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Home >> Signaling Pathways >> MAPK Signaling

MAPK Signaling(MAPK信号通路)

Products for  MAPK Signaling

  1. Cat.No. 产品名称 Information
  2. GC47931 PDE4B Inhibitor

    KVA-D-88

     A PDE4B inhibitor
  3. GC47771 NG 25 (hydrochloride hydrate) An inhibitor of MAP4K2 and TAK1
  4. GC47237 Dipyridamole-d16 A neuropeptide with diverse biological activities
  5. GC47166 Dabrafenib-d9

    达帕菲尼杂质,GSK2118436A-d9; GSK2118436-d9

     An internal standard for the quantification of dabrafenib
  6. GC47088 Cilostazol-d4

    西洛他唑-D4,OPC-13013-d4

     An internal standard for the quantification of cilostazol
  7. GC47045 Carvedilol-d5

    卡维地洛-D5,BM 14190-d5

     An internal standard for the quantification of carvedilol
  8. GC46957 Bumetanide-d5

    布美他尼 d5

     An internal standard for the quantification of bumetanide
  9. GC46808 ADTL-EI1712 A dual ERK1 and ERK5 inhibitor
  10. GC46554 2'-O-Monosuccinyladenosine-3',5'-cyclic monophosphate

    2’-O-Succinyl-cAMP, 2’-O-Succinyl-3’,5’-cyclic AMP

     An immunogenic derivative of cAMP
  11. GC61032 MCP110 MCP110 is an inhibitor of Ras/Raf-1 interaction. MCP110 disrupts the interaction of activated Ras with Raf and is potential for the treatment of human tumors.
  12. GC60886 GSK356278 A selective PDE4 inhbitor
  13. GC60812 ERK1/2 inhibitor 2 An ERK inhibitor
  14. GC60592 APS6-45 APS6-45(Compound 10) is an orally active tumor-calibrated inhibitor (TCI) that inhibits RAS/MAPK signaling and exhibits antitumor activity.
  15. GC60393 (-)-Zuonin A

    表加巴辛,D-Epigalbacin

     (-)-ZuoninA(D-Epigalbacin)是一种天然木质素，是有效的、选择性的JNKs抑制剂，对JNK1、JNK2和JNK3作用的IC50值分别为1.7μM,2.9μM和1.74μM。
  16. GC60262 N-Feruloyloctopamine

    N-阿魏酰章鱼胺

     N-Feruloyloctopamine，从 Garlic 皮中分离出来的，是一种抗氧化剂成分。N-Feruloyloctopamine 显着降低 Akt 和 p38 MAPK 磷酸化水平。
  17. GC60037 A-3 hydrochloride

    赤霉酸

     A-3 hydrochloride, a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases, againsts cAMP-dependent protein kinase (PKA) (Ki=4.3 ?M), casein kinase II (CK2) (Ki=5.1 ?M) and myosin light chain kinase (MLCK) (Ki=7.4 ?M), also inhibits Protein Kinase C (PKC) and casein kinase I (CK1) with Ki values of 47 ?M and 80 ?M, respectively.
  18. GC39815 Semapimod tetrahydrochloride

    CNI-1493; CPSI-2364 tetrahydrochloride

     Semapimod tetrahydrochloride (CNI-1493) 是促炎细胞因子产生 (proinflammatory cytokine) 的抑制剂，可抑制TNF-α、IL-1β 和 IL-6。Semapimod tetrahydrochloride 抑制巨噬细胞 p38 MAPK 和一氧化氮生成。Semapimod tetrahydrochloride 抑制 TLR4 信号 (IC50≈0.3 μM)。Semapimod tetrahydrochloride 在多种炎症和自身免疫性疾病中具有潜在的作用。
  19. GC39715 M2698

    MSC2363318A

     A dual inhibitor of p70S6K and Akt1
  20. GC39574 SR-318 A dual inhibitor of p38α and p38β MAPKs
  21. GC39485 CK2/ERK8-IN-1 A dual inhibitor of CK2 and ERK8
  22. GC39325 2,5-Dihydroxyacetophenone

    2,5-二羟基苯乙酮; 2',5'-二羟基苯乙酮

     2',5'-Dihydroxyacetophenone (DHAP, 2-Acetylhydroquinone, Quinacetophenone) is a mixture of dihydroxyacetophenone isomers is used in food flavouring. 2',5'-Dihydroxyacetophenone significantly inhibits NO production via the suppression of iNOS expression. 2',5'-Dihydroxyacetophenone significantly decreases levels of the pro-inflammatory cytokines TNF-α and IL-6 by blocking the ERK1/2 and NF-κB signaling pathways.
  23. GC50502 RI-STAD 2 AKAP disruptor; selectively binds PKA-RI with high affinity and blocks its interaction with AKAP; cell permeable
  24. GC50501 STAD 2 STAD 2 是 PKA-RII 的有效选择性破坏剂，Kd 为 6.2 nM。
  25. GC50407 st-Ht31 P Negative control for st-Ht31
  26. GC50406 st-Ht31 Inhibits PKA/AKAP interactions; cell permeable
  27. GC50400 CC 401 dihydrochloride A potent, specific pan-JNK inhibitor
  28. GC50316 Org 48762-0 Selective p38α/β inhibitor; orally bioavailable
  29. GC50295 TL4-12 TL4 12 是一种有效的选择性 GCK（生发中心激酶）抑制剂。
  30. GC50294 RMM 46 An inhibitor of RSK2
  31. GC50252 PF 06260933 dihydrochloride MAP4K4 (HGK) inhibitor; also inhibits MINK and TNIK
  32. GC50181 CW 008 PKA signaling activator; promotes osteogenesis from hMSCs
  33. GC46123 Comprehensive Kinase Screening Library For screening of a variety of kinase inhibitors
  34. GC39095 Isoliquiritin apioside

    芹糖异甘草苷

     Isoliquiritin apioside (ISLA, ILA), a component isolated from Glycyrrhizae radix rhizome (GR), significantly decreases PMA-induced increases in matrix metalloproteinase (MMP) activities and suppresses PMA-induced activation of mitogen-activated protein kinase (MAPK) and NF-κB. Isoliquiritin apioside possesses anti-metastatic and anti-angiogenic abilities in malignant cancer cells and ECs, with no cytotoxicity.
  35. GC39074 Tenuifoliside A

    细叶远志苷A

     Tenuifoliside A 分离自远志，具有抗凋亡和抗抑郁作用。在 C6 细胞中，Tenuifoliside A 表现出其神经营养作用，并通过 ERK/CREB/BDNF 信号通路促进细胞增殖。
  36. GC38917 Gossypetin

    棉花素

     A flavonoid with diverse biological activities
  37. GC46015 KY 05009 A TNIK inhibitor
  38. GC38804 JWG-071 JWG-071 是首次报道的 ERK5 激酶选择性化学探针。JWG-071 提高了 ERK5 活性和 BRD4 选择性。JWG-071 将是反卷积 ERK5 和 BRD4 药理学急需的化学探针。
  39. GC38791 GSK-25 GSK-25 是一种有效的、选择性的，具有口服活性的 ROCK1 抑制剂 (IC50=7 nM)。GSK-25 对 31 种激酶以及 RSK1 和 p70S6K 保持良好的选择性 (RSK1: IC50=398 nM, p70S6K: IC50=1 μM)。GSK-25 可抑制 P450 (CYP2C9、CYP2D6、CYP3A4的IC50 分别为2.5、5.2、2.5 μM)。
  40. GC38755 CKI-7 A CK1 inhibitor
  41. GC38738 Azosemide

    阿佐塞米

     Azosemide is a potent Na+–K+–2Cl? cotransporter NKCC1 inhibitor with IC50s of 0.246??M for hNKCC1A and 0.197??M for NKCC1B, respectively.
  42. GC45902 Trametinib-13C-d3

    GSK1120212-13C,d3; JTP-74057-13C,d3

     A neuropeptide with diverse biological activities
  43. GC38708 Esculin

    秦皮甲素

     A coumarin with antioxidant and anti-inflammatory activities
  44. GC38679 Urolithin B

    尿石素B

     A metabolite of ellagic acid
  45. GC38653 Selumetinib sulfate

    司美替尼硫酸盐,AZD6244 sulfate; ARRY-142886 sulfate

     Selumetinib (AZD6244) 是一种高效选择性的，非 ATP 竞争性的 MEK1/2 抑制剂， 抑制 MEK1 的 IC50 为 14 nM。Selumetinib (AZD6244) 抑制 MEK1/2 磷酸化水平。
  46. GC38609 Rotundic acid

    铁冬青酸

     Rotundic acid (Rutundic acid), a natural compound, exhibit cytotoxic activities toward human hepatocellular carcinoma (HepG2), malignant melanoma (A375), SCLC (NCI-H446), breast cancer (MCF-7), and colon cancer (HT-29) cell lines.RA induces cell cycle arrest, DNA damage, and apoptosis by modulating the AKT/mTOR and MAPK pathways.
  47. GC38518 AMG-548 dihydrochloride An inhibitor of p38α MAPK
  48. GC38319 Dihydrocaffeic acid

    二氢咖啡酸; 3,4-Dihydroxy-benzenepropanoic acid

     A polyphenol with diverse biological activities
  49. GC38202 DTP3 TFA DTP3 is a selective GADD45β/MKK7 (growth arrest and DNA-damage-inducible β/mitogen-activated protein kinase kinase 7) inhibitor and is able to restore MKK7/JNK activation. DTP3 inhibits cancer-selective NF-κB survival pathway.
  50. GC38053 WHI-P258 A negative control for JAK3 inhibition
  51. GA20623 Ac-muramyl-Ala-D-Glu-NH₂

    佐剂肽

     Ac-muramyl-Ala-D-Glu-NH₂ (MDP) 是一种合成的免疫反应肽，由连接到 L-Ala-D-isoGln 短氨基酸链上的 N-乙酰胞壁酸组成。

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