MAPK Signaling(MAPK信号通路)

Cat.No. 产品名称 Information

GC10110 PD318088

5-溴-N-(2,3-二羟基丙氧基)-3,4-二氟-2-[(2-氟-4-碘苯基)氨基]苯甲酰胺

An allosteric inhibitor of MEK1

GC12297 AT7867 A potent and orally bioavailable pan-Akt inhibitor

GC11497 BIRB 796 (Doramapimod)

达马莫德; BIRB 796

A potent inhibitor of p38 MAPK

GC18050 Pimasertib (AS-703026)

N-[(2S)-2,3-二羟基丙基]-3-[(2-氟-4-碘苯基)氨基]-4-吡啶甲酰胺,AS703026; MSC1936369B

A MEK1/2 inhibitor

GC16835 LY2228820

5-[2-(叔丁基)-4-(4-氟苯基)-1H-咪唑-5-基]-3-(2,2-二甲基丙基)-3H-咪唑并[4,5-B]吡啶-2-胺甲磺酸盐,LY2228820 dimesylate

A potent inhibitor of p38α MAP kinase

GC13968 SB202190 (FHPI)

4-(4-氟苯基)-2-(4-羟基苯基)-5-(4-吡啶基)-1H-咪唑

SB 202190是一种选择性p38 MAP激酶抑制剂,对p38α和p38β2的IC50分别为50 nM和100 nM。

GC12989 PD184352 (CI-1040)

2-[(2-氯-4-碘苯基)氨基]-N-(环丙基甲氧基)-3,4-二氟-苯甲酰胺,PD 184352

A potent MEK inhibitor

GC15359 SL-327 A selective MEK1/2 inhibitor

GC10505 GDC-0879

2,3-二氢-5-[1-(2-羟基乙基)-3-(4-吡啶基)-1H-吡唑-4-基]-1H-茚-1-酮肟

An inhibitor of B-Raf^V600E

GC15524 Bumetanide

布美他尼; Ro 10-6338; PF 1593

An NKCC1 inhibitor

GC12819 PD98059

2-(2-氨基-3-甲氧基苯基)-4H-1-苯并吡喃-4-酮

D98059是一种有效的选择性MEK抑制剂，IC50为2 μM。

GC17608 Lidocaine

利多卡因; Lignocaine

An Analytical Reference Standard

GC15344 SP 600125

吡唑蒽酮

SP 600125是一种具有口服活性的、可逆的、具有选择性的ATP竞争性JNK 抑制剂，对JNK1、JNK2和JNK3的IC₅₀分别为40、40和90nM。SP 600125常用于卵巢癌、肿瘤、帕金森病 (PD)、乳腺癌和哮喘的研究。

GC13595 SB 203580

4-(4-氟苯基)-2-(4-甲基亚磺酰基苯基)-5-(4-吡啶基)-1H-咪唑,SB 203580; RWJ 64809

SB 203580是p38-MAPK（有丝分裂原活化蛋白激酶）通路的特异性抑制剂。

GC16499 Sorafenib Tosylate

甲苯磺酸索拉非尼; Bay 43-9006 Tosylate

A multi-kinase inhibitor

GC17030 AZD6244(Selumetinib)

司美替尼; AZD6244; ARRY-142886

A highly selective inhibitor of MEK1/2

GC10111 Regorafenib

瑞戈非尼; BAY 73-4506

A multi-kinase inhibitor

GC17455 TAK-632 A selective pan-Raf inhibitor

GC15391 Cercosporamide

尾孢素酰胺,(-)-Cercosporamide

A potent inhibitor of fungal Pkc1 and mammalian Mnk isoforms

GC17577 NQDI 1 A selective inhibitor of ASK1

GC10282 Piperlongumine

荜茇酰胺; Piplartine

Piperlongumine是从Piper longum L.中提取的天然生物碱化合物，具有多种药理活性，包括抗肿瘤、脂质代谢调节、抗血小板聚集和镇痛活性等。

GC17255 Gliotoxin

胶霉毒素,Aspergillin

An immunosuppressive mycotoxin with diverse biological effects

GC11076 XMD8-92

2-[[2-乙氧基-4-(4-羟基-1-哌啶基)苯基]氨基]-5,11-二氢-5,11-二甲基-6H-嘧啶并[4,5-B][1,4]苯并二氮杂卓-6-酮

A selective ERK5 inhibitor

GC12691 XMD17-109

XMD17 109

A selective ERK5 inhibitor

GC13115 VX-11e

VX 11e, VX11e

A selective ERK inhibitor

GC15260 Trametinib DMSO solvate

曲美替尼二甲亚砜,GSK-1120212 DMSO solvate;Trametinib;JTP-74057;GSK-1120212;GSK1120212;GSK 1120212;JTP 74057;JTP74057

Trametinib DMSO solvate (GSK-1120212 (DMSO solvate);JTP-74057 (DMSO solvate)) 是一种具有口服活性的 MEK 抑制剂，抑制 MEK1 和 MEK2，IC50 约为 2 nM。 Trametinib DMSO solvate 激活自噬并诱导细胞凋亡。

GC13578 Skepinone-L

Skepinone L

An inhibitor of p38 MAPK

GC16001 SCH772984

(R)-1-(2--2-氧(4-(4-(嘧啶-2-基)苯基)对二氮己环-1-基)乙基)-N-(3-(吡啶-4-基)-1H--5INDAZOL-基)吡咯烷-3-甲酰胺,SCH 772984;SCH-772984

SCH772984是一种新型的、有效的、ATP竞争性的ERK1和ERK2抑制剂，IC₅₀值分别为4nM和1nM。

GC10054 SB 239063

反式-1-(4-羟基环己基)-4-(4-氟苯基)-5-(2-甲氧基嘧啶-4-基)咪唑,SB-239063;SB239063

A selective p38 MAPK inhibitor

GC10528 Salirasib

法尼基硫代水杨酸; S-Farnesylthiosalicylic acid; Farnesyl Thiosalicylic Acid; FTS

A Ras inhibitor with anti-cancer and anti-atherogenic activity

GC14534 Regorafenib monohydrate

瑞格非尼一水合物,BAY 73-4506 monohydrate

A multi-kinase inhibitor

GC14606 Regorafenib hydrochloride

瑞戈非尼盐酸盐; BAY 73-4506 hydrochloride

A multi-kinase inhibitor

GC13514 NG25

N-[4-[(4-乙基-1-哌嗪基)甲基]-3-(三氟甲基)苯基]-4-甲基-3-(1H-吡咯并[2,3-B]吡啶-4-基氧基)苯甲酰胺,NG 25;NG-25

An inhibitor of MAP4K2 and TAK1

GC11649 MLN 2480

6-氨基-5-氯-N-[(1R)-1-[5-[[[5-氯-4-(三氟甲基)-2-吡啶基]氨基]羰基]-2-噻唑基]乙基]-4-嘧啶甲酰胺,BIIB024, BIIB 024, BIIB-024, MLN2480, MLN 2480, MLN-2480

An oral pan-Raf kinase inhibitor

GC11277 MEK inhibitor

(3Z)-3-[[[3-[(二甲基氨基)甲基]苯基]氨基]苯基亚甲基]-2,3-二氢-N-甲基-2-氧代-1H-吲哚-6-甲酰胺,1H-Indole-6-carboxamide, 3-[[[3-[(dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-N-methyl-2-oxo-, (3Z)-

MEK 抑制剂是一种有效的 MEK 抑制剂，具有抗肿瘤效力。