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Home >> Signaling Pathways >> MAPK Signaling

MAPK Signaling(MAPK信号通路)

Products for  MAPK Signaling

  1. Cat.No. 产品名称 Information
  2. GC15821 PF-04880594

    3-[[4-[1-(2,2-二氟乙基)-3-(1H-吡咯并[2,3-B]吡啶-5-基)-1H-吡唑-4-基]-2-嘧啶基]氨基]-丙腈

     PF-04880594 是一种有效的选择性 RAF 抑制剂。 PF-04880594 抑制野生型和突变型 BRAF 和 CRAF。 PF-04880594 显示出抗肿瘤活性。
  3. GC17737 PD 169316

    4-[4-(4-氟苯基)-2-(4-硝基苯基)-1H-咪唑-5-基]吡啶

     A specific p38 MAPK inhibitor
  4. GC16543 TAK-715

    N-(4-(2-乙基-4-(3-甲基苯基)噻唑-5-基)吡啶-2-基)苯甲酰胺

     An inhibitor of p38α MAPK
  5. GC17508 VX-702

    6-[(氨基羰基)(2,6-二氟苯基)氨基]-2-(2,4-二氟苯基)-3-吡啶甲酰胺

     An inhibitor of p38 MAP kinases
  6. GC12926 VX-745

    VX-745

     A p38α MAPK inhibitor
  7. GC13286 ZM336372 An activator of the Raf-1 signalling pathway
  8. GC12970 Furosemide

    呋塞米

     A loop diuretic and an inhibitor of NKCC1 and NKCC2
  9. GC14643 AZD8330

    2-(2-氟-4-碘苯氨基)-N-(2-羟基乙氧基)-1,5-二甲基-6-氧代-1,6-二氢吡啶-3-甲酰胺,ARRY-424704; ARRY-704; AZD-8330; ARRY424704; ARRY704; AZD8330

     A MEK1/2 inhibitor
  10. GC15055 AZ 628

    AZ-628; AZ628

     A Raf kinase inhibitor
  11. GC15818 RAF265

    CHIR-265;RAF 265;RAF-265;CHIR265

     A B-Raf and VEGFR2 inhibitor
  12. GC10261 PH-797804

    PH797804;PH 797804

     A selective p38 MAPK inhibitor
  13. GC10647 FR 180204

    ERK Inhibitor II

     A potent, cell-permeable inhibitor of ERK1/2
  14. GC16845 CEP-32496

    CEP-32496; RXDX-105

     A potent inhibitor of B-Raf
  15. GC10069 NSC 23766 trihydrochloride Inhibitor of Rac1
  16. GC12843 MEK162 (ARRY-162, ARRY-438162)

    贝美替尼,MEK162; ARRY-162; ARRY-438162

     A MEK1/2 inhibitor
  17. GC15693 BIX 02188

    (3Z)-3-[[[3-[(二甲基氨基)甲基]苯基]氨基]苯亚甲基]-2,3-二氢-2-氧代-1H-吲哚-6-甲酰胺

     A potent MEK5 inhibitor
  18. GC12220 BIX 02189 An inhibitor of MEK5 and ERK5
  19. GC14289 Fasudil (HA-1077) HCl

    盐酸法舒地尔; HA-1077 Hydrochloride; AT-877 Hydrochloride

     Fasudil（法舒地尔；HA-1077；AT877）是一种非特异性RhoA/ROCK抑制剂，对ROCK1的Ki为0.33μM，IC50为0.158μM，对ROCK2和PKA、PKC、PKG的IC50分别为4.58μM、12.30μM、1.650μM。
  20. GC10110 PD318088

    5-溴-N-(2,3-二羟基丙氧基)-3,4-二氟-2-[(2-氟-4-碘苯基)氨基]苯甲酰胺

     An allosteric inhibitor of MEK1
  21. GC12297 AT7867 A potent and orally bioavailable pan-Akt inhibitor
  22. GC11497 BIRB 796 (Doramapimod)

    达马莫德; BIRB 796

     A potent inhibitor of p38 MAPK
  23. GC18050 Pimasertib (AS-703026)

    N-[(2S)-2,3-二羟基丙基]-3-[(2-氟-4-碘苯基)氨基]-4-吡啶甲酰胺,AS703026; MSC1936369B

     A MEK1/2 inhibitor
  24. GC16835 LY2228820

    5-[2-(叔丁基)-4-(4-氟苯基)-1H-咪唑-5-基]-3-(2,2-二甲基丙基)-3H-咪唑并[4,5-B]吡啶-2-胺甲磺酸盐,LY2228820 dimesylate

     A potent inhibitor of p38α MAP kinase
  25. GC13968 SB202190 (FHPI)

    4-(4-氟苯基)-2-(4-羟基苯基)-5-(4-吡啶基)-1H-咪唑

     SB 202190是一种选择性p38 MAP激酶抑制剂,对p38α和p38β2的IC50分别为50 nM和100 nM。
  26. GC12989 PD184352 (CI-1040)

    2-[(2-氯-4-碘苯基)氨基]-N-(环丙基甲氧基)-3,4-二氟-苯甲酰胺,PD 184352

     A potent MEK inhibitor
  27. GC15359 SL-327 A selective MEK1/2 inhibitor
  28. GC10505 GDC-0879

    2,3-二氢-5-[1-(2-羟基乙基)-3-(4-吡啶基)-1H-吡唑-4-基]-1H-茚-1-酮肟

     An inhibitor of B-RafV600E
  29. GC15524 Bumetanide

    布美他尼; Ro 10-6338; PF 1593

     An NKCC1 inhibitor
  30. GC12819 PD98059

    2-(2-氨基-3-甲氧基苯基)-4H-1-苯并吡喃-4-酮

     D98059是一种有效的选择性MEK抑制剂，IC50为2 μM。
  31. GC17608 Lidocaine

    利多卡因; Lignocaine

     An Analytical Reference Standard
  32. GC15344 SP 600125

    吡唑蒽酮

     SP 600125是一种具有口服活性的、可逆的、具有选择性的ATP竞争性JNK 抑制剂，对JNK1、JNK2和JNK3的IC50分别为40、40和90nM。SP 600125常用于卵巢癌、肿瘤、帕金森病 (PD)、乳腺癌和哮喘的研究。
  33. GC13595 SB 203580

    4-(4-氟苯基)-2-(4-甲基亚磺酰基苯基)-5-(4-吡啶基)-1H-咪唑,SB 203580; RWJ 64809

     SB 203580是p38-MAPK（有丝分裂原活化蛋白激酶）通路的特异性抑制剂。
  34. GC16499 Sorafenib Tosylate

    甲苯磺酸索拉非尼; Bay 43-9006 Tosylate

     A multi-kinase inhibitor
  35. GC17030 AZD6244(Selumetinib)

    司美替尼; AZD6244; ARRY-142886

     A highly selective inhibitor of MEK1/2
  36. GC10111 Regorafenib

    瑞戈非尼; BAY 73-4506

     A multi-kinase inhibitor
  37. GC17455 TAK-632 A selective pan-Raf inhibitor
  38. GC15391 Cercosporamide

    尾孢素酰胺,(-)-Cercosporamide

    A potent inhibitor of fungal Pkc1 and mammalian Mnk isoforms
  39. GC17577 NQDI 1 A selective inhibitor of ASK1
  40. GC10282 Piperlongumine

    荜茇酰胺; Piplartine

     Piperlongumine是从Piper longum L.中提取的天然生物碱化合物，具有多种药理活性，包括抗肿瘤、脂质代谢调节、抗血小板聚集和镇痛活性等。
  41. GC17255 Gliotoxin

    胶霉毒素,Aspergillin

     An immunosuppressive mycotoxin with diverse biological effects
  42. GC11076 XMD8-92

    2-[[2-乙氧基-4-(4-羟基-1-哌啶基)苯基]氨基]-5,11-二氢-5,11-二甲基-6H-嘧啶并[4,5-B][1,4]苯并二氮杂卓-6-酮

     A selective ERK5 inhibitor
  43. GC12691 XMD17-109

    XMD17 109

     A selective ERK5 inhibitor
  44. GC13115 VX-11e

    VX 11e, VX11e

     A selective ERK inhibitor
  45. GC15260 Trametinib DMSO solvate

    曲美替尼二甲亚砜,GSK-1120212 DMSO solvate;Trametinib;JTP-74057;GSK-1120212;GSK1120212;GSK 1120212;JTP 74057;JTP74057

     Trametinib DMSO solvate (GSK-1120212 (DMSO solvate);JTP-74057 (DMSO solvate)) 是一种具有口服活性的 MEK 抑制剂，抑制 MEK1 和 MEK2，IC50 约为 2 nM。 Trametinib DMSO solvate 激活自噬并诱导细胞凋亡。
  46. GC13578 Skepinone-L

    Skepinone L

     An inhibitor of p38 MAPK
  47. GC16001 SCH772984

    (R)-1-(2--2-氧(4-(4-(嘧啶-2-基)苯基)对二氮己环-1-基)乙基)-N-(3-(吡啶-4-基)-1H--5INDAZOL-基)吡咯烷-3-甲酰胺,SCH 772984;SCH-772984

     SCH772984是一种新型的、有效的、ATP竞争性的ERK1和ERK2抑制剂，IC50值分别为4nM和1nM。
  48. GC10054 SB 239063

    反式-1-(4-羟基环己基)-4-(4-氟苯基)-5-(2-甲氧基嘧啶-4-基)咪唑,SB-239063;SB239063

     A selective p38 MAPK inhibitor
  49. GC10528 Salirasib

    法尼基硫代水杨酸; S-Farnesylthiosalicylic acid; Farnesyl Thiosalicylic Acid; FTS

     A Ras inhibitor with anti-cancer and anti-atherogenic activity
  50. GC14534 Regorafenib monohydrate

    瑞格非尼一水合物,BAY 73-4506 monohydrate

     A multi-kinase inhibitor
  51. GC14606 Regorafenib hydrochloride

    瑞戈非尼盐酸盐; BAY 73-4506 hydrochloride

     A multi-kinase inhibitor

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