Na+/K+ ATPase(Na+/K+ ATP酶)

Na⁺/K⁺ ATPase (Sodium potassium pump) is a transmembrane protein complex found in all higher eukaryotes acting as a key energy-consuming pump maintaining ionic and osmotic balance in cells. Na⁺/K⁺ ATPase is an emerging cancer target that merits further investigation.

The constant activity of the Na⁺/K⁺-ATPase (NKA, or Na⁺ pump) is essential for re-establishing and maintaining this gradient. In cardiac and vascular smooth muscle the principal isoforms of the NKA are α1 and α2 and their physiological role is controlled both by their unique and independent signalling pathways, and their discrete subcellular distribution.

Products for Na+/K+ ATPase

Cat.No. 产品名称 Information
GC64887 Gitoxin
格列苯脲杂质A
Gitoxin 是 Na+/K+-ATPase 的抑制剂，是Digitoxin 的降解代谢物，因ZOH 基团靠近C-17β 位置，可改善药代动力学和药效学数据。
GC63832 Strophanthidin
葡萄球菌素
Strophanthidin 是一种天然的心脏糖苷。Strophanthidin 0.1 和 1 nmol/L 增加 Na+/K+-ATPase 活性，1~100 μ mol/L 抑制 Na+/K+-ATPase 活性，而 Strophanthidin 10 和 100 nmol/L 对 Na+/K+-ATPase活性无影响。Strophanthidin 增加舒张期和收缩期胞内 Ca2+ 浓度。
GC61628 Neriifolin
黄夹次甙乙; 17β-Neriifolin
Neriifolin是一种穿透中枢神经系统的强心苷，是一种Na+,K+-ATPase的抑制剂。Neriifolin可靶向beclin1，抑制LC3相关吞噬体的形成，改善实验性自身免疫性脑脊髓炎(EAE)的发展。Neriifolin诱导人肝癌HepG2细胞周期阻滞和凋亡。
GC61345 Transdermal Peptide Disulfide TFA
TD 1 Disulfide(peptide) TFA
TransdermalPeptideDisulfideTFA(TD1Disulfide(peptide)TFA)是由11个氨基酸组成的多肽，可以与Na+/K+-ATPasebeta-subunit(ATP1B1)结合，主要与ATP1B1的C末端相互作用。TransdermalPeptideDisulfideTFA能够增强一些大分子在皮肤中的传递。
GC38903 Deslanoside
去乙酰西地兰; Deacetyllanatoside C; Desacetyllanatoside C
A cardiac glycoside
GC38869 Transdermal Peptide TFA Transdermal Peptide TFA (TD 1 peptide TFA) 是由 11 个氨基酸组成的多肽，可以与 Na+/K+-ATPase beta-subunit (ATP1B1) 结合，主要与 ATP1B1 的 C 末端相互作用。Transdermal Peptide TFA 能够增强一些大分子在皮肤中的传递。
GC41514 Citreoviridin
黄绿青霉素
A mycotoxin that inhibits the mitochondrial ATPase
GC19522 Sodium oleate
油酸钠,cis-9-Octadecenoic acid sodium salt, Oleic acid sodium salt
A monounsaturated fatty acid
GC34013 Digitoxin
洋地黄毒苷
A cardiac glycoside with diverse biological activities
GC32130 (+)-SJ733 (SJ000557733)
SJ000557733

(+)-SJ733 (SJ000557733) 是一种抗疟疾药物，还可以抑制 Na+-ATPase PfATP4。
GC30927 Acevaltrate
乙酰缬草三酯
Acevaltrate, an active component derived from the herbal plant Valeriana jatamansi Jones, is strikingly potent to induce GBM cell apoptosis. Acevaltrate inhibits the Na+/K+-ATPase activity in the rat kidney and brain hemispheres with IC50 of 22.8 μM and 42.3 μM, respectively.
GC30535 Transdermal Peptide (TD 1 (peptide))
透皮短肽

Transdermal Peptide (TD 1 (peptide)) 由 11 个氨基酸组成，是第一个通过噬菌体展示发现的透皮增强肽。
GC30110 Oleic acid (9-cis-Octadecenoic acid)
油酸; 9-cis-Octadecenoic acid; 9Z-Octadecenoic acid
油酸（9-顺式-十八碳烯酸）是一种单不饱和的Omega-9脂肪酸，存在于植物和动物中。
GC18203 Annonacin A mitochondrial complex I inhibitor
GC18189 Marinobufagenin
南美蟾毒精
An α₁ Na⁺/K⁺ ATPase sodium pump inhibitor
GC12413 Rostafuroxin (PST 2238)
PST 2238
An endogenous ouabain blocker at the Na⁺/K⁺ ATPase
GC13108 Digoxin
地高辛,12β-Hydroxydigitoxin
地高辛（Digoxin）是一种强效的Na⁺/K⁺-ATP酶抑制剂，临床用于治疗心律失常和心力衰竭。
GC10579 Ouabain Octahydrate
乌本(箭毒)苷,哇巴因,Acocantherine; G-Strophanthin
Ouabain Octahydrate 是 Na+/K+-ATPase 的抑制剂，用于治疗充血性心力衰竭。
GC17086 Chlorpropamide
氯磺丙脲
A first generation sulfonylurea
GC13162 Prilocaine hydrochloride
盐酸丙胺卡因
An Analytical Reference Standard
GC15071 Prilocaine
丙胺卡因
An Analytical Reference Standard
GC17786 Istaroxime hydrochloride
ISTAROXIME盐酸盐,PST-2744 (hydrochloride);PST 2744 (hydrochloride);PST2744 (hydrochloride)
Istaroxime hydrochloride 是 Na+/K+-ATPase 抑制剂 (IC50=0.11 μM) 和肌质/内质网钙 ATPase 2 (SERCA 2) 激活剂。
GC11448 Istaroxime
PST-2744;PST 2744;PST2744
Istaroxime (PST2744) 是一种有效的 Na+,K+-ATPase 抑制剂，IC50 为 0.11 μM。
GN10144 Oleandrin
欧夹竹桃苷; PBI-05204
A glycoside with diverse biological activities
GN10029 Phloridzin
根皮苷; Floridzin; NSC 2833
An inhibitor of sodium-glucose cotransporters
GN10156 Ginsenoside Rb1
人参皂苷 Rb1; Gypenoside III
A triterpene saponin with diverse biological activities
GN10365 Bufalin
蟾毒灵
A cardiotonic steroid