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Home >> Signaling Pathways >> Metabolism >> PPAR

PPAR(过氧化物酶体增殖剂激活受体)

The peroxisome proliferator-activated receptors (PPARs), belonging to the nuclear receptor superfamily, are a group of nuclear receptor proteins that are composed of three isoforms, including PPARγ, PPARα and PPARδ, encoded by separate genes. PPARs have a modular structure characterized by the presence of two highly conserved domains, including the DNA binding domain (DBD) of two zinc fingers and the ligand binding domain (LBD) of 13 α-helices and a small 4-stranded β-sheet. PPARs are ligand-regulated transcription factors controlling gene expression by binding to specific response elements (PPREs) within promoters, where PPARs bind as heterodimers with a retinoid X receptor and interact with cofactors upon binding leading to the increasing of rate of transcription initiation.

Products for  PPAR

  1. Cat.No. 产品名称 Information
  2. GC72481 Naveglitazar Naveglitazar（LY519818）是一种非噻唑烷二酮过氧化物酶体增殖物激活受体（PPAR）α-γ双γ显性激动剂，在动物模型中显示出降低血糖的潜力。
  3. GC71367 PPARγ-IN-2 PPARγ-IN-2（化合物5a）是PPARγ抑制剂。
  4. GC70491 CC618 CC618是一种选择性过氧化物酶体增殖物激活受体（PPARβ/δ）拮抗剂，通过共价结合PPARβ／δ受体表现出拮抗作用。
  5. GC70423 ST247 ST247一种强效的PPARβ/δ反向激动剂。
  6. GC70251 Rivoglitazone Rivoglitazone是一种噻唑烷二酮衍生物PPARγ激动剂，用于2型糖尿病的研究。
  7. GC91298 (±)-Linalool-d3

    dl-Linalool-d3

    一种用于量化(±)-芳樟醇的内部标准。
  8. GC91136 XY-4

    PPARγ的激动剂
  9. GC90582 Perfluorooctanesulfonic Acid

    Heptadecafluorooctanesulfonic Acid, Perfluorooctane sulfonate, Perfluorooctylsulfonic Acid, PFOS

    一种全氟烷基物质
  10. GC69437 Mavodelpar

    REN001; HPP593

     Mavodelpar (REN001) 是一种选择性的 PPARδ 激动剂。Mavodelpar 抑制肾小球损伤和肾纤维化。Mavodelpar 可用于原发性线粒体肌病 (PMM) 和长链脂肪酸氧化障碍 (LC-FAOD) 的研究。
  11. GC69192 GSK1820795A GSK1820795A 作为替米沙坦类似物是 hGPR132a 的选择性拮抗剂。GSK1820795A阻断了 N-acylamides 对表达 hGPR132a 的酵母细胞的活化。GSK1820795A也是血管紧张素 II 拮抗剂和部分 PPARγ 激动剂 (compound 38) 。
  12. GC69137 FX-909 FX-909 是一种共价过氧化物酶体增殖体激活受体 γ (PPARG) 逆激动剂。FX-909 可用于肿瘤的研究。
  13. GC68756 Bezafibrate-d6

    苯扎贝特 d6

     Bezafibrate-d6 是 Bezafibrate 的氘代物。Bezafibrate 是 PPAR 的激动剂，对人和鼠 PPARα，PPARγ 和 PPARδ 的 EC50 分别为 50 μM，60 μM，20 μM 和 90 μM，55 μM，110 μM；Bezafibrate 是一种降血脂剂。
  14. GC68736 BAY-4931 BAY-4931 是一种有效的、共价的、选择性的 PPARγ 反向激动剂，IC50 为 0.17 nM。
  15. GC68730 BAY-0069 BAY-0069 是一种有效且具有选择性的 PPARγ 反向激活剂，对人 PPARγ 和鼠 PPARγ 的 IC50 分别为 6.3 nM 和 24 nM。BAY-0069 可用于癌症的研究。
  16. GC67866 PPARδ/γ agonist 1 sodium PPARδ/γ agonist 1 sodium 是一种化学性质独特，可透过血脑屏障的双重 PPAR delta/gamma 激动剂。PPARδ/γ agonist 1 sodium 可用于老年痴呆症的研究。
  17. GC65414 2-(Tetradecylthio)acetic acid

    十四烷基硫代乙酸

     2-Tetradecylthio acetic acid 是一种泛过氧化物酶体增殖物激活受体 (pan-PPAR) 激活剂。2-Tetradecylthio acetic acid 诱导低血脂。2-Tetradecylthio acetic acid 可降低啮齿动物的血浆脂质并增强肝脏脂肪酸氧化。2-Tetradecylthio acetic acid 增加参与脂肪酸摄取、活化、积累和氧化的基因的表达。
  18. GC64873 Leriglitazone hydrochloride

    Hydroxypioglitazone hydrochloride

     Leriglitazone (Hydroxypioglitazone) hydrochloride，吡格列酮的代谢产物。Leriglitazone (Hydroxypioglitazone) hydrochloride是 PPARγ 激动剂，通过稳定 PPARγ (AF-2) 共激活剂结合表面和增强共激活剂结合能力，提供高转录效力。Leriglitazone (Hydroxypioglitazone) hydrochloride 与 PPARγC (LBD) 结合，其 Ki 值为 1.2 μM，诱导 PPARγ (LBD) 转录效率，EC50 为 680 nM。
  19. GC64699 Bocidelpar

    ASP0367; MA-0211

     Bocidelpar 是过氧化物酶体增殖物激活受体 delta (PPAR-δ) 的调节剂。Bocidelpar 可改善杜兴肌营养不良 (DMD) 肌肉细胞中的线粒体生物合成和功能 (信息提取自专利 WO2017062468A1，compound 2b)。
  20. GC49884 Trigonelline-d3 (chloride)

    Trigonelline-d3 hydrochloride

     An internal standard for the quantification of trigonelline
  21. GC64099 AZD-9574 AZD-9574 is a novel PARP inhibitor which combines PARP1 selectivity, trapping and high CNS penetration in a single molecule.
  22. GC49521 MHY553

    NSC 33005

     An agonist of PPARα
  23. GC63358 5-Aminosalicylic Acid-D3 hydrochloride

    美沙拉胺-D3,Mesalamine-D3 hydrochloride; 5-ASA-D3 hydrochloride; Mesalazine-D3 hydrochloride

     5-Aminosalicylic Acid-D3 (Mesalamine-D3) hydrochloride 是 5-Aminosalicylic Acid hydrochloride 的氘代物。5-Aminosalicylic acid (Mesalamine) hydrochloride 是一种特异性的 PPARγ 激动剂，还抑制 p21-激活激酶1 (PAK1) 和 NF-κB。
  24. GC62974 FK614 FK614 是一种具有口服活性，有效的，选择性的 PPARγ 调制剂 (SPPARM)。FK614 对脂肪细胞分化各阶段 PPARγ 的激活有不同的影响。FK614 是一种非噻唑烷二酮类胰岛素增敏剂。FK614 可用于高血糖、高甘油三酯、葡萄糖耐受不良和 2 型糖尿病的研究。
  25. GC62836 AMG131

    2,4-二氯-N-[3,5-二氯-4-(喹啉-3-基氧基)苯基]苯磺酰胺,INT131

     AMG131 (INT131) 是一种有效且高度选择性的 PPARγ 部分激动剂，可与 PPARγ 结合，取代罗格列酮，Ki 为~10 nM。 AMG131 可用于研究 2 型糖尿病 (T2DM)。
  26. GC49087 Clofibric Acid-d4

    Chlorofibrinic acid-d4

     An internal standard for the quantification of clofibric acid
  27. GC62203 Falcarindiol

    法卡林二醇

     Falcarindiol (FAD, (3R,8S)-Falcarindiol, FaDOH) is a natural polyacetylene compound found rich in many plants of the Umbelliferae family. Falcarindiol suppresses LPS-stimulated expression of inducible nitric oxide synthase (iNOS), tumor necrosis factor alpha (TNFα), interleukin-6 (IL-6), and interleukin-1 beta (IL-1β). Falcarindiol attenuates the LPS-induced activation of JNK, ERK, STAT1, and STAT3 signaling molecules.
  28. GC61805 Cefminox sodium

    头孢米诺钠; MT-141

     Cefminox Sodium (Meicelin, MT-141) is the sodium salt form of cefminox, a semi-synthetic, second-generation, beta-lactamase-stable cephalosporin with antibacterial activity.
  29. GC48782 10,13-epoxy-11-methyl-Octadecadienoic Acid

    F2 Furan Fatty Acid, 3-methyl-5-pentyl-2-Furannonanoic Acid, 9M5

     A furan fatty acid
  30. GC48521 KRP 297

    MK-0767

     A dual agonist of PPARα and PPARγ
  31. GC48426 CAY10771 A dual agonist of FXR and PPARδ
  32. GC48272 ZLY032 A dual FFAR1 and PPARδ agonist
  33. GC48059 Rosiglitazone-d3

    罗格列酮 d3

     An internal standard for the quantification of rosiglitazone
  34. GC47866 Palmitoyl Ethanolamide-d5

    Palmidrold5, PEA15,15,16,16,16d5

     A neuropeptide with diverse biological activities
  35. GC47820 Oleoyl Ethanolamide-d4

    N-Oleoylethanolamide-d4; Oleamide MEA-d4; Oleic acid monoethanolamide-d4

     An internal standard for the quantification of oleoyl ethanolamide
  36. GC47819 Oleoyl Ethanolamide-d2

    N-Oleoylethanolamide-d2; Oleamide MEA-d2; Oleic acid monoethanolamide-d2

     An internal standard for the quantification of oleoyl ethanolamide
  37. GC47417 GW 9662-d5 A neuropeptide with diverse biological activities
  38. GC47397 Gemfibrozil-d6

    吉非罗齐-D6溶液,100PPM,CI-719-d6

     An internal standard for the quantification of gemfibrozil
  39. GC47337 Fenofibrate-d6

    非诺贝特 d6

     An internal standard for the quantification of fenofibrate
  40. GC47063 CAY10767 A PPARα agonist
  41. GC46757 9(Z),11(E)-Conjugated Linoleic Acid (sodium salt)

    cis-9,trans-11-Conjugated Linoleic Acid, 9(Z),11(E)-CLA

     An isomer of linoleic acid
  42. GC46448 15-deoxy-δ12,14-Prostaglandin J2-d9

    15d-PGJ2-d9; 15-Deoxy-Δ12,14-PGJ2-d9

     A neuropeptide with diverse biological activities
  43. GC46447 15-deoxy-δ12,14-Prostaglandin J2-d4

    15d-PGJ2-d4; 15-Deoxy-Δ12,14-PGJ2-d4

     An internal standard for the quantification of 15-deoxy-Δ12,14-prostaglandin J2
  44. GC46444 15-deoxy-δ12,14-Prostaglandin D2-d9

    15-deoxy-Δ12,14-PGD2-d9

     A neuropeptide with diverse biological activities
  45. GC46443 15-deoxy-δ12,14-Prostaglandin D2-d4

    15-deoxy-Δ12,14-PGD2-d4

     A neuropeptide with diverse biological activities
  46. GC46365 1,1'-(Azodicarbonyl)dipiperidine

    偶氮二甲酰二哌啶

     A Mitsunobu reagent
  47. GC46264 (±)8(9)-EET-d11

    (±)8,9-EET-d11, (±)8,9-EpETrE-d11

     A neuropeptide with diverse biological activities
  48. GC61187 Pioglitazone D4

    匹格列酮-D4,U 72107-d4

     An internal standard for the quantification of pioglitazone
  49. GC61055 Methyl oleanonate

    3-Oxoolean-12-en-28-oic acid methyl ester

     Methyloleanonate是从Pistacia中分离得到的三萜类PPARγ激动剂。Methyloleanonate是齐墩果酸衍生物，具有抗癌作用。
  50. GC61043 Mesalamine impurity P

    美沙拉嗪EP杂质P

     MesalamineimpurityP是Mesalamine的杂质。5-Aminosalicylicacid(Mesalamine)是一种特异性的 PPARγ 激动剂，还抑制p21-激活激酶1(PAK1)和 NF-κB。
  51. GC60710 Ciprofibrate impurity A

    环丙贝特杂质A

     CiprofibrateimpurityA是Ciprofibrate的一种杂质。Ciprofibrate是一种PPARα激动剂。

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