Ferroptosis(铁死亡)

Cat.No. 产品名称 Information

GC91783 FA16 FA16 is a ferroptosis inducer and an inhibitor of the system xc- cystine/glutamate transporter.

GC91691 viFSP1

Versatile Inhibitor of Ferroptosis Suppressor Protein 1,Versatile Inhibitor of FSP1

viFSP1 is a species-independent inhibitor of ferroptosis suppressor protein 1 (FSP1; IC50s = 34 and 83 nM for the human and mouse enzymes, respectively).

GC91623 Ferroptosis Inducer 24 Ferroptosis inducer 24 is an inducer of ferroptosis.

GC91613 FerroLOXIN-1 FerroLOXIN-1 is an inhibitor of the 15-lipoxygenase-2 (15-LO-2) and phosphatidylethanolamine-binding protein 1 (PEBP1) catalytic complex.

GC91598 GPX4 16

Glutathione Peroxidase 4 16

GPX4 16 is an inhibitor of glutathione peroxidase 4 (GPX4).

GC71840 L-Cystine-34S2 L-Cystine-34S2是34S标记的L-胱氨酸。

GC71839 L-Cystine-d4

L-Cystine-d4是氘标记的L-胱氨酸。

GC71837 L-Glutamine-13C5,15N2,d5 L-Glutamine-13C5,15N2,d5是氘、13C-和15-标记的L-谷氨酰胺。

GC71730 L-Glutathione reduced-13C2,15N L-Glutathione reduced-13C2,15N13C和15N标记的L-谷胱甘肽是否减少。

GC70824 Pioglitazone-d4 (alkyl) Pioglitazone-d4 (alkyl)（U 72107-d4（烷基））是氘标记的吡格列酮。

GC91380 N6F11

N6F11 is a novel, selective and potent inducer of iron death with anticancer and antitumour activity that promotes GPX4 degradation by binding to TRIM25 in cancer cells.

GC91157 C18

一种共价的GPX4抑制剂

GC90827 GPX4 24

Glutathione Peroxidase 4 24, PHGPx 24, Phospholipid Hydroperoxide Glutathione Peroxidase 24

一种GPX4抑制剂

GC90714 LOC1886

一种GPX4抑制剂

GC90713 FSEN1

Ferroptosis Sensitizer 1

FSP1的抑制剂

GC70157 YL-939 YL-939 是一种有效的铁死亡 (ferroptosis) 抑制剂。 YL-939 通过靶向 PHB2/铁蛋白/铁轴来抑制铁死亡。

GC68580 84-B10 84-B10 是一种 3-苯基戊二酸衍生物。84-B10 抑制 cisplatin 诱导的肾小管铁死亡。84-B10 减轻 cisplatin 诱导的线粒体损伤和氧化应激。84-B10 改善 cisplatin 诱导的急性肾损伤 (AKI)。

GC68479 MMRi62

MMRi62 是一种铁死亡 (Ferroptosis) 诱导剂，靶向 MDM2-MDM4 (抑癌基因 p53 负调控因子)。MMRi62 对胰腺导管腺癌 (PDAC) 细胞显示出 p53 独立的促凋亡 (Apoptosis) 活性，并诱导其自噬 (Autophagy)。MMRi62 诱导铁死亡，伴随着活性氧增加和铁蛋白重链 (FTH1) 溶酶体降解。MMRi62 还可导致突变型 p53 的蛋白酶体降解，并对具有 KRAS 和 TP53 高频突变特征的原位异种移植 PDAC 小鼠模型具有体内药效。

GC52413 5-Aminosalicylic Acid-d7

5-ASA-d7, Mesalamine-d7, Mesalazine-d7

An internal standard for the quantification of 5-aminosalicylic acid

GC52317 BCP-T.A. A ferroptosis inducer

GC52290 (R)-HTS-3 An inhibitor of LPCAT3

GC20109 Cefotiam hexetil hydrochloride

盐酸头孢替安酯; CTM-HE hydrochloride; SCE-2174 hydrochloride

Cefotiam hexetil hydrochloride 是可口服的第三代头孢菌素，是 cefotiam 的前药，但无抗菌作用。Cefotiam 是一种抗生素。

GC52190 Imidazole Ketone Erastin

IKE

Imidazole Ketone Erastin是一种有效的、代谢稳定的系统xc- 抑制剂和铁凋亡诱导剂。

GC52164 Cu-ATSP

copper-ATSP, CuII(atsp)

A copper-containing bis(thiosemicarbazone) complex

GC65163 Ardisiacrispin B

百两金皂苷B

Ardisiacrispin B在多因素耐药癌细胞中显示细胞毒性作用，通过铁中毒和凋亡细胞死亡。

GC65095 L-Glutamic acid-d5

L-谷氨酸 d5

L-Glutamic acid-d5 是 L-Glutamic acid 的氘代物。L-Glutamic acid 作为一种兴奋性氨基酸神经递质，为谷氨酸盐受体所有亚型(代谢型红藻氨酸、NMDA 和 AMPA)的激动剂。对 DA 从多巴胺能神经末梢释放的过程有激动作用。

GC65068 L-Glutamine 15N

L-Glutamic acid 5-amide 15N

L-Glutamine-15N (L-Glutamic acid 5-amide-15N) 是 15N 标记的 L-Glutamine。L-Glutamine (L-Glutamic acid 5-amide) 是在人体中大量存在且参与许多代谢过程的非必需氨基酸。L-Glutamine 为某些细胞中的氧化提供了碳源。

GC19936 Quisinostat dihydrochloride

QUISINOSTAT二盐酸盐,JNJ-26481585 dihydrochloride

A pan-HDAC inhibitor

GC49868 D-α-Tocopheryl Quinone

α-Tocopherylquinone

An oxidative metabolite of vitamin E

GC64352 L-Glutamic acid-15N

L-谷氨酸 15N

L-Glutamic acid-15N 是一种 15N 标记的 L-Glutamic acid。L-Glutamic acid 作为一种兴奋性氨基酸神经递质，为谷氨酸盐受体所有亚型(代谢型红藻氨酸、NMDA 和 AMPA)的激动剂。对 DA 从多巴胺能神经末梢释放的过程有激动作用。

GC49730 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE-d11

15(S)-HETE-SAPE-d11, 15(S)-Hydroxyeicosatetraenoic Acid-SAPE-d11, 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-Phosphatidylethanolamine-d11

An internal standard for the quantification of 1-stearoyl-2-15(S)-HETE-sn-glycero-3-PE

GC49697 GPX4 Inhibitor 26a

Glutathione Peroxidase 4 Inhibitor 26a

A GPX4 inhibitor

GC49691 PSP A two-photon fluorescent probe for H₂S_n

GC49560 L6H21 An inhibitor of the MD-2 and TLR4 interaction

GC49454 Complex 3 A fluorescent copper complex with anticancer activity

GC49308 Ungeremine

石蒜碱内铵盐

A betaine-type alkaloid with diverse biological activities

GC49058 DTPA

二乙烯三胺五醋酸,Diethylenetriaminepentaacetic acid; DTPA

A cell-impermeable metal chelating agent

GC49034 1(R)-(Trifluoromethyl)oleyl alcohol An oleic acid analog

GC62643 L-Buthionine-(S,R)-sulfoximine hydrochloride

L-Buthionine sulfoximine hydrochloride; L-BSO hydrochloride

An irreversible inhibitor of the γ-glutamylcysteine synthetase

GC62033 3α-Hydroxy pravastatin sodium

3Α-羟基普伐他汀钠

A metabolite of pravastatin

GC61895 Ammonium iron(III) citrate

柠檬酸铁 (III) 铵; Ammonium ferric citrate; FAC

Ammonium ferric citrate (Ferric ammonium citrate, Ammonium iron(III) citrate, Iron ammonium citrate, FerriSeltz) induces ferroptosis in non-small-cell lung carcinoma through the inhibition of GPX4-GSS/GSR-GGT axis activity.