Fatty Acid Synthase (FASN)(脂肪酸合成酶)

Fatty Acid Synthase (FASN) is a multifunctional homodimeric enzyme protein, and it is the major enzyme required for the anabolic conversion of dietary carbohydrates to fatty acids. Fatty acid synthase catalyzes the conversion of acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids.

Human fatty acid synthase is a large homodimeric multifunctional enzyme that synthesizes palmitic acid. The unique carboxyl terminal thioesterase domain of fatty acid synthase hydrolyzes the growing fatty acid chain and plays a critical role in regulating the chain length of fatty acid released. Also, the up-regulation of human fatty acid synthase in a variety of cancer makes the thioesterase a candidate target for therapeutic treatment.

Products for Fatty Acid Synthase (FASN)

Cat.No. 产品名称 Information
GC25411 Fasnall Fasnall, a thiophenopyrimidine, is a selective fatty acid synthase (FASN) inhibitor that shows potent anti-tumor activity.
GC67894 FASN-IN-5 FASN-IN-5 (example 11) 是 FASN 抑制剂，可用于研究 TH17 或 CSF1 介导的疾病或障碍，例如癌症、免疫障碍和肥胖症。
GC64974 FT113 FT113 is a potent inhibitor of fatty acid synthase (FAS/FASN) with ic50 of 213 nM.
GC62571 IPI-9119 IPI-9119 is a potent, selective, and irreversible inhibitor of fatty acid synthase (FASN), which can inhibit the FASN thioesterase domain by promoting acylation of the catalytic serine with an IC50 of 0.3 nM.
GC61896 trans-Chalcone
反-查耳酮
Trans-Chalcone, the backbone of flavonoids, also is a potent fatty acid synthase (FAS) with IC50 of 17.1 μg/mL, and α-amylase inhibitor, causes cellcycle arrest and induces apoptosis in the breastcancer cell line MCF-7, exerting antifungal and anticancer activities.
GC60832 FASN-IN-4 tosylate FASN-IN-4tosylate是高效的脂肪酸合酶FASN抑制剂，来自专利WO2012064642A1化合物实例29，IC50值为10nM。
GC38967 Lycorine
石蒜碱
An alkaloid with diverse biological activities
GC18496 Leelamine (hydrochloride)
脱氢松香胺盐酸盐
An inhibitor of pyruvate dehydrogenase kinase