Reactive Oxygen Species(活性氧)

Reactive oxygen species (ROS), such as superoxide anion (O₂^-), hydrogen peroxide (H₂O₂), and hydroxyl radical (HO•), consist of radical and non-radical oxygen species formed by the partial reduction of oxygen. Cellular ROS are generated endogenously during mitochondrial oxidative metabolism as well as in cellular response to xenobiotics, cytokines, and bacterial invasion.

ROS also activates MAPK pathways by the direct inhibition of MAPK phosphatases. Through PTEN, the PI3K pathway is subject to reversible redox regulation by ROS generated by growth factor stimulation. The activation of autophagy may be a cellular defense mechanism in response to ROS.

Products for Reactive Oxygen Species

Cat.No. 产品名称 Information
GC40298 N-acetyl-5-Aminosalicylic Acid
5-乙酰氨基水杨酸
A metabolite of 5-ASA and sulfasalazine
GC39756 N-Acetyl-D-cysteine
N-乙酰基-D-半胱氨酸
N-Acetyl-D-cysteine 具有抗氧化活性，通过与巯基反应清除 ROS，但不能进入谷胱甘肽代谢途径。
GC44301 N-acetyl-L-Cysteine amide
N-乙酰-L-胱氨酸
N-乙酰-L-半胱氨酸酰胺 (NACA) 是一种新型抗氧化剂，它是 N-乙酰半胱氨酸 (NAC) 的酰胺形式，因为它可渗透细胞膜和线粒体膜 . N-乙酰半胱氨酸酰胺可透过细胞膜和线粒体膜，穿过血脑屏障，具有比NAC更高的自由基清除能力、金属螯合活性和还原能力。
GC69530 N-Acetyldopamine dimer-2 N-Acetyldopamine dimer-2 (compound 2) 是具有抗氧化和抗炎活性的 N-acetyldopamine 二聚体可以从蝉皮的黄色粉末中分离出来。N-Acetyldopamine dimer-2 抑制氧化低密度脂蛋白 (LDL) 氧化、ROS 生成、NO 生成和 NF-κB 活性。
GC52073 N-formyl-2-Aminophenol
2’-Hydroxyformanilide, NSC 93900
A bacterial secondary metabolite with antioxidant activity
GC52007 N-hydroxylamine Dapsone
羟胺氨苯砜
An active metabolite of dapsone
GN10276 Naringenin
(S)-柚皮素
A citrus-derived flavonoid
GC70567 NecroX-7 NecroX-7是一种强效的自由基清除剂和HMGB1（高迁移率族盒1）抑制剂。
GN10550 Neosperidin dihydrochalcone
新橙皮苷二氢查尔酮; Neohesperidin DC; NHDC
A semisynthetic glycoside chalcone and artificial sweetener
GC40669 Nerol
橙花醇
A monoterpene
GC16889 Nisoldipine
尼索地平; BAY-k 5552
A calcium channel inhibitor
GC62196 Nisoldipine-d7
尼索地平 d7
Nisoldipine-d7 是 Nisoldipine 的氘代物。Nisoldipine(BAY-k 5552)是高效特异的 L 型 Cav1.2 通道阻断剂，IC50 为 10 nM。
GC11660 Nitisinone
尼替西农; NTBC; Nitisone; SC0735
An HPPD inhibitor
GN10325 Nobiletin
川陈皮素
A flavonoid with diverse biological activities
GC19765 Norbergenin
Norbergenin; Demethylbergenin,
Norbergenin 是 bergenin 的 O-去甲基衍生物，具有中等的抗氧化活性（在 DPPH 自由基清除中 IC50 为 13 μM；在超氧阴离子清除中为 32 μM）。
GC41152 Norgestrel
炔诺孕酮
A synthetic progestin
GC13345 NXY-059
4-[[(1,1-二甲基乙基)氧化亚氨基]甲基]-1,3-苯二磺酸二钠,NXY-059
A free radical spin trap
GC18673 OBA-09 A neuroprotective agent
GC33444 Octahydrocurcumin (Hexahydrobisdemethoxycurcumin)
八氢姜黄素; Hexahydrobisdemethoxycurcumin
An active metabolite of curcumin with diverse biological activities
GC34694 Octyl gallate
没食子酸辛酯; n-Octyl gallate; Stabilizer GA 8

Octyl gallate (Progallin O, n-Ocyl gallate, Stabilizer GA-8, Gallic acid octyl ester), a widely used food additive, shows antimicrobial and antioxidant activity.
GC47826 Omeprazole sulfone-d3
OMEP sulfone-d3, OMP sulfone-d3, OMZ sulfone-d3
An internal standard for the quantification of omeprazole sulfone
GC40921 Orsellinic Acid
苔色酸
A fungal metabolite with antioxidant and neuroprotective activities
GC38973 Osmundacetone
紫萁酮
Osmundacetone 是从 Osmundae Rhizoma 中分离出的一种天然产物。
GC48703 Palmarumycin C3 A fungal metabolite
GC49422 PAR2 (1-6) amide (human) (trifluoroacetate salt)
SLIGKV-NH2
A peptide agonist of PAR2
GC44589 Pelargonidin (chloride)
氯化花葵素

An anthocyanidin with diverse biological activities
GC47932 Pelargonidin 3-O-glucoside (chloride)
天竺葵素-3-氯化葡萄糖苷,Pelargonidin 3-O-glucoside chloride
An anthocyanin with transporter inhibitory and antioxidant properties
GC44594 Pentafluorobenzenesulfonyl fluorescein A selective, fluorescent probe for H₂O₂ detection
GC45777 Peonidin 3-O-glucoside (chloride)
氯化葡萄糖苷芍药素
An anthocyanin with diverse biological activities
GC44602 Peroxynitrite
四(1-甲基-4-吡啶基)卟啉锰; Sodium Peroxynitrite

体内NO与超氧化物反应生成过氧亚硝酸盐。
GC49015 Phenethyl isothiocyanate
2-苯基乙基异硫代氰酸酯
An isothiocyanate with anticancer activity
GC30080 Phillygenin (Phillygenol)
连翘脂素; Phillygenol; Epipinoresinol methyl ether; (+)-Phillygenin
A lignan with diverse biological activities
GC47955 Phloroglucinol
间苯三酚
A phenol with diverse biological activities
GC70477 Phox-I2 Phox-I2是p67phox-Rac1相互作用的选择性抑制剂，与p67phox以高亲和力结合，Kd约为150 nM。
GC71144 Phytoene desaturase-IN-1 Phytoene desaturase-IN-1是一种有效的八氢番茄红素脱饱和酶（PDS）抑制剂（Kd:65.9μM），通过与Phe301残基的π-π堆积效应。
GN10778 Picroside II
胡黄连苷II
A flavonoid with diverse biological activities
GN10120 Pinocembrin
乔松素; (+)-Pinocoembrin; Dihydrochrysin; Galangin flavanone
A flavonoid with diverse biological activities
GC18645 Piperitenone
NSC 667470

A monoterpene
GC71945 Piperkadsin A Piperkadsin A是ROS的强效抑制剂。
GC10282 Piperlongumine
荜茇酰胺; Piplartine
Piperlongumine是从Piper longum L.中提取的天然生物碱化合物，具有多种药理活性，包括抗肿瘤、脂质代谢调节、抗血小板聚集和镇痛活性等。
GC32946 PK11007 PK11000 stabilizes the DBD of both WT and mutant p53 proteins by covalent cysteine modification without compromising DNA binding and effective in inducing cell death.
GC46019 Pluviatolide
(-)-Pluviatolide
A lignan
GC44670 PPA The product of peroxidase-catalyzed reduction of PPHP
GC44672 PPHP A substrate used to quantitate peroxidase activity
GN10599 Procyanidin B2
原花青素 B2; Proanthocyanidin B2
Procyanidin B2 是一种天然黄酮类物质，具有抗肿瘤，抗氧化等作用。
GC47977 Propiconazole
丙环唑
A broad-spectrum triazole fungicide
GC47978 Propiconazole-d3 (nitrate) A neuropeptide with diverse biological activities
GC47979 Propiconazole-d7 An internal standard for the quantification of propiconazole
GC47980 Propionyl-L-carnitine-d3 (chloride)
L-Propionylcarnitine-d3 chloride; ST-261-d3

An internal standard for the quantification of propionyl-L-carnitine
GC49120 Prosaptide TX14(A) (trifluoroacetate salt)
Prosaposin-derived 14-mer Peptide TX14(A)
A peptide fragment of prosaposin and GPR37L1 and GPR37 agonist