MAPK Signaling(MAPK信号通路)

Cat.No. 产品名称 Information

GC62206 PLX-4720-d7 PLX-4720-d7 是 PLX-4720 的氘代物。PLX-4720 是一种有效的，选择性的 B-RafV600E 抑制剂，IC50 值为 13 nM；与对 c-Raf-1 的选择性相同，是野生型 B-Raf 选择性的 10 倍。

GC62146 XST-14 XST-14 是一种有效的，竞争性强且高度选择性的 ULK1 抑制剂，IC50 为 26.6 nM。XST-14 通过减少 ULK1 下游底物的磷酸化来诱导自噬抑制。XST-14 诱导肝细胞癌 (HCC) 细胞凋亡，并具有抗肿瘤作用。

GC61941 Eudesmin

桉脂素; (-)-Eudesmin; Eudesmine; (-)-Eudesmine

Eudesmin ((-)-Eudesmin) 通过抑制 S6K1 信号通路来干扰成脂分化。Eudesmin 具有多种作用，包括抗肿瘤，抗炎和抗菌活性。

GC61865 Cearoin

2,5-二羟基-4-甲氧基二苯甲酮

Cearoin 通过促进 ROS 产生和激活 ERK 来增强自噬 (autophagy) 和诱导细胞凋亡(apoptosis)。

GC61849 PKI 14-22 amide,myristoylated TFA PKI 14-22 amide,myristoylated TFA 是一种有效的 cAMP 依赖性 PKA 抑制剂。PKI 14-22 amide,myristoylated TFA 可降低 IgG 介导的吞噬反应，也可抑制中性粒细胞粘附。

GC61819 MK2-IN-3 MK2 Inhibitor III (MK2-IN-3) is an ATP-competitive MK2 (MAPKAP-K2) inhibitor with an IC50 value of 8.5 nM.

GC61747 Sp-cAMPS Sp-cAMPS，一种cAMP类似物，是一种依赖cAMP的PKAI和PKAII的有效激活剂。Sp-cAMPS还是一种有效的竞争性磷酸二酯酶(PDE3A)抑制剂，Ki为47.6µM。Sp-cAMPS以EC50为40μM来结合PDE10GAF域。

GC61512 PKA Inhibitor Fragment (6-22) amide TFA

PKI-(6-22)-amide TFA

PKA inhibitor fragment (6-22) amide TFA是一种cAMP依赖性蛋白激酶A（PKA）的合成肽抑制剂，K_i=1.7 nM。

GC61485 Raf inhibitor 2 Raf inhibitor 2 is a potent Raf kinase inhibitor with an IC50 of <1.0 μM.

GC61466 DMU-212

3,4,5,4'-四甲氧基二苯乙烯

DMU-212 is a methylated derivative of Resveratrol, with antimitotic, anti-proliferative, antioxidant and apoptosis promoting activities, which can induce mitotic arrest via induction of apoptosis and activation of extracellular-signal-regulated kinase1/2 (ERK1/2) protein.

GC61454 GW806742X hydrochloride GW806742Xhydrochloride是一种ATP模拟物，是一种有效的MLKL抑制剂，结合MLKL假激酶结构域，Kd值为9.3μM。GW806742Xhydrochloride具有抗VEGFR2的活性(IC50=2nM)。GW806742Xhydrochloride延缓MLKL膜移位并抑制坏死。

GC48920 β-Carboline-1-carboxylic Acid

1-Formic Acid-β-carboline

An alkaloid with diverse biological activities

GC48870 Anagrelide-13C3

BL 4162A-13C3, BMY 26538-01-13C3

An internal standard for the quantification of anagrelide

GC48652 Olomoucine II

2-[[[2-[[(1R)-1-(羟基甲基)丙基]氨基]-9-(1-甲基乙基)-9H-嘌呤-6-基]氨基]甲基]苯酚

A CDK inhibitor

GC48469 Moexipril-d5 An internal standard for the quantification of moexipril

GC48381 5'-pApA (sodium salt)

c-di-AMP Control, Cyclic di-AMP Negative Control

A linearized form of cyclic di-AMP

GC48329 PKA Inhibitor (5-24) (trifluoroacetate salt)

PKI (524), Protein Kinase A Inhibitor (524)

A synthetic peptide inhibitor of PKA

GC47931 PDE4B Inhibitor

KVA-D-88

A PDE4B inhibitor

GC47771 NG 25 (hydrochloride hydrate) An inhibitor of MAP4K2 and TAK1

GC47237 Dipyridamole-d16 A neuropeptide with diverse biological activities

GC47166 Dabrafenib-d9

达帕菲尼杂质,GSK2118436A-d9; GSK2118436-d9

An internal standard for the quantification of dabrafenib

GC47088 Cilostazol-d4

西洛他唑-D4,OPC-13013-d4

An internal standard for the quantification of cilostazol

GC47045 Carvedilol-d5

卡维地洛-D5,BM 14190-d5

An internal standard for the quantification of carvedilol

GC46957 Bumetanide-d5

布美他尼 d5

An internal standard for the quantification of bumetanide

GC46808 ADTL-EI1712 A dual ERK1 and ERK5 inhibitor

GC46554 2'-O-Monosuccinyladenosine-3',5'-cyclic monophosphate

2’-O-Succinyl-cAMP, 2’-O-Succinyl-3’,5’-cyclic AMP

An immunogenic derivative of cAMP

GC61032 MCP110 MCP110 is an inhibitor of Ras/Raf-1 interaction. MCP110 disrupts the interaction of activated Ras with Raf and is potential for the treatment of human tumors.

GC60886 GSK356278 A selective PDE4 inhbitor

GC60812 ERK1/2 inhibitor 2 An ERK inhibitor

GC60592 APS6-45 APS6-45(Compound 10) is an orally active tumor-calibrated inhibitor (TCI) that inhibits RAS/MAPK signaling and exhibits antitumor activity.

GC60393 (-)-Zuonin A

表加巴辛,D-Epigalbacin

(-)-ZuoninA(D-Epigalbacin)是一种天然木质素，是有效的、选择性的JNKs抑制剂，对JNK1、JNK2和JNK3作用的IC50值分别为1.7μM,2.9μM和1.74μM。

GC60262 N-Feruloyloctopamine

N-阿魏酰章鱼胺

N-Feruloyloctopamine，从 Garlic 皮中分离出来的，是一种抗氧化剂成分。N-Feruloyloctopamine 显着降低 Akt 和 p38 MAPK 磷酸化水平。

GC60037 A-3 hydrochloride

赤霉酸

A-3 hydrochloride, a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases, againsts cAMP-dependent protein kinase (PKA) (Ki=4.3 ?M), casein kinase II (CK2) (Ki=5.1 ?M) and myosin light chain kinase (MLCK) (Ki=7.4 ?M), also inhibits Protein Kinase C (PKC) and casein kinase I (CK1) with Ki values of 47 ?M and 80 ?M, respectively.

GC39815 Semapimod tetrahydrochloride

CNI-1493; CPSI-2364 tetrahydrochloride

Semapimod tetrahydrochloride (CNI-1493) 是促炎细胞因子产生 (proinflammatory cytokine) 的抑制剂，可抑制TNF-α、IL-1β 和 IL-6。Semapimod tetrahydrochloride 抑制巨噬细胞 p38 MAPK 和一氧化氮生成。Semapimod tetrahydrochloride 抑制 TLR4 信号 (IC50≈0.3 μM)。Semapimod tetrahydrochloride 在多种炎症和自身免疫性疾病中具有潜在的作用。

GC39715 M2698

MSC2363318A

A dual inhibitor of p70S6K and Akt1

GC39574 SR-318 A dual inhibitor of p38α and p38β MAPKs

GC39485 CK2/ERK8-IN-1 A dual inhibitor of CK2 and ERK8

GC39325 2,5-Dihydroxyacetophenone

2,5-二羟基苯乙酮; 2',5'-二羟基苯乙酮

2',5'-Dihydroxyacetophenone (DHAP, 2-Acetylhydroquinone, Quinacetophenone) is a mixture of dihydroxyacetophenone isomers is used in food flavouring. 2',5'-Dihydroxyacetophenone significantly inhibits NO production via the suppression of iNOS expression. 2',5'-Dihydroxyacetophenone significantly decreases levels of the pro-inflammatory cytokines TNF-α and IL-6 by blocking the ERK1/2 and NF-κB signaling pathways.

GC50502 RI-STAD 2 AKAP disruptor; selectively binds PKA-RI with high affinity and blocks its interaction with AKAP; cell permeable

GC50501 STAD 2 STAD 2 是 PKA-RII 的有效选择性破坏剂，Kd 为 6.2 nM。

GC50407 st-Ht31 P Negative control for st-Ht31

GC50406 st-Ht31 Inhibits PKA/AKAP interactions; cell permeable

GC50400 CC 401 dihydrochloride A potent, specific pan-JNK inhibitor

GC50316 Org 48762-0 Selective p38α/β inhibitor; orally bioavailable

GC50295 TL4-12 TL4 12 是一种有效的选择性 GCK（生发中心激酶）抑制剂。

GC50294 RMM 46 An inhibitor of RSK2

GC50252 PF 06260933 dihydrochloride MAP4K4 (HGK) inhibitor; also inhibits MINK and TNIK

GC50181 CW 008 PKA signaling activator; promotes osteogenesis from hMSCs

GC46123 Comprehensive Kinase Screening Library For screening of a variety of kinase inhibitors

GC39095 Isoliquiritin apioside

芹糖异甘草苷

Isoliquiritin apioside (ISLA, ILA), a component isolated from Glycyrrhizae radix rhizome (GR), significantly decreases PMA-induced increases in matrix metalloproteinase (MMP) activities and suppresses PMA-induced activation of mitogen-activated protein kinase (MAPK) and NF-κB. Isoliquiritin apioside possesses anti-metastatic and anti-angiogenic abilities in malignant cancer cells and ECs, with no cytotoxicity.

MAPK Signaling(MAPK信号通路)

Products for MAPK Signaling