PPAR(过氧化物酶体增殖剂激活受体)

The peroxisome proliferator-activated receptors (PPARs), belonging to the nuclear receptor superfamily, are a group of nuclear receptor proteins that are composed of three isoforms, including PPARγ, PPARα and PPARδ, encoded by separate genes. PPARs have a modular structure characterized by the presence of two highly conserved domains, including the DNA binding domain (DBD) of two zinc fingers and the ligand binding domain (LBD) of 13 α-helices and a small 4-stranded β-sheet. PPARs are ligand-regulated transcription factors controlling gene expression by binding to specific response elements (PPREs) within promoters, where PPARs bind as heterodimers with a retinoid X receptor and interact with cofactors upon binding leading to the increasing of rate of transcription initiation.

Products for PPAR

Cat.No. 产品名称 Information
GC47337 Fenofibrate-d6
非诺贝特 d6
An internal standard for the quantification of fenofibrate
GC47063 CAY10767 A PPARα agonist
GC46757 9(Z),11(E)-Conjugated Linoleic Acid (sodium salt)
cis-9,trans-11-Conjugated Linoleic Acid, 9(Z),11(E)-CLA
An isomer of linoleic acid
GC46448 15-deoxy-δ12,14-Prostaglandin J2-d9
15d-PGJ2-d9; 15-Deoxy-Δ12,14-PGJ2-d9
A neuropeptide with diverse biological activities
GC46447 15-deoxy-δ12,14-Prostaglandin J2-d4
15d-PGJ2-d4; 15-Deoxy-Δ12,14-PGJ2-d4
An internal standard for the quantification of 15-deoxy-Δ^12,14-prostaglandin J₂
GC46444 15-deoxy-δ12,14-Prostaglandin D2-d9
15-deoxy-Δ12,14-PGD2-d9
A neuropeptide with diverse biological activities
GC46443 15-deoxy-δ12,14-Prostaglandin D2-d4
15-deoxy-Δ12,14-PGD2-d4
A neuropeptide with diverse biological activities
GC46365 1,1'-(Azodicarbonyl)dipiperidine
偶氮二甲酰二哌啶
A Mitsunobu reagent
GC46264 (±)8(9)-EET-d11
(±)8,9-EET-d11, (±)8,9-EpETrE-d11
A neuropeptide with diverse biological activities
GC61187 Pioglitazone D4
匹格列酮-D4,U 72107-d4
An internal standard for the quantification of pioglitazone
GC61055 Methyl oleanonate
3-Oxoolean-12-en-28-oic acid methyl ester
Methyloleanonate是从Pistacia中分离得到的三萜类PPARγ激动剂。Methyloleanonate是齐墩果酸衍生物，具有抗癌作用。
GC61043 Mesalamine impurity P
美沙拉嗪EP杂质P
MesalamineimpurityP是Mesalamine的杂质。5-Aminosalicylicacid(Mesalamine)是一种特异性的 PPARγ 激动剂，还抑制p21-激活激酶1(PAK1)和 NF-κB。
GC60710 Ciprofibrate impurity A
环丙贝特杂质A
CiprofibrateimpurityA是Ciprofibrate的一种杂质。Ciprofibrate是一种PPARα激动剂。
GC60675 Caulophyllogenin
儿茶酚
Caulophyllogenin是一种从M.polimorpha中提取的三萜皂苷。Caulophyllogenin是PPARγ的部分激动剂，EC50值为12.6μM。Caulophyllogenin可用于研究2型糖尿病，肥胖症，代谢综合征和炎症。
GC39701 Convallatoxin
铃兰毒苷
Convallatoxin 是从 Adonis amurensis Regel et Radde 分离得到的强心苷。Convallatoxin 通过激活 PPARγ 和抑制 NF-κB 改善结肠炎。Convallatoxin 是一种 P-糖蛋白 (P-gp) 底物，并识别 Val982 是参与其转运的重要氨基酸。Convallatoxin 是配体诱导的 MOR 胞吞作用的增强剂，具有很高的效力和功效。具有抗炎和抗增殖特性。
GC50019 GW 1929 hydrochloride A non-thiazolidinedione activator of PPARγ
GC39271 (±)-Naringenin
(±)-柚皮素
A citrus-derived flavonoid
GC39191 iRucaparib-AP6 iRucaparib-AP6 是高效且特异的 PARP1 降解剂，基于 Rucaparib (PROTAC 的方法)。 iRucaparib-AP6 是一种 "非捕获性" PARP1 降解剂，可同时阻断 PARP1 的催化活性和支架作用。
GC45981 Pristanic Acid-d3
降植烷酸

An internal standard for the quantification of pristanic acid
GC45921 (±)8(9)-EET-d11 methyl ester
(±)8,9-EpETrE-d11 methyl ester
A neuropeptide with diverse biological activities
GC45829 Troglitazone-d4
CS-045-d4
Troglitazone-d4 是氘标记的曲格列酮。 Troglitazone 是一种 PPARγ 激动剂，对人和鼠 PPARγ 受体的 EC50 分别为 550 nM 和 780 nM。
GC45726 Bezafibrate-d4
苯扎贝特-D4,BM15075-d4
An internal standard for the quantification of bezafibrate
GC45567 SR 1903 A modulator of RORγ and LXR receptors
GC45566 SR 16832 A dual-site covalent antagonist of PPARγ
GC45506 MD001 A dual agonist of PPARα and PPARγ
GC37889 VCE-004.8
VCE-?004.8
VCE-004.8 (VCE-004.8) 是一种具有口服活性的特异性 PPARγ；和 CB2 受体双重激动剂。
GC37622 Seladelpar sodium salt
MBX-8025 sodium salt; RWJ-800025 sodium salt
Seladelpar sodium salt (MBX-8025) 是一种具有口服活性的、选择性的 PPARδ 激动剂，EC50 值为 2 nM。它对 PPARδ 的选择性分别是对 PPARα 和 PPARγ 的 750 和 2500 多倍。
GC36867 Pemafibrate racemate Pemafibrate racemate (K13675 racemate) 是 pemafibrate 的外消旋体，为 PPARα 的激动剂，对 h-PPARα，h-PPARγ 和 h-PPARδ 的 EC50 值分别为 1 nM，>10 μM 和 1.7 μM。
GC36146 Glabrone
光果甘草酮
Glabrone 是从甘草根中分离的一种异黄酮。Glabrone 具有抗流感活性和显著的 PPAR-γ 配体结合活性。
GC35698 Ciprofibrate D6
环丙贝特 D6
An internal standard for the quantification of ciprofibrate
GC35518 Bilobetin
白果素
A biflavonoid with diverse biological activities
GC35358 Ankaflavin
红曲黄素
Ankaflavin 是从Monascus-Fermented 红米中提取得到的，是PPARγ 的激动剂，具有抗炎活性。Ankaflavin 具有选择性的细胞毒性作用，诱导癌细胞死亡。
GC35349 Angeloylgomisin H
当归酰戈米辛 H
Angeloylgomisin H 是一种木脂素类化合物，可从五味子 (Schisandra rubriflora) 中提取。Angeloylgomisin H 通过激活 PPAR-γ 来改善胰岛素刺激的葡萄糖摄取潜力。
GC35308 Alpinetin
山姜素
Alpinetin, a composition of Alpinia katsumadai Hayata, has been reported to have a number of biological properties, such as antibacterial, antitumor and other important therapeutic activities. Alpinetin is a flavonoid isolated from Alpinia katsumadai Hayata, activates activates PPAR-γ, with potent anti-inflammatory activity.
GC35281 Aleglitazar
阿格列扎; R1439; RO0728804
Aleglitazar(R1439; RO-0728804)是PPAR-α/γ激动剂，IC50分别为2.8 nM/4.6 nM。
GC35143 4-O-Methyl honokiol
4--O-甲基和厚朴酚
A phenol with diverse biological activities
GC45186 ZLN005 (hydrochloride) A small molecule activator of PGC-1α expression
GC44851 Rosiglitazone (potassium salt)
罗格列酮钾盐,BRL 49653 potassium
A PPARγ agonist
GC44645 Pioglitazone (potassium salt)
U 72107 potassium
A PPARγ agonist
GC44191 MHY908 A PPARα and PPARγ dual agonist
GC43880 Hydroxy Pioglitazone
羟基匹格列酮,Hydroxypioglitazone
A major metabolite of pioglitazone
GC43800 GW 9578 A potent, selective PPARα agonist
GC43743 Gemfibrozil 1-O-β-Glucuronide
吉非罗齐酰基β-D-葡萄糖醛酸
A major metabolite of gemfibrozil
GC43723 Galactosylsphingosine (d18:1)
神经鞘氨醇半乳糖苷,Galactosylsphingosine
A bioactive sphingolipid
GC43653 trans,trans-Farnesyl pyrophosphate ammonium salt
trans,trans-Farnesyl pyrophosphate ammonium salt
An intermediate in sterol biosynthesis
GC43180 CAY10592 A selective partial PPARδ agonist
GC43174 CAY10573 A PPAR pan-agonist
GC43162 CAY10506 A PPARγ agonist
GC42890 Azelaoyl PAF A potent PPARγ agonist
GC42791 Amorfrutin B A PPARγ agonist