PDE(磷酸二酯酶)

PDE (phosphodiesterases) catalyze the hydrolysis of cGMP and/or cAMP. Stimulus such as light, neurotransmitter and hormone trigger PDE to regulate various biological response including vascular smooth muscle proliferation/contraction, hormone secretion and plate aggregation etc.

Products for PDE

Cat.No. 产品名称 Information
GC11730 IBMX
3-异丁基-1-甲基黄嘌呤,3-Isobutyl-1-methylxanthine; Isobutylmethylxanthine
IBMX 是一种非特异性磷酸二酯酶 (PDE) 抑制剂，可抑制 PDE3、PDE4 和 PDE5，IC50 值为 6.5、26.3 和 31.7 µm，但 PDE8A、PDE8B 和 PDE9 除外。
GC13495 Trequinsin hydrochloride
盐酸曲林菌素,HL 725
An inhibitor of PDE3
GC12909 Zaprinast
2-(2-丙氧苯基)-8-氮杂次黄嘌呤,M&B 22948
A cGMP phosphodiesterase inhibitor
GC13842 Ro 20-1724
4-(3-丁氧基-4-甲氧基苯基)咪唑啶-2-酮,4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone

A selective PDE4 inhibitor
GC12824 Dibutyryl-cAMP, sodium salt
Dibutyryl cAMP sodium salt; DBcAMP sodium salt
Dibutyryl-cAMP, sodium salt，又称为Bucladesine，是一种细胞膜可透性环核苷酸类似物，能模拟内源性cAMP的作用，并作为磷酸二酯酶抑制剂。
GC13287 Udenafil
乌地那非; DA8159
A PDE5 inhibitor
GC13191 Irsogladine
伊索拉定; Dicloguamine
A gastroprotective agent
GC17673 Dipyridamole
双嘧达莫
A PDE5A inhibitor
GC13444 Doxofylline
多索茶碱
A bronchodilator
GC17422 Pimobendan hydrochloride
盐酸匹莫苯丹; UD-CG115 hydrochloride
An inhibitor of PDE3
GC12060 Deltarasin hydrochloride A KRAS inhibitor
GC14868 Milrinone
米力农; Win 47203
An inhibitor of PDE3
GC16658 Vinpocetine
长春西汀; Ethyl apovincaminate
An inhibitor of PDE1
GC15242 Vardenafil
伐地那非
Vardenafil 是一种具有口服活性的选择性磷酸二酯酶 5 (PDE5) 抑制剂，IC50 为 0.7 nM。
GC10944 Butein
紫铆因; 2’,3,4,4’-tetrahydroxy Chalcone
A plant polyphenol
GC16426 Zardaverine
扎达维林
A dual inhibitor of PDE3 and PDE4
GC11369 Sildenafil
西地那非; UK-92480

西地那非，作为一种磷酸二酯酶 5 (PDE-5) 抑制剂，用于治疗肺动脉高压 (PAH)。
GC14510 PF-8380
4-[3-氧代-3-(2-氧代-2,3-二氢苯并恶唑-6-基)丙基]哌嗪-1-羧酸3,5-二氯苄酯,PF 8380;PF8380
An inhibitor of autotaxin
GC10648 PF-04447943
PF 04447943;PF04447943
A PDE9A inhibitor
GC17221 Olprinone Hydrochloride
盐酸奥普力农; Loprinone Hydrochloride
An inhibitor of PDE3
GC11072 Nortadalafil
去甲基他达那非; Demethyl Tadalafil
诺他达拉非是去甲基他达拉非，它是一种 PDE5 抑制剂，目前以药丸形式销售，用于治疗勃起功能障碍 (ED)，名称为 Cialis；并以 Adcirca 的名义用于治疗肺动脉高压。
GC13076 Deltarasin A KRAS inhibitor
GC11472 AN-2728
克立硼罗; AN-2728; PF-06930164
A selective PDE4 inhibitor
GC11273 Anagrelide HCl
盐酸阿那格雷; BL4162A
A PDE3 inhibitor
GC10077 S- (+)-Rolipram
(+)-Rolipram; (S)-Rolipram
S- (+)-Rolipram ((+)-Rolipram) 是一种环状 AMP(cAMP) 特异性磷酸二酯酶 4 (PDE4) 抑制剂，IC50 为 1100 nM。
GC12764 Aminophylline
氨茶碱
A phosphodiesterase inhibitor and adenosine receptor antagonist
GC13652 Dyphylline
二羟丙茶碱; Diprophylline
An adenosine receptor antagonist and phosphodiesterase inhibitor
GC12808 Pimobendan
匹莫苯丹; UD-CG115
An inhibitor of PDE3
GC15890 Cilostazol
西洛他唑; OPC 13013
A PDE3A inhibitor
GC16856 Avanafil
阿伐那非; TA1790
A potent and selective PDE5 inhibitor
GC14180 GSK256066
6-[[3-[(二甲基氨基)羰基]苯基]磺酰]-4-[(3-甲氧基苯基)氨基]-8-甲基-3-喹啉甲酰胺
A potent PDE4 inhibitor
GC17598 Cilomilast
西洛司特; SB-207499
A PDE4 inhibitor
GC16629 Rolipram
诺普利兰,(R,S)-Rolipram; SB 95952; ZK 62711
A phosphodiesterase-4 inhibitor
GC17074 Tadalafil
他达那非; IC-351
A PDE5 inhibitor
GC15194 PF-2545920
2-[[4-[1-(甲基-11C)-4-(4-吡啶基)-1H-吡唑-3-基]苯氧基]甲基]喹啉
A potent inhibitor of PDE10A
GC10588 Vardenafil HCl Trihydrate
盐酸瓦地那非三水合物
An inhibitor of PDE5 and PDE6
GC17685 Sildenafil Citrate
西地那非柠檬酸盐; UK-92480 citrate
A PDE5 inhibitor
GC16347 Roflumilast
罗氟司特
A PDE4 inhibitor
GC10420 Apremilast (CC-10004)
阿普司特; CC-10004
An orally available PDE4 inhibitor
GN10231 Fraxin
秦皮甙,Fraxetol 8-glucoside; Fraxoside
A coumarin glycoside
GN10278 Icariin
淫羊藿甙; Ieariline
淫羊藿甙是一种黄酮醇糖苷。淫羊藿甙抑制PDE5和PDE4活性的IC₅₀分别为432 nM和73.50 μM。
GN10659 Theophylline
茶碱,Theolix
A phosphodiesterase inhibitor and adenosine receptor antagonist