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Home >> Signaling Pathways >> PI3K/Akt/mTOR Signaling

PI3K/Akt/mTOR Signaling(PI3K/Akt/mTOR 信号传导)

  1. Cat.No. 产品名称 Information
  2. GC18810 GSK3β Inhibitor XI

    GSK-3BETA抑制剂XI

    A potent inhibitor of GSK3β
  3. GC18583 D-α-Hydroxyglutaric Acid

    R-2-羟基戊二酸,(R)-2-Hydroxyglutarate; (R)-2-Hydroxyglutaric acid; (R)-2-Hydroxypentanedioic acid

    An α-hydroxy acid
  4. GC18479 SAR260301

    (S)-2-(2-(2-甲基吲哚啉-1-基)-2-氧代乙基)-6-吗啉嘧啶-4(3H)-酮

     A selective PI3Kβ inhibitor
  5. GC18374 API-1

    NSC 177223

     An Akt inhibitor
  6. GC18322 CAY10567

    BML257

     An Akt1 translocation inhibitor
  7. GC18208 YLF-466D

    3-[[(3E)-3-[(4-氯苯基)苯基亚甲基]-2,3-二氢-2-氧代-1H-吲哚-1-基]甲基]苯甲酸,C24

     An AMPK activator
  8. GC18164 UCB9608

    (S)-4-(6-氨基-1-甲基-1H-吡唑并[3,4-D]嘧啶-4-基)-N-(4-甲氧基-2-甲基苯基)-3-甲基哌嗪-1-甲酰胺

     UCB9608 是一种有效、选择性和口服活性的 PI4KIIIβ 抑制剂，IC50 为 11 nM，对 PI3KC2 α、β 和 γ 脂质激酶具有选择性。
  9. GC11607 Rapalink-1 第三代二价 mTOR 抑制剂 RapaLink-1 通过惰性化学接头将雷帕霉素与 MLN0128 结合。 RapaLink-1 显示出比雷帕霉素或 mTOR 激酶抑制剂 (TORKi) 更好的功效，可有效阻断癌症衍生的激活 mTOR 突变体。 RapaLink-1 可以穿过血脑屏障。 RapaLink-1 与 FKBP12 的结合导致 mTORC1 的靶向和持久抑制。 RapaLink-1 通过改善自噬在抗磷脂综合征中发挥抗血栓作用。抗癌活性。
  10. GC10228 GDC-0084 PI3K and mTOR inhibitor, brain-permeable
  11. GC13992 3-Guanidinopropionic Acid

    胍基丙酸; RGX-202; 3-Guanidinopropionic acid

     A creatine analog
  12. GC15841 Alsterpaullone

    阿特波龙,9-Nitropaullone,NSC 705701

     A dual CDK and GSK3 inhibitor
  13. GC15553 KP372-1 An Akt inhibitor
  14. GC15595 GSK2269557 A selective inhibitor of PI3Kδ
  15. GC10857 UCN-01

    NSC 638850,​7-hydroxy Staurosporine

     A nonspecific protein kinase inhibitor
  16. GC11907 NSC 210902 A selective CK2 inhibitor
  17. GC11190 AMPK activator

    D942

     A cell-permeable activator of AMPK
  18. GC16187 GSK-3β Inhibitor II

    4-[5-[[(3-碘苯基)甲基]硫基]-1,3,4-恶二唑-2-基]吡啶,Tip-oxadiazole

     An inhibitor of GSK3β signaling
  19. GC11910 AS-041164 Selective inhibitor of PI3Kγ
  20. GC16534 Ampkinone A small molecule activator of AMPK
  21. GC15740 OXA-01 A selective dual inhibitor of mTORC1 and mTORC2
  22. GC16960 4,5,6,7-Tetrabromobenzimidazole

    4,5,6,7-四溴苯并咪唑,Casein Kinase II Inhibitor XII,TBBz

     A selective inhibitor of CK2
  23. GC14181 TBCA

    Casein Kinase II Inhibitor III,Tetrabromocinnamic Acid

     An inhibitor of casein kinase 2
  24. GC12416 INK1117

    [6-(2-氨基-5-苯并恶唑基)咪唑并[1,2-A]吡啶-3-基]-4-吗啉基甲酮,MLN1117,TAK-117;Serabelisib

    A selective inhibitor of PI3Kα
  25. GC13176 CP21R7

    GSK-3Β抑制剂(CP21R7),CP21

     A GSK3β inhibitor used to differentiate stem cells
  26. GC12889 PX 866

    PX-866

     An inhibitor of PI3K
  27. GC10436 VPS34-IN1

    Vacuolar Protein Sorting 34 Inhibitor 1, Vps34 Inhibitor 1

     A potent and selective inhibitor of Vps34
  28. GC11248 AZD8835 An inhibitor of PI3Kα and PI3Kδ
  29. GC15679 GSK2292767 A potent and selective inhibitor of PI3Kδ
  30. GC13648 CC-223

    CC-223; ATG-008

     A potent, selective inhibitor of mTOR
  31. GC16039 LJH685

    2,6-二氟-4-[4-[4-(4-甲基-1-哌嗪基)苯基]-3-吡啶基]苯酚

     An inhibitor of RSKs
  32. GC14679 PIK-III

    Vacuolar Protein Sorting 34 Inhibitor 2, Vps34-IN2, Vps34 Inhibitor 2

     A selective inhibitor of Vps34
  33. GC16654 CC-115 A dual inhibitor of mTOR and DNA-PK
  34. GC14371 LY3023414

    LY3023414

     LY3023414 (LY3023414) potently and selectively inhibits class I PI3K isoforms, DNA-PK, and mTORC1/2 with IC50s of 6.07 nM, 77.6 nM, 38 nM, 23.8 nM, 4.24 nM and 165 nM for PI3Kα, PI3Kβ, PI3Kδ , PI3Kγ, DNA-PK 和 mTOR, 分别。 LY3023414 在低纳摩尔浓度下有效抑制 mTORC1/2。
  35. GC16601 LJI308 An inhibitor of RSKs
  36. GC11724 GSK621

    6-氯-5-(2'-羟基-3'-甲氧基-[1,1'-联苯]-4-基)-3-(3-甲氧基苯基)-1H-吡咯并[3,2-D]嘧啶-2,4(3H,5H)-二酮

     An AMPK activator
  37. GC13913 AMG319 Potent, selective PI3Kδ inhibitor
  38. GC12576 AZD8186

    8-[(1R)-1-[(3,5-二氟苯基)氨基]乙基]-N,N-二甲基-2-(4-吗啉基)-4-氧代-4H-1-苯并吡喃-6-甲酰胺

     A PI3Kβ/δ inhibitor
  39. GC12375 PF-4989216

    4-(4-氰基-2-氟苯基)-2-吗啉-5-(1H-1,2,4-三唑-5-基)噻吩-3-腈

     An orally bioavailable PI3K inhibitor
  40. GC13790 MHY1485 MHY1485 是一种有效的 mTOR 激活剂，可抑制自噬以及自噬体与溶酶体之间的融合。
  41. GC17500 SU6656 Inhibitor of Src kinases
  42. GC15615 BX517(PDK1 inhibitor2)

    PDK1 Inhibitor II

     An inhibitor of PDK1
  43. GC10860 Acalisib (GS-9820)

    GS-9820; CAL-120

     An inhibitor of p110δ
  44. GC12089 LY2584702 A p70S6K inhibitor
  45. GC17338 GNE-317 A dual PI3Kα and mTOR inhibitor
  46. GC11325 CX-4945 sodium salt

    CX-4945 sodium salt

     A potent, orally bioavailable CK2 inhibitor
  47. GC10752 Bikinin

    Abrasin

     An inhibitor of Arabidopsis shaggy-related kinases
  48. GC11471 SAR405 SAR405是一种Vps34抑制剂(IC50=1.2 nM)，SAR405抑制mTOR抑制引起的自噬。
  49. GC12162 ZLN024 hydrochloride An allosteric activator of AMPK
  50. GC16475 Afuresertib

    GSK2110183

     A pan-Akt inhibitor
  51. GC16617 IM-12

    GSK3β Inhibitor XIX

     A GSK3β inhibitor

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