Raf

Cat.No. 产品名称 Information

GC15055 AZ 628

AZ-628; AZ628

A Raf kinase inhibitor

GC15818 RAF265

CHIR-265;RAF 265;RAF-265;CHIR265

A B-Raf and VEGFR2 inhibitor

GC16845 CEP-32496

CEP-32496; RXDX-105

A potent inhibitor of B-Raf

GC11497 BIRB 796 (Doramapimod)

达马莫德; BIRB 796

A potent inhibitor of p38 MAPK

GC10505 GDC-0879

2,3-二氢-5-[1-(2-羟基乙基)-3-(4-吡啶基)-1H-吡唑-4-基]-1H-茚-1-酮肟

An inhibitor of B-Raf^V600E

GC16499 Sorafenib Tosylate

甲苯磺酸索拉非尼; Bay 43-9006 Tosylate

A multi-kinase inhibitor

GC10111 Regorafenib

瑞戈非尼; BAY 73-4506

A multi-kinase inhibitor

GC17455 TAK-632 A selective pan-Raf inhibitor

GC14534 Regorafenib monohydrate

瑞格非尼一水合物,BAY 73-4506 monohydrate

A multi-kinase inhibitor

GC14606 Regorafenib hydrochloride

瑞戈非尼盐酸盐; BAY 73-4506 hydrochloride

A multi-kinase inhibitor

GC11649 MLN 2480

6-氨基-5-氯-N-[(1R)-1-[5-[[[5-氯-4-(三氟甲基)-2-吡啶基]氨基]羰基]-2-噻唑基]乙基]-4-嘧啶甲酰胺,BIIB024, BIIB 024, BIIB-024, MLN2480, MLN 2480, MLN-2480

An oral pan-Raf kinase inhibitor

GC12486 Dabrafenib Mesylate (GSK-2118436)

甲磺酸达拉非尼; GSK2118436 Mesylate; GSK 2118436B

A Raf kinase inhibitor

GC17860 CEP-32496 hydrochloride

CEP 32496 hydrochloride;CEP32496 hydrochloride

A potent inhibitor of B-Raf

GC12151 B-Raf inhibitor

N-[4-[(4-乙基-1-哌嗪基)甲基]-3-(三氟甲基)苯基]-4-甲基-3-[(6-甲基-7H-吡咯并[2,3-D]嘧啶-4-基)氧基]苯甲酰胺

B-Raf inhibitor 是一种有效的双重 TGFβ-activated kinase 1 (TAK1) 和 mitogen-activated protein kinase kinase kinase 2 (MAP4K2) 抑制剂，IC50 分别为 41.1 nM 和 18.2 nM。

GC12482 BRAF inhibitor

N-[2,4-二氟-3-[[5-(3-吡啶基)-1H-吡咯并[2,3-B]吡啶-3-基]羰基]苯基]-2-丙磺酰胺

BRAF 抑制剂是从专利 WO/2011103196 A1 化合物 P-0850 中提取的 B-Raf 抑制剂。

GC14732 PLX-4720

N-[3-[(5-氯-1H-吡咯并[2,3-B]吡啶-3-基)羰基]-2,4-二氟苯基]-1-丙磺酰胺,PLX4720, PLX-4720, PLX 4720

An orally-available inhibitor of the B-raf mutant B-Raf^V600E

GC17369 Sorafenib

索拉非尼; Bay 43-9006

索拉非尼Sorafenib是Raf-1和B-Raf的多激酶抑制剂，IC50分别为6 nM和22 nM;Sorafenib对VEGFR-2 VEGFR-3 PDGFR-β Flt-3和c-KIT也有抑制作用，IC50值分别为90 nM、20 nM、57 nM、59 nM和68 nM;索拉非尼能诱导自噬细胞凋亡和激活铁死亡，并具有抗肿瘤活性。

GC13412 Vemurafenib (PLX4032, RG7204)

维罗非尼; PLX4032; RG7204; RO5185426

An inhibitor of mutant V600E and wild type B-Raf

Products for Raf