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Home >> Signaling Pathways >> Obesity, Appetite Control & Diabetes

Obesity, Appetite Control & Diabetes(肥胖，食欲控制 & 糖尿病)

Obesity, Appetite Control & Diabetes

Satiety, appetite, and craving are CNS drives, whereas metabolism and energy utilization are peripheral endocrine actions.
Stephen M. Stahl, M.D., Ph.D. read more

Products for  Obesity, Appetite Control & Diabetes

  1. Cat.No. 产品名称 Information
  2. GC92134 Glucose-dependent Insulinotropic Polypeptide (human) (trifluoroacetate salt)

    Gastric Inhibitory Peptide; GIP

     Glucose-dependent Insulinotropic Polypeptide (human) (trifluoroacetate salt)是一种内源性42个氨基酸的肽促胰岛素素激素，在葡萄糖反应中诱导胰岛素分泌。
  3. GC92133 Glucose-dependent Insulinotropic Polypeptide (1-42) (porcine) (trifluoroacetate salt)

    Gastric Inhibitory Peptide (1-42); GIP (1-42)

     Glucose-dependent Insulinotropic Polypeptide (1-42) (porcine) (trifluoroacetate salt)是一种内源性42个氨基酸的肽肠促胰岛素激素，可诱导胰岛素分泌。
  4. GC92132 SAR441255 (sodium salt) SAR441255 (sodium salt)是胰高血糖素样肽1受体GLP-1R、葡萄糖依赖性促胰岛素多肽受体GIPR和胰高血糖激素受体GCGR的肽三重激动剂。
  5. GC92131 NN1177 (trifluoroacetate salt) NN1177 (trifluoroacetate salt)是胰高血糖素受体（GCGR）和胰高血糖激素样肽1受体（GLP-1R）的双肽激动剂。
  6. GC92128 Dapiglutide (sodium salt) Dapiglutide (sodium salt)是一种双胰高血糖素样肽1受体GLP-1R和GLP-2R激动剂。
  7. GC92125 Liraglutide (acetate)

    NN 2211

     Liraglutide (acetate)是胰高血糖素样肽1（GLP-1）受体的强效激动剂，也是含有棕榈酸基团的GLP-1（7-37）的合成衍生物。
  8. GC92122 KBP-066 (trifluoroacetate salt) KBP-066 (trifluoroacetate salt)是一种胰淀素和降钙素双重CT受体激动剂。
  9. GC92119 GLP-1 (7-36) acid (human, mouse, rat, porcine, bovine)

    Glucagon-like Peptide 1 (7-36) acid

     GLP-1 (7-36) acid (human, mouse, rat, porcine, bovine)是激素和GLP-1受体（GLP-1R）激动剂GLP-1（7-36）酰胺的衍生物。
  10. GC92118 Taspoglutide (acetate)

    [Aib8,35]hGLP-1(7-36)NH2; BIM-51077C

     Taspoglutide (acetate)是胰高血糖素样肽1受体的激动剂（GLP-1R；人受体Ki=1.1nM）。
  11. GC92116 Semaglutide Main Chain (9-37)

    Semaglutide Intermediate 29; Semapeptide

     Semaglutide Main Chain (9-37)是合成semaglutide的肽起始原料。
  12. GC92095 Ac-(D-Arg)-CEH-(D-Phe)-RWC-NH2 (trifluoroacetate salt)

    Ac-dR[CEHdFRWC]-NH2

     Ac-(D-Arg)-CEH-(D-Phe)-RWC-NH2 (trifluoroacetate salt)是一种环肽和黑素皮质素受体4 （MC4R）的激动剂。
  13. GC92093 GLP-1 (7-17) (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt)

    Glucagon-like Peptide 1 (7-17)

     GLP-1 (7-17) (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt)是内源性肠促胰岛素GLP-1的肽片段。
  14. GC92088 GLP-1 (28-36) amide (trifluoroacetate salt)

    Glucagon-like Peptide 1 (28-36) amide; Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-NH2

     胰高血糖素样肽1GLP-1 (28-36) amide (trifluoroacetate salt)是内源性GLP-1R激动剂GLP-1（7-36）酰胺的肽和活性代谢产物。
  15. GC92079 GLP-1 (7-15) (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt)

    Glucagon-like Peptide 1 (7-15)

     GLP-1 (7-15) (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt)是内源性肠促胰岛素激素GLP-1的肽片段。
  16. GC92058 GLP-1 (7-13) (human, mouse, rat, bovine) (trifluoroacetate salt)

    Glucagon-like Peptide 1 (7-13); His-Ala-Glu-Gly-Thr-Phe-Thr-OH

     GLP-1 (7-13) (human, mouse, rat, bovine) (trifluoroacetate salt)是内源性肠促胰岛素激素GLP-1的肽片段。
  17. GC92043 9(10)-Nitrooleate

    9(10)-Nitrooleic Acid; OA-NO2; 9(10)-nitro-9-trans-Octadecenoic Acid

     9(10)-Nitrooleate是一种硝基烯内源性脂质信号分子9-硝基油酸酯的混合物。
  18. GC91981 Sergliflozin A Sergliflozin A是钠葡萄糖共转运蛋白2的抑制剂（SGLT2；Ki=2.39 nM用于人类转运蛋白），也是依他硼酸司格列净的活性代谢产物。
  19. GC91977 TrkB Agonist Prodrug R13

    TrkB-IN-1; Tropomyosin-related Kinase B Agonist Prodrug R13; Tropomyosin-related Kinase B Inhibitor 1

     TrkB Agonist Prodrug R13（R13）是原肌球蛋白相关激酶B（TrkB）激活剂7,8-二羟基黄酮的前药形式。
  20. GC91966 Ppc-1 Ppc-1是一种异戊二烯基喹啉羧酸，最初从假念珠菌中分离出来，具有多种生物活性。
  21. GC91934 Insulin Sensitizer C59 Insulin Sensitizer C59是胰岛素诱导的葡萄糖转运蛋白4（Glut4）质膜易位的增强剂。
  22. GC91933 E17241

    4-(1,3-Dithiolan-2-yl)-N-(3-hydroxypyridin-2-yl)benzamide

     E17241是编码ATP结合盒转运蛋白1的基因ABCA1表达的诱导剂；亚家族A（ABCA1）。
  23. GC91929 KOTX1 KOTX1是醛脱氢酶1A3 (ALDH1A3；IC50 = 5.14 nM)。
  24. GC91922 6,6-Dimethyl-3-(4-methylbenzoyl)-4,5,6,7-tetrahydro-1-benzothiophen-2-amine 6,6-Dimethyl-3-(4-methylbenzoyl)-4,5,6,7-tetrahydro-1-benzothiophen-2-amine是胰高血糖素样肽1受体GLP-1R阳性变构调节剂PAM。
  25. GC91544 Fmoc-L-Lys[Oct-(OtBu)-Glu-(OtBu)-AEEA-AEEA]-OH

    Fmoc-Lys(tBuOCO-(CH2)16-CO-Glu(AEEA-AEEA)-OtBu)-OH

     Fmoc-L-Lys[Oct-(OtBu)-Glu-(OtBu)-AEEA-AEEA]-OH is a building block in the synthesis of the glucagon-like peptide 1 receptor (GLP-1R) agonist semaglutide .
  26. GC91493 Semaglutide Side Chain Semaglutide side chain is a synthetic intermediate.
  27. GC72222 Survodutide Survodutide（BI 456906）是一种强效的选择性胰高血糖素受体/GLP-1受体（GCGR/GLP-1R）双重激动剂，在CHO-K1细胞中的EC50分别为0.52 nM和0.33 nM。
  28. GC72096 Bamadutide Bamadutide（SAR425899）是一种强效的双胰高血糖素样肽-1受体/胰高血糖激素受体激动剂。
  29. GC70855 LSN3318839 LSN3318839是一种口服有效的胰高血糖素样肽-1受体(GLP-1R)的阳性变构调节剂。
  30. GC91480 Exendin-4 (3-39) amide (trifluoroacetate salt)

    Exendin (3-39)

     Exendin-4 (3-39)酰胺是一种糖肽样肽1受体（GLP-1R）激动剂，也是exendin-4 (48-86)酰胺的活性代谢物。
  31. GC91449 Ipamorelin (acetate)

    Aib-His-D-2-Nal-D-Phe-Lys-NH2; NNC 26-0161

     Ipamorelin是一种五肽生长激素分泌素（GHS）和GHS受体1a（GHS-R1a）激动剂。
  32. GC26233 Docosahexaenoic Acid-d5

    C22:6 n-3-d5 C22:6(4Z,7Z,10Z,13Z,16Z,19Z)-d5 Cervonic Acid-d5 DHA-d5 4,7,10,13,16,19-Docosahexaenoic Acid-d5

    Docosahexaenoic acid-d5 (DHA-d5) is intended for use as an internal standard for the quantification of DHA (Item No. 90310) by GC- or LC-MS.
  33. GC91123 C18 Ganglioside GM3-d3 (d18:1/18:0-d3) (ammonium salt, synthetic)

    C18 GM3-d3, N-ω-CD3-Octadecanoyl monosialoganglioside GM3, Monosialoganglioside GM3-d3, N-Stearoyl Monosialoganglioside GM3-d3

    一种用于量化神经节苷脂GM3的内部标准。
  34. GC91083 Tiopronin-Cysteine Disulfide

    α-Mercaptopropionylglycine-Cysteine Disulfide

    一种硫普罗宁的代谢产物。
  35. GC91042 Tauro-Obeticholic Acid (sodium salt)

    Obeticholic Acid Taurine Conjugate, Tauro-OCA, Tauro-6-Ethyl-CDCA, Tauro-6-Ethylchenodeoxycholic Acid, T-ECDCA

    一种欧贝替胆酸的活性代谢物。
  36. GC91037 ZLY28

    一种FXR激动剂和FABP1抑制剂。
  37. GC90949 Adenosine-5'-O-(3-thiotriphosphate) (sodium salt)

    Adenosine 5'-(γ-thio)-triphosphate, ATPγS

    一种P2Y11受体激动剂。
  38. GC90819 2,3,7,8-Tetrachlorodibenzofuran

    PCDF 83, 2,3,7,8-TCDF, TCDF

    一种多氯二苯并呋喃和二恶英
  39. GC90698 Eicosapentaenoic Acid-d5 ethyl ester

    EPA-d5 ethyl ester

    一种用于量化乙酰化二十碳五烯酸乙酯的内部标准。
  40. GC90582 Perfluorooctanesulfonic Acid

    Heptadecafluorooctanesulfonic Acid, Perfluorooctane sulfonate, Perfluorooctylsulfonic Acid, PFOS

    一种全氟烷基物质
  41. GC90496 β-Cortolone

    20β-Cortolone, NSC 56997

    一种皮质醇的代谢产物。
  42. GC90363 10(11)-Cl-BBQ

    一种作为AhR激动剂的混合物。
  43. GC90312 1-Palmitoyl-d9-2,3-Dipalmitoyl-sn-glycerol

    Glycerol Tripalmitate-d9, TG(16:0-d9/16:0/16:0), Tripalmitin-d9, 1,2,3-Tripalmitoyl-sn-glycerol-d9, Tripalmitoylglycerol-d9

    一种用于量化1,2,3-三棕榈酰-rac-甘油的内部标准。
  44. GC69439 Mazdutide

    IBI-362; LY-3305677; OXM-3

     Mazdutide (IBI-362; LY-3305677) 是一种长效合成胃泌酸调节素类似物。Mazdutide 也是胰高血糖素样肽 (GLP-1R) 与胰高血糖素受体 (GCGR) 的共激动剂。Mazdutide 具有安全性和耐受性，可用于肥胖和 2 型糖尿病 (T2D) 的研究。
  45. GC20142 Beta-Sitosterol (purity>98%)

    β-谷甾醇 (purity>98%); β-Sitosterol (purity>98%); 22,23-Dihydrostigmasterol (purity>98%))
  46. GC20130 2-NBG-1

    NBDGlucose
  47. GC52507 Orexin A amide (bovine, human, mouse, rat) (trifluoroacetate salt)

    Hypocretin 1, OXA

     A hypothalamic neuropeptide
  48. GC52506 Ghrelin (human) (trifluoroacetate salt)

    Lenomorelin

     A growth hormone releasing peptide
  49. GC52504 Human Vitamin D Receptor Reporter Assay System

    NR1I1, VDR

     A nuclear receptor cell-based reporter assay
  50. GC52502 Peptide YY (3-36) (trifluoroacetate salt)

    Pancreatic Peptide YY, Peptide Tyrosine Tyrosine

     A satiety hormone
  51. GC52497 Lactosylceramide (porcine RBC)

    LacCer

     A sphingolipid

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