P450

Cytochrome P450 are a family of heme-containing monoxygenases catalyzing the metabolism of xenobiotics in the body where P450 enzymes use O2 and two electrons provided by NAD(P)H with the help of redox partner flavoproteins and iron-sulfur proteins to catalyze the monooxygenation of a variety of substrates. Based on how electrons from NAD(P)H are delivered to the catalytic site, P450 enzymes are divided into four classes, including Class I requiring both an FAD-containing reductase and an iron sulfur redoxin, Class II requiring only an FAD/FMN-containg P450 reductase, Class III requiring no electron donor and Class IV requiring electrons directly from NAD(P)H.

Products for P450

Cat.No. 产品名称 Information
GC45270 (±)10(11)-EDP Ethanolamide
10,11-EDP-EA, 10,11-EDP epoxide, 10,11-epoxy Docosapentaenoic Ethanolamide
An ω-3 endocannabinoid epoxide and CB receptor agonist
GC45269 (±)10(11)-DiHDPA
(±)10,11-DiHDPE
An epoxygenase metabolite of DHA
GC45239 δ4-Abiraterone
阿比特龙代谢物,Δ4-Abiraterone; CB-7627; Abiraterone D4A metabolite
An active metabolite of abiraterone
GC45208 α-hydroxy Metoprolol
Α-羟基美托洛尔
An active metabolite of metoprolol
GC45151 Voriconazole N-oxide
伏立康唑N-氧化物
A major metabolite of voriconazole
GC45023 tetranor-12(R)-HETE
8(R)-HHxTrE, tetranor-12(R)-Hydroxyeicosatetraenoic Acid, 2,3,4,5-Tetranor 12(R)-HETE
A metabolite of 12(R)-HETE
GC44975 SW203668 (trifluoroacetate salt) An irreversible inhibitor of stearoyl-CoA desaturase
GC44917 Sorafenib N-oxide
索拉非尼N氧化物
An active metabolite of sorafenib
GC44907 S-NEPC A colorimetric substrate for sEH
GC44882 Seneciphylline
千里光菲灵碱
An alkaloid with diverse biological activities
GC44819 Resorufin benzyl ether
7-苄氧基试卤灵
A fluorometric substrate for CYP450-linked enzymes
GC44799 Quinidine N-oxide A quinidine metabolite
GC44668 Posaconazole D-Glucuronide
Posaconazole N-β-D-Glucuronide
A metabolite of posaconazole
GC44555 Pantoprazole sulfone
泮托拉唑杂质A
A pantoprazole metabolite
GC44554 Pantoprazole Sulfide
泮托拉唑硫醚
A pantoprazole metabolite
GC44492 O-Desmethyl Metoprolol
O-去甲基美托洛尔
A major active metabolite of metoprolol
GC44451 Norfluoxetine (hydrochloride)
去甲氟西汀,Desmethylfluoxetine
An active metabolite of fluoxetine
GC44351 N-Desmethyl Sildenafil (citrate) A major metabolite of sildenafil
GC44350 N-Desmethyl Sildenafil
N-去甲基西地那非,Desmethylsildenafil; UK-103,320
A major metabolite of sildenafil
GC44348 N-desmethyl Bendamustine
盐酸苯达莫司汀乙酯水解杂质
An active metabolite of bendamustine
GC44345 N-Desethyl Vardenafil
N-去乙基伐地那非
A vardenafil metabolite
GC44299 N-Acetyl-4-benzoquinone imine
N-乙酰基-4-苯醌亚胺
A reactive CYP450 metabolite of acetaminophen
GC44033 Lansoprazole sulfone
兰索拉唑磺酸盐
A metabolite of lansoprazole
GC43879 Hydroxy Ebastine An ebastine metabolite
GC43743 Gemfibrozil 1-O-β-Glucuronide
吉非罗齐酰基β-D-葡萄糖醛酸
A major metabolite of gemfibrozil
GC43627 Erythromycin lactobionate
红霉素乳糖酸盐
A macrolide antibiotic and water-soluble form of erythromycin
GC43626 Erythromycin A N-oxide
红霉素A氧化物
A potential impurity in commercial preparations of erythromycin
GC43621 Epoxy Fluor 7 A sensitive fluorescent substrate for soluble epoxide hydrolase
GC43440 Dibenzylfluorescein
DBF, NSC 645658
A fluorogenic cytochrome P450 substrate
GC43401 Dehydro Nifedipine
4-(2硝基苯基)-2,6-二甲基吡啶-3,5二羧酸二甲酯
An active metabolite of nifedipine
GC43400 Dehydro Aripiprazole (hydrochloride)
脱氢阿立哌唑盐酸盐
The primary, active metabolite of aripiprazole
GC43278 Clindamycin Sulfoxide
克林霉素亚砜
An active metabolite of clindamycin
GC43158 CAY10462 A potent, selective 20-HETE synthase inhibitor
GC42888 Azamulin
阿扎莫林,Antibiotic TDM 85-530
A selective CYP3A inhibitor
GC42887 Axitinib Sulfoxide
阿西替尼杂质A
A major inactive metabolite of axitinib
GC42879 Avanafil metabolite M4 An active metabolite of avanafil
GC42878 Avanafil metabolite M16 A major inactive metabolite of avanafil
GC42626 8-hydroxy Efavirenz
8-羟基依法韦伦
A major metabolite of efavirenz
GC42586 6α-hydroxy Paclitaxel
6-羟基泰素
A metabolite of paclitaxel
GC42584 6-O-desmethyl Donepezil
6-O-去甲基多奈哌齐
An active metabolite of donepezil
GC42580 6-hydroxy Chlorzoxazone
6-.羟基氯唑沙宗,NSC 24955
A metabolite of chlorzoxazone
GC42551 5-hydroxymethyl Tolterodine (formate)
5-羟甲基托特罗定
An active metabolite of tolterodine and fesoterodine
GC42550 5-hydroxy-6-methoxy (S)-Duloxetine
度洛西汀杂质
A metabolite of (S)-duloxetine
GC42546 5-hydroxy Diclofenac
5-羟基双氯芬酸
An active metabolite of diclofenac
GC42409 4-hydroxy Nebivolol (hydrochloride) A major metabolite of nebivolol
GC42405 4-hydroxy Atorvastatin (calcium salt)
4-羟基阿托伐他汀（钙盐）
A metabolite of atorvastatin
GC42402 4-hydroxy (S)-Duloxetine β-D-Glucuronide (sodium salt)
LY550408
An inactive metabolite of (S)-duloxetine
GC42085 20-hydroxy N-Arachidonoyl Taurine A potential CYP450 metabolite of N-arachidonoyl-taurine
GC42083 20-HETE Ethanolamide
20-hydroxy AEA, 20-hydroxy Arachidonoyl Ethanolamide, 20-Hydroxyeicosatetraenoic Acid Ethanolamide
A putative CYP450 metabolite of AEA
GC41945 16-hydroxy Hexadecanoic Acid
16-羟基棕榈酸
CYP450 metabolite of palmitic acid