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Home >> Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel

Potassium Channel(钾离子通道)

Potassium channels are voltage-gated ion channels that selectively permeate potassium ion through the excitable membrane. It regulates the release of neurotransmitters, insulin secretion, smooth muscle contraction and heart rate etc.

Products for  Potassium Channel

  1. Cat.No. 产品名称 Information
  2. GC33003 Daurisoline ((R,R)-Daurisoline)

    蝙蝠葛苏林碱; (R,R)-Daurisoline

     An alkaloid with diverse biological activities
  3. GC32673 Almokalant (H 234/09)

    阿莫兰特,H 234?/09

     Almokalant (H 234/09) 是一种 III 类抗心律失常药物，作为钾通道阻滞剂，可抑制时间依赖性延迟整流器 K+ 电流的特定成分 (Ikr)。
  4. GC32660 U89232 U-89232可能是一种选择性的心脏KATP通道开启剂。
  5. GC32646 MK-7145 MK-7145是ROMK的一个抑制剂，其IC50值为0.045μM。
  6. GC32629 KRN4884 KRN4884是一种K+通道开放剂。在细胞内ATP(1mM)存在下，KRN4884(0.1-3μM)激活KATP通道(EC50=0.55μM),这种作用存在浓度依赖性。
  7. GC32587 Clofilium tosylate

    氯非铵甲苯磺酸盐

     Clofiliumtosylate是一种钾通道(potassiumchannel)阻滞剂，作用于人早幼粒细胞白血病(HL-60)细胞，激活caspase-3而诱导凋亡。具有抗心律失常作用。
  8. GC32509 RPR-260243 RPR-260243是HERG钾离子通道激活剂。
  9. GC32501 YM758 YM758是一个特异性的窦房结If电流抑制剂。
  10. GC32490 Naminidil (BMS 234303-01)

    BMS 234303-01

     Naminidil (BMS 234303-01) 是一种氰基胍 KATP 开放剂。
  11. GC32478 Pirmenol hydrochloride (Cl-845)

    盐酸吡美诺; Cl-845; (±)-Pirmenol hydrochlorid

     A class I antiarrhythmic agent
  12. GC31686 Tannic acid

    单宁酸

     Tannic acid (Gallotannic acid), a polyphenolic compound, is a CXCL12/CXCR4 inhibitor with antiangiogenic, anti-inflammatory and antitumor activity.
  13. GC31505 MCHr1 antagonist 2 MCHr1antagonist2是一种黑色素聚集激素受体1(melaninconcentratinghormonereceptor1)拮抗剂，IC50值为65nM；MCHr1antagonist2同时抑制hERG，在IMR-32细胞中，IC50值为4.0nM。
  14. GC31405 BMS-191095 BMS-191095是线粒体ATP敏感性（mitoKATP）的钾离子通道活化剂。
  15. GC31200 Myomodulin

    肌调蛋白

    Myomodulin是存在于软体动物，昆虫和腹足动物中的神经多肽。
  16. GC31184 Phe-Met-Arg-Phe, amide

    Phe-Met-Arg-Phe,amide是一种神经肽，在肽能神经元中激活K+电流，ED50为23nM，这种作用具有剂量依赖性。
  17. GC31141 Antihistamine-1 Antihistamine-1是能够渗透血脑屏障的H1-抗组胺药(Ki=6.9nM),它也是CYP2D6和hERG通道的抑制剂，其IC50值分别为5.4和0.8μM。
  18. GC31062 ML402

    ML402是选择性的TREK-1激活剂。
  19. GC31057 Naluzotan (PRX 00023)

    N-[3-[4-[4-[(环己基甲基磺酰基)氨基]丁基]哌嗪-1-基]苯基]乙酰胺,PRX 00023

     Naluzotan (PRX 00023) 是一种新型的、有效的、选择性的氨基磺酰胺 5-HT1A 激动剂，IC50 和 Ki 分别为 20 nM 和 5.1 nM，用于治疗焦虑和抑郁。也是一种弱 hERG K+ 通道阻断剂，IC50 为 3800 nM。
  20. GC30914 Butamben (Butyl 4-aminobenzoate)

    4-氨基苯甲酸丁酯,Butyl 4-aminobenzoate

     Butamben (Butyl 4-aminobenzoate) is a long-duration local anesthetic used for the treatment of chronic pain.
  21. GC30910 Eucalyptol (1,8-Cineole)

    NSC 6171

     Eucalyptol是5-HT3受体,钾通道,TNF-α和IL-1β的抑制剂。
  22. GC30891 Almitrine mesylate (Almitrine bismesylate)

    甲磺酸阿米三嗪,Almitrine bismesylate; Almitrine bismethanesulfonate; Almitrine dimesylate

     Almitrine mesylate (Almitrine bismesylate, Almitrine dimethanesulfonate, Almitrine dimesylate), a pharmacologically unique respiratory stimulant, acts as an agonist of peripheral chemoreceptors located on the carotid bodies. Almitrine mesylate inhibits the activity of Ca2+-dependent K+ channel by decreasing its open probability with IC50 of 0.22 μM.
  23. GC30280 Chlorpromazine D6 hydrochloride

    盐酸氯丙嗪 D6

     An internal standard for the quantification of chlorpromazine
  24. GC30267 Pinacidil monohydrate

    吡那地尔一水合物; P-1134 monohydrate

     A potassium channel opener
  25. GC19480 AUT1 A positive modulator of Kv3.1b, Kv3.2a, and Kv3.3
  26. GC19183 GSK369796 Dihydrochloride

    N-tert-butyl Isoquine

     An antimalarial agent
  27. GC19004 SKA-121 A positive-gating modulator of IKCa1/KCa3.1 channels
  28. GC18629 VU0071063 A Kir6.2/SUR1 activator
  29. GC18210 GAL-021 A BKCa channel blocker
  30. GC18203 Annonacin A mitochondrial complex I inhibitor
  31. GC15117 ML-297

    CID-56642816,VU0456810

     A selective GIRK1/2 activator
  32. GC11351 VU590 (hydrochloride)

    CID-4536383,ML-111

     inhibitor of KCNJ1
  33. GC17001 Verruculogen

    疣孢青霉原

     A tremorgenic mycotoxin
  34. GC10497 Hexachlorophene

    Nabac, NSC 9887, NSC 49115

    KCNQ1/KCNE1 potassium channel activator
  35. GC13490 E-4031 An antiarrhythmic, ERG potassium channel blocker
  36. GC13353 Spadin An inhibitor of K2P2.1/TREK1
  37. GC14029 Retigabine

    瑞替加滨

     An Analytical Reference Standard
  38. GC14705 Tolbutamide Sodium A SUR1/Kir6.2 channel inhibitor
  39. GC14515 Azimilide

    阿齐利特,NE-10064

     A class III antiarrhythmic agent
  40. GC10560 ICA 110381 ICA 110381 (Compound 16) 是一种 KCNQ2/Q3 钾通道开放剂，用于治疗癫痫。
  41. GC17909 NS 6180 An inhibitor of IKCa1/KCa3.1 channels
  42. GC10540 NS 11021 A BKCa channel opener
  43. GC11061 ML 213

    N-(2,4,6-三甲基苯基)-双环[2.2.1]庚烷-2-甲酰胺

     A selective activator of KCNQ2 and KCNQ4 channels
  44. GC15855 NS 3623 An ion channel modulator
  45. GC13455 VU 591 hydrochloride VU 591 hydrochloride 是一种有效的、选择性的肾外髓质钾通道 (ROMK 或 Kir1.1) 抑制剂，IC50 为 0.24 μM。
  46. GC16095 MaxiPost

    BMS-204352

     A KCa1.1/BK channel activator
  47. GC10492 ML 277

    CID-53347902

     An activator of KCNQ1
  48. GC16502 Psora 4

    5-(4-Phenylbutoxy)psoralen

     An inhibitor of Kv1.3 channels
  49. GC10352 GW 542573X Activator of small-conductance Ca2+-activated K+ channels (KCa2)
  50. GC16447 ICA 069673 A Kv7 channel activator
  51. GC17280 NS 5806 An Ito current activator

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