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Home >> Signaling Pathways >> Immunology/Inflammation >> STING

STING

STING (Stimulator of Interferon Genes) is a transmembrane protein localized to the endoplasmic reticulum that undergoes a conformational change in response to direct binding of cyclic dinucleotides (CDNs), resulting in a downstream signaling cascade involving TBK1 activation, IRF-3 phosphorylation, and production of IFN-β and other cytokines.

STING is a pattern recognition receptor of cyclic dinucleotides as well as an innate immune adaptor protein that enables signaling from cytoplasmic receptors to the transcription factor interferon regulatory factor 3. Initiation of these pathways leads to the expression of type I interferons and proteins associated with antiviral and antitumor immunity. Small molecules capable of triggering STING-dependent cellular processes are effective at blocking virus replication, enhancing vaccine efficacy, and facilitating immune response to cancer cells.

Products for  STING

  1. Cat.No. 产品名称 Information
  2. GC62609 E7766 disodium E7766 disodium 是一种大环桥连 STING 激动剂，Kd 为 40 nM。E7766 disodium 显示出强大的泛基因型和抗肿瘤活性。
  3. GC52334 ENPP1 Inhibitor 4e

    cGAMP-compound 4e

     An ENPP1 inhibitor
  4. GC64257 Gelsevirine

    钩吻绿碱

     Gelsevirine 是 Gelsemium elegans 中的主要生物碱，具有有效的抗焦虑作用。Gelsevirine 的抗焦虑机制可能与大脑中甘氨酸受体的激动作用有关。Gelsevirine 具有抗增殖活性，对 SW480 细胞和 MGC80-3 细胞的 IC50 值分别为 1.41 mM 和 1.22 mM。
  5. GC34610 H-151 H-151是STING的低分子量拮抗剂,可阻断激活诱导的STING棕榈酰化,对STING信号传导有显著抑制作用,可用于自身炎症性疾病的研究。
  6. GC63012 IACS-8803 diammonium IACS-8803 diammonium 是一种高效环状二核苷酸的 STING 激动剂，具有强大的全身抗肿瘤作用。
  7. GC62586 IACS-8803 disodium IACS-8803 disodium 是一种高效环状二核苷酸的 STING 激动剂，具有强大的全身抗肿瘤作用。
  8. GC43894 IKK2 Inhibitor VI

    5-Phenyl-2-ureidothiophene-3-carboxylic Acid Amide

     An inhibitor of IKK2
  9. GC52291 KAS 08 A STING activator
  10. GC91789 LB244 LB244 is an irreversible STING antagonist.
  11. GC49673 M04 A STING agonist
  12. GC18988 ML RR-S2 CDA (ammonium salt)

    ADU-S100铵盐,MIW815 ammonium salt; ML RR-S2 CDA ammonium salt

     An activator of STING
  13. GC61092 MSA-2

    5,6-dimethoxy-γ-oxo-benzobthiophene-2-Butanoic Acid

     MSA-2是一种口服非核苷酸干扰素基因刺激因子（STING）激动剂，对人的STING亚型WT和HAQ的EC50分别为8.3和24μM。
  14. GC63082 MSA-2 dimer MSA-2 dimer 是一种具有选择性和口服活性的非核苷酸 STING 激动剂 (Kd=145 μM)，有长期抗肿瘤和免疫原活性。MSA-2 dimer 作为非共价二聚体与 STING 结合，其渗透率高于循环二核苷酸。
  15. GC44388 NF-κB Control

    SN50M

     A negative control peptide used with NF-κB inhibitor
  16. GC48985 NF-κB Inhibitor (trifluoroacetate salt)

    SN50 Peptide

     A cell-permeable peptide that blocks nuclear import of NF-κB
  17. GC91777 NVS-STG2 NVS-STG2 is an agonist of stimulator of interferon genes (STING).
  18. GC13693 Omaveloxolone (RTA-408)

    RTA 408

     A synthetic triterpenoid that blocks Keap1/Nrf2 signaling
  19. GC91595 PDIC-NC PDIC-NC is an activator of stimulator of interferon genes (STING) and an anticancer agent.
  20. GC91688 PDIC-NN PDIC-NN is an intermediate in the synthesis of PDIC-NS , an activator of stimulator of interferon genes (STING) with anticancer activity.
  21. GC91820 PDIC-NS PDIC-NS is an activator of stimulator of interferon genes (STING).
  22. GC66392 PROTAC STING Degrader-1 PROTAC STING Degrader-1 (Compound SP23) 是一种 STING PROTAC 降解剂，其 DC50 为 3.2 μM。PROTAC STING Degrader-1 具有抗炎活性。
  23. GC91096 S-72

    一种微管聚合抑制剂。
  24. GC67719 SN-001 SN-001 是一种 STING 抑制剂，IC50 为 3.82 μM。
  25. GC63905 SN-008 SN-008 是 SN-011 的低活性类似物，可用来作为阴性对照。
  26. GC49400 SN-011

    N-(3-(4-氟苯基磺酰氨基)-4-羟基苯基)-[1,1'-联苯]-4-甲酰胺

     A STING antagonist
  27. GC61293 SR-717 SR-717 是一种稳定的环磷酸鸟苷-磷酸腺苷 (cGAMP) 模拟物，具有抗肿瘤活性。
  28. GC44948 StA-IFN-1 An IFN induction pathway inhibitor
  29. GC48109 STING Agonist 12b A STING agonist
  30. GC90784 STING Agonist 12L

    Stimulator of Interferon Genes Agonist 12L

    STING激动剂
  31. GC48110 STING Agonist 1a A STING agonist
  32. GC90785 STING Agonist 23

    Stimulator of Interferon Genes Agonist 23

    STING激动剂
  33. GC45570 STING Agonist C11 An agonist of the STING pathway
  34. GC90982 STING Agonist D61

    D61, Stimulator of Interferon Genes Agonist D61

    STING激动剂
  35. GC12943 STING agonist-1

    G10

     An indirect activator of STING signaling
  36. GC65282 STING agonist-12

    STING Agonist-12

     A STING agonist
  37. GC69959 STING agonist-20 STING agonist-20 (compound 95) 是一种有效的 STING 激动剂，用于合成 XMT-2056。STING agonist-20 可作为疫苗佐剂，用于癌症以及其他炎症，免疫性疾病的研究。
  38. GC69961 STING agonist-22 STING agonist-22 (CF501) 是一种有效的非核苷酸 STING 激动剂。 STING agonist-22 是一种佐剂，通过激活 STING 来诱导 I 型干扰素 (IFN-I) 反应和促炎细胞因子的产生。 STING agonist-22 可用作增强原始蛋白疫苗的佐剂，产生有效、广泛和长期的免疫保护。 STING agonist-22 可用于 SARS-CoV-2 变异和 sarbecovirus 疾病研究。
  39. GC37692 STING agonist-3

    CS-0029879, Diamidobenzimidazole STING Agonist, diABZI-3, EX-A3217, HY-103665, STING Agonist-3

     A STING agonist
  40. GC69962 STING agonist-3 trihydrochloride STING agonist-3 trihydrochloride 源于专利 WO2017175147A1 (实施例10)，是一种选择性和非核苷酸的小分子 STING 激动剂，pEC50 和 pIC50 分别为 7.5 和 9.5。STING agonist-3 trihydrochloride 具有持久的抗肿瘤作用，并且在改善癌症研究方面具有巨大潜力。
  41. GC37693 STING agonist-4

    CS-0087594, Diamidobenzimidazole STING Agonist-2, diABZI-4, HY-123943, STING Agonist-4, STING Agonist diABZI Compound 2

     A STING agonist
  42. GC66008 STING agonist-7 STING agonist-7 是一种非核苷酸 STING 激动剂，选择性结合小鼠 STING 而不是人类 STING。STING agonist-7 穿透细胞膜较差。
  43. GC69963 STING agonist-8 dihydrochloride STING agonist-8 dihydrochloride (5-AB) 是一种有效 STING 激动剂，在 THP1-Dual KI-hSTING-R232 细胞中的 EC50 为 27 nM。
  44. GC34322 STING ligand-1 STINGligand-1是一种STING配体，作用于HAQSTING的IC50为68nM。
  45. GC71186 STING-IN-4 STING-IN-4（化合物1）是一种STING抑制剂，可抑制STING表达，从而减少STING和核因子-κB（NF-κB）信号传导的激活。
  46. GC71189 STING-IN-5 STING-IN-5是一种强效的STING抑制剂，抑制LPS诱导的巨噬细胞中NO的合成，IC50值为1.15μM。
  47. GC46227 STING18 A competitive STING ligand
  48. GC52084 YSK05 An ionizable cationic amino lipid

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