P450
Cytochrome P450 are a family of heme-containing monoxygenases catalyzing the metabolism of xenobiotics in the body where P450 enzymes use O2 and two electrons provided by NAD(P)H with the help of redox partner flavoproteins and iron-sulfur proteins to catalyze the monooxygenation of a variety of substrates. Based on how electrons from NAD(P)H are delivered to the catalytic site, P450 enzymes are divided into four classes, including Class I requiring both an FAD-containing reductase and an iron sulfur redoxin, Class II requiring only an FAD/FMN-containg P450 reductase, Class III requiring no electron donor and Class IV requiring electrons directly from NAD(P)H.
Products for P450
- Cat.No. 产品名称 Information
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GC63469
Abiraterone-D4
阿比特龙D4,CB-7598-D4
Abiraterone-D4 (CB-7598-D4) 是 Abiraterone 的氘代物。Abiraterone 是一种有效的不可逆的 CYP17A1 抑制剂,具有抗雄激素活性,抑制细胞色素 p450 酶 CYP17 的 17α-羟化酶和 17,20-裂合酶活性,IC50 值 分别为 2.5 nM 和 15 nM. -
GC63272
β-Apo-8’-carotenal
ψ-胡萝卜醛; Apocarotenal
Apocarotenal is a carotenoid found in spinach and citrus fruits and plays a role as a precursor of vitamin A. -
GC63199
Soticlestat
TAK-935; OV935
A cholesterol 24-hydroxylase/CYP46A1 inhibitor -
GC49439
(±)11(12)-DiHET MaxSpec® Standard
(±)11,12-DiHETrE
A quantitative analytical standard guaranteed to meet MaxSpec® identity, purity, stability, and concentration specifications -
GC49429
6-keto Lithocholic Acid
3Α-羟基-6K-5Β-胆甾烷-24-酸
A metabolite of lithocholic acid -
GC49421
Atorvastatin lactone-d5
An internal standard for the quantification of atorvastatin lactone
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GC49410
CVT-2738
N-(2,6-二甲基苯基)-1-哌嗪乙酰胺
An active metabolite of ranolazine -
GC49409
Desmethyl Ranolazine
雷诺嗪杂质
A metabolite of ranolazine -
GC49403
Benzarone
苯扎隆,Fragivix
An active metabolite of benzbromarone -
GC49399
N-Desbutyl Dronedarone (hydrochloride)
N-[2-丁基-3-[4-[3-(丁基氨基)丙氧基]苯甲酰基]-5-苯并呋喃基]甲磺酰胺盐酸盐,SR35021 hydrochloride
An active metabolite of dronedarone -
GC49362
2-Amino-3,8-dimethylimidazo-[4,5-f]-quinoxaline
2-氨基-3,8-二甲基咪唑并喹喔啉
A food-derived carcinogen -
GC49355
Norfluoxetine-d5 (hydrochloride)
诺氟西汀-D5
An internal standard for the quantification of norfluoxetine -
GC49320
7-Ethoxy-4-(trifluoromethyl)coumarin
7-乙氧基-4-(三氟甲基)香豆素
A fluorogenic substrate for CYPs -
GC49291
rac-N-desmethyl Ivabradine-d6 (hydrochloride)
An internal standard for the quantification of N-desmethyl ivabradine
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GC49288
Dolutegravir M1
多替拉韦杂质
A metabolite of dolutegravir -
GC49281
SPA70
Specific PXR Antagonist 70
A PXR antagonist -
GC49230
Ferroprotoporphyrin
羟高铁血红素
An iron-containing cofactor -
GC49212
trans-carboxy Glimepiride
格列美脲杂质8
A metabolite of glimepiride -
GC49202
Desmethyl Mirtazapine (hydrochloride)
盐酸去甲基米氮平
A metabolite of mirtazapine -
GC49195
Indapamide-13C-d3
An internal standard for the quantification of indapamide
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GC49189
(E/Z)-4-hydroxy Tamoxifen-d5
Afimoxifene-d5, 4-OHT-d5
An internal standard for the quantification of (E/Z)-4-hydroxy tamoxifen -
GC49185
Mirtazapine N-oxide
米氮平杂质A
A metabolite of mirtazapine -
GC49169
3,8’-Biapigenin
I3,II8-Biapigenin, 3,8\-Biapigenin
A biflavonoid with diverse biological activities -
GC49159
2-(1-Piperazinyl)pyrimidine
1-(2-嘧啶基)哌嗪
An α2-AR antagonist and active metabolite of azapirones -
GC49146
Colupulone
类蛇麻酮
A β-acid with diverse biological activities -
GC49133
N-hydroxy Riluzole
N-羟基利鲁唑
A metabolite of riluzole -
GC49118
10-hydroxy Warfarin
10-羟基华法林(非对映体的混合物)
A metabolite of (R)-warfarin
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GC49107
Rosuvastatin lactone
瑞舒伐他汀-5S-内酯
The lactone form of rosuvastatin -
GC49096
Cobaltic Protoporphyrin IX (chloride)
原卟啉氯化钴
An inducer of HO-1 activity -
GC49055
Tebuconazole-d9
戊唑醇 d9
An internal standard for the quantification of tebuconazole -
GC49030
7-Ethoxycoumarin
7-乙氧基香豆素; 7-O-Ethylumbelliferone
A CYP450 substrate -
GC62491
BMS-986202
BMS-986202 是一种有效的,选择性的,具有口服活性的 Tyk2 抑制剂,可与 Tyk2 JH2 结合,IC50 为 0.19 nM,Ki 为 0.02 nM。BMS-986202 对包括 Jak 家族成员在内的其他激酶具有高度选择性。BMS-986202 还是 CYP2C19 的弱抑制剂,IC50 为 14 μM。BMS-986202 可用于 IL-23 驱动的棘皮症,抗 CD40 诱导的结肠炎和自发性狼疮的研究。
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GC62476
Nampt-IN-5
Nampt-IN-5 是一种有效的烟酰胺磷酸核糖基转移酶 (NAMPT) 抑制剂。Nampt-IN-5 还抑制 CYP3A4 活性。Nampt-IN-5 可抑制 A2780 和 COR-L23 细胞,IC50 值分别为 0.7 nM 和 3.9 nM。
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GC62304
Dapaconazole
1-[2-(2,4-二氯苯基)-2-[[4-(三氟甲基)苯基]甲氧基]乙基]-1H-咪唑
Dapaconazole 作为一种抗真菌化合物,抑制 sterol 14α-demethylase cytochrome P450 活性的 IC50 值为 1.4 μM。 -
GC61814
5,7-Dimethoxyflavone
柯因二甲醚
5,7-Dimethoxyflavone (5,7-DMF) is an inhibitor of cytochrome P450 (CYP) 3As that markedly decreases the expression of CYP3A11 and CYP3A25 in the liver. 5,7-Dimethoxyflavone (5,7-DMF) is also a potent Breast Cancer Resistance Protein (BCRP, ABCG2) inhibitor. 5,7-Dimethoxyflavone (5,7-DMF) is one of the major components of Kaempferia parviflora with anti-obesity, anti-inflammatory, and antineoplastic effects. -
GC61811
Verapamil
维拉帕米; (±)-Verapamil; CP-16533-1
Verapamil HCl (CP-16533-1,(±)-Verapamil hydrochloride) is an L-type calcium channel blocker that is a class IV anti-arrhythmia agent. Verapamil inhibits both permeability-glycoprotein (P-gp) and CYP3A4. -
GC61722
2,6-Dimethylquinoline
2,6-二甲基喹啉
2,6-Dimethylquinoline是一种来自Peucedantupraeruptorum根的天然成分,是CYP1A2的抑制剂,IC50为3.3µM。2,6-Dimethylquinoline也抑制CYP2B6的活性,IC50为480µM。 -
GC61574
AS1810722
AS1810722是口服有效的STAT6抑制剂,IC50为1.9nM。AS1810722显示出良好的CYP3A4抑制作用。AS1810722是一种稠合双环嘧啶衍生物,具有用于过敏性疾病,例如哮喘和特应性疾病研究的潜力。
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GC61465
SDZ285428
SDZ285428是一种CYP51抑制剂。SDZ285428抑制Trypanosomacruzi(TC)CYP51,I/E2<1(5min)及I/E2=9(1h)。SDZ285428抑制Trypanosomabrucei(TB)CYP51,I/E2<1(5min)及I/E2=35(1h)。
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GC18252
Diallyl Sulfide
二烯丙基硫醚
An organosulfur compound -
GC48804
N-desmethyl Olanzapine
N-去甲基奥氮平
A major metabolite of olanzapine -
GC48493
PCI 45227
依鲁替尼代谢物,PCI-45227
An active metabolite of ibrutinib -
GC48461
rac-trans-4-hydroxy Glyburide
4-trans-hydroxycyclohexyl Glyburide, 4-trans-hydroxy Glibenclamide
An active metabolite of glyburide -
GC47979
Propiconazole-d7
An internal standard for the quantification of propiconazole
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GC47923
Paraxanthine-d6
1,7-Dimethylxanthine-d6
An internal standard for the quantification of paraxanthine -
GC47756
N-desmethyl Rosuvastatin (sodium salt hydrate)
An active metabolite of rosuvastatin
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GC47367
Fluvastatin (sodium salt hydrate)
An HMG-CoA reductase inhibitor
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GC47234
Diosmetin-d3
香叶木素 d3
An internal standard for the quantification of diosmetin -
GC47195
Desethylchloroquine-d4
N-Desethylchloroquine-d4
An internal standard for the quantification of desethylchloroquine -
GC47193
Desethyl Hydroxychloroquine-d4
Desethylhydroxychloroquine-d4
An internal standard for the quantification of desethyl hydroxychloroquine