P450

Cytochrome P450 are a family of heme-containing monoxygenases catalyzing the metabolism of xenobiotics in the body where P450 enzymes use O2 and two electrons provided by NAD(P)H with the help of redox partner flavoproteins and iron-sulfur proteins to catalyze the monooxygenation of a variety of substrates. Based on how electrons from NAD(P)H are delivered to the catalytic site, P450 enzymes are divided into four classes, including Class I requiring both an FAD-containing reductase and an iron sulfur redoxin, Class II requiring only an FAD/FMN-containg P450 reductase, Class III requiring no electron donor and Class IV requiring electrons directly from NAD(P)H.

Products for P450

Cat.No. 产品名称 Information
GC52062 7-Benzyloxy-4-(trifluoromethyl)coumarin
7-苄氧基-4-三氟甲基香豆素
A fluorogenic substrate for CYP1A2 and CYP3A
GC52060 Trimipramine N-oxide
10,11-二氢-N,N,BETA-三甲基-5H-二苯并[B,F]氮杂卓-5-丙胺N-氧化物
An active metabolite of trimipramine
GC52045 N-desmethyl Azelastine
氮卓斯汀杂质
An active metabolite of azelastine
GC52038 Desthiazolylmethyl Ritonavir
利托那韦杂质L
A ritonavir degradation product
GC52024 Aripiprazole N-oxide
阿立哌唑-N1-氧化物
A metabolite of aripiprazole
GC52019 Norpropranolol (hydrochloride)
(±)-Desisopropylpropranolol, N-Desisopropylpropranolol
An active metabolite of propranolol
GC52007 N-hydroxylamine Dapsone
羟胺氨苯砜
An active metabolite of dapsone
GC49875 (±)-N-desmethyl Venlafaxine (hydrochloride)
盐酸文拉法辛杂质D
A minor active metabolite of venlafaxine
GC49866 Desmethyl Carvedilol
O-去甲卡维地洛
An active metabolite of carvedilol
GC49855 Harmalol (hydrochloride hydrate)
骆驼蓬酚盐酸盐(二水)
A β-carboline alkaloid and an active metabolite of harmaline
GC49851 Norquetiapine
11-(1-哌嗪基)二苯并[B,F][1,4]硫氮杂卓
An active metabolite of quetiapine
GC49842 Digoxigenin Bisdigitoxoside
Bisdigoxigenin
A Na⁺/K⁺-ATPase inhibitor
GC49832 Hydroxymetronidazole
羟基甲硝唑,Metronidazole-OH
An active metabolite of metronidazole
GC49817 Desethoxy Quetiapine (hydrochloride)
喹硫平羟基杂质二盐酸盐
An active metabolite of quetiapine
GC64010 Abiraterone decanoate Abiraterone decanoate 是一种有效的 Abiraterone 前药。Abiraterone decanoate 通过肌肉内 (IM) 递送提供 Abiraterone 的受控释放和长效 CYP17 抑制。
GC63958 6α-Hydroxy Paclitaxel-d5
紫杉醇杂质
6α-Hydroxy Paclitaxel-d5 是 6α-Hydroxy paclitaxel 的氘代物。6α-Hydroxy paclitaxel 是紫杉醇的初级代谢物。6α-Hydroxy paclitaxel 对有机阴离子转运多肽 1B1/SLCO1B1 (OATP1B1) 具有与紫杉醇相似的时间依赖性抑制效力，但它对 OATP1B3 不具有时间依赖性作用。6α-Hydroxy paclitaxel 可用于癌症研究。
GC63872 Dagrocorat hydrochloride
PF-00251802 hydrochloride
Dagrocorat (PF-00251802) hydrochloride 是一种具有口服活性，选择性和高亲和性部分糖皮质激素受体的激动剂。Dagrocorat hydrochloride 也是一种时间依赖性可逆抑制剂，对 CYP3A (IC50=1.3 μM) 和CYP2D6 (Ki=0.57 μM) 有抑制作用。Dagrocorat hydrochloride 可用于类风湿性关节炎的研究。
GC49686 N-desmethyl Regorafenib N-oxide
瑞戈非尼杂质14
An active metabolite of regorafenib
GC49629 6β-hydroxy Prednisolone
泼尼松龙杂质D
A metabolite of prednisolone
GC49627 Rabeprazole sulfone
雷贝拉唑杂质E
A metabolite of rabeprazole
GC49583 N-desmethyl Sertraline (hydrochloride)
N-desmethyl Sertraline
A metabolite of sertraline
GC49559 Hydroxymethyl Tolperisone (hydrochloride) A metabolite of tolperisone
GC49544 8-hydroxy Mirtazapine
8-羟基米安色林
A metabolite of mirtazapine
GC49503 Thujopsene
罗汉柏烯
A sesquiterpene with diverse biological activities
GC49501 Nirvanol
5-乙基-5-苯基海因
An active metabolite of mephenytoin
GC63469 Abiraterone-D4
阿比特龙D4,CB-7598-D4
Abiraterone-D4 (CB-7598-D4) 是 Abiraterone 的氘代物。Abiraterone 是一种有效的不可逆的 CYP17A1 抑制剂，具有抗雄激素活性，抑制细胞色素 p450 酶 CYP17 的 17α-羟化酶和 17,20-裂合酶活性，IC50 值分别为 2.5 nM 和 15 nM.
GC63272 β-Apo-8’-carotenal
ψ-胡萝卜醛; Apocarotenal
Apocarotenal is a carotenoid found in spinach and citrus fruits and plays a role as a precursor of vitamin A.
GC63199 Soticlestat
TAK-935; OV935
A cholesterol 24-hydroxylase/CYP46A1 inhibitor
GC49439 (±)11(12)-DiHET MaxSpec® Standard
(±)11,12-DiHETrE
A quantitative analytical standard guaranteed to meet MaxSpec^® identity, purity, stability, and concentration specifications
GC49429 6-keto Lithocholic Acid
3Α-羟基-6K-5Β-胆甾烷-24-酸
A metabolite of lithocholic acid
GC49421 Atorvastatin lactone-d5 An internal standard for the quantification of atorvastatin lactone
GC49410 CVT-2738
N-(2,6-二甲基苯基)-1-哌嗪乙酰胺
An active metabolite of ranolazine
GC49409 Desmethyl Ranolazine
雷诺嗪杂质
A metabolite of ranolazine
GC49403 Benzarone
苯扎隆,Fragivix
An active metabolite of benzbromarone
GC49399 N-Desbutyl Dronedarone (hydrochloride)
N-[2-丁基-3-[4-[3-(丁基氨基)丙氧基]苯甲酰基]-5-苯并呋喃基]甲磺酰胺盐酸盐,SR35021 hydrochloride
An active metabolite of dronedarone
GC49362 2-Amino-3,8-dimethylimidazo-[4,5-f]-quinoxaline
2-氨基-3,8-二甲基咪唑并喹喔啉
A food-derived carcinogen
GC49355 Norfluoxetine-d5 (hydrochloride)
诺氟西汀-D5
An internal standard for the quantification of norfluoxetine
GC49320 7-Ethoxy-4-(trifluoromethyl)coumarin
7-乙氧基-4-(三氟甲基)香豆素
A fluorogenic substrate for CYPs
GC49291 rac-N-desmethyl Ivabradine-d6 (hydrochloride) An internal standard for the quantification of N-desmethyl ivabradine
GC49288 Dolutegravir M1
多替拉韦杂质
A metabolite of dolutegravir
GC49281 SPA70
Specific PXR Antagonist 70
A PXR antagonist
GC49230 Ferroprotoporphyrin
羟高铁血红素
An iron-containing cofactor
GC49212 trans-carboxy Glimepiride
格列美脲杂质8
A metabolite of glimepiride
GC49202 Desmethyl Mirtazapine (hydrochloride)
盐酸去甲基米氮平
A metabolite of mirtazapine
GC49195 Indapamide-13C-d3 An internal standard for the quantification of indapamide
GC49189 (E/Z)-4-hydroxy Tamoxifen-d5
Afimoxifene-d5, 4-OHT-d5
An internal standard for the quantification of (E/Z)-4-hydroxy tamoxifen
GC49185 Mirtazapine N-oxide
米氮平杂质A
A metabolite of mirtazapine
GC49169 3,8’-Biapigenin
I3,II8-Biapigenin, 3,8\-Biapigenin
A biflavonoid with diverse biological activities
GC49159 2-(1-Piperazinyl)pyrimidine
1-(2-嘧啶基)哌嗪
An α₂-AR antagonist and active metabolite of azapirones
GC49146 Colupulone
类蛇麻酮
A β-acid with diverse biological activities