Reactive Oxygen Species(活性氧)

Reactive oxygen species (ROS), such as superoxide anion (O₂^-), hydrogen peroxide (H₂O₂), and hydroxyl radical (HO•), consist of radical and non-radical oxygen species formed by the partial reduction of oxygen. Cellular ROS are generated endogenously during mitochondrial oxidative metabolism as well as in cellular response to xenobiotics, cytokines, and bacterial invasion.

ROS also activates MAPK pathways by the direct inhibition of MAPK phosphatases. Through PTEN, the PI3K pathway is subject to reversible redox regulation by ROS generated by growth factor stimulation. The activation of autophagy may be a cellular defense mechanism in response to ROS.

Products for Reactive Oxygen Species

Cat.No. 产品名称 Information
GC49868 D-α-Tocopheryl Quinone
α-Tocopherylquinone
An oxidative metabolite of vitamin E
GC33606 D-(+)-Glucono-1,5-lactone (Gluconic acid lactone)
葡萄糖酸内酯,Gluconic acid lactone
Gluconolactone is a naturally occurring polyhydroxy acid with metal chelating, moisturizing and antioxidant activity.
GC18583 D-α-Hydroxyglutaric Acid
R-2-羟基戊二酸,(R)-2-Hydroxyglutarate; (R)-2-Hydroxyglutaric acid; (R)-2-Hydroxypentanedioic acid

An α-hydroxy acid
GC16306 Dapsone
氨苯砜; 4,4′-Diaminodiphenyl sulfone; DDS
An anti-inflammatory, antimalarial, and antibacterial compound
GC47172 Dapsone-d8
氘代氨苯砜,4,4′-Diaminodiphenyl sulfone-d8; DDS-d8
An internal standard for the quantification of daspone
GC16795 DCA
二氯乙酸钠
DCA 是癌细胞中的代谢调节剂'；具有抗癌活性的线粒体。 DCA 抑制 PDHK，导致肿瘤微环境中的乳酸减少。 DCA 增加活性氧 (ROS) 生成并促进癌细胞凋亡。 DCA 也可作为 NKCC 抑制剂。
GC72791 Delmitide acetate
RDP-58 acetate
Delmitide acetate是一种口服活性d-异构体十肽，具有强效抗炎活性。
GC43410 DEPMPO
5-(二乙氧基磷酰)-5-甲基-1-吡咯啉-N-氧化物,5-(Diethoxyphosphoryl)-5-methyl-1-pyrroline-N-oxide
A spin trap for superoxide radical detection
GC43411 DEPMPO-biotin A biotinylated spin trap
GC43439 Diallyl Trisulfide
二烯丙基三硫化物
A natural H₂S donor
GC18517 Diapocynin An inhibitor of NADPH-oxidase
GC45662 Dieugenol
去氢双丁香酚
A neolignan with antioxidative and antiparasitic activities
GC43462 Dihydrolipoic Acid
(+/-)-二氢硫辛酸,DHLA
A reduced form of α-lipoic acid
GC74090 Dimethyl fumarate-d2
富马酸二甲酯-d2
Dimethyl fumarate-d2是氘标记的富马酸二甲酯。
GC47234 Diosmetin-d3
香叶木素 d3
An internal standard for the quantification of diosmetin
GC12520 Diphenyleneiodonium chloride
二苯基氯化碘盐,DPI
二苯碘铵 (DPI) 氯化物 (DPIC) 作为 NADH/NADPH 氧化酶抑制剂，对 Mtb 和 S. aureus 具有有效的抗菌活性。
GC47237 Dipyridamole-d16 A neuropeptide with diverse biological activities
GC47238 Diquat (bromide)
敌草快
An herbicide
GC47239 Diquat-d12 (bromide) A neuropeptide with diverse biological activities
GC47240 Diquat-d4 (bromide) A neuropeptide with diverse biological activities
GC10981 Disodium (R)-2-Hydroxyglutarate
(R)-2-羟基戊二酸二钠盐; Disodium (R)-2-hydroxyglutarate
An α-hydroxy acid
GC11702 DL-Carnitine HCl
混旋肉碱盐酸盐,DL-Carnitine chloride
DL-Carnitine HCl 存在两种异构体，称为 D 和 L。
GC49081 DL-o-Tyrosine
DL-O-络氨酸,NSC 72345; Ortho-tyrosine; o-DL-Tyrosine; o-Tyrosine
A phenylalanine hydroxylation product
GC40557 DMNQ
NSC 69355
Inducer of intracellular ROS generation
GC43569 DPPP
二苯基-1-芘基膦,DPPP
A fluorescent probe for detection of hydroperoxides
GC71480 Drpitor1a Drpitor1a是一种强效的Drp1抑制剂。
GC91590 DTPD-Q
2,5-Bis(o-tolylamino)cyclohexa-2,5-diene-1,4-dione,DTPD-quinone
DTPD-Q is an oxidized derivative of the antioxidant and methylphenyl substituted p-phenylenediamine DTPD.
GC10331 Ebselen
依布硒; SPI-1005; PZ-51; CCG-39161
Ebselen一种具有谷胱甘肽过氧化物酶样活性的硒代有机化合物，是一种抗炎和抗氧化剂。Ebselen是肌醇单磷酸酶（IMPase）的抑制剂，IC₅₀为1.5μM。
GC38149 Ecabet sodium
依卡倍特钠,TA-2711
An antiulcerative and gastroprotective agent
GN10422 Echinacoside
松果菊苷
A glycoside with diverse biological activities
GN10504 Echinocystic acid
刺囊酸
A triterpene with diverse biological activities
GC32887 Efaproxiral (RSR13)
乙丙昔罗,RSR13
An allosteric hemoglobin modifier
GC14586 Efaproxiral Sodium
乙丙昔罗钠,RSR13 sodium
An allosteric hemoglobin modifier
GC15548 Ellagic acid
鞣花酸
Polyphenolic antioxidant
GC31671 Emeramide (BDTH2)
N,N'-二(2-巯基乙基)间苯二甲酰胺,BDTH2
An antioxidant heavy metal chelator
GC67214 Emoxypine succinate
美昔得乐琥珀酸盐
Emoxypine succinate 是一种抗氧化剂。 Emoxypine succinate 可用于创伤后的研究。
GC41290 EMPO
5-(Ethoxycarbonyl)-5-methyl-1-Pyrroline-N-Oxide
A free radical spin trap
GC35996 Epiberberine chloride
表小檗碱氯化物
An alkaloid with diverse biological activities
GC19819 Ermanin
堪非醇3,4'-二-O-甲醚
Ermanin 是一种从 Tanacetum microphyllum 中分离出来的类黄酮。
GC47306 Esculin (hydrate)
Aesculin, Enallachrome
A coumarin with antioxidant and anti-inflammatory activities
GC32965 Ethoxyquin
乙氧基喹啉
An antioxidant used in animal feed
GC61669 Ethyl 3,4-dihydroxybenzoate
3,4-二羟基苯甲酸乙酯,Ethyl protocatechuate
Ethyl3,4-dihydroxybenzoate(Ethylprotocatechuate)是一种抗氧化剂，是一种在花生种子的种皮中发现的脯氨酰羟化酶(prolyl-hydroxylase)抑制剂。Ethyl3,4-dihydroxybenzoate通过激活NO合酶(NOsynthase)并产生线粒体ROS来保护心肌。Ethyl3,4-dihydroxybenzoate可诱导ESCC细胞自噬(autophagy)和凋亡(apoptosis)。Ethyl3,4-dihydroxybenzoate是胶原蛋白合成抑制剂，具有骨骼保护作用。
GN10519 Ethyl ferulate
阿魏酸乙酯
A lipophilic antioxidant
GC16517 Eugenol
丁香酚
丁香酚是一种存在于丁香中的精油，具有抗菌、驱虫和抗氧化活性。
GC65475 Euparin
泽兰素
Euparin 是苯并呋喃的单体化合物，是一种活性氧 (ROS) 抑制剂。 Euparin 对脊髓灰质炎病毒具有抗病毒活性，并且还具有抗抑郁作用。
GC91783 FA16 FA16 is a ferroptosis inducer and an inhibitor of the system xc- cystine/glutamate transporter.
GC43656 FBBBE
Fluorescein bis (benzyl boronic ester)
A fluorescent probe for intracellular H₂O₂ production
GC73543 FC-116 FC-116是一种有效抑制小鼠肿瘤生长的微管蛋白抑制剂。
GC18325 Ferrichrome (iron-free)
Desferrichrome
A fungal hydroxamate siderophore
GC91910 Ferroptosis Inhibitor D1 Ferroptosis Inhibitor D1是一种自由基清除剂和铁下垂抑制剂。