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Home >> Signaling Pathways >> Immunology/Inflammation >> Reactive Oxygen Species

Reactive Oxygen Species(活性氧)

Reactive oxygen species (ROS), such as superoxide anion (O2-), hydrogen peroxide (H2O2), and hydroxyl radical (HO•), consist of radical and non-radical oxygen species formed by the partial reduction of oxygen. Cellular ROS are generated endogenously during mitochondrial oxidative metabolism as well as in cellular response to xenobiotics, cytokines, and bacterial invasion.

ROS also activates MAPK pathways by the direct inhibition of MAPK phosphatases. Through PTEN, the PI3K pathway is subject to reversible redox regulation by ROS generated by growth factor stimulation. The activation of autophagy may be a cellular defense mechanism in response to ROS.

Products for  Reactive Oxygen Species

  1. Cat.No. 产品名称 Information
  2. GC32439 Ferulic acid sodium (Sodium ferulate)

    阿魏酸钠; Coniferic acid sodium

     A phenol with diverse biological activities
  3. GC49344 Fisetin-d5 An internal standard for the quantification of fisetin
  4. GC47387 G6PDi-1

    4-((5-氧代-6,7,8,9-四氢-5H-环庚并[D]嘧啶-2-基)氨基)噻吩-2-甲腈

     An inhibitor of G6PDH
  5. GN10388 Gallic acid

    没食子酸; 3,4,5-Trihydroxybenzoic acid

     A phenol with diverse biological activities
  6. GC61436 Gallic acid hydrate

    没食子酸-水合物; 3,4,5-Trihydroxybenzoic acid hydrate

     A phenol with diverse biological activities
  7. GC49420 Gallic Acid-d2

    3,4,5-Trihydroxybenzoic Acid-d2

     An internal standard for the quantification of gallic acid
  8. GN10741 Garcinone D

    伽升沃 D

     A xanthone with diverse biological activities
  9. GC47397 Gemfibrozil-d6

    吉非罗齐-D6溶液,100PPM,CI-719-d6

     An internal standard for the quantification of gemfibrozil
  10. GC49106 Gentisein

    1,3,7-三羟基-9H-氧杂蒽-9-酮,NSC 329491; 1,3,7-Trihydroxyxanthone

     A xanthone with diverse biological activities
  11. GC45706 GHK-Cu (acetate)

    Gly-His-Lys-Cu(II)

     A tripeptide-copper(II) complex
  12. GC20007 Ginsenoside CK

    20(S)-人参皂苷 C-K; Compound K

    Ginsenoside C-K, a bacterial metabolite of G-Rb1, exhibits anti-inflammatory effects by reducing iNOS and COX-2. Ginsenoside C-K exhibits an inhibition against the activity of CYP2C9 and CYP2A6 in human liver microsomes with IC50s of 32.0±3.6 μM and 63.6±4.2 μM, respectively.
  13. GN10098 Glabridin

    光甘草定

     A natural isoflavonoid with diverse actions
  14. GC92088 GLP-1 (28-36) amide (trifluoroacetate salt)

    Glucagon-like Peptide 1 (28-36) amide; Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-NH2

     胰高血糖素样肽1GLP-1 (28-36) amide (trifluoroacetate salt)是内源性GLP-1R激动剂GLP-1（7-36）酰胺的肽和活性代谢产物。
  15. GC32999 Glucoraphanin

    萝卜硫苷

     A natural compound with protective effects
  16. GC30263 Glucosamine (D-Glucosamine)

    氨基葡萄糖; D-Glucosamine; Chitosamine

     Glucosamine (2-amino-2-deoxy-D-glucose) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. It is commonly used as a treatment for osteoarthritis. Glucosamine（GS） treatment selectively downregulates HIF-1α at the protein level in YD-8 cells via interference of production of the citric acid cycle metabolites.
  17. GN10669 Glucosamine sulfate

    硫酸氨基葡萄糖; D-Glucosamine sulfate

     氨基葡萄糖硫酸盐（D-氨基葡萄糖硫酸盐）是一种氨基糖，是糖基化蛋白质和脂质生化合成的重要前体，用作膳食补充剂。
  18. GC49271 Glufosinate-d3 (hydrochloride) An internal standard for the quantification of glufosinate
  19. GC31353 Glutathione oxidized (L-Glutathione oxidized)

    氧化型谷胱甘肽; L-Glutathione oxidized; GSSG; Oxiglutatione

     An oxidized form of GSH
  20. GC71733 Glutathione oxidized-13C4,15N2 Glutathione oxidized-13C4,15N213C和15N标记的谷胱甘肽被氧化。
  21. GC36176 Gomisin D

    戈米辛 D

     A lignan with diverse biological activities
  22. GC91598 GPX4 16

    Glutathione Peroxidase 4 16

     GPX4 16 is an inhibitor of glutathione peroxidase 4 (GPX4).
  23. GC18788 Graphislactone A An antioxidant
  24. GC32681 GSK2795039 A NOX2 inhibitor
  25. GA10800 H-Cys(Me)-OH

    S-甲基-L-半胱氨酸,L-S-Methylcysteine

     H-Cys(Me)-OH 是一种天然产物，在由甲硫氨酸亚砜还原酶 A (MSRA) 介导的催化抗氧化系统中充当底物，具有抗氧化、神经保护和抗肥胖活性。
  26. GC30006 H2DCFDA (DCFH-DA)

    2',7'-二氯荧光素二乙酸酯,DCFH-DA; 2',7'-Dichlorodihydrofluorescein diacetate

     H2DCFDA（DCFH-DA）是一种氧化还原敏感的荧光探针，可用于测量细胞内活性氧水平。
  27. GC49855 Harmalol (hydrochloride hydrate)

    骆驼蓬酚盐酸盐(二水)

     A β-carboline alkaloid and an active metabolite of harmaline
  28. GN10613 Hesperidin

    橙皮苷; Hesperetin 7-rutinoside

     A natural flavanone rutinoside
  29. GC33479 Hexaconazole ((-)-Hexaconazol)

    己唑醇; (-)-Hexaconazol

     A triazole fungicide
  30. GC34116 Hexahydrocurcumin

    六氢姜黄素

     A natural product and an active metabolite of curcumin
  31. GC64595 HKSOX-1 (5/6-mixture) HKSOX-1 是一种荧光探针，用于成像和检测活细胞以及体内的内源性超氧化物。 HKSOX-1 对超氧阴离子自由基具有极好的选择性和敏感性。
  32. GC34617 HO-1-IN-1 HO-1-IN-1 (Compound 2) 是一种血红素加氧酶 1 (HO-1) 抑制剂，IC50 为 0.25 μM.
  33. GC34618 HO-1-IN-1 hydrochloride Heme Oxygenase-1-IN-1 (Compound 2) hydrochloride 是一种血红素加氧酶 1 (HO-1) 抑制剂，IC50 为 0.25 μM.
  34. GC43870 HPF

    Hydroxyphenyl Fluorescein; 羟苯基荧光素;HPF

    A cell permeable, fluorescent dye for detection of highly reactive oxygen species
  35. GC47436 HT-2 Toxin-13C22

    HT-2毒素-13C22溶液

     An internal standard for the quantification of HT-2 toxin
  36. GC19193 HTHQ

    1-O-hexyl-2,3,5-trimethylhydroquinone; HX-1171; BTT-105

     An antioxidant
  37. GC36262 Huangjiangsu A

    黄姜A

     Huangjiangsu A 是从 D. villosa 中分离的原三角藻皂苷元。Huangjiangsu A 抗 H2O2-诱导的细胞毒性和 ROS 生成，具有肝保护作用。
  38. GC91099 HUP-55

    一种脯氨酸内切肽酶抑制剂
  39. GC47439 Hydralazine-d4 (hydrochloride)

    盐酸肼屈嗪 d4 (盐酸盐)

     A neuropeptide with diverse biological activities
  40. GC52190 Imidazole Ketone Erastin

    IKE

     Imidazole Ketone Erastin是一种有效的、代谢稳定的系统xc- 抑制剂和铁凋亡诱导剂。
  41. GC49290 Indoxyl Sulfate-d5 (potassium salt) An internal standard for the quantification of indoxyl sulfate
  42. GC61440 Iprodione

    异菌脲

     Iprodione是一种二甲酰亚胺类杀菌剂，具有高度特异性的作用，能够通过产生自由氧自由基(ROS)引起氧化损伤，但它似乎没有物种选择性。
  43. GC39600 Iron sucrose

    蔗糖铁; Iron saccharate

     Iron sucrose (Iron saccharate, Sucroferric oxyhydroxide) is an intravenously administered iron product indicated in the treatment of iron deficiency anemia.
  44. GC13795 Isobavachalcone

    补骨脂乙素; Corylifolinin; Isobacachalcone

     A chalcone and flavonoid with diverse biological activities
  45. GN10264 Isochlorogenic acid A

    异绿原酸 A; 3,5-Dicaffeoylquinic acid; 3,5-CQA

     A natural phenolic compound with diverse biological activities
  46. GC39109 Isodeoxyelephantopin

    异去氧苦地胆苦素

     Isodeoxyelephantopin 是一种倍半萜烯内酯，可从Elephantopus scaber 中分离得到。Isodeoxyelephantopin 可诱导活性氧的生成，抑制NF-κB 的激活。Isodeoxyelephantopin 还能调节LncRNA 的表达，有抗乳腺癌的作用。
  47. GC52027 Isolariciresinol

    异落叶松脂素,(+)-Cyclolariciresinol

     A lignan with diverse biological activities
  48. GN10041 Isoquercitrin

    (3-槲皮素)-β-D-葡萄糖苷,Isotrifoliin;

     A natural flavonoid and antioxidant
  49. GC71923 Isorabaichromone Isorabaichromone是一种强效抗氧化剂。
  50. GC31272 Isosteviol ((-)-Isosteviol)

    异甜菊醇; (-)-Isosteviol; iso-Steviol

     Isosteviol (ISV) is mainly obtained by acid hydrolysis of stevioside, the sweet food additive extracted from the plant Stevia Rebaudiana Bertoni (Bertoni). It possesses various biological activities including anti-hyperglycemic, anti-hypertensive, anti-tumor, anti-inflammatory, and antioxidant effects.
  51. GC38803 J14 J14 是一种可逆 sulfiredoxin 抑制剂，IC50 为 8.1 μM。J14 通过抑制 sulfiredoxin 诱导氧化应激 (导致细胞内 ROS 积累)，从而导致细胞毒性和癌细胞死亡。

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