PDE(磷酸二酯酶)

PDE (phosphodiesterases) catalyze the hydrolysis of cGMP and/or cAMP. Stimulus such as light, neurotransmitter and hormone trigger PDE to regulate various biological response including vascular smooth muscle proliferation/contraction, hormone secretion and plate aggregation etc.

Products for PDE

Cat.No. 产品名称 Information
GC30915 BAY 73-6691 racemate BAY73-6691racemate是一个磷酸二酯酶9(phosphodiesterase9）抑制剂，来自专利WO2017070293A1。
GC30879 PDE1-IN-2 PDE1-IN-2是PDE1的抑制剂,来自专利WO2016/55618A1，化合物实例31。对PDE1C,PDE1B和PDE1A的IC50值分别为6，140和164nM。
GC30841 ITI214 free base A PDE1 inhibitor
GC30828 PF-05180999
PF-999
A PDE2A inhibitor
GC30811 ITI214 A PDE1 inhibitor
GC30657 PDE IV-IN-1 PDEIV-IN-1是一种有效的phosphodiesteraseIV抑制剂，可用于哮喘，慢性阻塞性肺病和其他炎症性疾病的研究。
GC30437 ER21355
ER21355是一种磷酸二酯酶5(phosphodiesterase5)的抑制剂，用于治疗前列腺疾病。
GC30390 Autotaxin modulator 1 Autotaxinmodulator1是出自专利WO2014018881A1中的新型Autotaxin调节剂。
GC19343 Balipodect
TAK-063
A potent inhibitor of PDE10A
GC19314 RVT-501
RVT-501; E6005
An inhibitor of PDE4
GC19168 GLPG1690
Ziritaxestat
GLPG1690(Ziritaxestat) 是一种新型的autotaxin (ATX)抑制剂，IC₅₀为131 nM, K_i为15 nM。它能有效阻止特发性肺纤维化的进展。
GC19111 CP671305 A potent PDE4D inhibitor
GC19068 BI-409306
BI-409306
A potent and selective PDE9A inhibitor
GC10869 HA-155
Autotaxin Inhibitor IV
A selective autotaxin inhibitor
GC13275 Ibudilast
异丁司特; KC-404; AV-411; MN-166
An inhibitor of PDE4
GC11125 Sp-Cyclic AMPS (sodium salt)
Sp-cAMPS
A cAMP derivative
GC16072 ML-030
CID-11757146
A selective inhibitor of PDE4A
GC13956 2-Acetamidophenyl 5-chloro-2-nitrophenyl sulfide
2'-(5-chloro-2-nitrophenylthio)-Acetanilide
An inhibitor of PDE7
GC11782 Ophiobolin A
蛇孢菌素A,Cochliobolin,NSC 114340
A calmodulin antagonist
GC10796 Eggmanone
EGM1
A selective phosphodiesterase 4 inhibitor
GC16849 MBCQ An inhibitor of PDE5
GC10859 Amino Tadalafil
氨基他达拉非
An analog of tadalafil
GC15037 Sildenafil mesylate
甲磺酸西地那非
A PDE5 inhibitor
GC17999 TC-E 5005 PDE10A inhibitor
GC13121 Piclamilast
吡拉米司特,RP 73401; RPR 73401
A PDE4 inhibitor
GC11789 T 0156 hydrochloride T 0156 hydrochloride 是一种有效的选择性 5 型磷酸二酯酶 (PDE5) 抑制剂。
GC16048 BC 11-38 A potent and selective PDE11 inhibitor
GC14697 HA 130 A reversible autotaxin inhibitor
GC15189 Gisadenafil besylate
UK 369003-26
A PDE5 inhibitor
GC16632 CDP 840 hydrochloride
GR259653X
CDP 840 hydrochloride (GR259653X) 是一种有效的、选择性的和口服活性的磷酸二酯酶 IV (PDE IV) 抑制剂。
GC15475 RS 25344 hydrochloride
1-(3-硝基苯基)-3-(吡啶-4-基甲基)吡啶并[2,3-D]嘧啶-2,4(1H,3H)-二酮盐酸盐
RS 25344 hydrochloride 是一种选择性 cAMP-磷酸二酯酶 4 (PDE 4; PDE IV) 抑制剂，对人淋巴细胞的 IC50 为 0.28 nM。
GC13657 Mesopram
美索普兰-13C-D3
PDE4 inhibitor, orally active
GC10542 CP 80633
CP-80,633
Inhibitor of phosphodiesterase type 4
GC15472 BRL 50481
N,N,2-三甲基-5-硝基苯磺酰胺
A potent, selective inhibitor of PDE7
GC12059 YM 976 A PDE4 inhibitor
GC11313 ICI 63197
三氮唑嘧啶酮
A PDE3 and PDE4 inhibitor
GC10004 Enoximone
烯氟酮
A PDE3 inhibitor
GC14398 Siguazodan
氰胍佐旦
Siguazodan (SKF 94836) 是一种有效的、选择性的、具有口服活性的磷酸二酯酶 III (PDE-III) 抑制剂，IC50 为 117 nM。
GC10109 Cilostamide
OPC3689西洛酰胺,OPC3689
A selective inhibitor of PDE3
GC12878 MMPX
8-甲氧基甲基-3-异丁酰-1-甲基黄嘌呤
calmodulin-sensitive cyclic GMP phosphodiesterase inhibitor
GC12771 Etazolate hydrochloride PDE-4 inhibitor and selective GABA-A receptor modulator
GC11684 MY-5445
1-(3-氯苯胺基)-4-苯基酞嗪
A PDE5 inhibitor
GC11730 IBMX
3-异丁基-1-甲基黄嘌呤,3-Isobutyl-1-methylxanthine; Isobutylmethylxanthine
IBMX 是一种非特异性磷酸二酯酶 (PDE) 抑制剂，可抑制 PDE3、PDE4 和 PDE5，IC50 值为 6.5、26.3 和 31.7 µm，但 PDE8A、PDE8B 和 PDE9 除外。
GC13495 Trequinsin hydrochloride
盐酸曲林菌素,HL 725
An inhibitor of PDE3
GC12909 Zaprinast
2-(2-丙氧苯基)-8-氮杂次黄嘌呤,M&B 22948
A cGMP phosphodiesterase inhibitor
GC13842 Ro 20-1724
4-(3-丁氧基-4-甲氧基苯基)咪唑啶-2-酮,4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone

A selective PDE4 inhibitor
GC12824 Dibutyryl-cAMP, sodium salt
Dibutyryl cAMP sodium salt; DBcAMP sodium salt
A cell-permeable, cAMP analog
GC13287 Udenafil
乌地那非; DA8159
A PDE5 inhibitor
GC13191 Irsogladine
伊索拉定; Dicloguamine
A gastroprotective agent
GC17673 Dipyridamole
双嘧达莫
A PDE5A inhibitor