AMPK(AMP活化蛋白激酶)

Cat.No. 产品名称 Information

GC71941 Foenumoside B Foenumoside B是从珍珠菜中分离得到的一种三萜皂苷。

GC71450 PXL770 PXL770是一种直接的AMP激酶激活剂。

GC71333 AMPK activator 13 AMPK activator 13是一种有效的AMPK激活剂。

GC70439 PF-739 PF-739是AMPK的口服活性非选择性激活剂。

GC70337 MARK-IN-4 MARK-IN-4是一种有效的微管亲和调节激酶（MARK）抑制剂，IC50为1nM。

GC25648 MOTS-c MOTS-c, a mitochondria-derived peptide (MDP), exerts antinociceptive and anti-inflammatory effects through activating AMPK pathway and inhibiting MAP kinases-c-fos signaling pathway.

GC67961 AMPK-IN-3 AMPK-IN-3 (化合物 67) 是一种强效的、选择性的 AMPK 抑制剂，其对AMPK (α2)、AMPK (α1) 和 KDR 的 IC50 值分别为 60.7、107 和 3820 nM。AMPK-IN-3 对 AMPK 的抑制不影响细胞活力或导致 K562 细胞的明显细胞毒性。AMPK-IN-3 可用于癌症的研究。

GC67772 BAY-3827 BAY-3827 是强效的、选择性的 AMPK 抑制剂，IC50 值为 1.4 nM (10 µM ATP) 和 15 nM (2 mM ATP)。BAY-3827 对其他 331 种被测激酶的选择性超过 500 倍相比于 AMPK。AMPK 抑制乙酰 CoA 羧化酶 1 的磷酸化，并在雄激素依赖的前列腺癌细胞株中显示出强效的抗增殖活性。

GC66024 Aldometanib

LXY-05-029

Aldometanib (LXY-05-029) 是一种醛缩酶抑制剂。Aldometanib 可以激活溶酶体腺苷-磷酸活化蛋白激酶 AMPK 并降低血糖。Aldometanib 可用于代谢稳态的研究。

GC66002 PF-06685249

PF-249

PF-06685249 (PF-249) 是一种有效的、具有口服活性的变构 AMPK 激活剂，对重组 AMPK α1β1γ1 的 EC50 为 12 nM。PF-06685249 可用于糖尿病肾病研究。

GC63934 Karanjin

水黄皮素

Karanjin 是 Fordia cauliflora 中主要的活性呋喃黄酮醇成分。Karanjin 通过提高 AMPK 的方式诱导骨骼肌细胞 GLUT4 易位。Karanjin 可通过细胞周期阻滞诱导癌细胞死亡，促进细胞凋亡。

GC62841 AMPK activator 4 AMPK activator 4 是一种有效 AMPK 激活剂，并且不抑制线粒体复合物 I。AMPK activator 4 选择性地激活肌肉组织中的 AMPK。AMPK activator 4 剂量依赖性地改善正常小鼠的糖耐量，显著降低 db/db 糖尿病小鼠的空腹血糖水平和改善胰岛素抵抗。具有降血糖作用。

GC62548 COH-SR4 COH-SR4 suppresses adipogenesis in 3T3-L1 cells through indirect activation of AMPK and downstream modulation of the Mammalian target of rapamycin complex 1 (mTORC1) signaling pathway, which blocks important regulators involved in protein synthesis, cell cycle progression, and expression of key transcription factors and their target adipogenic genes involved in lipid synthesis.

GC62135 BC1618 An inhibitor of FBXO48

GC61855 Galegine hydrochloride

1-(3-甲基丁-2-烯-1-基)盐酸胍

Galegine hydrochloride, 一种胍衍生物，有助于小鼠减轻体重。胍类是从 G. officinalis 中提取的化合物，产生双胍、二甲双胍和苯甲双胍。Galegine hydrochloride 激活 3T3-L1 脂肪细胞、L6 肌管、H4IIE 大鼠肝癌和 HEK293 人肾细胞系中的 AMPK。Galegine hydrochloride 具有抗菌活性，对金黄色葡萄球菌菌株 (Staphylococcus aureus) 的最低抑菌浓度为 4 mg/L。

GC61382 Xanthoangelol

黄色当归醇

Xanthoangelol, a chalcone found in the roots of Angelica keiskei, is a nonselective monoamine oxidase (MAO) inhibitor and a potent dopamine β-hydroxylase (DBH) inhibitor. It has anti-inflammatory, antibiotic and pro-apoptotic activities.

GC61045 Metformin D6 hydrochloride

二甲双胍盐酸,1,1-Dimethylbiguanide-d6 hydrochloride

An internal standard for the quantification of metformin

GC61029 Marein

马里甙

A glucoside chalcone with diverse biological activities

GC60258 MT 63-78 MT 63-78 是一种有效的直接 AMPK 激活剂，EC50 为 25 μM。M 63-78 还诱导细胞有丝分裂阻滞和细胞凋亡 (apoptosis)。MT 63-78 通过抑制脂肪生成和 mTORC1 途径来阻止前列腺癌的生长。MT 63-78 具有抗肿瘤作用。

GC60245 Metformin

二甲双胍; 1,1-Dimethylbiguanide

二甲双胍（1,1-二甲基双胍）主要介导 AMPK 的激活，AMPK 是一种参与调节细胞能量代谢的丝氨酸/苏氨酸蛋白激酶，可导致癌细胞中 mTOR 信号传导和蛋白质合成的减少。

GC39377 EB-3D EB-3D is a potent and selective inhibitor of choline kinase α (ChoKα) with IC50 of 1 μM for ChoKα1. EB-3D induces deregulation of the AMPK-mTOR pathway and apoptosis in leukemia T-cells.

GC38815 Methyl cinnamate

肉桂酸甲酯; Methyl 3-phenylpropenoate

Methyl cinnamate, an active component of Zanthoxylum armatum, is a widely used natural flavor compound with antimicrobial and tyrosinase inhibitor activities. Methyl Cinnamate Inhibits Adipocyte Differentiation via Activation of the CaMKK2--AMPK Pathway in 3T3-L1 Preadipocytes.

GC38679 Urolithin B

尿石素B

A metabolite of ellagic acid

GC38567 Nepodin

羊蹄素,Musizin

A naphthol with diverse biological activities

GC38422 Euphorbiasteroid

千金子甾醇

A tricyclic diterpene

GC38209 Kahweol

咖啡豆醇

A natural diterpene with anti-inflammatory and antiangiogenic properties

GC38101 Demethyleneberberine

去亚甲基小檗碱

去亚甲基小檗碱(DMB)作为药用植物黄柏的天然活性成分，具有良好的生物活性。

GC37970 ZLN024

2-[[2-(2-溴-4-甲基苯氧基)乙基]硫基]嘧啶

An allosteric activator of AMPK

GC37694 STO-609 A CaMKK inhibitor

GC36178 Gomisin J

戈米辛J

A lignan with diverse biological activities

GC35327 AMPK activator 1 AMPK activator 1 是一种代表性的 AMPK 激活剂，EC50<0.1 μM。详细信息请参考专利文献 WO2013116491A1 中的化合物 No.1-75。

GC35124 3α-Hydroxymogrol

3α-羟基罗汉果醇

3α-Hydroxymogrol 是从罗汉果中得到的三萜类化合物，为有效的 AMPK 激活剂，可增强 AMPK 的磷酸化水平。

GC42987 Buformin (hydrochloride)

盐酸丁双胍; 1-Butylbiguanide hydrochloride

An antihyperglycemic biguanide

GC42776 Amarogentin

苦龙胆酯苷

A secoiridoid glycoside with diverse biological activities

GC33765 Palmitelaidic Acid (9-trans-Hexadecenoic acid)

软脂酸; 9-trans-Hexadecenoic acid; trans-Palmitoleic acid

A dietary fatty acid

GC31470 MK8722

(3S,3AS,6S,6AS)-6-((5-([1,1'-联苯]-4-基)-6-氯-1H-咪唑并[4,5-B]吡啶-2-基)氧基)六氢呋喃[3,2-B]呋喃-3-醇

MK-8722 is a potent, direct, allosteric activator of all 12 mammalian pan-AMPK complexes.

GC31411 EX229

AMPK Activator 991

An AMPK activator

GC31383 Chitosan oligosaccharide COS

壳聚糖低聚乳酸酯,COS

Chitosan oligosaccharide (COS) is an oligomer of β-(1?4)-linked d-glucosamine, of which actions involve the modulation of several important pathways including the suppression of nuclear factor kappa B (NF-κB) and mitogen-activated protein kinases (MAPK) and the activation of AMP-activated protein kinase (AMPK).

GC31361 MK-3903 An AMPK activator

GC31348 7-Methoxyisoflavone

7-甲氧基异黄酮

A synthetic isoflavone

GC30056 Danthron (Dantron)

1,8-二羟基蒽醌; Dantron; Chrysazin; 1,8-Dihydroxyanthraquinone

Danthron (Chrysazin, Antrapurol) functions in regulating glucose and lipid metabolism by activating AMPK. Danthron is a natural product extracted from the traditional Chinese medicine rhubarb. Danthron used to be a laxativa and now is currently used as an antioxidant in synthetic lubricants, in the synthesis of experimental antitumor agents, as a fungicide and as an intermediate for making dyes.