBE
A fluorescent probe for detection of peroxynitrite
GC70571 CP-312 CP-312是一种强效的血红素加氧酶-1（HO-1）诱导剂。
GC91673 CPPD-Q
CPPD-quinone
CPPD-Q is a p-phenylenediamine quinone (PPD-Q) and an oxidized derivative of the antiozonant CPPD.
GC52164 Cu-ATSP
copper-ATSP, CuII(atsp)
A copper-containing bis(thiosemicarbazone) complex
GC49557 Cu-GTSM
CuII(gtsm), copper-GTSM
A copper-containing compound with diverse biological activities
GC43335 Cyanidin 3-O-arabinoside
矢车菊素-3-O-阿拉伯糖苷
An anthocyanin antioxidant
GC18488 Cyclo(L-Leu-L-Trp) A diketopiperazine metabolite
GC65545 Cyclo(L-Phe-L-Pro)
环(PHE-PRO)
Cyclo(L-Phe-L-Pro) 可从 Pseudomonas fluorescens 和 Pseudomonas alcaligenes 无细胞培养上清液中分离得到，是一种抗真菌环状二肽。Cyclo(L-Phe-L-Pro)通过干扰视黄酸诱导基因-I (RIG-I) 的激活来抑制 IFN-β 产生。Cyclo(L-Phe-L-Pro) 还具有自由基清除活性，IC50 为 24 µM。
GC34894 CycLuc1 CycLuc1是一种可渗透血脑屏障的荧光素酶(luciferase)底物。
GC45877 CYM 5478 An S1P₂ agonist
GN10698 Cynarin
洋蓟素
Cynarin 是一种抗窒息剂，具有多种生物活性，包括抗氧化、抗组胺和抗病毒活性。
GC43352 CYPMPO
2-(5,5-二甲基-2-氧代-1,3,2-二氧磷杂环己烷-2-基)-1-羟基-2-甲基-3,4-二氢-2H-1lambda5-吡咯-1-基,RR 071
A novel spin trap for hydroxyl and superoxide radical detection
GC33779 Cysteamine (β-Mercaptoethylamine)
巯基乙胺
2-Aminoethanethiol (cysteamine, β-Mercaptoethylamine, 2-Mercaptoethylamine, Thioethanolamine, Mercaptamine) is a radiation-protective agent that oxidizes in air to form cystamine.
GC13502 Cysteamine HCl
半胱胺盐酸盐; 2-Aminoethanethiol hydrochloride; 2-Mercaptoethylamine hydrochloride
A radioprotective aminothiol
GC49868 D-α-Tocopheryl Quinone
α-Tocopherylquinone
An oxidative metabolite of vitamin E
GC33606 D-(+)-Glucono-1,5-lactone (Gluconic acid lactone)
葡萄糖酸内酯,Gluconic acid lactone
Gluconolactone is a naturally occurring polyhydroxy acid with metal chelating, moisturizing and antioxidant activity.
GC18583 D-α-Hydroxyglutaric Acid
R-2-羟基戊二酸,(R)-2-Hydroxyglutarate; (R)-2-Hydroxyglutaric acid; (R)-2-Hydroxypentanedioic acid

An α-hydroxy acid
GC16306 Dapsone
氨苯砜; 4,4′-Diaminodiphenyl sulfone; DDS
An anti-inflammatory, antimalarial, and antibacterial compound
GC47172 Dapsone-d8
氘代氨苯砜,4,4′-Diaminodiphenyl sulfone-d8; DDS-d8
An internal standard for the quantification of daspone