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Home >> Signaling Pathways >> Metabolism >> PPAR

PPAR(过氧化物酶体增殖剂激活受体)

The peroxisome proliferator-activated receptors (PPARs), belonging to the nuclear receptor superfamily, are a group of nuclear receptor proteins that are composed of three isoforms, including PPARγ, PPARα and PPARδ, encoded by separate genes. PPARs have a modular structure characterized by the presence of two highly conserved domains, including the DNA binding domain (DBD) of two zinc fingers and the ligand binding domain (LBD) of 13 α-helices and a small 4-stranded β-sheet. PPARs are ligand-regulated transcription factors controlling gene expression by binding to specific response elements (PPREs) within promoters, where PPARs bind as heterodimers with a retinoid X receptor and interact with cofactors upon binding leading to the increasing of rate of transcription initiation.

Products for  PPAR

  1. Cat.No. 产品名称 Information
  2. GC14531 Glycerophospho-N-Oleoyl Ethanolamine Precursor of oleoyl ethanolamide
  3. GC12289 3-Thiatetradecanoic Acid

    3-TDA

     An analog of myristic acid
  4. GC12760 LT175 A dual PPARα/γ ligand
  5. GC16301 Cetaben

    西他苯

     A non-fibrate hypolipidemic drug
  6. GC14595 MCC-555

    Isaglitazone,Netoglitazone,RWJ 241947

     A structural homolog of rosiglitazone
  7. GC12400 N-Octadecyl-N'-propyl-sulfamide A potent PPARα activator
  8. GC11732 GW 590735 A potent and selective agonist of PPARα
  9. GC11477 Darglitazone

    达格列酮,CP 86,325

     A PPARγ agonist
  10. GC14246 Muraglitazar

    莫格他唑 ,BMS-298585

     A PPARα and PPARγ dual agonist
  11. GC15995 BMS 687453 A potent PPARα agonist
  12. GC11916 GQ-16 A PPARγ partial agonist
  13. GC14584 Fenofibric acid

    非诺贝特酸; FNF acid

     An agonist of PPARα, PPARγ, and PPARδ and an active metabolite of fenofibrate
  14. GC14187 GW 6471 GW 6471 是一种有效的双重 PPARα/γ 拮抗剂，其具有体内外抗增殖活性。GW 6471与 PPARα 和 PPARγ 的结合亲和力的IC50 值分别为95.3 ± 42.0 nM 和39.4 ± 18.2 nM。GW 6471可用于癌症的研究。
  15. GC10381 AUDA A potent inhibitor of soluble epoxide hydrolase
  16. GC16944 SR 1664 An inhibitor of Cdk5-mediated PPARγ phosphorylation
  17. GC15673 CP 775146 A PPARα agonist
  18. GC18037 Tesaglitazar

    (S)-2-乙氧基-3-{4-[2-(4-甲磺酰基苯基)-乙氧基-苯基]-丙酸

     A PPARα/γ agonist
  19. GC12252 S26948 A PPARγ agonist
  20. GC17824 GSK 0660 A PPARβ/δ antagonist
  21. GC12062 nTZDpa PPARγ partial agonist
  22. GC11586 SR 202

    米福贝特,SR-202

     An antagonist of agonist-induced PPARγ transcriptional activity
  23. GC18024 GW 7647

    2-[[4-[2-[[环己基氨基)羰基](4-环己基丁基)氨基]乙基]苯基]硫基]-2-甲基丙酸

     A selective PPARα agonist
  24. GC16103 Oleylethanolamide

    油酰单乙醇胺,N-Oleoylethanolamide; Oleamide MEA; Oleic acid monoethanolamide

     An endogenous, potent agonist for PPARα
  25. GC13829 BADGE

    2,2-双-(4-甘胺氧苯)丙烷

     A PPARγ ligand that disrupts hormone-mediated cell differentiation
  26. GC17135 Ciglitazone

    环格列酮; ADD-3878; U-63287

     A potent, selective PPARγ ligand
  27. GC13960 15-deoxy-Δ-12,14-Prostaglandin J2

    15-deoxy-Δ12,14-PGJ2

     Contains 90-95% of the trans,trans-Δ12,14 isomer
  28. GC17377 Clofibrate

    氯贝丁酯

     A selective PPARα agonist
  29. GC14543 Bezafibrate

    苯扎贝特; BM15075

     A non-selective PPAR agonist
  30. GC14915 Gemfibrozil

    吉非罗齐; CI-719

     A PPARα and PPARγ agonist
  31. GC12250 Fenofibrate

    非诺贝特

     A PPARα agonist
  32. GC16607 Mesalamine

    5-氨基水杨酸; Mesalamine; 5-ASA; Mesalazine

     An NSAID and active metabolite of sulfasalazine, balsalazide, and olsalazine
  33. GC14948 Pioglitazone

    吡格列酮; U 72107

     Pioglitazone属于格列酮类或噻唑烷二酮类,是一系列口服降糖药。
  34. GC18147 Tretinoin (Aberela)

    维生素A酸; Vitamin A acid; all-trans-Retinoic acid; ATRA

    Tretinoin (Aberela) 是一种维生素 A 衍生的非肽类亲脂性小分子，可作为核 RA 受体 (RAR) 的配体，将其从转录抑制因子转化为激活因子 .在培养的人系膜细胞中，维甲酸 (Aberela) 以剂量和时间依赖性方式增加还原型谷胱甘肽含量和过氧化氢酶活性，从而阻止 H2O2 的细胞毒性。
  35. GC15272 Troglitazone

    曲格列酮; CS-045

     Selective PPARγ agonist
  36. GC16125 L-165041

    L 165041;L165041

     An agonist of PPARβ/δ
  37. GC13639 Inolitazone dihydrochloride

    5-[[4-[[6-(4-氨基-3,5-二甲基苯氧基)-1-甲基-1H-苯并咪唑-2-基]甲氧基]苯基]甲基]-2,4-噻唑烷二酮二盐酸盐,Efatutazone;CS-7017;RS5444;CS 7017;RS 5444

     Inolitazone dihydrochloride (Efatutazone dihydrochloride) 是一种新型的高亲和力 PPARγ 激动剂，其生物活性依赖于 PPARγ，抑制生长的 IC50 为 0.8 nM。
  38. GC13204 Inolitazone

    5-[[4-[[6-(4-氨基-3,5-二甲基苯氧基)-1-甲基-1H-苯并咪唑-2-基]甲氧基]苯基]甲基]-2,4-噻唑啉二酮,Efatutazone; CS-7017; RS5444

     Inolitazone 是一种新型的高亲和力 PPARγ 激动剂，其生物活性依赖于 PPARγ，抑制生长的 IC50 为 0.8 nM。
  39. GC11423 GW1929

    N-(2-苯甲酰基苯基)-O-[2-(甲基-2-吡啶基氨基)乙基]-L-酪氨酸,GW 1929;GW-1929

     A non-thiazolidinedione activator of PPARγ
  40. GC12134 FH535

    2,5-二氯-N-(2-甲基-4-硝基苯基)苯磺酰胺,FH 535;FH-535

     An inhibitor of β-catenin signaling
  41. GC11170 Choline Fenofibrate

    非诺贝特胆碱; ABT-335

     非诺贝特胆碱 (ABT-335) 是一种非诺贝酸的胆碱盐，可在胃肠道中释放游离的非诺贝酸。
  42. GC12894 Balaglitazone

    巴格列酮,DRF-2593;NN-2344;DRF2593;NN2344;DRF 2593;NN 2344

     A partial agonist of PPARγ
  43. GC11152 Pioglitazone HCl

    盐酸吡格列酮,U 72107A; AD 4833

     A PPARγ agonist
  44. GC15516 Rosiglitazone HCl

    盐酸罗格列酮; BRL 49653 hydrochloride

     A PPARγ agonist
  45. GC15318 GW501516

    2-(4-((2-(4-(三氟甲基)苯基)-5-甲基噻唑-4-基)甲基硫基)-2-甲基苯氧基)乙酸,GW 1516; GSK-516

     A selective PPARδ-agonist with anti-obesity activity
  46. GC14983 GW0742

    GW 0742

     A selective agonist of PPARδ
  47. GC13633 Ciprofibrate

    环丙贝特; Win35833

     A selective PPARα agonist
  48. GC14403 WY-14643 (Pirinixic Acid)

    匹立尼酸,WY 14643,WY14643

     PPAR activator
  49. GC16444 Rosiglitazone

    罗格列酮; BRL 49653

     Rosiglitazone是一种具有口服活性的过氧化物酶体增殖物活化受体γ（PPARγ ）选择性激动剂，选择性地激活含有PPARγ配体结合域（LBD）的嵌合体，而不是PPARα和PPARδ，EC50为60 nM，Kd为40 nM。
  50. GC16009 GSK3787

    GSK-3787,GSK 3787

     A selective, irreversible PPARβ/δ antagonist
  51. GC11318 Rosiglitazone maleate

    马来酸罗格列酮; BRL 49653C

     A PPARγ agonist

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