P450

Cytochrome P450 are a family of heme-containing monoxygenases catalyzing the metabolism of xenobiotics in the body where P450 enzymes use O2 and two electrons provided by NAD(P)H with the help of redox partner flavoproteins and iron-sulfur proteins to catalyze the monooxygenation of a variety of substrates. Based on how electrons from NAD(P)H are delivered to the catalytic site, P450 enzymes are divided into four classes, including Class I requiring both an FAD-containing reductase and an iron sulfur redoxin, Class II requiring only an FAD/FMN-containg P450 reductase, Class III requiring no electron donor and Class IV requiring electrons directly from NAD(P)H.

Products for P450

Cat.No. 产品名称 Information
GC40835 (±)14(15)-EET methyl ester
(±)14,15EpETrE methyl ester
An esterified version of (±)14(15)-EET
GC40802 (±)12(13)-DiHOME
Isoleukotoxin diol
A diol form of (±)12,13-EpOME
GC40801 (±)9(10)-DiHOME
(±)-苏式-9,10-二羟基-12(Z)-十八碳烯酸
A diol form of (±)9(10)-EpOME
GC40638 Alclometasone Dipropionate
阿氯米松双丙酸酯,Sch 22219
A corticosteroid
GC40572 7-keto Cholesterol
胆甾-3-羟基-5-烯-7-酮,SC-4722, 7-酮胆固醇
7-keto Cholesterol是一种与血管疾病相关的主要氧甾醇，广泛存在于动脉粥样硬化斑块中，具有比胆固醇更强的致动脉粥样硬化作用。
GC40540 (±)9(10)-EpOME
Coronaric Acid, (±)9,10EODE, Leukotoxin
The 9,10-cis epoxide of linoleic acid
GC40539 (±)12(13)-EpOME
(±)12,13-EODE, Isoleukotoxin, (±)-Vernolic Acid
The 12,13-cis epoxide form of linoleic acid
GC40534 20-hydroxy Prostaglandin F2α
20hydroxy PGF2α
A CYP450 ω-oxidation metabolite of PGF_2α
GC40529 7-hydroxy Warfarin
7-羟基华法林
A phase I metabolite of (-)-warfarin
GC40528 11α-hydroxy Testosterone A CYP3A metabolite of testosterone
GC40466 (±)11(12)-EET
11,12-EET
A racemic version of a CYP450 metabolite of arachidonic acid
GC40465 9(S)-HETE
9(S)-Hydroxyeicosatetraenoic Acid
A monohydroxy fatty acid and RXRγ agonist
GC40464 9(R)-HETE
9(R)-Hydroxyeicosatetraenoic Acid
Enantiomer of (±)9-HETE; RXRγ activator
GC40458 19(S)-HETE
19(S)-Hydroxyeicosatetraenoic Acid
Potent vasodilator of renal preglomerular vessels
GC40457 19(R)-HETE
19(R)-Hydroxyeicosatetraenoic Acid
A potent vasodilator of renal arterioles
GC40456 17(S)-HETE
17(S)-Hydroxyeicosatetraenoic Acid
A potent inhibitor of proximal tubule ATPase activity
GC40455 17(R)-HETE
17(R)-Hydroxyeicosatetraenoic Acid
An inactive isomer of 17-HETE
GC40454 16(S)-HETE
16(S)-Hydroxyeicosatetraenoic Acid
A potent inhibitor of proximal tubule ATPase activity
GC40447 12(R)-HETE
12(R)-Hydroxyeicosatetraenoic Acid
An active metabolite of arachidonic acid
GC40443 (±)9-HETE
(±)9-Hydroxyeicosatetraenoic Acid
A monohydroxy fatty acid
GC40440 (±)8(9)-EET
(±)8,9EpETrE
A racemic version of a CYP450 metabolite of arachidonic acid
GC40438 (±)5(6)-EET
(±)-顺式-5,6-环氧-8(Z),11(Z),14(Z)-二十碳三烯酸
A racemic version of a CYP450 metabolite of arachidonic acid
GC40437 (±)5(6)-DiHET lactone
(±)5,6DiHETrE lactone
A lactone form of (±)5(6)-DiHET
GC40436 (±)18-HETE
(±)18-Hydroxyeicosatetraenoic Acid
A vasodilator of renal arterioles
GC40435 (±)17-HETE
(±)-Hydroxyeicosatetraenoic Acid
A potent inhibitor of proximal tubule ATPase activity
GC40434 (±)16-HETE
(±)16-Hydroxyeicosatetraenoic Acid
A potent inhibitor of proximal tubule ATPase activity
GC40430 (±)14(15)-EET
(±)14,15-EET, (±)14,15-EpETrE
An arachidonic acid metabolite
GC40425 14,15-EE-8(Z)-E
14,15Epoxyeicosa8(Z)enoic Acid
A potent vasodilator
GC40424 14,15-EE-5(Z)-E
14,15Epoxyeicosa5(Z)enoic Acid
An antagonist of EDHF-mediated vasodilation
GC40389 (±)7(8)-DiHDTE
(±)7(8)-DiHDoTE
An oxylipin
GC40388 (±)19(20)-DiHDTE
(±)19(20)-DiHDoTE
An oxylipin
GC40386 (±)11(12)-EpETE
(±)11,12-EEQ, (±)11,12-Epoxyeicosatetraenoic Acid
Epoxygenase metabolite of EPA
GC40377 20-HEPE An EPA metabolite
GC40365 (±)8(9)-EpETE
(±)8,9-EEQ, (±)8,9-epoxy Eicosatetraenoic Acid
Epoxygenase metabolite of EPA
GC40363 (±)5(6)-DiHETE lactone A lactone form of (±)5(6)-DiHETE
GC40360 (±)14(15)-EpETE
(±)14,15 EEQ, (±)14,15epoxy Eicosatetraenoic Acid
An EPA congener of (±)14(15)-EpETrE with EDHF activity
GC40341 Tetrahydro-11-deoxy Cortisol
四氢化-11-脱氧皮质醇
A metabolite of 11-deoxycortisol
GC40301 Tamoxifen N-oxide
他莫昔芬N-氧化物
A metabolite of tamoxifen
GC40279 (±)11(12)-DiHET
(±)11,12DiHETrE
An epoxide metabolite and potent vasodilator
GC40272 (±)8(9)-DiHET
(±)8,9DiHETrE
A CYP450 metabolite of arachidonic acid
GC40268 (±)14(15)-DiHET
(±)14,15DiHETrE
A urinary metabolite of (±)14(15)-EET
GC40258 Tetrahydropiperine
四氢胡椒碱
A derivative of piperine
GC40228 Fluvastatin-d6 (sodium salt) An internal standard for the quantification of fluvastatin
GC40112 (±)-Climbazole-d4
甘宝素-D4溶液,100PPM,BAY-e 6975-d4
An internal standard for the quantification of climbazole
GC34132 Bergamottin (5-Geranoxypsoralen)
佛手柑素,5-Geranoxypsoralen; Bergamotine; Bergaptin
A naturally occurring furanocoumarin with diverse biological activities
GC33909 Bergaptol (5-Hydroxypsoralen)
香柑醇,5-Hydroxypsoralen; 4-Hydroxybergapten
Bergaptol (5-Hydroxypsoralen, 5-Hydroxyfuranocoumarin) is a natural furanocoumarin found in the essential oils of citrus including lemon and bergamot.Bergaptol is a potent inhibitors of debenzylation activity of CYP3A4 enzyme with an IC50 value of 24.92 μM.
GC33870 Veledimex racemate (RG-115932 racemate)
INXN-1001 racemate; RG-115932 racemate
Veledimex消旋体（RG-115932消旋体）（INXN-1001消旋体）是veledimex的消旋体。
GC33862 Pyributicarb (TSH-888)
稗草畏,TSH-888
Pyributicarb (TSH-888) 是一种氨基甲酸酯类除草剂，是 CYP3A4 基因和人孕烷 X 受体 (hPXR) 的有效激活剂。
GC33833 Tetrahydrocurcumin (HZIV 81-2)
四氢姜黄素; HZIV 81-2
A metabolite of curcumin with diverse biological activities
GC33780 RG-12525 (NID 525)
NID 525
RG-12525 (NID 525) 是一种特异性、竞争性和口服有效的肽白三烯、LTC4、LTD4 和 LTE4 拮抗剂，抑制 LTC4、LTD4 和 LTE4 诱导的豚鼠实质条收缩，IC50 为 2.6 nM，2.5 nM和 7 nM，分别； RG-12525 (NID 525) 也是一种过氧化物酶体增殖物激活受体 gamma (PPAR-gamma) 激动剂，IC50 约为 60 nM，是 CYP3A4 的有效抑制剂，Ki 值为 0.5 μM。