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Home >> Signaling Pathways >> PI3K/Akt/mTOR Signaling

PI3K/Akt/mTOR Signaling(PI3K/Akt/mTOR 信号传导)

  1. Cat.No. 产品名称 Information
  2. GC33130 Recilisib (Ex-RAD)

    ON 01210

     Recilisib (Ex-RAD) (ON 01210) 是一种辐射防护剂，可激活细胞中的 AKT、PI3K 活性。
  3. GC33115 Pomiferin (NSC 5113)

    橙桑黄酮; NSC 5113

    Pomiferin (NSC 5113) (NSC 5113) 作为 HDAC 的潜在抑制剂，其 IC50 为 1.05 μM，并且还有效抑制 mTOR (IC50, 6.2 μM)。
  4. GC33014 NSC781406 A dual inhibitor of PI3K and mTOR
  5. GC33010 GSK2110183 hydrochloride GSK2110183 hydrochloride 是 GSK2110183 的结构类似物。
  6. GC32995 JNJ-47117096 hydrochloride (MELK-T1 hydrochloride)

    MELK-T1 hydrochloride

     JNJ-47117096 hydrochloride (MELK-T1 hydrochloride) 是有效的选择性 MELK 抑制剂，IC50 为 23 nM，也有效抑制 Flt3，IC50 为 18 nM。
  7. GC32939 Akt1 and Akt2-IN-1

    3-苯基-2-[4-[[4-[5-(2-吡啶)-1H-1,2,4-三唑-3-基]-1-哌啶]甲基]苯基]-1,6-萘啶-5(6H)-酮

     Akt1andAkt2-IN-1是一种有效的变构抑制剂,抑制Akt1(IC50=3.5nM)和Akt2(IC50=42nM)。
  8. GC32932 Vps34-IN-2 Vps34-IN-2是一种新型的，有效且有选择性的Vps34抑制剂，在Vps34酶促测定和GFP-FYVE细胞测定中的IC50值分别为2和82nM。
  9. GC32916 Parsaclisib (INCB050465)

    INCB050465

     Parsaclisib (INCB050465, INCB-50465, IBI376) is a potent and highly selective PI3Kδ(PI3K delta) inhibitor with an IC50 of 1 nM at 1 mM ATP in biochemical assay and approximately 20,000-fold selectivity for PI3Kα, PI3Kβ, PI3Kγ and 57 other kinases.
  10. GC32892 PF-AKT400 (AKT protein kinase inhibitor)

    (S)-N-[[3-氨基-1-(5-乙基-7H-吡咯并[2,3-D]嘧啶-4-基)吡咯烷-3-基]甲基]-2,4-二氟苯甲酰胺,AKT protein kinase inhibitor

     PF-AKT400（AKT 蛋白激酶抑制剂）是一种广泛选择性、强效、ATP 竞争性 Akt 抑制剂，对 PKBα 的选择性高出 900 倍； (IC50=0.5 nM) 比 PKA (IC50=450 nM)。
  11. GC32891 PQR620 PQR620 is a novel, selective, orally bioavailable and brain penetrant dual TORC1/2 inhibitor. PQR620 has anti-tumor activity across 56 lymphoma models with a median IC50 of 250 nM after 72 h of exposure.
  12. GC32847 PI4KIIIbeta-IN-9 PI4KIIIbeta-IN-9是一种有效的PI4KIIIβ抑制剂，IC50为7nM。PI4KIIIbeta-IN-9也抑制PI3Kδ和PI3Kγ，IC50分别为152nM和1046nM。
  13. GC32828 Tenalisib (RP6530)

    RP6530

     Tenalisib (RP6530) is a potent and selective dual PI3Kδ/γ inhibitor with IC50 values of 24.5 nM and 33.2 nM for PI3Kδ and PI3Kγ, respectively. Its selectivity over α and β isoforms are more than 300-fold and 100-fold, respectively.
  14. GC32794 Ipatasertib dihydrochloride (GDC-0068 (dihydrochloride))

    (2S)-2-(4-氯苯基)-1-[4-[(5R,7R)-6,7-二氢-7-羟基-5-甲基-5H-环戊并嘧啶-4-基]-1-哌嗪基]-3-[(1-甲基乙基)氨基]-1-丙酮二盐酸盐,GDC-0068 dihydrochloride; RG-7440 dihydrochloride

     A pan-Akt inhibitor
  15. GC32767 3BDO

    3BDO,MTOR激酶激活剂,自噬抑制剂

     A butyrolactone derivative and autophagy inhibitor
  16. GC32736 MELK-8a hydrochloride

    NVS-MELK8a hydrochloride

     A MELK inhibitor
  17. GC32718 M3814 (nedisertib)

    M3814

     Nedisertib (M3814, Peposertib, MSC2490484A) is an orally bioavailable, highly potent and selective inhibitor of DNA activated protein kinase (DNA-PK) with IC50 of < 3 nM.
  18. GC32710 GDC-0077 (RG6114)

    GDC-0077; RG6114

     Inavolisib (GDC-0077, RG6114, RO-7113755) is a potent selective inhibitor of PI3K alpha (PI3Kα) with an IC50 of 0.038 nM. GDC-0077 is >300-fold more selective for PI3K alpha over the other class I PI3K isoforms (beta, delta, and gamma) and >2000-fold more selective over PIK family members. GDC-0077 binds to the ATP binding site of PI3K and inhibits the phosphorylation of PIP2 to PIP3.
  19. GC32510 Loureirin A

    龙血素 A

     Loureirin A is a flavonoid extracted from the red resin of the herbs of Dracaena cochinchinensis, which is known as Dragon's Blood. Loureirin A inhibits platelet activation by an impairment of PI3K/Akt signaling. Loureirin A inhibits Akt phosphorylation.
  20. GC32381 BF738735 BF738735是一种磷脂酰肌醇4-激酶IIIβ(PI4KIIIβ)抑制剂，IC50为5.7nM。
  21. GC32254 Deltonin

    三角叶薯蓣皂苷

     Deltonin是从盾叶薯蓣中得到的甾体皂苷，能够抑制ERK1/2和AKT的活化，具有抗肿瘤的活性。
  22. GC32199 T-00127_HEV1 T-00127_HEV1是一个phosphatidylinositol4-kinaseIIIbeta(PI4KB)抑制剂，其IC50值为60nM。
  23. GC32163 BQR-695 (NVP-BQR695)

    NVP-BQR695

     An antimalarial compound
  24. GC32118 KDU691 An antimalarial compound
  25. GC31756 IPI-3063 IPI-3063 is a potent and selective p110δ inhibitor with biochemical IC50 of 2.5?±?1.2 nM and IC50 values for the other class I PI3K isoforms (p110α, p110β, p110γ) are at least 400-fold higher.
  26. GC31751 PI3Kδ-IN-2

    YY-20394

    PI3Kδ-IN-2 (YY-20394) 是 PI3K&#948 的强效、口服生物利用度和选择性抑制剂；提取自专利WO 2015055071 A1，化合物10； IC50 为 6.4 nM。
  27. GC31666 Seletalisib (UCB5857)

    UCB5857

     Seletalisib (UCB-5857) is a novel small-molecule inhibitor of PI3Kδ with an IC50 value of 12 nM and shows significant selectivity to PI3Kδ with respect to the other class I PI3K isoforms (between 24- and 303-fold).
  28. GC31661 APY0201 An inhibitor of PIKFYVE
  29. GC31536 N-Oleoyl glycine

    A putative substrate for peptidyl glycine α-amidating enzyme
  30. GC31470 MK8722

    (3S,3AS,6S,6AS)-6-((5-([1,1'-联苯]-4-基)-6-氯-1H-咪唑并[4,5-B]吡啶-2-基)氧基)六氢呋喃[3,2-B]呋喃-3-醇

     MK-8722 is a potent, direct, allosteric activator of all 12 mammalian pan-AMPK complexes.
  31. GC31411 EX229

    AMPK Activator 991

     An AMPK activator
  32. GC31383 Chitosan oligosaccharide COS

    壳聚糖低聚乳酸酯,COS

     Chitosan oligosaccharide (COS) is an oligomer of β-(1?4)-linked d-glucosamine, of which actions involve the modulation of several important pathways including the suppression of nuclear factor kappa B (NF-κB) and mitogen-activated protein kinases (MAPK) and the activation of AMP-activated protein kinase (AMPK).
  33. GC31361 MK-3903 An AMPK activator
  34. GC31348 7-Methoxyisoflavone

    7-甲氧基异黄酮

     A synthetic isoflavone
  35. GC30884 LX2343 An inhibitor of BACE1 and PI3K
  36. GC30777 PI4KIIIbeta-IN-10 PI4KIIIbeta-IN-10是一种有效的PI4KIIIβ抑制剂，IC50为3.6nM。
  37. GC30770 LM22B-10 An activator of TrkB and TrkC
  38. GC30582 Crosstide A peptide substrate for Akt
  39. GC30229 Cbz-B3A Cbz-B3A是mTORC1转导的有效选择性抑制剂，与泛素1、2、4结合，Cbz-B3A还能抑制eIF4E结合蛋白的磷酸化。
  40. GC30156 Brevianamide F (Cyclo(L-Pro-L-Trp))

    Cyclo(L-Pro-L-Trp)

     An alkaloid with diverse biological activities
  41. GC30056 Danthron (Dantron)

    1,8-二羟基蒽醌; Dantron; Chrysazin; 1,8-Dihydroxyanthraquinone

     Danthron (Chrysazin, Antrapurol) functions in regulating glucose and lipid metabolism by activating AMPK. Danthron is a natural product extracted from the traditional Chinese medicine rhubarb. Danthron used to be a laxativa and now is currently used as an antioxidant in synthetic lubricants, in the synthesis of experimental antitumor agents, as a fungicide and as an intermediate for making dyes.
  42. GC19471 Leniolisib

    CDZ173

     An inhibitor of PI3Kδ
  43. GC19411 IITZ-01 IITZ-01 是一种有效的溶酶体自噬抑制剂，具有单剂抗肿瘤活性，对 PI3Kγ 的 IC50 为 2.62 μM。
  44. GC19390 YU238259 An inhibitor of homology-dependent DNA repair
  45. GC19355 Umbralisib

    TGR-1202; RP5264

     A PI3K p110δ inhibitor
  46. GC19328 SF2523 A dual inhibitor of PI3K and BRD4
  47. GC19300 PQR309

    PQR309

     PQR309 是一种有效的脑渗透性口服生物利用度泛 I 类 PI3K/mTOR 抑制剂，对 PI3Kα、PI3Kδ、PI3Kβ、PI3Kγ 和 mTOR 的 IC50 分别为 33nM、451nM、661nM、708nM 和 89nM .PQR309 在人脑胶质瘤细胞中通过抑制增殖、诱导细胞凋亡、诱导 G1 细胞周期停滞、抑制侵袭和迁移等方式发挥抗肿瘤作用。
  48. GC19286 PF-06409577 An AMPK activator
  49. GC19283 PF-04979064 PF-04979064 是一种有效的选择性 PI3K/mTOR 双激酶抑制剂，对 PI3Kα 和 mTOR 的 Kis 分别为 0.13 nM 和 1.42 nM。
  50. GC19269 O-304 A pan-activator of AMPK
  51. GC19256 MTX-211

    Mol 211

     MTX-211 (Mol 211) 是 EGFR 和 PI3K 的双重抑制剂，IC50 值 <100 nM。 MTX-211可用于癌症和其他疾病的研究。

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