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Home >> Signaling Pathways >> Metabolism >> P450

P450

Cytochrome P450 are a family of heme-containing monoxygenases catalyzing the metabolism of xenobiotics in the body where P450 enzymes use O2 and two electrons provided by NAD(P)H with the help of redox partner flavoproteins and iron-sulfur proteins to catalyze the monooxygenation of a variety of substrates. Based on how electrons from NAD(P)H are delivered to the catalytic site, P450 enzymes are divided into four classes, including Class I requiring both an FAD-containing reductase and an iron sulfur redoxin, Class II requiring only an FAD/FMN-containg P450 reductase, Class III requiring no electron donor and Class IV requiring electrons directly from NAD(P)H.

Products for  P450

  1. Cat.No. 产品名称 Information
  2. GC49133 N-hydroxy Riluzole

    N-羟基利鲁唑

     A metabolite of riluzole
  3. GC49118 10-hydroxy Warfarin

    10-羟基华法林(非对映体的混合物)

    A metabolite of (R)-warfarin
  4. GC49107 Rosuvastatin lactone

    瑞舒伐他汀-5S-内酯

     The lactone form of rosuvastatin
  5. GC49096 Cobaltic Protoporphyrin IX (chloride)

    原卟啉氯化钴

     An inducer of HO-1 activity
  6. GC49055 Tebuconazole-d9

    戊唑醇 d9

     An internal standard for the quantification of tebuconazole
  7. GC49030 7-Ethoxycoumarin

    7-乙氧基香豆素; 7-O-Ethylumbelliferone

     A CYP450 substrate
  8. GC62491 BMS-986202 BMS-986202 是一种有效的，选择性的，具有口服活性的 Tyk2 抑制剂，可与 Tyk2 JH2 结合，IC50 为 0.19 nM，Ki 为 0.02 nM。BMS-986202 对包括 Jak 家族成员在内的其他激酶具有高度选择性。BMS-986202 还是 CYP2C19 的弱抑制剂，IC50 为 14 μM。BMS-986202 可用于 IL-23 驱动的棘皮症，抗 CD40 诱导的结肠炎和自发性狼疮的研究。
  9. GC62476 Nampt-IN-5 Nampt-IN-5 是一种有效的烟酰胺磷酸核糖基转移酶 (NAMPT) 抑制剂。Nampt-IN-5 还抑制 CYP3A4 活性。Nampt-IN-5 可抑制 A2780 和 COR-L23 细胞，IC50 值分别为 0.7 nM 和 3.9 nM。
  10. GC62304 Dapaconazole

    1-[2-(2,4-二氯苯基)-2-[[4-(三氟甲基)苯基]甲氧基]乙基]-1H-咪唑

     Dapaconazole 作为一种抗真菌化合物，抑制 sterol 14α-demethylase cytochrome P450 活性的 IC50 值为 1.4 μM。
  11. GC61971 Liarozole

    利阿唑,R75251

     A CYP26A1 inhibitor
  12. GC61814 5,7-Dimethoxyflavone

    柯因二甲醚

     5,7-Dimethoxyflavone (5,7-DMF) is an inhibitor of cytochrome P450 (CYP) 3As that markedly decreases the expression of CYP3A11 and CYP3A25 in the liver. 5,7-Dimethoxyflavone (5,7-DMF) is also a potent Breast Cancer Resistance Protein (BCRP, ABCG2) inhibitor. 5,7-Dimethoxyflavone (5,7-DMF) is one of the major components of Kaempferia parviflora with anti-obesity, anti-inflammatory, and antineoplastic effects.
  13. GC61811 Verapamil

    维拉帕米; (±)-Verapamil; CP-16533-1

     Verapamil是 L 型钙通道阻滞剂和肾上腺素能受体拮抗剂，常用于高血压、心律失常和心绞痛的研究。
  14. GC61722 2,6-Dimethylquinoline

    2,6-二甲基喹啉

     2,6-Dimethylquinoline是一种来自Peucedantupraeruptorum根的天然成分，是CYP1A2的抑制剂，IC50为3.3µM。2,6-Dimethylquinoline也抑制CYP2B6的活性，IC50为480µM。
  15. GC61574 AS1810722 AS1810722是口服有效的STAT6抑制剂，IC50为1.9nM。AS1810722显示出良好的CYP3A4抑制作用。AS1810722是一种稠合双环嘧啶衍生物，具有用于过敏性疾病，例如哮喘和特应性疾病研究的潜力。
  16. GC61465 SDZ285428 SDZ285428是一种CYP51抑制剂。SDZ285428抑制Trypanosomacruzi(TC)CYP51，I/E2<1(5min)及I/E2=9(1h)。SDZ285428抑制Trypanosomabrucei(TB)CYP51，I/E2<1(5min)及I/E2=35(1h)。
  17. GC19691 Pyrene

    芘

     A polycyclic aromatic hydrocarbon
  18. GC18252 Diallyl Sulfide

    二烯丙基硫醚

     An organosulfur compound
  19. GC48804 N-desmethyl Olanzapine

    N-去甲基奥氮平

     A major metabolite of olanzapine
  20. GC48738 (±)12-HETE-d8

    (±)12-Hydroxyeicosatetraenoic Acid-d8

     An internal standard for the quantification of 12-HETE
  21. GC48493 PCI 45227

    依鲁替尼代谢物,PCI-45227

     An active metabolite of ibrutinib
  22. GC48461 rac-trans-4-hydroxy Glyburide

    4-trans-hydroxycyclohexyl Glyburide, 4-trans-hydroxy Glibenclamide

     An active metabolite of glyburide
  23. GC48044 Resolvin E1-d4

    RvE1d4, 5S,12R,18R-trihydroxy-EPA-d4, 5S,12R,18R-trihydroxy-6Z,8E,10E,14Z,16E-EPA-d4, 5,12,18R-triHEPE-d4

     A neuropeptide with diverse biological activities
  24. GC47979 Propiconazole-d7 An internal standard for the quantification of propiconazole
  25. GC47978 Propiconazole-d3 (nitrate) A neuropeptide with diverse biological activities
  26. GC47923 Paraxanthine-d6

    1,7-Dimethylxanthine-d6

     An internal standard for the quantification of paraxanthine
  27. GC47826 Omeprazole sulfone-d3

    OMEP sulfone-d3, OMP sulfone-d3, OMZ sulfone-d3

     An internal standard for the quantification of omeprazole sulfone
  28. GC47756 N-desmethyl Rosuvastatin (sodium salt hydrate) An active metabolite of rosuvastatin
  29. GC47367 Fluvastatin (sodium salt hydrate) An HMG-CoA reductase inhibitor
  30. GC47304 Erythromycin-13C-d3

    红霉素 13Cd3

     A neuropeptide with diverse biological activities
  31. GC47234 Diosmetin-d3

    香叶木素 d3

     An internal standard for the quantification of diosmetin
  32. GC47196 Desloratadine-d4

    Sch34117-d4

     An internal standard for the quantification of desloratadine
  33. GC47195 Desethylchloroquine-d4

    N-Desethylchloroquine-d4

     An internal standard for the quantification of desethylchloroquine
  34. GC47193 Desethyl Hydroxychloroquine-d4

    Desethylhydroxychloroquine-d4

     An internal standard for the quantification of desethyl hydroxychloroquine
  35. GC47118 Colchicoside

    秋水仙碱苷

     A glycoside form of 3-demethylcolchicine
  36. GC47112 Cobicistat-d8 A neuropeptide with diverse biological activities
  37. GC47064 CAY10770 An inhibitor of CYP4Z1
  38. GC47040 Carebastine-d5

    卡依巴司丁 d5

     An internal standard for the quantification of carebastine
  39. GC46933 Bitertanol

    联苯三唑醇

     A triazole fungicide
  40. GC46842 Amiodarone-d4 (hydrochloride)

    盐酸胺碘酮-d4

     An internal standard for the quantification of amiodarone
  41. GC46835 Alyssin

    5-Methylsulfinylpentyl isothiocyanate, 5-Methylsulfinylpentyl ITC

     An isothiocyanate with diverse biological activities
  42. GC46775 Abiraterone Acetate-d4

    CB7630-d4

     醋酸阿比特龙-d4 (CB7630-d4) 是氘标记的醋酸阿比特龙。醋酸阿比特龙 (CB7630) 是一种口服的、有效的、选择性的、不可逆的 CYP17A1 抑制剂，具有抗雄激素活性。醋酸阿比特龙是阿比特龙 (CB7598) 的前药形式。
  43. GC46754 9(S)-HETE-d8

    9(S)-Hydroxyeicosatetraenoic Acid-d8

     A neuropeptide with diverse biological activities
  44. GC46751 9(R)-HETE-d8

    9(R)-Hydroxyeicosatetraenoic Acid-d8

     A neuropeptide with diverse biological activities
  45. GC46710 5-OxoETE-d7

    5-KETE-d7

     A neuropeptide with diverse biological activities
  46. GC46678 4β-hydroxy Cholesterol-d7

    4-Β-羟基胆固醇-D7

     An internal standard for the quantification of 4β-hydroxy cholesterol
  47. GC46525 20-HETE-d6

    20-Hydroxyarachidonic acid-d6; 20-Hydroxyeicosatetraenoic acid-d6

     An internal standard for the quantification of 20-HETE
  48. GC46476 19S(20R)-EpDPA

    19S,20R-EDP, 19S,20R-EpDPE, 19S,20R-epoxy DPA, 19S,20R-epoxy Docosapentaenoic Acid

     A neuropeptide with diverse biological activities
  49. GC46475 19R(20S)-EpDPA

    19R,20S-epoxy Docosapentaenoic Acid, 19R,20S-epoxy DPA, 19R,20S-EDP, 19R,20S-EpDPE

     A DHA metabolite
  50. GC46471 17β-hydroxy Exemestane-d3 A neuropeptide with diverse biological activities
  51. GC46464 17R(18S)-EpETE

    17R,18S-EEQ, 17R,18S-epoxy Eicosatetraenoic Acid

     An EPA metabolite and activator of KCa1.1/BK channels

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