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Home >> Signaling Pathways >> Metabolism >> P450

P450

Cytochrome P450 are a family of heme-containing monoxygenases catalyzing the metabolism of xenobiotics in the body where P450 enzymes use O2 and two electrons provided by NAD(P)H with the help of redox partner flavoproteins and iron-sulfur proteins to catalyze the monooxygenation of a variety of substrates. Based on how electrons from NAD(P)H are delivered to the catalytic site, P450 enzymes are divided into four classes, including Class I requiring both an FAD-containing reductase and an iron sulfur redoxin, Class II requiring only an FAD/FMN-containg P450 reductase, Class III requiring no electron donor and Class IV requiring electrons directly from NAD(P)H.

Products for  P450

  1. Cat.No. 产品名称 Information
  2. GC63469 Abiraterone-D4

    阿比特龙D4,CB-7598-D4

     Abiraterone-D4 (CB-7598-D4) 是 Abiraterone 的氘代物。Abiraterone 是一种有效的不可逆的 CYP17A1 抑制剂，具有抗雄激素活性，抑制细胞色素 p450 酶 CYP17 的 17α-羟化酶和 17,20-裂合酶活性，IC50 值 分别为 2.5 nM 和 15 nM.
  3. GC63272 β-Apo-8’-carotenal

    ψ-胡萝卜醛; Apocarotenal

     Apocarotenal is a carotenoid found in spinach and citrus fruits and plays a role as a precursor of vitamin A.
  4. GC63199 Soticlestat

    TAK-935; OV935

     A cholesterol 24-hydroxylase/CYP46A1 inhibitor
  5. GC49439 (±)11(12)-DiHET MaxSpec® Standard

    (±)11,12-DiHETrE

     A quantitative analytical standard guaranteed to meet MaxSpec® identity, purity, stability, and concentration specifications
  6. GC49429 6-keto Lithocholic Acid

    3Α-羟基-6K-5Β-胆甾烷-24-酸

     A metabolite of lithocholic acid
  7. GC49421 Atorvastatin lactone-d5 An internal standard for the quantification of atorvastatin lactone
  8. GC49410 CVT-2738

    N-(2,6-二甲基苯基)-1-哌嗪乙酰胺

     An active metabolite of ranolazine
  9. GC49409 Desmethyl Ranolazine

    雷诺嗪杂质

     A metabolite of ranolazine
  10. GC49403 Benzarone

    苯扎隆,Fragivix

     An active metabolite of benzbromarone
  11. GC49399 N-Desbutyl Dronedarone (hydrochloride)

    N-[2-丁基-3-[4-[3-(丁基氨基)丙氧基]苯甲酰基]-5-苯并呋喃基]甲磺酰胺盐酸盐,SR35021 hydrochloride

     An active metabolite of dronedarone
  12. GC49362 2-Amino-3,8-dimethylimidazo-[4,5-f]-quinoxaline

    2-氨基-3,8-二甲基咪唑并喹喔啉

     A food-derived carcinogen
  13. GC49355 Norfluoxetine-d5 (hydrochloride)

    诺氟西汀-D5

     An internal standard for the quantification of norfluoxetine
  14. GC49320 7-Ethoxy-4-(trifluoromethyl)coumarin

    7-乙氧基-4-(三氟甲基)香豆素

     A fluorogenic substrate for CYPs
  15. GC49291 rac-N-desmethyl Ivabradine-d6 (hydrochloride) An internal standard for the quantification of N-desmethyl ivabradine
  16. GC49288 Dolutegravir M1

    多替拉韦杂质

     A metabolite of dolutegravir
  17. GC49281 SPA70

    Specific PXR Antagonist 70

     A PXR antagonist
  18. GC49230 Ferroprotoporphyrin

    羟高铁血红素

     An iron-containing cofactor
  19. GC49212 trans-carboxy Glimepiride

    格列美脲杂质8

     A metabolite of glimepiride
  20. GC49202 Desmethyl Mirtazapine (hydrochloride)

    盐酸去甲基米氮平

     A metabolite of mirtazapine
  21. GC49195 Indapamide-13C-d3 An internal standard for the quantification of indapamide
  22. GC49189 (E/Z)-4-hydroxy Tamoxifen-d5

    Afimoxifene-d5, 4-OHT-d5

     An internal standard for the quantification of (E/Z)-4-hydroxy tamoxifen
  23. GC49185 Mirtazapine N-oxide

    米氮平杂质A

     A metabolite of mirtazapine
  24. GC49169 3,8’-Biapigenin

    I3,II8-Biapigenin, 3,8\-Biapigenin

     A biflavonoid with diverse biological activities
  25. GC49159 2-(1-Piperazinyl)pyrimidine

    1-(2-嘧啶基)哌嗪

     An α2-AR antagonist and active metabolite of azapirones
  26. GC49146 Colupulone

    类蛇麻酮

     A β-acid with diverse biological activities
  27. GC49133 N-hydroxy Riluzole

    N-羟基利鲁唑

     A metabolite of riluzole
  28. GC49118 10-hydroxy Warfarin

    10-羟基华法林(非对映体的混合物)

    A metabolite of (R)-warfarin
  29. GC49107 Rosuvastatin lactone

    瑞舒伐他汀-5S-内酯

     The lactone form of rosuvastatin
  30. GC49096 Cobaltic Protoporphyrin IX (chloride)

    原卟啉氯化钴

     An inducer of HO-1 activity
  31. GC49055 Tebuconazole-d9

    戊唑醇 d9

     An internal standard for the quantification of tebuconazole
  32. GC49030 7-Ethoxycoumarin

    7-乙氧基香豆素; 7-O-Ethylumbelliferone

     A CYP450 substrate
  33. GC62491 BMS-986202 BMS-986202 是一种有效的，选择性的，具有口服活性的 Tyk2 抑制剂，可与 Tyk2 JH2 结合，IC50 为 0.19 nM，Ki 为 0.02 nM。BMS-986202 对包括 Jak 家族成员在内的其他激酶具有高度选择性。BMS-986202 还是 CYP2C19 的弱抑制剂，IC50 为 14 μM。BMS-986202 可用于 IL-23 驱动的棘皮症，抗 CD40 诱导的结肠炎和自发性狼疮的研究。
  34. GC62476 Nampt-IN-5 Nampt-IN-5 是一种有效的烟酰胺磷酸核糖基转移酶 (NAMPT) 抑制剂。Nampt-IN-5 还抑制 CYP3A4 活性。Nampt-IN-5 可抑制 A2780 和 COR-L23 细胞，IC50 值分别为 0.7 nM 和 3.9 nM。
  35. GC62304 Dapaconazole

    1-[2-(2,4-二氯苯基)-2-[[4-(三氟甲基)苯基]甲氧基]乙基]-1H-咪唑

     Dapaconazole 作为一种抗真菌化合物，抑制 sterol 14α-demethylase cytochrome P450 活性的 IC50 值为 1.4 μM。
  36. GC61814 5,7-Dimethoxyflavone

    柯因二甲醚

     5,7-Dimethoxyflavone (5,7-DMF) is an inhibitor of cytochrome P450 (CYP) 3As that markedly decreases the expression of CYP3A11 and CYP3A25 in the liver. 5,7-Dimethoxyflavone (5,7-DMF) is also a potent Breast Cancer Resistance Protein (BCRP, ABCG2) inhibitor. 5,7-Dimethoxyflavone (5,7-DMF) is one of the major components of Kaempferia parviflora with anti-obesity, anti-inflammatory, and antineoplastic effects.
  37. GC61811 Verapamil

    维拉帕米; (±)-Verapamil; CP-16533-1

     Verapamil HCl (CP-16533-1,(±)-Verapamil hydrochloride) is an L-type calcium channel blocker that is a class IV anti-arrhythmia agent. Verapamil inhibits both permeability-glycoprotein (P-gp) and CYP3A4.
  38. GC61722 2,6-Dimethylquinoline

    2,6-二甲基喹啉

     2,6-Dimethylquinoline是一种来自Peucedantupraeruptorum根的天然成分，是CYP1A2的抑制剂，IC50为3.3µM。2,6-Dimethylquinoline也抑制CYP2B6的活性，IC50为480µM。
  39. GC61574 AS1810722 AS1810722是口服有效的STAT6抑制剂，IC50为1.9nM。AS1810722显示出良好的CYP3A4抑制作用。AS1810722是一种稠合双环嘧啶衍生物，具有用于过敏性疾病，例如哮喘和特应性疾病研究的潜力。
  40. GC61465 SDZ285428 SDZ285428是一种CYP51抑制剂。SDZ285428抑制Trypanosomacruzi(TC)CYP51，I/E2<1(5min)及I/E2=9(1h)。SDZ285428抑制Trypanosomabrucei(TB)CYP51，I/E2<1(5min)及I/E2=35(1h)。
  41. GC18252 Diallyl Sulfide

    二烯丙基硫醚

     An organosulfur compound
  42. GC48804 N-desmethyl Olanzapine

    N-去甲基奥氮平

     A major metabolite of olanzapine
  43. GC48493 PCI 45227

    依鲁替尼代谢物,PCI-45227

     An active metabolite of ibrutinib
  44. GC48461 rac-trans-4-hydroxy Glyburide

    4-trans-hydroxycyclohexyl Glyburide, 4-trans-hydroxy Glibenclamide

     An active metabolite of glyburide
  45. GC47979 Propiconazole-d7 An internal standard for the quantification of propiconazole
  46. GC47923 Paraxanthine-d6

    1,7-Dimethylxanthine-d6

     An internal standard for the quantification of paraxanthine
  47. GC47756 N-desmethyl Rosuvastatin (sodium salt hydrate) An active metabolite of rosuvastatin
  48. GC47367 Fluvastatin (sodium salt hydrate) An HMG-CoA reductase inhibitor
  49. GC47234 Diosmetin-d3

    香叶木素 d3

     An internal standard for the quantification of diosmetin
  50. GC47195 Desethylchloroquine-d4

    N-Desethylchloroquine-d4

     An internal standard for the quantification of desethylchloroquine
  51. GC47193 Desethyl Hydroxychloroquine-d4

    Desethylhydroxychloroquine-d4

     An internal standard for the quantification of desethyl hydroxychloroquine

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