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Home >> Signaling Pathways >> MAPK Signaling

MAPK Signaling(MAPK信号通路)

Products for MAPK Signaling

Cat.No. 产品名称 Information
GC12904 BI 78D3
JNK Inhibitor X, c-Jun N-terminal Kinase Inhibitor X
A competitive inhibitor of JNK
GC10204 AEG 3482
6-苯基咪唑并[2,1-B]-1,3,4-噻二唑-2-磺酰胺
An inhibitor of p75^NTR- and NRAGE-induced apoptosis
GC12321 PKI 14-22 amide, myristoylated A PKA inhibitor
GC16313 SL 0101-1
3'',4''-二-O-乙酰基阿福豆苷,SL0101
A selective inhibitor of RSK
GC10693 c-JUN peptide JNK/c-Jun interaction inhibitor
GC15525 cGMP Dependent Kinase Inhibitor Peptide
Arginyllysylarginylalanylarginyllysylglutamic acid, Protein Kinase G Inhibitor
A cGMP-dependent protein kinase inhibitor
GC10941 cAMPS-Rp, triethylammonium salt
Rp-cAMPS
A non-hydrolyzable analog of cAMP
GC12706 cAMPS-Sp, triethylammonium salt cAMPS-Sp，三乙基铵盐，一种 cAMP 类似物，是一种有效的、竞争性 cAMP 诱导的 cAMP 依赖性 PKA I 和 II 的激活（Kis 分别为 12.5 μ；M 和 4.5 μ；M）拮抗剂。
GC14648 KT 5720
蛋白激酶仰制剂KT5720
A potent inhibitor of PKA
GC12824 Dibutyryl-cAMP, sodium salt
Dibutyryl cAMP sodium salt; DBcAMP sodium salt
Dibutyryl-cAMP, sodium salt，又称为Bucladesine，是一种细胞膜可透性环核苷酸类似物，能模拟内源性cAMP的作用，并作为磷酸二酯酶抑制剂。
GC16929 8-Bromo-cAMP, sodium salt
8-溴腺苷-3',5'-环单磷酸钠,8-Br-Camp sodium salt
8-Bromo-cAMP (8-Bromo-cAMP, sodium salt)是一种细胞渗透性cAMP类似物，是cAMP依赖性蛋白激酶激活剂（PKA激活剂）,它能抑制肿瘤细胞生长，促进肿瘤分化。
GC13869 Fasudil
法舒地尔; HA-1077; AT877
Fasudil（法舒地尔；HA-1077；AT877）是一种非特异性RhoA/ROCK抑制剂，对ROCK1的K_i为0.33μM，IC₅₀为0.158μM，对ROCK2和PKA、PKC、PKG的IC₅₀分别为4.58μM、12.30μM、1.650μM。
GC16007 Methylthiouracil
甲硫氧嘧啶; MTU
甲基硫氧嘧啶是一种抗甲状腺药物。
GC10074 H 89 2HCl
H-89二盐酸盐
H-89 2HCl 是一种有效的选择性 camp 依赖性蛋白激酶 A 抑制剂，IC50 值为 48 nM，对 PKG、PKC、酪蛋白激酶和其他激酶表现出较弱的抑制作用。
GC12982 BIX 02565 A RSK2 inhibitor with multiple off target effects
GC17031 VRT752271
4-[5-氯-2-[(1-甲基乙基)氨基]-4-吡啶基]-N-[(1S)-1-(3-氯苯基)-2-羟基乙基]-1H-吡咯-2-甲酰胺,BVD-523; VRT752271
VRT752271 (BVD-523; VRT752271) 是一种有效的、具有口服活性、高度选择性、ATP 竞争性和可逆的 ERK1/2 激酶共价抑制剂，对 ERK2 的 IC50 <0.3 nM。 VRT752271 (BVD-523; VRT752271) 抑制 A375 黑色素瘤细胞系中的磷酸化 ERK2 (pERK) 和下游激酶 RSK (pRSK)。
GC10689 PF-4708671 PF-4708671 是一种新型的细胞渗透性 S6K1 抑制剂，特异性抑制 S6K1 亚型，Ki 为 20 nM，IC50 为 160 nM。
GC14247 GDC-0623
RG 7421; MEK inhibitor 1
A potent, ATP-uncompetitive inhibitor of MEK1
GC16576 LGX818
康奈非尼,LGX818
An inhibitor of mutant B-Raf kinase
GC16872 Refametinib
瑞法替尼,BAY 869766; RDEA119;
An allosteric inhibitor of MEK1/2
GC15187 Dabrafenib (GSK2118436)
达拉非尼; GSK2118436A; GSK2118436
A Raf kinase inhibitor
GC14907 B-Raf inhibitor 1 dihydrochloride An inhibitor of Raf kinases
GC11599 B-Raf inhibitor 1
N1-(4-氯苯基)-6-甲基-N5-[3-(9H-嘌呤-6-基)-2-吡啶]-1,5-异喹啉二胺
An inhibitor of Raf kinases
GC10209 TAK-733 A MEK1 inhibitor
GC13529 CC-401
3-[3-[2-(1-哌啶基)乙氧基]苯基]-5-(1H-1,2,4-三唑-5-基)-1H-吲唑
A potent, specific pan-JNK inhibitor
GC11890 SB590885
5-[2-[4-[2-(二甲基氨基)乙氧基]苯基]-5-(4-吡啶基)-1H-咪唑-4-基]-2,3-二氢-1-茚酮肟
A potent inhibitor of B-Raf
GC11685 GW5074 A potent inhibitor of Raf-1
GC13468 BI-D1870 An inhibitor of RSK1-4
GC13001 SB 203580 hydrochloride
SB 203580 hydrochloride; RWJ 64809 hydrochloride
A water soluble p38 MAPK inhibitor
GC11488 TCS JNK 5a
JNK Inhibitor IX
A selective inhibitor of JNK2 and JNK3
GC12141 RO4987655
CH4987655
A MEK inhibitor
GC10030 EHop-016 A Rac1 and Rac3 inhibitor
GC15821 PF-04880594
3-[[4-[1-(2,2-二氟乙基)-3-(1H-吡咯并[2,3-B]吡啶-5-基)-1H-吡唑-4-基]-2-嘧啶基]氨基]-丙腈
PF-04880594 是一种有效的选择性 RAF 抑制剂。 PF-04880594 抑制野生型和突变型 BRAF 和 CRAF。 PF-04880594 显示出抗肿瘤活性。
GC17737 PD 169316
4-[4-(4-氟苯基)-2-(4-硝基苯基)-1H-咪唑-5-基]吡啶
A specific p38 MAPK inhibitor
GC16543 TAK-715
N-(4-(2-乙基-4-(3-甲基苯基)噻唑-5-基)吡啶-2-基)苯甲酰胺
An inhibitor of p38α MAPK
GC17508 VX-702
6-[(氨基羰基)(2,6-二氟苯基)氨基]-2-(2,4-二氟苯基)-3-吡啶甲酰胺
An inhibitor of p38 MAP kinases
GC12926 VX-745
VX-745
A p38α MAPK inhibitor
GC13286 ZM336372 An activator of the Raf-1 signalling pathway
GC12970 Furosemide
呋塞米
A loop diuretic and an inhibitor of NKCC1 and NKCC2
GC14643 AZD8330
2-(2-氟-4-碘苯氨基)-N-(2-羟基乙氧基)-1,5-二甲基-6-氧代-1,6-二氢吡啶-3-甲酰胺,ARRY-424704; ARRY-704; AZD-8330; ARRY424704; ARRY704; AZD8330
A MEK1/2 inhibitor
GC15055 AZ 628
AZ-628; AZ628
A Raf kinase inhibitor
GC15818 RAF265
CHIR-265;RAF 265;RAF-265;CHIR265
A B-Raf and VEGFR2 inhibitor
GC10261 PH-797804
PH797804;PH 797804
A selective p38 MAPK inhibitor
GC10647 FR 180204
ERK Inhibitor II
A potent, cell-permeable inhibitor of ERK1/2
GC16845 CEP-32496
CEP-32496; RXDX-105
A potent inhibitor of B-Raf
GC10069 NSC 23766 trihydrochloride Inhibitor of Rac1
GC12843 MEK162 (ARRY-162, ARRY-438162)
贝美替尼,MEK162; ARRY-162; ARRY-438162
A MEK1/2 inhibitor
GC15693 BIX 02188
(3Z)-3-[[[3-[(二甲基氨基)甲基]苯基]氨基]苯亚甲基]-2,3-二氢-2-氧代-1H-吲哚-6-甲酰胺
A potent MEK5 inhibitor
GC12220 BIX 02189 An inhibitor of MEK5 and ERK5
GC14289 Fasudil (HA-1077) HCl
盐酸法舒地尔; HA-1077 Hydrochloride; AT-877 Hydrochloride
Fasudil（法舒地尔；HA-1077；AT877）是一种非特异性RhoA/ROCK抑制剂，对ROCK1的K_i为0.33μM，IC₅₀为0.158μM，对ROCK2和PKA、PKC、PKG的IC₅₀分别为4.58μM、12.30μM、1.650μM。