P450

Cytochrome P450 are a family of heme-containing monoxygenases catalyzing the metabolism of xenobiotics in the body where P450 enzymes use O2 and two electrons provided by NAD(P)H with the help of redox partner flavoproteins and iron-sulfur proteins to catalyze the monooxygenation of a variety of substrates. Based on how electrons from NAD(P)H are delivered to the catalytic site, P450 enzymes are divided into four classes, including Class I requiring both an FAD-containing reductase and an iron sulfur redoxin, Class II requiring only an FAD/FMN-containg P450 reductase, Class III requiring no electron donor and Class IV requiring electrons directly from NAD(P)H.

Products for P450

Cat.No. 产品名称 Information
GC41837 1,3,7-Trimethyluric Acid
1,3,7-三甲基尿酸,8-oxo Caffeine, NSC 11259
A metabolite of caffeine
GC41720 (R)-Omeprazole (sodium salt)
5-甲氧基-2-[(4-甲氧基-3,5-二甲基-2-吡啶基)-甲基]-3H-苯并咪唑钠盐
An inactive isomer of a gastric proton pump inhibitor
GC41694 (3S)-hydroxy Quinidine
(3S)-3-羟基奎尼定
An active quinidine metabolite
GC41665 (±)8(9)-EET Ethanolamide
(±)8,9-EET Ethanolamide
A cytochrome P450 metabolite of AEA
GC41663 (±)7(8)-DiHDPA A major metabolite of DHA
GC41662 (±)5(6)-EET Ethanolamide
(±)5,6EpETrE Ethanolamide
A potential cytochrome P450 metabolite of AEA
GC41660 (±)4(5)-EpDPA methyl ester
(±)4,5EDP methyl ester, (±)4,5epoxy Docosapentaenoic Acid methyl ester, (±)4,5epoxy DPA methyl ester, (±)4(5)-EpDPE methyl ester
Stable precursor of (±)4(5)-EpDPA, a CYP450 metabolite of DHA
GC41656 (±)2-(14,15-Epoxyeicosatrienoyl) Glycerol
(±)214,15EG
A cytochrome P450 metabolite of 2-AG
GC41655 (±)19(20)-EDP Ethanolamide
19,20-DHEA epoxide, 19,20-epoxy Docosapentaenoic Acid Ethanolamide, 19,20-EDP-EA, 19,20-EDP epoxide
An ω-3 endocannabinoid epoxide and CB receptor agonist
GC41654 (±)19(20)-DiHDPA
(±)19,20DiHDoPE
An epoxygenase metabolite of DHA
GC41653 (±)16(17)-DiHDPA An epoxygenase metabolite of DHA
GC41652 (±)14(15)-EpEDE
(±)14,15Epoxyeicosadienoic Acid
A monoepoxide derived from 8,11,14-eicosatrienoic acid
GC41651 (±)14(15)-EET-SI
14,15-EpETrE-SI, 14(15)-EET-SI, 14(15)EETsulfonimide
A potent, metabolically stable analog of 14(15)-EpETrE
GC41650 (±)14(15)-EET Ethanolamide
(±)14,15EpETrE Ethanolamide, (±)14(15)Epoxy Eicosatrienoyl Ethanolamide
A potential cytochrome P450 metabolite of AEA
GC41648 (±)13(14)-DiHDPA
13(14)-DiHDPA, 13(14)-DiHDoPE, 13,14-DiHDPE
A metabolite of DHA
GC41611 Curcumenol
莪术醇,(+)-Curcumenol
A sesquiterpene
GC41480 3'-hydroxy Lidocaine
3'-羟基利多卡因
A metabolite of lidocaine
GC41474 20-hydroxy Prostaglandin E2
20hydroxy PGE2
An intermediate in the metabolism of PGE₂
GC41380 N-desmethyl Rosiglitazone
N-去甲罗格列酮
A major metabolite of rosiglitazone
GC41373 Methysticin
麻醉椒苦素
A natural kavalactone
GC41339 Pioglitazone Ketone
吡格列酮
An active metabolite of pioglitazone
GC41319 (±)5(6)-EpETE methyl ester
(±)5,6EEQ methyl ester, (±)5,6epoxy Eicosatetraenoic Acid methyl ester
A stable derivative of 5(6)-EpETE
GC41318 (±)17(18)-EpETE methyl ester
(±)17,18-EEQ methyl ester, (±)17,18-epoxy Eicosatetraenoic Acid methyl ester
An esterified form of (±)17(18)-EpETE
GC41312 5-hydroxy Omeprazole
5-羟基奥美拉唑
A major metabolite of omeprazole
GC41302 6',7'-Epoxybergamottin
5-(6',7'-环氧)香叶基氧基补骨脂素
A potent CYP3A4 inhibitor from grapefruit
GC41300 17β-hydroxy Exemestane
亚甲基宝丹酮
An active metabolite of exemestane
GC41288 (±)17(18)-EpETE-Ethanolamide
17,18-EEQ-EA, (±)17,18-EEQ-Ethanolamide, (±)17(18)-EpETE-EA, 17,18-epoxy-Eicosatetraenoic Acid Ethanolamide
An ω-3 endocannabinoid epoxide
GC41264 CAY10434 A potent, selective 20-HETE synthase inhibitor
GC41212 (±)10(11)-EpDPA
(±)10,11-EDP, (±)10,11-EpDPE, (±)10,11-epoxy DPA, (±)10,11-epoxy Docosapentaenoic Acid
A DHA epoxygenase metabolite
GC41203 (±)7(8)-EpDPA
(±)7,8-EDP, (±)7,8-EpDPE, (±)7,8-epoxy DPA, (±)7,8-epoxy Docosapentaenoic Acid
A DHA epoxygenase metabolite
GC41201 (±)4(5)-DiHDPA lactone A lactone derived from DHA
GC41199 (±)19(20)-EpDPA
(±)19,20 EDP, (±)19,20-epoxy Docosapentaenoic Acid, (±)19,20-epoxy DPA, (±)19,20-EpDPE
A DHA epoxygenase metabolite
GC41194 (±)16(17)-EpDPA
(±)16,17 EDP, (±)16,17-epoxy Docosapentaenoic Acid, (±)16,17-epoxy DPA, (±)16,17-EpDPE
A DHA congener of (±)14(15)-EpETrE
GC41191 (±)13(14)-EpDPA
13,14-EpDPE
A DHA epoxygenase metabolite
GC41151 Decursinol angelate Decursinol angelate is a pyranocoumarin that has been found in the Korean medicinal herb A.
GC41143 (±)11,12-DiHETE An EPA metabolite
GC41128 5(S),6(R)-11-trans DiHETE A metabolite of LTA₄
GC41120 (±)8,9-DiHETE A major metabolite of EPA
GC41119 (±)5(6)-DiHETE Possible metabolite of EPA
GC41117 (±)17(18)-DiHETE
(±)17,18-dihydroxy-eicosa-5,8,11,14-Tetraenoic Acid
An epoxygenase metabolite of EPA
GC41116 (±)14(15)-DiHETE
(±)14,15dihydroxyeicosa5,8,11,17Tetraenoic Acid
A metabolite of EPA
GC41104 20-carboxy Arachidonic Acid
20carboxy AA, 20COOHAA
A metabolite of 20-HETE
GC40968 21-hydroxy Eplerenone
21-羟基依普利酮
A major metabolite of eplerenone
GC40954 (±)-N-3-Benzylnirvanol
(S)-N-3-benzyl Nirvanol
A racemic mixture of (+)-N-3-benzylnirvanol and (–)-N-3-benzylnirvanol
GC40906 (±)7(8)-EpDTE
(±)7(8)-EpDoTE
An oxylipin
GC40905 (±)19(20)-EpDTE
(±)19(20)-EpDoTE
An oxylipin
GC40888 (±)14(15)-EpEDE methyl ester
(±)14,15Epoxyeicosadienoic Acid methyl ester
A lipid soluble analog of (±)14(15)-EpEDE
GC40841 (±)11(12)-EET methyl ester
(±)11,12EpETrE methyl ester
A stable epoxide with a role in the recovery of depleted Ca²⁺ pools
GC40838 (±)8(9)-EET methyl ester
(±)8,9EpETrE methyl ester
An esterified version of (±)8(9)-EET
GC40836 (±)5(6)-EET methyl ester
(±)5,6EpETrE methyl ester
A stable, hydrolyzable derivative of (±)5(6)-EET