nAChR(烟碱型乙酰胆碱受体)

nAChRs (nicotinic acetylcholine receptors) are neuron receptor proteins that signal for muscular contraction upon a chemical stimulus. They are cholinergic receptors that form ligand-gated ion channels in the plasma membranes of certain neurons and on the presynaptic and postsynaptic sides of theneuromuscular junction. Nicotinic acetylcholine receptors are the best-studied of the ionotropic receptors. Like the other type of acetylcholine receptor-the muscarinic acetylcholine receptor (mAChR)-the nAChR is triggered by the binding of the neurotransmitter acetylcholine (ACh). Just as muscarinic receptors are named such because they are also activated by muscarine, nicotinic receptors can be opened not only by acetylcholine but also by nicotine —hence the name "nicotinic".

Products for nAChR

Cat.No. 产品名称 Information
GC34959 (+)-Sparteine
(+)-鹰爪豆碱
A quinolizidine alkaloid
GC44209 Mivacurium (chloride)
二氯美维库铵
An antagonist of nAChRs and muscarinic M₂ and M₃ receptors
GC43877 Hydroxy Bupropion
羟基1-(3-氯苯基)-2-[(1,1-二甲基乙基)氨基]-1-丙酮盐酸盐,Hydroxy Bupropion
An Analytical Reference Standard
GC43261 Cholesteryl Myristate
胆固醇肉豆蔻酸; Cholesteryl myristate; Cholesteryl tetradecanoate
A cholesterol ester
GC34079 Monepantel (AAD1566)
AAD1566
Monepantel (AAD1566) 是一种有机驱虫药，可作为烟碱乙酰胆碱受体 (nAChR) 亚基的线虫特异性进化枝的正变构调节剂。
GC33741 Nelonicline (ABT-126)
ABT-126
Nelonicline (ABT-126) (ABT-126) 是一种具有口服活性和选择性的 α7 烟碱样受体激动剂，对 α7 人脑中的 nAChRs (Ki=12.3 nM) 具有高亲和力。
GC32185 Dinotefuran (MTI-446)
呋虫胺; MTI-446
A neonicotinoid insecticide
GC31313 S16961 (S169611)
S169611
S16961 (S169611) 是一种烟碱受体激动剂。
GC31209 Cyclodrine hydrochloride
盐酸环戊君
Cyclodrinehydrochloride是一种胆碱能(毒蕈碱，烟碱)受体(mAChR和nAChR)拮抗剂。
GC31084 (-)-(S)-B-973B
(-)-(S)-B-973B为一种有效的α7nAChR别构激动剂和正别构调节剂，具有镇痛作用。
GC30866 Anabasine ((S)-Anabasine)
(+)-假木贼碱; (S)-Anabasine; (+)-Anabasine
Anabasine ((S)-Anabasine) ((S)-Anabasine ((S)-Anabasine)) 是一种生物碱，在烟草 (Nicotiana) 中是一种微量成分。
GC30807 ZSET1446 (ST-101)
ST-101
ZSET1446 (ST-101) 是一种新型认知增强剂，可显着改善各种类型的阿尔茨海默病 (AD) 模型中的学习缺陷。
GC19351 Tebanicline hydrochloride
ABT594盐酸盐
A potent agonist of neuronal α4β2 subunit-containing nAChRs
GC18631 4BP-TQS An agonist of α7 subunit-containing nAChRs
GC10913 GTS 21 dihydrochloride
(3E)-3-[(2,4-二甲氧基苯基)亚甲基]-3,4,5,6-四氢-2,3'-联吡啶二盐酸盐,DMXB-A; DMBX-anabaseine
An agonist of α7-containing nAChRs
GC12959 SIB 1553A hydrochloride A β4 subunit-selective nAChR agonist
GC12119 CCMI
AVL-3288; UCI-4083
CCMI (AVL-3288) 是一种有效且选择性的 α7 nAChR 阳性变构调节剂，不通过正构位点结合或激活 α7 nAChRs，并导致激动剂诱导的 α7 nAChRs 电流显着正向调节。
GC11757 3-Bromocytisine
3-Br-cytisine
3-Bromocytisine (3-Br-cytisine) 是一种有效的 nACh 受体激动剂，对 hα4β4、hα4β2 和 hα7-nACh 的 IC50 分别为 0.28、0.30 和 31.6 nM。
GC12593 Desformylflustrabromine hydrochloride
Deformylflustrabromine hydrochloride; dFBr hydrochloride
Desformylflustrabromine hydrochloride 是 α4β2 神经元烟碱乙酰胆碱受体 (nAChR) 的选择性激动剂，pEC50 为 6.48。
GC13064 NS 1738
NSC 213859
A positive allosteric modulator of α7-containing nAChRs
GC10329 Mecamylamine hydrochloride
盐酸美加明
A noncompetitive nicotinic antagonist
GC12952 PNU 282987 A potent, selective agonist of α7-containing nAChRs
GC13678 Methyllycaconitine citrate
甲基牛扁亭柠檬酸盐; MLA
Methyllycaconitine citrate (MLA)，一种从飞燕草种子中分离出来的降二萜类生物碱。
GC16937 Carbamoylcholine chloride
Carbachol

Cholinergic receptor agonist
GC16911 CGS 9343B
CGS-9343B; KW 5617
A calmodulin inhibitor
GC14157 (-)-Lobeline hydrochloride
盐酸洛贝林; α-Lobeline hydrochloride; L-Lobeline hydrochloride
An alkaloid with diverse biological activities
GC14410 (±)-Epibatidine
CMI 545
An agonist of α4β2 subunit-containing nAChRs
GC12226 Cisatracurium Besylate
顺苯磺酸阿曲库铵; 51W89
A competitive antagonist of nAChRs and non-depolarizing muscle relaxant
GC15667 Atracurium Besylate
苯磺酸阿曲库铵,BW-33A
A neuromuscular blocking drug
GC11773 Pancuronium dibromide
泮库溴铵
Pancuronium dibromide 是一种双季铵盐类固醇，是一种神经肌肉松弛剂。
GC13542 Adiphenine HCl
盐酸阿地芬宁
An anticholinergic agent
GC15178 Hexamethonium Bromide
六甲溴铵
A nondepolarizing neuromuscular blocking agent
GC16255 Decamethonium Bromide
十烃溴铵
A depolarizing neuromuscular blocking agent
GC14339 Benzethonium Chloride
苄索氯铵
Benzethonium chloride 抑制非洲爪蟾卵母细胞中的人重组 α7 和 α4β2 神经元烟碱乙酰胆碱受体。
GC10443 Meclofenoxate hydrochloride
盐酸甲氯酚酯
A nootropic agent
GC11643 PNU-120596
NSC 216666
An α7 neuronal nAChR modulator
GC17695 Aniracetam
茴拉西坦; Ro 13-5057
An Analytical Reference Standard
GC16143 Varenicline Hydrochloride
6,7,8,9-四氢-6,10-甲桥-6H-吡嗪并[2,3-H][3]苯并氮杂卓盐酸盐,CP 526555 hydrochloride
Varenicline Hydrochloride (CP 526555 hydrochloride) 是一种高亲和力、选择性的 α4β2 尼古丁乙酰胆碱受体 (nAChR) 部分激动剂和完整的 α7 nAChR 激动剂。
GC12762 Varenicline
伐尼克兰; CP 526555
Varenicline (CP 526555) 是一种有效的 α4β2 烟碱乙酰胆碱受体 (nAChR) 部分激动剂，EC50 值为 2.3 μM。
GC10948 Varenicline Tartrate
酒石酸伐尼克兰; CP 526555-18
An agonist of α7 and α4β2 nAChRs
GC11210 Vecuronium Bromide
维库溴铵; ORG NC 45
A non-depolarizing muscle relaxant
GC12102 RJR-2403 oxalate
(3E)-N-甲基-4-(3-吡啶基)-3-丁烯-1-胺草酸盐,(E)-Metanicotine oxalate; Rivanicline oxalate; RJR 2403 oxalate
RJR-2403 oxalate (RJR-2403 oxalate; (E)-Metanicotine oxalate) 是一种神经元烟碱受体激动剂，对 α4β2 亚型 (Ki=26 nM) 具有高选择性； > 1,000 倍的选择性比 α7 受体（Ki = 3.6 μM）。
GC11091 EVP-6124 hydrochloride
(R)-7-氯-N-(奎宁环-3-基)苯并[B]噻吩-2-甲酰胺盐酸盐,EVP 6124 hydrochloride;EVP6124 hydrochloride
A partial agonist of α7 subunit-containing nAChRs
GC15941 EVP-6124
EVP 6124;EVP6124
A partial agonist of α7 subunit-containing nAChRs
GC15014 A-867744
4-[5-(4-氯苯基)-2-甲基-3-丙酰基吡咯-1-基]苯磺酰胺,A 867744;A867744
A positive allosteric modulator of α7 nAChRs
GN10311 N－Methylcytisine
N-甲基野靛碱,Caulophylline
An alkaloid with diverse biological activities
GN10126 Cytisine
金雀花碱; Cytisine; Sophorine; Baptitoxine
An alkaloid and a partial agonist of nAChRs