MAPK Signaling(MAPK信号通路)

Cat.No. 产品名称 Information

GC44085 L-Sulforaphene

莱菔素

A natural isothiocyanate

GC44022 L-858,051 (hydrochloride) A water-soluble activator of adenylate cyclase

GC43885 Hypothemycin

寄端霉素

A resorcylic acid lactone polyketide with diverse biological activities

GC43803 HA-1077 (hydrochloride)

盐酸法舒地尔,HA-1077 dihydrochloride; AT-877 dihydrochloride

A ROCK inhibitor

GC43798 Guanylyl Imidodiphosphate (lithium salt)

Gpp(NH)p lithium

Guanylyl Imidodiphosphate (lithium salt)是一种稳定的GTP类似物，是腺苷酸环化酶的有效激活剂。

GC43734 Ganglioside GQ1b Mixture (sodium salt)

神经节苷脂GQ1B四钠盐

A mixture of ganglioside G_Q1b

GC43624 ERK Inhibitor

Extracellular Regulated Kinase Inhibitor

An ERK inhibitor

GC43611 Enniatin B1

恩镰孢菌素 B1

An antibiotic ionophore

GC43610 Enniatin A1

恩镰孢菌素 A1

An ionophore antibiotic

GC43341 Cyclic GMP

鸟苷-3ˊ,5ˊ-环磷酸一钠盐

A second messenger

GC43332 Cuspin-1

Chemical Upregulator of SMN Protein-1

An upregulator of SMN protein

GC43198 CAY10717 A multi-targeted kinase inhibitor

GC43167 CAY10561

Pyrazolylpyrrole ERK Inhibitor

A selective inhibitor of ERK

GC43065 C2 Phytoceramide (t18:0/2:0)

N-Acetyl Phytosphingosine, C2:0 Phytoceramide, Cer(t18:0/2:0), Ceramide (t18:0/2:0), NAPS

A bioactive sphingolipid

GC42968 BPIQ-II (hydrochloride)

PD 158294

A potent, selective EGFR inhibitor

GC42622 8-bromo-Cyclic AMP

8-溴腺苷-3',5'-环单磷酸

A PKA activator

GC42616 7-oxo Staurosporine

BMY 41950, RK-1409

An antibiotic with diverse biological activities

GC41740 (S)-p38 MAPK Inhibitor III

(S)-p38 MAP Kinase Inhibitor III, (S)-p38 Mitogen-activated Protein Kinase Inhibitor III

A cell-permeable p38 MAP kinase inhibitor

GC41656 (±)2-(14,15-Epoxyeicosatrienoyl) Glycerol

(±)214,15EG

A cytochrome P450 metabolite of 2-AG

GC41635 Phosphodiesterase 4 Inhibitor

PDE4 Inhibitor

An inhibitor of PDE4

GC41573 Theaflavin 3,3'-digallate

茶黄素-3,3'-双没食子酸; TF-3; ZP10

Theaflavin 3,3'-digallate（茶黄素-3,3'-双没食子酸; TF-3; ZP10）是一种有效的寨卡病毒（ZIKV）蛋白酶抑制剂，IC₅₀值为2.3μM。

GC41423 5-trans Prostaglandin E2

transDinoprostone, 5,6trans PGE2

An impurity in commercial lots of PGE₁

GC40650 CAY10706 A TrxR inhibitor

GC40484 Ferulic Acid methyl ester

阿魏酸甲酯; Methyl ferulate

A lipophilic antioxidant

GC40352 Cafestol

咖啡醇

A natural diterpene which increases serum cholesterol

GC34918 MW-150 dihydrochloride dihydrate

MW01-18-150SRM dihydrochloride dihydrate

An inhibitor of p38α MAPK

GC34831 Tauroursodeoxycholate dihydrate

牛磺熊去氧胆酸二水合物; Tauroursodeoxycholic acid dihydrate; TUDCA dihydrate; UR 906 dihydrate

Tauroursodeoxycholatedihydrate(TUDCAdihydrate;UR906dihydrate;Taurolitedihydrate)是一种内质网应激抑制剂。Tauroursodeoxycholate显著降低凋亡分子如caspase-3和caspase-12表达。Tauroursodeoxycholate也抑制ERK。

GC34650 Longdaysin

Longdaysin is a Casein Kinase inhibitor with IC50 values of 8.8 μM, 5.6 μM, 52 μM and 29 μM for CKIδ, CKIα, ERK2 and CDK7.

GC19507 LUT-014 LUT-014 是一种 B-Raf 抑制剂，IC50 为 11.7 nM，用于减少与 EGFR 抑制剂治疗相关的剂量限制性痤疮样病变。

GC40231 Milrinone-d3 An internal standard for the quantification of milrinone

GC40213 Regorafenib-13C-d3

瑞戈非尼-13C-D3,BAY 73-4506-13C,d3

An internal standard for the quantification of regorafenib

GC40054 CCT241161 A multi-kinase inhibitor

GC34342 BAY885 An ERK5 inhibitor

GC34275 L-JNKI-1 L-JNKI-1是一种针对JNK的细胞渗透性多肽抑制剂。

GC34208 GNE 220 Hydrochloride GNE220(Hydrochloride)是一种有效的选择性MAP4K4抑制剂，其IC50值为7nM。

GC34197 FMK-MEA

FMK-MEA 是一种有效的选择性 p90 核糖体 S6 激酶 (RSK) 抑制剂。

GC34181 Tauroursodeoxycholate (TUDCA)

牛磺熊去氧胆酸; Tauroursodeoxycholic acid; TUDCA; UR 906

牛磺酸脱氧胆酸盐(TUDCA)是包括肝细胞在内的多种细胞的细胞保护剂,也是癌症细胞凋亡的诱导剂。

GC34140 TC13172

TC13172是MLKL的抑制剂，作用于HT-29细胞，其EC50值为2nM。

GC34072 Talmapimod (SCIO-469)

他匹莫德; SCIO-469

A p38 MAPK inhibitor

GC34057 TBHQ (tert-Butylhydroquinone)

特丁基对苯二酚; tert-Butylhydroquinone

TBHQ(tert-Butylhydroquinone)是一种强效的酚类抗氧化剂，能够减轻氧化应激和炎症反应。

GC33857 Omtriptolide

昂曲托来

Omtriptolide(PG490-88)是从中草药纯化的雷公藤内酯的水溶性衍生物前药。

GC33844 Isovitexin (Saponaretin)

异牡荆黄素; Saponaretin; Homovitexin

Isovitexin 是从西番莲、大麻和棕榈得到的黄酮类物质，具有抗氧化、抗炎的活性；Isovitexin 作用与 JNK1/2 的抑制剂类似，能够抑制 NF-κB 的活化。

GC33831 Lidocaine hydrochloride (Lignocaine hydrochloride)

盐酸利多卡因; Lignocaine hydrochloride

An Analytical Reference Standard

GC33771 Metadoxine

美他多辛

Metadoxine (Metadoxil, Metasin, pyridoxine-pyrrolidone carboxylat), also known as pyridoxine-pyrrolidone carboxylate, is a drug used to treat chronic and acute alcohol intoxication. Metadoxine is a novel 5-HT2B receptor antagonist with a possible therapeutic role in treating ADHD.

GC33388 MEK-IN-1 MEK-IN-1是来自专利WO2008076415A1的MEK抑制剂。

GC33305 Balamapimod (MKI 833)

MKI 833

Balamapimod (MKI 833) (MKI 833) 是一种可逆的 Ras/Raf/MEK 抑制剂，具有潜在的抗肿瘤活性。

GC33238 SJFδ SJFδ是一种含10个原子连接桥的PROTAC。SJFδ降解p38α，DC50为46.17nM，但不降解其他p38亚型(p38α,p38β和p38γ)。

GC33229 SJFα SJFα是一种含13个原子连接桥的PROTAC。SJFα降解p38α，DC50为7.16nM，但降解p38δ效果较差(DC50=299nM)，且在浓度高达2.5μM时也不会降解其他p38亚型(β和γ)。

GC33206 ERK-IN-1 ERK-IN-1（化合物 B）是一种可口服的 ERK1 和 ERK2 抑制剂，用于治疗以激活 MAPK 通路突变为特征的增殖性疾病。该活性尤其与 KRAS 突变 NSCLC、BRAF 突变 NSCLC、KRAS 突变胰腺癌、KRAS 突变结直肠癌 (CRC) 和 KRAS 突变卵巢癌的治疗有关。 ERK-IN-1 hydrochloride 也可以抑制 RAF。

GC33142 MK2-IN-1 (MK2 Inhibitor) MK2-IN-1 (MK2 Inhibitor) 是一种有效的、选择性的 MAPKAPK2(MK2) 抑制剂 (IC50=0.11 uM)，具有非 ATP 竞争性结合模式。

MAPK Signaling(MAPK信号通路)

Products for MAPK Signaling