Membrane Transporter/Ion Channel(跨膜转运)

Cat.No. 产品名称 Information

GC47458 Ipragliflozin-13C6 A neuropeptide with diverse biological activities

GC47423 Heptaminol

6-氨基-2-甲基-2-庚醇

An aliphatic amine with cardiotonic and sympathomimetic activities

GC47402 Glimepiride-d4 A neuropeptide with diverse biological activities

GC47354 Flonicamid

氟啶虫酰胺

A pyridinecarboxamide insecticide

GC47352 FK-506-13C-d2

他克莫司-13C,FK506-13C,d2; Fujimycin-13C,d2; FR900506-13C,d2

An internal standard for the quantification of FK-506

GC47338 Fenoxycarb

苯氧威

A non-neurotoxic carbamate insecticide

GC47321 Etifoxine-13C-d3

艾替伏辛 13C-d3

A neuropeptide with diverse biological activities

GC47260 Dofetilide-d4

多非利特 D4; UK 68789 D4

An internal standard for the quantification of dofetilide

GC47237 Dipyridamole-d16 A neuropeptide with diverse biological activities

GC47158 Cypermethrin

氯氰菊酯

A type II pyrethroid insecticide

GC47155 Cyfluthrin

氟氯氰菊酯,beta-Cyfluthrin

A pyrethroid insecticide

GC47149 Cyclopiazonic Acid-13C20

CPA-13C20

A neuropeptide with diverse biological activities

GC47100 Clevidipine-d7

氯维地平 d7

A neuropeptide with diverse biological activities

GC47022 Camostat-d6 (hydrochloride) A neuropeptide with diverse biological activities

GC47021 Caloxin 2A1 (trifluoroacetate salt)

VSNSNWPSFPSSGGG-NH2

A neuropeptide with diverse biological activities

GC46957 Bumetanide-d5

布美他尼 d5

An internal standard for the quantification of bumetanide

GC46891 ATPA (hydrate) An agonist of GluR5

GC46841 Amiloride (hydrochloride) (hydrate)

MK-870

具有多种生物活性的神经肽

GC46831 Alloisolithocholic Acid

石胆酸杂质,AILCA

An allomonohydroxy bile acid

GC46806 Adenosine 5'-diphosphate (potassium salt hydrate)

5'-ADP, ADP

A neuropeptide with diverse biological activities

GC46744 8-Bromoadenosine 5′-triphosphate (sodium salt hydrate)

8-bromo ATP

A neuropeptide with diverse biological activities

GC46464 17R(18S)-EpETE

17R,18S-EEQ, 17R,18S-epoxy Eicosatetraenoic Acid

An EPA metabolite and activator of K_Ca1.1/BK channels

GC46366 1,2,3,4-Tetrahydro-β-carboline

1,2,3,4-四氢-9H-吡啶[3,4-B]并吲哚

A serotonin reuptake inhibitor and metabolite of tryptamine

GC46344 (R,S)-AMPA (hydrate)

αamino3hydroxy5methyl4Isoxazolepropionic Acid

A neuropeptide with diverse biological activities

GC46339 (R)-4-Amino-3-hydroxybutyric Acid

(R)-(-)-4-氨基-3-羟基丁酸

A GABA receptor modulator

GC46312 (±)-Verapamil-d3 (hydrochloride)

(±)-Verapamil-d3 hydrochloride; CP-16533-1-d3 hydrochloride

A neuropeptide with diverse biological activities

GC46260 (±)17(18)-EpETE

(±)17,18-EEQ, (±)17,18-epoxy Eicosatetraenoic Acid

A neuropeptide with diverse biological activities

GC61379 VU0463271 quarterhydrate VU0463271quarterhydrate是神经特异性氯钾协同转运蛋白2(KCC2)的有效抑制剂，其IC50值为61nM。

GC61374 Vonoprazan Fumarate

富马酸沃诺拉赞; TAK-438

A selective and reversible proton pump inhibitor

GC61345 Transdermal Peptide Disulfide TFA

TD 1 Disulfide(peptide) TFA

TransdermalPeptideDisulfideTFA(TD1Disulfide(peptide)TFA)是由11个氨基酸组成的多肽，可以与Na+/K+-ATPasebeta-subunit(ATP1B1)结合，主要与ATP1B1的C末端相互作用。TransdermalPeptideDisulfideTFA能够增强一些大分子在皮肤中的传递。

GC61342 TPC2-A1-N TPC2-A1-N是一种亲脂性的、膜透异位选择性双孔通道2（TPC2)小分子激动剂。TPC2-A1-N通过在独立结合位点模拟NAADP和PI(3,5)P2的生理作用发挥作用。TPC2-A1-N对溶酶体活性有反向作用，并以TPC2依赖的方式增加溶酶体腔内的pH。

GC61317 Tebanicline dihydrochloride

Ebanicline dihydrochloride; ABT-594 dihydrochloride

Tebaniclinedihydrochloride(Ebaniclinedihydrochloride)是nAChR的调节物，具有有效的口服止痛活性。抑制cytisine与神经元nAChR的结合的Ki值为37pM。

GC61292 SR33805 SR33805是一种有效的Ca2+通道拮抗剂，在去极化和极化条件下的EC50值分别为4.1nM和33nM。SR33805阻止L型而不是T型Ca2+通道。SR33805可用于研究急性或慢性心脏衰竭。

GC61288 Spadin TFA SpadinTFA是一种从血液中释放的前肽衍生的天然肽，能够阻断TREK-1(KCNK2或K2P2.1)通道的活性。SpadinTFA与TREK-1特异性结合，亲和力为10nM。SpadinTFA是一种有效的抗抑郁药。

GC61251 Rosuvastatin D3

ZD 4522 D3

RosuvastatinD3(ZD4522D3)是Rosuvastatin的一种氘代化合物。Rosuvastatin(ZD4522)是一种竞争性HMG-CoA还原酶抑制剂，IC50为11nM。Rosuvastatin有效阻断人类醚-a-go-go相关基因(hERG)电流，IC50为195nM，延迟心脏复极化，从而延长动作电位持续时间(APDs)和校正QT间期(QTc)间隔。

GC61250 Ropivacaine

罗哌卡因

Ropivacaine is a member of the amino amide class of local anesthetics.

GC61248 RO2959 monohydrochloride RO2959monohydrochloride是一种有效的选择性CRAC通道抑制剂，IC50为402nM。RO2959monohydrochloride是由Orai1/Stim1通道介导的钙存储进入(SOCE)的有效阻滞剂，IC50为25nM。RO2959monohydrochloride还是人IL-2产生的有效抑制剂，有效阻断T细胞受体触发的基因表达和T细胞功能途径。

GC61186 Picrotoxinin

木防己苦毒宁

Picrotoxinin, a potent convulsant, is a chloride channel blocker. Picrotoxinin is a noncompetitive GABAA receptor antagonist, which negatively modulates the action of GABA on GABAAA receptors.

GC61175 PF-06305591 dihydrate PF-06305591dihydrate是一种有效的、高选择性的电压门控钠通道NaV1.8的阻断剂，其IC50值为15nM。具有良好的临床前体外ADME(吸收、分布、代谢和排泄)和安全性。

GC61155 Omeprazole sodium

奥美拉唑钠,H 16868 sodium

An irreversible inhibitor of the gastric proton pump

GC61141 NSC 15364

1,3-二(4-氨基苯基)脲

NSC15364是一种VDAC1寡聚化和细胞凋亡(apoptosis)抑制剂。

GC61139 Nothofagin

1-(3-BETA-D-吡喃葡萄糖基-2,4,6-三羟基苯基)-3-(4-羟基苯基)-1-丙酮

Nothofagin是一种二氢查尔酮，是从如意宝(Aspalathuslinearis)中分离得到的。Nothofagin通过阻断钙(calcium)内流来下调NF-κB的转运。Nothofagin具有抗氧化活性，可改善各种炎症反应，例如脓毒症反应和血管炎症。

GC61110 Nav1.1 activator 1 Nav1.1activator1(compound4)是强有效的、能透过血脑屏障的、Nav1.1激动剂，0.03μM可增加衰减Nav1.1电流的时间常数τ。对Nav1.2、Nav1.5、Nav1.6有显著的选择性。

GC61066 Minoxidil sulfate

米诺地尔硫酸盐

Minoxidil (U-58838) is a potent direct-acting peripheral vasodilator that reduces peripheral resistance and produces a fall in blood pressure.

GC61046 Methocarbamol D5

美索巴莫 D5

An internal standard for the quantification of methocarbamol

GC60975 Lansoprazole Sulfide D4

兰索拉唑硫醚-D4

LansoprazoleSulfideD4是LansoprazoleSulfide的氘代物。LansoprazoleSulfide是质子泵抑制剂Lansoprazole的活性代谢产物。LansoprazoleSulfide是一种口服活性抗结核药，细胞内的IC50值为0.59µM，肉汤中的IC50值为0.46µM。

GC60929 Ilaprazole sodium

艾普拉唑钠,IY-81149 sodium

A gastric proton pump inhibitor

GC60890 Guvacine

去甲槟榔次碱

An inhibitor of GABA uptake

GC60862 GABAA receptor agent 1

2-(4-氯苯基)-6-硝基-1H-苯并[D]咪唑

GABAA receptor agent 1 is a high affinity ligand for Gamma-aminobutyric acid A (GABAA) receptor that exerts potent anticonvulsant activity.

GC60834 Fenamic acid

甲芬那酸; N-苯基邻氨基苯甲酸; N-Phenylanthranilic acid

Fenamic acid (N-Phenylanthranilic acid, 2-(Phenylamino)benzoic acid, 2-Anilinobenzoic acid, Diphenylamine-2-carboxylic acid) serves as a parent structure for several nonsteroidal anti-inflammatory drugs (NSAIDs), including mefenamic acid, tolfenamic acid, flufenamic acid, and meclofenamic acid.