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Home >> Signaling Pathways >> Immunology/Inflammation >> Reactive Oxygen Species

Reactive Oxygen Species(活性氧)

Reactive oxygen species (ROS), such as superoxide anion (O2-), hydrogen peroxide (H2O2), and hydroxyl radical (HO•), consist of radical and non-radical oxygen species formed by the partial reduction of oxygen. Cellular ROS are generated endogenously during mitochondrial oxidative metabolism as well as in cellular response to xenobiotics, cytokines, and bacterial invasion.

ROS also activates MAPK pathways by the direct inhibition of MAPK phosphatases. Through PTEN, the PI3K pathway is subject to reversible redox regulation by ROS generated by growth factor stimulation. The activation of autophagy may be a cellular defense mechanism in response to ROS.

Products for  Reactive Oxygen Species

  1. Cat.No. 产品名称 Information
  2. GN10805 Protopanaxdiol

    20 (S)-原人参二醇; 20-Epiprotopanaxadiol; 20(S)-APPD

     A sapogenin with anticancer and antibacterial activities
  3. GN10237 Protopine

    原阿片碱,Corydinine

     An alkaloid with diverse biological activities
  4. GC14847 Psoralidin

    补骨脂定

     A furanocoumarin with anti-cancer activity
  5. GC40006 Pyranonigrin A

    7-hydroxy Pyranonigrin S

     A fungal metabolite with antioxidant activity
  6. GC48019 Quercetin (hydrate)

    槲皮素二水合物

     A flavonoid with diverse biological activities
  7. GC48020 Quercetin-d3 (hydrate) A neuropeptide with diverse biological activities
  8. GN10814 Quercitrin

    槲皮苷; Quercetin 3-rhamnoside

     A flavonoid glycoside
  9. GC62399 RA375 RA375 是 RPN13 (26S 蛋白酶体亚基) 抑制剂。RA375 激活 UPR 信号、ROS 产生和凋亡。RA375 的抗肿瘤活性是 RA190的 10 倍。
  10. GC66363 Randialic acid B Randialic acid B 是一种三萜化合物，是一种甲酰肽受体 1 (FPR1) 拮抗剂。Randialic acid B 阻断人中性粒细胞中的 FPR1 并在体内减轻银屑病样炎症。
  11. GC48029 RC363 An inhibitor of ferroptosis
  12. GC48030 RC574

    An inhibitor of ferroptosis
  13. GC49790 Reuterin

    罗氏菌素,3-Hydroxypropionaldehyde; 3-Hydroxypropanal

     A bacterial glycerol metabolite with antibacterial activity
  14. GC34758 Reynoutrin

    槲皮素-3-D-木糖甙,Quercetin-3-D-xyloside; Reinutrin

    A flavonoid glycoside with diverse biological activities
  15. GN10475 Rhein

    大黄酸; Rheic Acid; Rhubarb yellow; Monorhein

     An anthraquinone derivative
  16. GC37531 Riboflavin Tetrabutyrate

    核黄素四丁酸酯；四丁酸核糖黄素酯

     Riboflavin tetrabutyrate is a lipophilic flavin derivative with antioxidative and lipid peroxide-removing activity.
  17. GC67903 RIDR-PI-103 RIDR-PI-103 是一种活性氧 (ROS) 诱导的药物释放前药，具有与泛 PI3K 抑制剂 (PI-103) 连接的自环化部分。Doxorubicin 和 RIDR-PI-103 在 MDA-MB-361 和 MDA-MB-231 细胞中显示出抑制癌细胞增殖的协同作用。
  18. GC39239 Rifamycin S

    利福霉素S

     Rifamycin S, a quinone and an antibiotic against Gram-positive bacteria (including MRSA), is a clinical drug used to treat tuberculosis and leprosy. Rifamycin S generates reactive oxygen species (ROS) and inhibits microsomal lipid peroxidation.
  19. GC48401 Risuteganib (trifluoroacetate salt)

    ALG-1001

     An anti-integrin peptide
  20. GC69831 ROS-ERS inducer 1 ROS-ERS inducer 1 是一种 II 型 ICD (免疫原性细胞死亡) 诱导剂。ROS-ERS inducer 1 是一种源自 4,5-二芳基咪唑的 Pt(II)-N-杂环卡宾 (Pt(II)-NHC) 复合物。ROS-ERS inducer 1 成功诱导内质网应激 (ERS) 伴随活性氧 (ROS) 的产生，并最终导致 HCC 细胞中损伤相关分子模式 (DAMP) 的释放。ROS-ERS inducer 1 显示出比 Cisplatin 高得多的抗癌活性。
  21. GC39100 Rutaevin

    吴茱萸苦素

     Rutaevin 从 Euodia rutaecarpa 中分离。 Rutaevin 能够抑制 Raw 264.7 巨噬细胞中 LPS 诱导的 NO 的产生。
  22. GN10693 Rutin

    芦丁; Rutoside; Quercetin 3-O-rutinoside

     芦丁 (Rutoside) 是一种在许多植物中发现的类黄酮，具有广泛的生物活性，包括抗炎、抗糖尿病、抗氧化、神经保护、肾保护、保肝和降低 Aβ 寡聚体活性。
  23. GC44860 S1QEL1.1

    S1QEL

     A suppressor of IQ electron leak
  24. GC12517 Sasapyrine

    双水杨酸酯; Salicylsalicylic acid; Disalicylic acid

     An NSAID and a prodrug form of salicylic acid
  25. GC46219 Satratoxin H A trichothecene mycotoxin
  26. GN10132 Schizandrin B

    五味子乙素; γ-Schisandrin; Wuweizisu B

     A dibenzocyclooctadiene with diverse biological activities
  27. GC48973 Sekikaic Acid A lichen metabolite with diverse biological activities
  28. GC62242 Sideroxylin Sideroxylin 是一种从 Callistemon lanceolatus 中分离的 C-甲基化黄酮，对金黄色葡萄球菌具有抗菌活性。Sideroxylin 可抑制卵巢癌细胞增殖并诱导凋亡 (apoptosis)，导致 DNA 断裂，线粒体膜去极化，产生活性氧 (ROS)。
  29. GN10292 Silibinin

    水飞蓟宾,Silibinin A; Silymarin I

     Hepatoprotective flavonoid and 5-LO inhibitor
  30. GC70480 Simvastatin acid calcium hydrate Simvastatin acid calcium hydrate是一种强效的HMG-CoA还原酶（HMGCR）抑制剂。
  31. GC30033 Sinapine thiocyanate

    芥子碱硫氰酸盐

     Sinapine thiocyanate is the thiocyanate salt form of Sinapine, which shows favorable biological activities such as antioxidant and radio-protective activities.
  32. GC31511 Sinapinic acid (Sinapic acid)

    芥子酸; Sinapic acid

     A phenylpropanoid hydroxycinnamic acid with diverse biological activities
  33. GC72573 Sodium 2-oxopropanoate-13C Sodium 2-oxopropanoate-13C是13C标记的2-氧丙酸钠。
  34. GC13616 Sodium ascorbate

    维生素C钠; Sodium ascorbate; Sodium L-ascorbate; Vitamin C sodium salt

     抗坏血酸钠（Sodium L-ascorbate）是一种电子供体，是一种内源性抗氧化剂。抗坏血酸钠选择性抑制 Cav3.2 通道，IC50 为 6.5 μM.抗坏血酸钠也是一种胶原蛋白沉积增强剂和弹性生成抑制剂。
  35. GC37661 Sodium formononetin-3'-sulfonate

    芒柄花黄素-3'-磺酸钠,Sul-F

     Sodium formononetin-3'-sulfonate (Sul-F)是formononetin的水溶性衍生物。
  36. GC62370 Sodium thiocyanate

    硫氰酸钠; Thiocyanate sodium

     Sodium Thiocyanate (NaSCN, Sodium rhodanide, Sodium sulfocyanate, Sodium rhodanate), one of the main sources of the thiocyanate anion, is used as a precursor for the synthesis of pharmaceuticals and other specialty chemicals. Sodium thiocyanate (NaSCN) reduces IL-6, whereas increases IL-10 levels. Sodium thiocyanate also reduces ROS.
  37. GC63197 Sonlicromanol

    KH176

    Sonlicromanol (KH176) 是具有口服活性的活性氧 (ROS) 的调节剂。可用于线粒体疾病的研究。
  38. GC63198 Sonlicromanol hydrochloride

    KH176 hydrochloride

     Sonlicromanol (KH176) hydrochloride 是 Trolox 的衍生物，是可透过血脑屏障的 ROS-redox 调节剂。Sonlicromanol (KH176) hydrochloride 可用于线粒体相关疾病研究。
  39. GC44918 SOTS-1 (technical grade)

    Superoxide Thermal Source, Di(4Carboxybenzyl)Hyponitrite

    A chemical source of superoxide anion in aqueous solution
  40. GC64234 Spiraeoside

    绣线菊甙,Quercetin 4′-O-glucoside

     Spiraeoside 是具有口服活性的天然产物，具有抗氧化活性，抑制活性氧和丙二醛的生成。Spiraeoside 具有抗过敏、抗炎、抗肿瘤活性。
  41. GC32216 Squalene (Super Squalene)

    角鲨烯; Super Squalene; trans-Squalene; AddaVax

     A biosynthetic precursor to steroids
  42. GC40922 SRS11-92

    AA9

     A ferroptosis inhibitor
  43. GC44947 SRS16-86 A ferroptosis inhibitor
  44. GC49500 Stobadine

    2,8-二甲基-2,3,4,4A,5,9B-六氢-1H-吡啶并[4,3-B]吲哚二盐酸盐

     A pyridoindole antioxidant
  45. GC31709 Succinobucol (AGI-1067)

    AGI-1067; Probucol monosuccinate

     A probucol derivative with diverse biological activities
  46. GC37700 Succinyl phosphonate trisodium salt

    琥珀酰膦酸盐

     Succinyl phosphonate trisodium salt (SP) 琥珀酰膦酸三钠盐是 α-酮戊二酸脱氢酶 (KGDHC ) 抑制剂，可有效抑制肌肉，细菌，脑和人成纤维细胞中的 KGDHC。Succinyl phosphonate trisodium salt (SP) 抑制 2-氧代戊二酸脱氢酶 (OGDH)，以细胞特异性代谢依赖性方式损害癌细胞的活力。Succinyl phosphonate trisodium salt (SP) 抑制谷氨酸诱导的谷氨酸刺激的海马神经元中的 ROS 产生。
  47. GC30532 Sulcotrione

    磺草酮

    Sulcotrione是β-三酮除草剂，可以抑制羟基苯基丙酮酸双加氧酶(HPPD)。
  48. GC48764 Sydowinin B

    MS-347b

     A xanthone polyketide with immunosuppressant activity
  49. GC48120 T-2 Toxin-13C24

    Fusariotoxin T-2-13C24, Insariotoxin-13C24, Mycotoxin T-2-13C24

     A neuropeptide with diverse biological activities
  50. GC44989 TAN 420E

    Dihydroherbimycin A

     A bacterial metabolite
  51. GC49426 Taurine-d4

    牛磺酸-D4,2-Aminoethanesulfonic acid-d4

     An internal standard for the quantification of taurine

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