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Home >> Signaling Pathways >> Immunology/Inflammation >> STING

STING

STING (Stimulator of Interferon Genes) is a transmembrane protein localized to the endoplasmic reticulum that undergoes a conformational change in response to direct binding of cyclic dinucleotides (CDNs), resulting in a downstream signaling cascade involving TBK1 activation, IRF-3 phosphorylation, and production of IFN-β and other cytokines.

STING is a pattern recognition receptor of cyclic dinucleotides as well as an innate immune adaptor protein that enables signaling from cytoplasmic receptors to the transcription factor interferon regulatory factor 3. Initiation of these pathways leads to the expression of type I interferons and proteins associated with antiviral and antitumor immunity. Small molecules capable of triggering STING-dependent cellular processes are effective at blocking virus replication, enhancing vaccine efficacy, and facilitating immune response to cancer cells.

Products for  STING

  1. Cat.No. 产品名称 Information
  2. GC49912 13C20,15N10-Cyclic di-GMP (sodium salt)

    13C20,15N10-c-di-GMP, 13C20,15N10-Cyclic diguanylate, 13C20,15N10-3’,5’-Cyclic diguanylic Acid

     An internal standard for the quantification of cyclic di-GMP
  3. GC42080 2'2'-cGAMP (sodium salt)

    Adenosine-Guanosine 2’,2’-cyclic monophosphate, cGAMP(2’-5’), 2’,2’-Cyclic GMP-AMP

     A synthetic dinucleotide
  4. GC42090 2'3'-cGAMP (sodium salt)

    Guanosine-Adenosine 2',3'-cyclic monophosphate, 2'-3'-Cyclic GMP-AMP

     A second messenger and inducer of IFN-β production
  5. GC25014 3',3'-cGAMP

    3',3'-cyclic GMP-AMP, Cyclic GMP-AMP, cGAMP

     3',3'-cGAMP (3',3'-cyclic GMP-AMP, Cyclic GMP-AMP, cGAMP) activates the endoplasmic reticulum (ER)-resident receptor stimulator of interferon genes (STING), thereby inducing an antiviral state and the secretion of type I IFNs.
  6. GC42245 3'3'-cGAMP (sodium salt)

    AdenosineGuanosine 3',3'-cyclic monophosphate, 3',3'-Cyclic GMP-AMP, c-GpAp

     A second messenger and inducer of IFN-β production
  7. GC48381 5'-pApA (sodium salt)

    c-di-AMP Control, Cyclic di-AMP Negative Control

     A linearized form of cyclic di-AMP
  8. GC48375 5'-pGpG (sodium salt)

    c-di-GMP Control, Cyclic di-GMP Negative Control

     A linearized form of cyclic di-GMP
  9. GC49238 93-O17S An ionizable cationic lipidoid
  10. GC31649 ADU-S100 (ML RR-S2 CDA)

    MIW815; ML RR-S2 CDA

     ADU-S100 (ML RR-S2 CDA) (MIW815) 是干扰素基因刺激物 (STING) 的激活剂，可导致有效的全身性肿瘤消退和免疫。
  11. GC39161 ADU-S100 disodium salt

    MIW815 disodium salt; ML RR-S2 CDA disodium salt

     ADU-S100 disodium salt（MIW815 disodium salt）是干扰素基因刺激蛋白（STING）的激活剂，Kd为4.61±0.42μM。
  12. GC74005 AK59 AK59是一种STING降解剂，通过利用HERC4（一种hect结构域E3连接酶）起作用。
  13. GC71433 Anti-inflammatory agent 70 Anti-inflammatory agent 70（N-Me-SP23）是一种STING蛋白降解剂，抑制STING信号通路。
  14. GC42880 Avenanthramide-C methyl ester Inhibitor of NF-κB activation
  15. GC91659 BDW-OH BDW-OH is an active metabolite of the STING agonist and prodrug BDW568 .
  16. GC91379 BDW568 BDW568是干扰素基因刺激剂（STING）的激动剂，也是BDW-OH.1的前药形式。
  17. GC91947 BH400 BH400是过氧化物酶体增殖物激活受体α (PPARα)的激动剂和干扰素基因刺激因子抑制剂(STING；Ic50 = 8.1 μm)。
  18. GC42953 BMS 345541 (trifluoroacetate salt) BMS 345541 is a cell permeable inhibitor of the IκB kinases IKKα and IKKβ (IC50s = 4 and 0.3 μM).
  19. GC90705 BSP-16

    LF250

    STING激动剂
  20. GC46983 C-170 A STING inhibitor
  21. GC46984 C-171 A STING inhibitor
  22. GC33823 C-176 (STING inhibitor 1)

    N-(4-碘苯基)-5-硝基呋喃-2-甲酰胺

     C-176（STING 抑制剂 1）强烈降低 STING 介导的，但不降低 RIG-I 或 TBK1 介导的 IFNβ 报告基因活性。
  23. GC38494 C-178

    N-(二苯并[B,D]呋喃-3-基)-5-硝基呋喃-2-甲酰胺

     A STING inhibitor
  24. GC13643 c-di-AMP

    环二腺苷酸; Cyclic diadenylate; Cyclic-di-AMP

     C-di-AMP是STING(刺激内质网的蛋白)的激动剂,通过与该跨膜蛋白结合,激活TBK3-IRF3信号通路,进而引发I型IFN和TNF的产生。
  25. GC62893 c-di-AMP diammonium

    Cyclic diadenylate diammonium; Cyclic-di-AMP diammonium

     c-di-AMP diammonium 是 STING 激动剂，其与 STING 结合，从而激活 TBK3-IRF3 信号传导途径，随后引发 I 型 IFN 和 TNF 产生。c-di-AMP diammonium 是一种细菌第二信使，主要在革兰氏阳性细菌中，可调节细胞生长，存活以及毒力。c-di-AMP diammonium 也调节宿主免疫反应。c-di-AMP diammonium 可作为一种有效的粘膜佐剂，刺激体液和细胞反应。
  26. GC64445 c-di-AMP disodium

    Cyclic diadenylate disodium; Cyclic-di-AMP disodium

     A bacterial second messenger
  27. GC62198 c-di-AMP sodium

    c-di-AMP, Cyclic di-Adenosine monophosphate, 3',5'-Cyclic diadenylic acid, Cyclic diadenylate

     C-di-AMP是STING(刺激内质网的蛋白)的激动剂,通过与该跨膜蛋白结合,激活TBK3-IRF3信号通路,进而引发I型IFN和TNF的产生。
  28. GC50687 c-Di-AMP sodium salt Endogenous STING and DDX41 agonist; mediates DDX41-STING interaction
  29. GC50292 c-Di-GMP sodium salt Endogenous STING and DDX41 agonist; activates STING-dependent signaling
  30. GC43176 CAY10575

    IKK2 Inhibitor 3, Polo-like Kinase Inhibitor 1

     An IKKβ and Plk1 inhibitor
  31. GC18782 CAY10657 A likely inhibitor of IKK2 kinase
  32. GC47054 CAY10748 A STING agonist
  33. GC14727 CCCP

    羰基氰化氯苯腙,Carbonyl cyanide 3-chlorophenylhydrazone; Carbonyl Cyanide m-Chlorophenylhydrazone

     Carbonylcyanide-3-chlorophenylhydrazone (CCCP) 是一种质子载体，可导致线粒体内膜中的质子梯度解偶联，从而抑制 ATP 合成速率。
  34. GC31696 cGAMP (Cyclic AMP-GMP)

    Cyclic GMP-AMP; 3',3'-cGAMP

     cGAMP (Cyclic AMP-GMP) (Cyclic GMP-AMPP) 在后生动物中作为内源性第二信使发挥作用，并响应胞质 DNA 触发干扰素产生。
  35. GC63758 cGAMP diammonium

    Cyclic GMP-AMP diammonium; 3',3'-cGAMP diammonium

     cGAMP (Cyclic GMP-AMPP) diammonium 作为内源性第二信使发挥作用，并触发干扰素的产生以响应胞浆 DNA。cGAMP diammonium 激活干扰素基因刺激因子 (STING)，激活导致产生 I 型干扰素和其他免疫介质的信号级联。
  36. GC34329 ChX710 ChX710可以启动I型干扰素对胞质DNA的反应，诱导ISRE启动子序列、特异性细胞干扰素刺激基因(ISGs)和干扰素调节因子(IRF)3的磷酸化。
  37. GC31875 CL656 (c-[2'FdAMP(S)-2'FdIMP(S)])

    c-[2’FdAMP(S)-2’FdIMP(S)]

     CL656 (c-[2'FdAMP(S)-2'FdIMP(S)]) 是干扰素基因 (STING) 刺激物的激活剂。
  38. GC45413 Cridanimod (sodium salt)

    吖啶酮乙酸钠

     An inducer of type I interferon production
  39. GC47128 CU-32 A cGAS inhibitor
  40. GC47129 CU-76 A cGAS inhibitor
  41. GC43339 Cyclic di-AMP (sodium salt)

    c-di-AMP, Cyclic di-Adenosine monophosphate, 3',5'-Cyclic diadenylic acid, Cyclic diadenylate

     A bacterial second messenger
  42. GC15048 Cyclic di-GMP

    环二鸟苷酸,c-di-GMP; cyclic diguanylate; 5GP-5GP

     A bacterial second messenger and cyclic dinucleotide
  43. GC19526 Cyclic di-GMP disodium

    c-di-GMP, Cyclic diguanylate, 3',5'-Cyclic diguanylic acid

     A bacterial second messenger and cyclic dinucleotide
  44. GC43340 Cyclic di-IMP (sodium salt)

    c-di-IMP, Cyclic di-inosine monophosphate

     A synthetic second messenger
  45. GC48397 Cyclic di-UMP (sodium salt)

    c-di-UMP, c-UpUp, Cyclic di-Uridine monophosphate, 3’3’-Cyclic UMP-UMP

     A pyrimidine-containing CDN
  46. GC62917 Cyclic-di-GMP diammonium

    c-di-GMP diammonium; cyclic diguanylate diammonium; 5GP-5GP diammonium

     Cyclic di-GMP (c-di-GMP) diammonium 是一种 STING 激活剂和无处不在的第二信使，调节生物膜的形成、运动和各种细菌的毒力。
  47. GC62372 Cyclic-di-GMP sodium

    c-di-GMP sodium; cyclic diguanylate sodium; 5GP-5GP sodium

     A bacterial second messenger and cyclic dinucleotide
  48. GC35853 diABZI STING agonist-1 An agonist of the STING pathway
  49. GC35854 diABZI STING agonist-1 Tautomerism diABZI STING agonist (diABZI STING agonist-1, Compound 3, Tautomerism) is a potent non-nucleotide STING agonist and has tremendous potential to improve treatment of cancer in humans.
  50. GC35855 diABZI STING agonist-1 trihydrochloride

    Diamidobenzimidazole STING Agonist-1, STING Agonist (Compound 3), STING Agonist diABZI

     diABZI STING agonist-1 trihydrochloride 作为一种 STING 激动剂，通过未知受体内化到细胞质中并诱导 STING 的激活和二聚化，然后是 TBK1/IRF3 磷酸化，从而导致 I 型 IFN 反应。
  51. GC63473 diABZI-C2-NH2 diABZI-C2-NH2是一种含有伯胺功能的活性类似物，是一种 STING 激动剂。

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