PI3K/Akt/mTOR Signaling(PI3K/Akt/mTOR 信号传导)

Cat.No. 产品名称 Information

GC44587 PDMP (hydrochloride)

DL-erythro/threo-PDMP

An inhibitor of sphingolipid biosynthesis

GC44475 NVP-BEZ235 (hydrochloride)

Dactolisib

Dual inhibitor of PI3K and mTOR

GC43790 GSK3 Inhibitor XIII

Glycogen Synthase Kinase 3 Inhibitor XIII

An inhibitor of GSK3

GC43585 eCF309 A selective mTOR inhibitor

GC43515 D-myo-Inositol-1,3,4,5,6-pentaphosphate (sodium salt)

Ins(1,3,4,5,6)P5, 1,3,4,5,6IP5

An anticancer inositol phosphate

GC43514 D-myo-Inositol-1,3,4,5,6-pentaphosphate (ammonium salt)

Ins(1,3,4,5,6)P5, 1,3,4,5,6IP5 (sodium salt)

An anticancer inositol phosphate

GC43354 Cysmethynil

Icmt Inhibitor

An inhibitor of protein prenylation

GC43303 Compound 28 An inhibitor of mTOR

GC43302 Compound 23

mTOR Inhibitor WYE-23

An inhibitor of mTOR

GC43149 CAY10404 A COX-2 inhibitor

GC42987 Buformin (hydrochloride)

盐酸丁双胍; 1-Butylbiguanide hydrochloride

An antihyperglycemic biguanide

GC42974 Brassinin

芸苔宁,Brassinine

An anticancer phytoalexin

GC42856 AS-605240 (potassium salt) A potent inhibitor of PI3Kγ

GC42776 Amarogentin

苦龙胆酯苷

A secoiridoid glycoside with diverse biological activities

GC42759 Akt Inhibitor IV

6-(2-苯并噻唑基)-1-乙基-2-[2-(甲基苯基氨基)乙烯基]-3-苯基-1H-苯并咪唑碘化物

An inhibitor of Akt activation

GC42747 Afuresertib (hydrochloride)

GSK2110183 hydrochloride

A pan-Akt inhibitor

GC42237 3,5-dimethyl PIT-1 An inhibitor of PIP₃/protein binding

GC42018 1-O-Octadecyl-2-O-methyl-sn-glycerol

2Methyl1octadecylsnglycerol, PIA 7

A PIA metabolite

GC41992 1-Deoxynojirimycin (hydrochloride)

去氧野艽霉素盐酸盐,Duvoglustat hydrochloride

An iminosugar with diverse biological activities

GC41979 17β-hydroxy Wortmannin Inhibitor of phosphoinoside 3-kinase

GC41573 Theaflavin 3,3'-digallate

茶黄素-3,3'-双没食子酸; TF-3; ZP10

Theaflavin 3,3'-digallate（茶黄素-3,3'-双没食子酸; TF-3; ZP10）是一种有效的寨卡病毒（ZIKV）蛋白酶抑制剂，IC₅₀值为2.3μM。

GC41527 Viridiol

绿毛菌醇

A phytotoxin

GC40947 2,3-Dimethoxy-5-methyl-p-benzoquinone

2,3-二甲氧基-5-甲基-1,4-苯醌,CoQ0

An intermediate in the synthesis of ubiquinones that has anticancer activity

GC40650 CAY10706 A TrxR inhibitor

GC40561 DNA-PK Inhibitor IV

2-羟基-4-N-吗啉基苯甲醛

DNA-PK inhibitor IV is an inhibitor of DNA-dependent protein kinase (DNA-PK) with an IC50 value of 400 nM for the DNA-PK-dependent phosphorylation of a p53 peptide substrate.

GC19540 α-Linolenic Acid

α-亚麻酸

An essential ω-3 polyunsaturated fatty acid

GC34909 JR-AB2-011 JR-AB2-011 is a potent inhibitor of mTOR-mLST8-mSIN1-Rictor complex (mTORC2) which can block mTORC2 signaling and Rictor association with mTOR at lower effective concentrations.

GC34749 Rac-Nedisertib Rac-Nedisertib(Rac-M3814)是Nedisertib的外消旋体，为有效的DNA-PK抑制剂，IC50值小于3nM。

GC34444 (R)-Nedisertib (R)-Nedisertib((R)-M3814)是一种活性较弱的Nedisertib的R型异构体，对DNA-PK的IC50值为7-30nM。

GC34121 CC-115 hydrochloride A dual inhibitor of mTOR and DNA-PK

GC34053 SOLENOPSIN Solenopsin是一种ATP-竞争型AKT抑制剂，withIC50值为10μM.

GC33765 Palmitelaidic Acid (9-trans-Hexadecenoic acid)

软脂酸; 9-trans-Hexadecenoic acid; trans-Palmitoleic acid

A dietary fatty acid

GC19484 BAY1125976 An allosteric inhibitor of Akt1/2

GC33385 PQR-530 A dual inhibitor of PI3Kα and mTOR

GC33357 K-80003 (TX-803)

TX-803

K-80003 (TX-803) 是 tRXRα 的有效抑制剂；依赖 Akt 激活和癌细胞生长。

GC33355 FT-1518 FT-1518是一种选择性的，可口服的，有效的新一代mTORC1和mTORC2抑制剂，具有抗肿瘤的活性。

GC33325 VX-984 (M9831)

M9831

VX-984 (M9831) (M9831) 是一种具有口服活性、强效、选择性和 BBB 穿透的 DNA-PK 抑制剂。 VX-984 (M9831) 有效抑制 NHEJ（非同源末端连接）并增加 DSB（DNA 双链断裂）。 VX-984 (M9831) 可用于胶质母细胞瘤 (GBM) 和非小细胞肺癌 (NSCLC) 研究。

GC33308 AKT-IN-1

6-[4-(1-氨基环丁基)苯基]-5-苯基-3-吡啶甲酰胺

AKT-IN-1是一种变构AKT抑制剂，IC50为1.042μM。

GC33162 Duvelisib R enantiomer (IPI-145 R enantiomer)

IPI-145 R enantiomer; INK1197 R enantiomer

Duvelisib R 对映异构体是一种 PI3K 抑制剂，是 Duvelisib 活性较低的对映异构体。

GC33145 BEBT-908 (PI3Kα inhibitor 1)

PI3Kα抑制剂1,PI3Kα inhibitor 1

BEBT-908 (PI3Kα inhibitor 1) (PI3Kα inhibitor 1) 是一种选择性 PI3Kα从专利US/20120088764A1中提取的抑制剂化合物243，IC50<0.1 μM, PI3Kα抑制剂 1 还抑制 HDAC (0.1 μM≤IC50≤1 μM)。

GC33135 GSK2110183 Afuresertib (GSK2110183) is a potent, orally bioavailable Akt inhibitor with Ki of 0.08 nM, 2 nM, and 2.6 nM for Akt1, Akt2, and Akt3, respectively. Phase 2.

GC33130 Recilisib (Ex-RAD)

ON 01210

Recilisib (Ex-RAD) (ON 01210) 是一种辐射防护剂，可激活细胞中的 AKT、PI3K 活性。

GC33115 Pomiferin (NSC 5113)

橙桑黄酮; NSC 5113

Pomiferin (NSC 5113) (NSC 5113) 作为 HDAC 的潜在抑制剂，其 IC50 为 1.05 μM，并且还有效抑制 mTOR (IC50, 6.2 μM)。

GC33014 NSC781406 A dual inhibitor of PI3K and mTOR

GC33010 GSK2110183 hydrochloride GSK2110183 hydrochloride 是 GSK2110183 的结构类似物。

GC32995 JNJ-47117096 hydrochloride (MELK-T1 hydrochloride)

MELK-T1 hydrochloride

JNJ-47117096 hydrochloride (MELK-T1 hydrochloride) 是有效的选择性 MELK 抑制剂，IC50 为 23 nM，也有效抑制 Flt3，IC50 为 18 nM。

GC32939 Akt1 and Akt2-IN-1

3-苯基-2-[4-[[4-[5-(2-吡啶)-1H-1,2,4-三唑-3-基]-1-哌啶]甲基]苯基]-1,6-萘啶-5(6H)-酮

Akt1andAkt2-IN-1是一种有效的变构抑制剂,抑制Akt1(IC50=3.5nM)和Akt2(IC50=42nM)。

GC32932 Vps34-IN-2 Vps34-IN-2是一种新型的，有效且有选择性的Vps34抑制剂，在Vps34酶促测定和GFP-FYVE细胞测定中的IC50值分别为2和82nM。

GC32916 Parsaclisib (INCB050465)

INCB050465

Parsaclisib (INCB050465, INCB-50465, IBI376) is a potent and highly selective PI3Kδ(PI3K delta) inhibitor with an IC50 of 1 nM at 1 mM ATP in biochemical assay and approximately 20,000-fold selectivity for PI3Kα, PI3Kβ, PI3Kγ and 57 other kinases.

GC32892 PF-AKT400 (AKT protein kinase inhibitor)

(S)-N-[[3-氨基-1-(5-乙基-7H-吡咯并[2,3-D]嘧啶-4-基)吡咯烷-3-基]甲基]-2,4-二氟苯甲酰胺,AKT protein kinase inhibitor

PF-AKT400（AKT 蛋白激酶抑制剂）是一种广泛选择性、强效、ATP 竞争性 Akt 抑制剂，对 PKBα 的选择性高出 900 倍； (IC50=0.5 nM) 比 PKA (IC50=450 nM)。