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Home >> Signaling Pathways >> MAPK Signaling >> MNK

MNK(丝裂原活化蛋白激酶相互作用激酶)

MNK (MAP kinase-interacting kinases) is a group of serine/threonine kinase that phosphorylates eukaryotic initiation factor 4E (eIF4E) in the MAPK signaling pathways. It plays an important role in cell transformation and tumor progression.

Products for  MNK

  1. Cat.No. 产品名称 Information
  2. GC73896 VNPP433-3β

    Galeterone 3β-imidazole

     VNPP433-3β是一种分子胶降解剂，可降解雄激素受体（AR）及其剪接变体（AR Vs）和MAP激酶相互作用丝氨酸/苏氨酸蛋白激酶Mnk1/2。
  3. GC73118 EB1 EB1是MNK激酶的抑制剂，ic50值分别为0.69 μM （MNK1）和9.4 μM （MNK2）。
  4. GC70832 MNK1/2-IN-5 MNK1/2-IN-5是一种强效且选择性的MNK1/2抑制剂，作为治疗剂。
  5. GC70565 QL-X-138 QL-X-138是一种有效的选择性BTK/MNK双激酶抑制剂，与BTK共价结合，与MNK非共价结合。
  6. GC69013 DS12881479 DS12881479 是一种有效的选择性 Mnk1 抑制剂，其 IC50 值为21 nM. DS12881479 可用于癌症研究。
  7. GC33033 ETC-206

    4-[6-[4-(4-吗啉基羰基)苯基]咪唑并[1,2-A]吡啶-3-基]苄腈

     An inhibitor of MKNK1 and MKNK2
  8. GC32937 SLV-2436 (SEL201-88)

    SEL201-88; SEL-201

     SEL-201 (SLV-2436, SEL201-88) is a highly potent and ATP-competitive inhibitor of MNK1 and MNK2 with IC50 of 10.8 ?nM and 5.4 nM, respectively.
  9. GC19131 Tomivosertib

    6'-[(6-氨基-4-嘧啶基)氨基]-8'-甲基螺[环己烷-1,3'(2'H)-咪唑并[1,5-A]吡啶]-1',5'-二酮,eFT508

     A potent inhibitor of MNK1 and MNK2
  10. GC10666 CGP 57380

    N3-(4-氟苯基)-1H-吡唑并[3,4-D]嘧啶-3,4-二胺

     Inhibitor of MAPK-interacting kinase1
  11. GC15391 Cercosporamide

    尾孢素酰胺,(-)-Cercosporamide

    A potent inhibitor of fungal Pkc1 and mammalian Mnk isoforms

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