Ferroptosis(铁死亡)

Cat.No. 产品名称 Information

GC34939 UAMC-3203 hydrochloride A ferroptosis inhibitor

GC40228 Fluvastatin-d6 (sodium salt) An internal standard for the quantification of fluvastatin

GC40226 Curcumin-d6

(1E,4Z,6E)-5-羟基-1,7-二[4-羟基-3-(甲氧基-D3)苯基]-1,4,6-庚三烯-3-酮,Diferuloylmethane-d6; Natural Yellow 3-d6; Turmeric yellow-d6

An internal standard for the quantification of curcumin

GC40211 Ferrostatin-1 Diyne A ferroptosis inhibitor

GC40193 UAMC-3203 A ferroptosis inhibitor

GC34070 Brusatol (NSC 172924)

鸦胆子苦醇; NSC 172924

A quassinoid with diverse biological activities

GC34058 NADPH tetrasodium salt

还原型辅酶Ⅱ四钠

NADPH tetrasodium salt是还原型烟酰胺腺嘌呤二核苷酸磷酸（NADPH）的一种钠盐形式，NADPH是细胞内必需的辅因子，充当电子供体。

GC34057 TBHQ (tert-Butylhydroquinone)

特丁基对苯二酚; tert-Butylhydroquinone

TBHQ(tert-Butylhydroquinone)是一种强效的酚类抗氧化剂，能够减轻氧化应激和炎症反应。

GC33469 NADPH tetracyclohexanamine

还原型辅酶II四钠

A reduced form of NADP⁺

GC33098 L-Buthionine-(S,R)-sulfoximine (L-Butionine sulfoximine)

丁硫氨酸-亚砜亚胺,L-BSO

An irreversible inhibitor of the γ-glutamylcysteine synthetase

GC33023 D,L-Buthionine-(S,R)-sulfoximine (Butionine sulfoximine)

丁基硫,Buthionine sulfoximine; BSO

A γ-glutamylcysteine synthetase inhibitor

GC32723 CDDO-Im (RTA-403)

RTA-403; TP-235; CDDO-Imidazolide

An activator of Nrf2 signaling

GC32237 CIL56

2,7-双(哌啶-1-基磺酰基)-9H-芴-9-酮肟,CA3

An inducer of non-apoptotic cell death

GC31940 Docebenone (AA 861)

多西苯醌,AA 861

A 5-LO inhibitor

GC31492 Vildagliptin dihydrate (LAF237 dihydrate)

维格列汀二水合物; LAF237 dihydrate; NVP-LAF 237 dihydrate

A DPP-4 inhibitor

GC30788 L-Glutamic acid monosodium salt (Monosodium glutamate)

谷氨酸单钠盐

L-Glutamic acid monosodium salt is the sodium salt of glutamic acid, found naturally in tomatoes, cheese and other foods. L-Glutamic acid monosodium salt acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). (S)-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals.

GC30512 Vatiquinone (EPI-743)

α-Tocotrienol quinone; PTC-743; Vatiquinone; NCT04378075

A metabolite of α-tocotrienol with antioxidant and ferroptosis inhibitory activity

GC30067 Butylhydroxyanisole (Butylated hydroxyanisole)

丁基羟基茴香醚; Butylated hydroxyanisole; BHA; E320

丁基羟基茴香醚（Butylated hydroxyanisole）（Butylated hydroxyanisole）是一种抗氧化剂，用作食品添加剂防腐剂。

GC30039 FIN56 FIN56 是一种新型的铁死亡诱导剂，它通过增加 GPX4 的降解来触发铁死亡。

GC19457 Trolox

奎诺二甲基丙烯酸酯

Vitamin E derivative with antioxidant properties

GC19254 ML385 ML385是一种特定的核因子红细胞2相关因子2（NRF2）抑制剂。

GC18705 ML-210

DPI10

A GPX4 inhibitor

GC10331 Ebselen

依布硒; SPI-1005; PZ-51; CCG-39161

A peroxynitrite scavenger

GC14591 Hemin chloride

氯化血红素; Hemin chloride

氯化血红素是血红素加氧酶(HO)-1的底物，可诱导多种细胞表达HO-1，发挥抗氧化和抗炎作用。

GC16517 Eugenol

丁香酚

丁香酚是一种存在于丁香中的精油，具有抗菌、驱虫和抗氧化活性。

GC10042 Vitamin E

天然维生素E

脂溶性维生素

GC12431 RSL3

(1S,3R)-RSL3

RSL3被认为是一种强效的诱导铁死亡剂，其作用依赖于GPX4的活性。

GC13554 Deferoxamine mesylate

甲磺酸去铁胺; Desferrioxamine B mesylate; DFOM

Deferoxamine mesylate 是一种通过形成稳定的复合物来螯合铁的药物，该复合物可防止铁进入进一步的化学反应，并用于治疗输血依赖性贫血患者的慢性铁过载。

GC15399 Dp44mT

2-(二-2-吡啶基亚甲基)-N,N-二甲基肼基硫代甲酰胺

An iron chelator with antiproliferative effects

GC15681 Liproxstatin-1

利普司他丁-1

Liproxstatin-1 是一种有效的铁死亡抑制剂，可以防止铁死亡诱导剂，例如丁硫氨酸亚砜胺 (BSO)、erastin 和 (1S,3R)-RSL3 (RSL3)。

GC11882 GKT137831

2-(2-氯苯基)-4-[3-(二甲基氨基)苯基]-5-甲基-1H-吡唑并[4,3-C]吡啶-3,6(2H,5H)-二酮,GKT137831; GKT831

A dual NOX1/NOX4 inhibitor

GC12205 PD 146176

NSC168807

PD 146176 是一种有效的选择性网织红细胞 15-LOX-1 抑制剂。

GC12203 L-Glutathione Reduced

还原型谷胱甘肽; GSH; γ-L-Glutamyl-L-cysteinyl-glycine

Nucleophilic co-substrate to glutathione transferases and electron donor to glutathione peroxidases

GC17309 Withaferin A

醉茄素A

A steroidal lactone with diverse biological activities

GC10889 Artesunate

青蒿琥酯

青蒿琥酯（Artesunate）是一种抗疟疾化合物，是信号转导及转录激活蛋白3（STAT-3）和膜谷胱甘肽S-转移酶（EXP1）的抑制剂。

GC10451 U-73122

1-[6-[((17Β)-3-雌酮-1,3,5[10]-三烯-17-基)氨基]乙基]-1H-吡咯-2,5-二酮

U-73122是有效的、选择性的磷脂酶C（PLC）抑制剂，IC₅₀值约为1-2.1µM，也可抑制5-脂氧合酶（5-LO）。

GC15972 Idebenone

艾地苯醌

An analog of CoQ₁₀ with neuroprotective effects

GC10132 Ciclopirox

环吡酮胺; HOE296b

An iron chelator, antifungal, and anticancer agent

GC18101 Deferiprone

去铁酮

An iron chelator

GC11120 Ciclopirox ethanolamine

环吡酮乙醇胺盐; Ciclopirox ethanolamine; HOE 296

An iron chelator, antifungal, and anticancer agent

GC12698 BAY 87-2243 A mitochondrial complex I inhibitor and inducer of ferroptosis

GC13083 Siramesine

Lu 28-179

A selective σ₂ receptor agonist

GC14948 Pioglitazone

吡格列酮; U 72107

Pioglitazone属于格列酮类或噻唑烷二酮类,是一系列口服降糖药。

GC15222 Siramesine hydrochloride

西拉美新盐酸盐; Lu 28-179 hydrochloride

Siramesine (Lu 28-179) hydrochloride 是一种有效的 sigma-2 受体激动剂。 Siramesine hydrochloride 对 sigma-2 受体具有亚纳摩尔亲和力 (IC50=0.12 nM)，对 sigma-2 受体的选择性是 sigma-1 受体的 140 倍 (IC50=17 nM)。盐酸西拉美新通过破坏线粒体而不是溶酶体触发细胞死亡。抗癌活性。