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Home >> Signaling Pathways >> Metabolism >> P450

P450

Cytochrome P450 are a family of heme-containing monoxygenases catalyzing the metabolism of xenobiotics in the body where P450 enzymes use O2 and two electrons provided by NAD(P)H with the help of redox partner flavoproteins and iron-sulfur proteins to catalyze the monooxygenation of a variety of substrates. Based on how electrons from NAD(P)H are delivered to the catalytic site, P450 enzymes are divided into four classes, including Class I requiring both an FAD-containing reductase and an iron sulfur redoxin, Class II requiring only an FAD/FMN-containg P450 reductase, Class III requiring no electron donor and Class IV requiring electrons directly from NAD(P)H.

Products for  P450

  1. Cat.No. 产品名称 Information
  2. GC61971 Liarozole

    利阿唑,R75251

     A CYP26A1 inhibitor
  3. GC61814 5,7-Dimethoxyflavone

    柯因二甲醚

     5,7-Dimethoxyflavone (5,7-DMF) is an inhibitor of cytochrome P450 (CYP) 3As that markedly decreases the expression of CYP3A11 and CYP3A25 in the liver. 5,7-Dimethoxyflavone (5,7-DMF) is also a potent Breast Cancer Resistance Protein (BCRP, ABCG2) inhibitor. 5,7-Dimethoxyflavone (5,7-DMF) is one of the major components of Kaempferia parviflora with anti-obesity, anti-inflammatory, and antineoplastic effects.
  4. GC61811 Verapamil

    维拉帕米; (±)-Verapamil; CP-16533-1

     Verapamil是 L 型钙通道阻滞剂和肾上腺素能受体拮抗剂，常用于高血压、心律失常和心绞痛的研究。
  5. GC61722 2,6-Dimethylquinoline

    2,6-二甲基喹啉

     2,6-Dimethylquinoline是一种来自Peucedantupraeruptorum根的天然成分，是CYP1A2的抑制剂，IC50为3.3µM。2,6-Dimethylquinoline也抑制CYP2B6的活性，IC50为480µM。
  6. GC61574 AS1810722 AS1810722是口服有效的STAT6抑制剂，IC50为1.9nM。AS1810722显示出良好的CYP3A4抑制作用。AS1810722是一种稠合双环嘧啶衍生物，具有用于过敏性疾病，例如哮喘和特应性疾病研究的潜力。
  7. GC61465 SDZ285428 SDZ285428是一种CYP51抑制剂。SDZ285428抑制Trypanosomacruzi(TC)CYP51，I/E2<1(5min)及I/E2=9(1h)。SDZ285428抑制Trypanosomabrucei(TB)CYP51，I/E2<1(5min)及I/E2=35(1h)。
  8. GC19691 Pyrene

    芘

     A polycyclic aromatic hydrocarbon
  9. GC18252 Diallyl Sulfide

    二烯丙基硫醚

     An organosulfur compound
  10. GC48804 N-desmethyl Olanzapine

    N-去甲基奥氮平

     A major metabolite of olanzapine
  11. GC48738 (±)12-HETE-d8

    (±)12-Hydroxyeicosatetraenoic Acid-d8

     An internal standard for the quantification of 12-HETE
  12. GC48493 PCI 45227

    依鲁替尼代谢物,PCI-45227

     An active metabolite of ibrutinib
  13. GC48461 rac-trans-4-hydroxy Glyburide

    4-trans-hydroxycyclohexyl Glyburide, 4-trans-hydroxy Glibenclamide

     An active metabolite of glyburide
  14. GC48044 Resolvin E1-d4

    RvE1d4, 5S,12R,18R-trihydroxy-EPA-d4, 5S,12R,18R-trihydroxy-6Z,8E,10E,14Z,16E-EPA-d4, 5,12,18R-triHEPE-d4

     A neuropeptide with diverse biological activities
  15. GC47979 Propiconazole-d7 An internal standard for the quantification of propiconazole
  16. GC47978 Propiconazole-d3 (nitrate) A neuropeptide with diverse biological activities
  17. GC47923 Paraxanthine-d6

    1,7-Dimethylxanthine-d6

     An internal standard for the quantification of paraxanthine
  18. GC47826 Omeprazole sulfone-d3

    OMEP sulfone-d3, OMP sulfone-d3, OMZ sulfone-d3

     An internal standard for the quantification of omeprazole sulfone
  19. GC47756 N-desmethyl Rosuvastatin (sodium salt hydrate) An active metabolite of rosuvastatin
  20. GC47367 Fluvastatin (sodium salt hydrate) An HMG-CoA reductase inhibitor
  21. GC47304 Erythromycin-13C-d3

    红霉素 13Cd3

     A neuropeptide with diverse biological activities
  22. GC47234 Diosmetin-d3

    香叶木素 d3

     An internal standard for the quantification of diosmetin
  23. GC47196 Desloratadine-d4

    Sch34117-d4

     An internal standard for the quantification of desloratadine
  24. GC47195 Desethylchloroquine-d4

    N-Desethylchloroquine-d4

     An internal standard for the quantification of desethylchloroquine
  25. GC47193 Desethyl Hydroxychloroquine-d4

    Desethylhydroxychloroquine-d4

     An internal standard for the quantification of desethyl hydroxychloroquine
  26. GC47118 Colchicoside

    秋水仙碱苷

     A glycoside form of 3-demethylcolchicine
  27. GC47112 Cobicistat-d8 A neuropeptide with diverse biological activities
  28. GC47064 CAY10770 An inhibitor of CYP4Z1
  29. GC47040 Carebastine-d5

    卡依巴司丁 d5

     An internal standard for the quantification of carebastine
  30. GC46933 Bitertanol

    联苯三唑醇

     A triazole fungicide
  31. GC46842 Amiodarone-d4 (hydrochloride)

    盐酸胺碘酮-d4

     An internal standard for the quantification of amiodarone
  32. GC46835 Alyssin

    5-Methylsulfinylpentyl isothiocyanate, 5-Methylsulfinylpentyl ITC

     An isothiocyanate with diverse biological activities
  33. GC46775 Abiraterone Acetate-d4

    CB7630-d4

     醋酸阿比特龙-d4 (CB7630-d4) 是氘标记的醋酸阿比特龙。醋酸阿比特龙 (CB7630) 是一种口服的、有效的、选择性的、不可逆的 CYP17A1 抑制剂，具有抗雄激素活性。醋酸阿比特龙是阿比特龙 (CB7598) 的前药形式。
  34. GC46754 9(S)-HETE-d8

    9(S)-Hydroxyeicosatetraenoic Acid-d8

     A neuropeptide with diverse biological activities
  35. GC46751 9(R)-HETE-d8

    9(R)-Hydroxyeicosatetraenoic Acid-d8

     A neuropeptide with diverse biological activities
  36. GC46710 5-OxoETE-d7

    5-KETE-d7

     A neuropeptide with diverse biological activities
  37. GC46678 4β-hydroxy Cholesterol-d7

    4-Β-羟基胆固醇-D7

     An internal standard for the quantification of 4β-hydroxy cholesterol
  38. GC46525 20-HETE-d6

    20-Hydroxyarachidonic acid-d6; 20-Hydroxyeicosatetraenoic acid-d6

     An internal standard for the quantification of 20-HETE
  39. GC46476 19S(20R)-EpDPA

    19S,20R-EDP, 19S,20R-EpDPE, 19S,20R-epoxy DPA, 19S,20R-epoxy Docosapentaenoic Acid

     A neuropeptide with diverse biological activities
  40. GC46475 19R(20S)-EpDPA

    19R,20S-epoxy Docosapentaenoic Acid, 19R,20S-epoxy DPA, 19R,20S-EDP, 19R,20S-EpDPE

     A DHA metabolite
  41. GC46471 17β-hydroxy Exemestane-d3 A neuropeptide with diverse biological activities
  42. GC46464 17R(18S)-EpETE

    17R,18S-EEQ, 17R,18S-epoxy Eicosatetraenoic Acid

     An EPA metabolite and activator of KCa1.1/BK channels
  43. GC46438 14S(15R)-EET

    14S,15R-EpETrE

     A cytochrome P450 metabolite of arachidonic acid
  44. GC46387 1,3,7-Trimethyluric Acid-d9

    TMU-d9, 8-oxo Caffeine-d9

     An internal standard for the quantification of 1,3,7-trimethyluric acid
  45. GC46284 (±)-Cotinine-d3

    氘代甲基可替宁,(±)-Cotinine-d3; (Rac)-NIH-10498-d3

     An internal standard for the quantification of cotinine
  46. GC46268 (±)9-HETE-d8

    (±)9-Hydroxyeicosatetraenoic Acid-d8

     A neuropeptide with diverse biological activities
  47. GC46264 (±)8(9)-EET-d11

    (±)8,9-EET-d11, (±)8,9-EpETrE-d11

     A neuropeptide with diverse biological activities
  48. GC46262 (±)5(6)-EET-d11

    (±)5,6-EET-d11

     A neuropeptide with diverse biological activities
  49. GC46260 (±)17(18)-EpETE

    (±)17,18-EEQ, (±)17,18-epoxy Eicosatetraenoic Acid

     A neuropeptide with diverse biological activities
  50. GC46257 (±)12(13)-EpOME-d4

    (±)12,13-EODE-d4, Isoleukotoxin-d4, (±)Vernolic Acidd4

     A neuropeptide with diverse biological activities
  51. GC46256 (±)12(13)-DiHOME-d4

    Isoleukotoxin diold4

     A neuropeptide with diverse biological activities

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