TRP Channel(瞬时受体电位离子通道)

TRP (transient receptor potential) channels are a family of cation channels that sense various external and celluar signals such as mechanical stress, temperature, cellular messengers and exogenous chemicals. It is implicated in vascular tone , neurological disorders, kidney diseases, hypomagnesemia and hypocalcemia etc.

Products for TRP Channel

Cat.No. 产品名称 Information
GC19291 PF-4840154 A TRPA1 channel agonist
GC19025 AM-0902 AM-0902 是一种有效的选择性瞬时受体电位 A1 (TRPA1) 拮抗剂，对 rTRPA1 和 hTRPA1 的 IC50 分别为 71 和 131 nM。
GC18564 MK6-83 A TRPML1 activator
GC18296 M8-B (hydrochloride) A selective TRPM8 antagonist
GC17940 GSK1016790A GSK1016790A是一种有效的选择性瞬时受体电位香草酸4（TRPV4）通道激动剂。
GC13930 N-(p-amylcinnamoyl) Anthranilic Acid
2-(3-(4-戊基苯基)丙烯酰胺基)苯甲酸,ACA
A TRP channel blocker and PLA₂ inhibitor
GC14761 Mavatrep
JNJ-39439335
Mavatrep (JNJ-39439335) 是一种具有口服活性、选择性和有效的 TRPV1 拮抗剂，对 hTRPV1 通道具有高亲和力 (Ki=6.5 nM)。
GC14635 RQ-00203078 A TRPM8 antagonist
GC12597 Optovin A photoactivatable TRPA1 ligand
GC16850 ML SA1
2-[2-氧代-2-(2,2,4-三甲基-3,4-二氢-2H-喹啉-1-基)-乙基]-异吲哚-1,3-二酮
A TRPML1 agonist
GC13457 ML 204
CID230710, 2-piperidino-Lepidine, NSC 25850
A selective TRPC4 channel blocker
GC15208 TC-I 2000 A TRPM8 antagonist
GC17091 A 784168 A TRPV1 antagonist
GC13679 6-Iodonordihydrocapsaicin
葡聚糖凝胶
Vanilloid receptor antagonist
GC16917 GSK 2193874
GSK2193874游离态
A TRPV4 channel antagonist
GC11701 A 967079
(1E,3E)-1-(4-氟苯基)-2-甲基-1-戊烯-3-酮肟
A potent inhibitor of the TRPA1 channel
GC12260 HC 067047 A selective TRPV4 antagonist
GC14537 AMTB hydrochloride A TRPM8 antagonist
GC11185 TCS 5861528
TCS 5861528
A TRPA1 channel blocker
GC14276 BCTC
N-(4-叔丁苯基)-4-(3-氯吡啶-2-基)哌嗪-1-甲酰胺
A potent TRPV1 antagonist
GC14649 Pyr3 A TRPC3 inhibitor
GC17267 RN 1734
2,4-二氯-N-(异丙基)-N-[2-[(异丙基)氨基]乙基]苯磺酰胺
A TRPV4 antagonist
GC15346 RN 1747 RN 1747 是一种选择性瞬时受体电位阳离子通道亚家族 V 成员 4 (TRPV4) 激动剂，对 hTRPV4、mTRPV4 和 rTRPV4 的 EC50 值分别为 0.77 μM、4.0 μM 和 4.1 μM。
GC13994 Phenamil Phenamil 是瞬时受体电位 (TRP) 和酸敏感离子通道 (ASIC) 的选择性抑制剂。
GC15893 EIPA
5-(N-乙基-N-异丙基)阿米洛利,L-593,754, MH 12-43, 5-(N-ethyl-N-isopropyl)-Amiloride
EIPA 抑制 TRPP3 介导的 Ca2+- 激活电流，IC50 值为 10.5 μM 。
GC15427 JNJ 17203212
4-(3-(三氟甲基)吡啶-2-基)-N-(5-三氟甲基)吡啶-2-基)哌嗪-1-甲酰胺
A TRPV1 antagonist
GC18020 AP 18
4-(4-氯苯基)-3-甲基丁-3-烯-2-肟
A reversible channel blocker of TRPA1
GC14248 SB 452533 SB 452533 是一种有效的选择性 TRPV1 拮抗剂，pKb 为 7.8。
GC12580 Polygodial
水蓼二醛,Poligodial; Tadeonal
A natural antifungal sesquiterpene
GC16760 WS 12
凉味剂WS-12,AR-15512; AVX-012
A TRPM8 agonist
GC14387 WS 3
重复
A non-specific proliferative molecule
GC18069 Cardamonin
小豆蔻明; (E)-Cardamomin; (E)-Alpinetin chalcone

A chalconoid with anti-inflammatory and anti-tumor activity
GC11926 AMG 9810
(2E)-N-(2,3-二氢-1,4-苯并二噁英-6-基)-3-[4-(1,1-二甲基乙基)苯基]-2-丙酰胺
A TRPV1 antagonist
GC17879 OLDA
N-Oleoyldopamine
A synthetic endocannabinoid analog and potent 5-lipoxygenase inhibitor
GC14997 SB 366791
3-(4-氯苯基)-N-(3-甲氧基苯基)-2-丙烯酰胺
A TRPV1 antagonist
GC17562 2-APB
二苯基硼酸-2-氨基乙酯,2-APB
2-APB是一种钙离子通道的非特异性拮抗剂，通常被用于研究钙信号传导，如细胞凋亡、肌肉收缩和神经传导等方面。
GC14641 SKF 96365 hydrochloride
1-[2-(4-甲氧基)-2-[3-(4-甲氧基苯基)丙氧基]乙基]咪唑
An inhibitor of voltage-gated calcium channels
GC16467 Olvanil
奥伐尼,NE-19550; N-Vanillyloleamide
A structural analog of capsaicin
GC12520 Diphenyleneiodonium chloride
二苯基氯化碘盐,DPI
二苯碘铵 (DPI) 氯化物 (DPIC) 作为 NADH/NADPH 氧化酶抑制剂，对 Mtb 和 S. aureus 具有有效的抗菌活性。
GC11906 Ononetin
芒柄花酚
A deoxybenzoin with diverse biological activities
GC10873 α-Spinasterol
菠甾醇
A TRPV1 antagonist
GC11613 L-R4W2 L-R4W2 是香草素受体 1 (VR1, TRPV1) 的有效拮抗剂，IC50 为 0.1 μM。
GC10221 9-Phenanthrol
9-羟基菲,9-Hydroxyphenanthrene; NSC 50554
A TRPM4 inhibitor
GC15417 STEARDA
N-[2-(3,4-二羟基苯基)乙基]十八烷酰胺
potentiates TRPV1-mediated effects of NADA
GC16700 PALDA
PALDA
A naturally-occurring N-acyl dopamine
GC10188 6'-Iodoresiniferatoxin TRPV1 (VR1) vanilloid receptor partial agonist
GC11293 PPAHV
vanilloid TRPV1 (VR1) receptor agonist
GC16801 5'-Iodoresiniferatoxin TRPV1 (VR1) receptor antagonist
GC12783 Resiniferatoxin Resiniferatoxin (RTX)是一种超强辣椒素类似物,是一种结合瞬时受体电位通道,香草蛋白亚家族成员1 (TRPV1)的香草蛋白激动剂。
GC12769 Nonivamide
辣椒素,Pelargonic acid vanillylamide; Nonanoic acid vanillylamide; Pseudocapsaicin
A TRPV1 agonist