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Home >> Signaling Pathways >> PI3K/Akt/mTOR Signaling

PI3K/Akt/mTOR Signaling(PI3K/Akt/mTOR 信号传导)

  1. Cat.No. 产品名称 Information
  2. GC19227 LTURM34 An inhibitor of DNA-PK
  3. GC19202 IPI549

    IPI-549

     An inhibitor of PI3Kγ
  4. GC19161 GDC-0326 A selective inhibitor of PI3Kα
  5. GC19145 ETP-46321 ETP-46321 是一种有效且具有口服生物利用度的 PI3Kα 和 PI3Kδ 抑制剂，Kiapps 分别为 2.3 和 14.2 nM。
  6. GC19114 CZ415 An mTOR inhibitor
  7. GC19109 CNX-1351 A PI3Kα inhibitor
  8. GC19036 ARQ-092

    Miransertib

     An orally bioavailable pan-Akt inhibitor
  9. GC18884 CAY10626 A dual PI3Kα/mTOR kinase inhibitor
  10. GC18852 S14161

    8-乙氧基-2-(4-氟苯基)-3-硝基-2H-1-苯并吡喃

     An inhibitor of cyclin D transactivation
  11. GC18810 GSK3β Inhibitor XI

    GSK-3BETA抑制剂XI

    A potent inhibitor of GSK3β
  12. GC18583 D-α-Hydroxyglutaric Acid

    R-2-羟基戊二酸,(R)-2-Hydroxyglutarate; (R)-2-Hydroxyglutaric acid; (R)-2-Hydroxypentanedioic acid

    An α-hydroxy acid
  13. GC18479 SAR260301

    (S)-2-(2-(2-甲基吲哚啉-1-基)-2-氧代乙基)-6-吗啉嘧啶-4(3H)-酮

     A selective PI3Kβ inhibitor
  14. GC18374 API-1

    NSC 177223

     An Akt inhibitor
  15. GC18322 CAY10567

    BML257

     An Akt1 translocation inhibitor
  16. GC18208 YLF-466D

    3-[[(3E)-3-[(4-氯苯基)苯基亚甲基]-2,3-二氢-2-氧代-1H-吲哚-1-基]甲基]苯甲酸,C24

     An AMPK activator
  17. GC18164 UCB9608

    (S)-4-(6-氨基-1-甲基-1H-吡唑并[3,4-D]嘧啶-4-基)-N-(4-甲氧基-2-甲基苯基)-3-甲基哌嗪-1-甲酰胺

     UCB9608 是一种有效、选择性和口服活性的 PI4KIIIβ 抑制剂，IC50 为 11 nM，对 PI3KC2 α、β 和 γ 脂质激酶具有选择性。
  18. GC11607 Rapalink-1 第三代二价 mTOR 抑制剂 RapaLink-1 通过惰性化学接头将雷帕霉素与 MLN0128 结合。 RapaLink-1 显示出比雷帕霉素或 mTOR 激酶抑制剂 (TORKi) 更好的功效，可有效阻断癌症衍生的激活 mTOR 突变体。 RapaLink-1 可以穿过血脑屏障。 RapaLink-1 与 FKBP12 的结合导致 mTORC1 的靶向和持久抑制。 RapaLink-1 通过改善自噬在抗磷脂综合征中发挥抗血栓作用。抗癌活性。
  19. GC10228 GDC-0084 PI3K and mTOR inhibitor, brain-permeable
  20. GC13992 3-Guanidinopropionic Acid

    胍基丙酸; RGX-202; 3-Guanidinopropionic acid

     A creatine analog
  21. GC15841 Alsterpaullone

    阿特波龙,9-Nitropaullone,NSC 705701

     A dual CDK and GSK3 inhibitor
  22. GC15553 KP372-1 An Akt inhibitor
  23. GC15595 GSK2269557 A selective inhibitor of PI3Kδ
  24. GC10857 UCN-01

    NSC 638850,​7-hydroxy Staurosporine

     A nonspecific protein kinase inhibitor
  25. GC11907 NSC 210902 A selective CK2 inhibitor
  26. GC11190 AMPK activator

    D942

     A cell-permeable activator of AMPK
  27. GC16187 GSK-3β Inhibitor II

    4-[5-[[(3-碘苯基)甲基]硫基]-1,3,4-恶二唑-2-基]吡啶,Tip-oxadiazole

     An inhibitor of GSK3β signaling
  28. GC11910 AS-041164 Selective inhibitor of PI3Kγ
  29. GC16534 Ampkinone A small molecule activator of AMPK
  30. GC15740 OXA-01 A selective dual inhibitor of mTORC1 and mTORC2
  31. GC16960 4,5,6,7-Tetrabromobenzimidazole

    4,5,6,7-四溴苯并咪唑,Casein Kinase II Inhibitor XII,TBBz

     A selective inhibitor of CK2
  32. GC14181 TBCA

    Casein Kinase II Inhibitor III,Tetrabromocinnamic Acid

     An inhibitor of casein kinase 2
  33. GC12416 INK1117

    [6-(2-氨基-5-苯并恶唑基)咪唑并[1,2-A]吡啶-3-基]-4-吗啉基甲酮,MLN1117,TAK-117;Serabelisib

    A selective inhibitor of PI3Kα
  34. GC13176 CP21R7

    GSK-3Β抑制剂(CP21R7),CP21

     A GSK3β inhibitor used to differentiate stem cells
  35. GC12889 PX 866

    PX-866

     An inhibitor of PI3K
  36. GC10436 VPS34-IN1

    Vacuolar Protein Sorting 34 Inhibitor 1, Vps34 Inhibitor 1

     A potent and selective inhibitor of Vps34
  37. GC11248 AZD8835 An inhibitor of PI3Kα and PI3Kδ
  38. GC15679 GSK2292767 A potent and selective inhibitor of PI3Kδ
  39. GC13648 CC-223

    CC-223; ATG-008

     A potent, selective inhibitor of mTOR
  40. GC16039 LJH685

    2,6-二氟-4-[4-[4-(4-甲基-1-哌嗪基)苯基]-3-吡啶基]苯酚

     An inhibitor of RSKs
  41. GC14679 PIK-III

    Vacuolar Protein Sorting 34 Inhibitor 2, Vps34-IN2, Vps34 Inhibitor 2

     A selective inhibitor of Vps34
  42. GC16654 CC-115 A dual inhibitor of mTOR and DNA-PK
  43. GC14371 LY3023414

    LY3023414

     LY3023414 (LY3023414) potently and selectively inhibits class I PI3K isoforms, DNA-PK, and mTORC1/2 with IC50s of 6.07 nM, 77.6 nM, 38 nM, 23.8 nM, 4.24 nM and 165 nM for PI3Kα, PI3Kβ, PI3Kδ , PI3Kγ, DNA-PK 和 mTOR, 分别。 LY3023414 在低纳摩尔浓度下有效抑制 mTORC1/2。
  44. GC16601 LJI308 An inhibitor of RSKs
  45. GC11724 GSK621

    6-氯-5-(2'-羟基-3'-甲氧基-[1,1'-联苯]-4-基)-3-(3-甲氧基苯基)-1H-吡咯并[3,2-D]嘧啶-2,4(3H,5H)-二酮

     An AMPK activator
  46. GC13913 AMG319 Potent, selective PI3Kδ inhibitor
  47. GC12576 AZD8186

    8-[(1R)-1-[(3,5-二氟苯基)氨基]乙基]-N,N-二甲基-2-(4-吗啉基)-4-氧代-4H-1-苯并吡喃-6-甲酰胺

     A PI3Kβ/δ inhibitor
  48. GC12375 PF-4989216

    4-(4-氰基-2-氟苯基)-2-吗啉-5-(1H-1,2,4-三唑-5-基)噻吩-3-腈

     An orally bioavailable PI3K inhibitor
  49. GC13790 MHY1485 MHY1485 是一种有效的 mTOR 激活剂，可抑制自噬以及自噬体与溶酶体之间的融合。
  50. GC17500 SU6656 Inhibitor of Src kinases
  51. GC15615 BX517(PDK1 inhibitor2)

    PDK1 Inhibitor II

     An inhibitor of PDK1

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