AMPK(AMP活化蛋白激酶)

AMPK (5'AMP-activated protein kinase) acts as a metabolic master switch regulating several intracellular systems including the cellular uptake of glucose, the β-oxidation of fatty acids and the biogenesis of GLUT4 (glucose transporter 4) and mitochondria.

Products for AMPK

Cat.No. 产品名称 Information
GC19269 O-304 A pan-activator of AMPK
GC18208 YLF-466D
3-[[(3E)-3-[(4-氯苯基)苯基亚甲基]-2,3-二氢-2-氧代-1H-吲哚-1-基]甲基]苯甲酸,C24
An AMPK activator
GC13992 3-Guanidinopropionic Acid
胍基丙酸; RGX-202; 3-Guanidinopropionic acid
A creatine analog
GC11190 AMPK activator
D942
A cell-permeable activator of AMPK
GC16534 Ampkinone A small molecule activator of AMPK
GC11724 GSK621
6-氯-5-(2'-羟基-3'-甲氧基-[1,1'-联苯]-4-基)-3-(3-甲氧基苯基)-1H-吡咯并[3,2-D]嘧啶-2,4(3H,5H)-二酮
An AMPK activator
GC12162 ZLN024 hydrochloride An allosteric activator of AMPK
GC13185 HTH-01-015 A selective NUAK1 inhibitor
GC12324 RSVA 405 RSVA 405 是一种有效的口服活性 AMPK 激活剂，EC50 为 1 μM。
GC17204 PT 1 An activator of AMPK
GC12364 SAMS Peptide A specific substrate for AMPK
GC13466 Flufenamic acid
氟芬那酸
An NSAID and COX inhibitor
GC17443 Metformin HCl
盐酸二甲双胍; 1,1-Dimethylbiguanide hydrochloride

A biguanide with diverse biological activities
GC10461 Phenformin HCl
盐酸苯乙福明; Phenethylbiguanide hydrochloride
An antihyperglycemic biguanide
GC10956 Imeglimin hydrochloride
(6R)-1,6-二氢-N2,N2,6-三甲基-1,3,5-三嗪-2,4-二胺盐酸盐,EMD 387008 hydrochloride
Imeglimin hydrochloride (EMD 387008) 是一种口服降糖剂。
GC10576 Imeglimin
EMD 387008
Imeglimin (EMD 387008) 是一种口服降糖剂。
GC10580 AICAR phosphate
5-氨基-1-核糖基咪唑-4-甲酰胺磷酸盐,Acadesine phosphate; AICA Riboside phosphate

An activator of AMPK
GC17243 Dorsomorphin (Compound C)
6-[4-[2-(1-哌啶基)乙氧基]苯基]-3-(4-吡啶基)吡唑并[1,5-A]嘧啶,Compound C
Dorsomorphin（Compound C）是一种细胞渗透的AMPK抑制剂。
GC16549 WZ4003 A selective NUAK1 and NUAK2 inhibitor
GC12560 Dorsomorphin (Compound C) 2HCl
BML-275 2HCl,Compound C 2HCl
IC50:Dorsomorphin 以剂量依赖性方式抑制 BMP4 诱导的 BMP 反应性 SMAD 磷酸化（半数最大抑制浓度 (IC50) =0.47 mM）。
GC13696 GSK690693
4-[2-(4-氨基-1,2,5-恶二唑-3-基)-1-乙基-7-[(3S)-3-哌啶基甲氧基]-1H-咪唑并[4,5-C]吡啶-4-基]-2-甲基-3-丁炔-2-醇
GSK690693 是一种 ATP 竞争性低纳摩尔 Akt 激酶抑制剂，对 Akt1、2 和 3 的 IC50 值分别为 2、13 和 9 nM。
GC17567 Doxorubicin (Adriamycin) HCl
盐酸阿霉素; Hydroxydaunorubicin hydrochloride

An anthracycline antitumor antibiotic
GC16994 Doxorubicin
阿霉素; Hydroxydaunorubicin
多柔比星（Doxorubicin，简称DOX），也被称为阿霉素，是一种蒽环类化合物，具有最广泛的活性谱。
GC11234 A-769662
4-羟基-3-(2'-羟基-1,1'-联苯-4-基)-6-氧代-6,7-二氢噻吩并[2,3-B]吡啶-5-甲腈,A-769662;A769662

A-769662是AMP活化蛋白激酶的激活剂，EC₅₀值为0.8μM。
GN10222 Cimigenol-3-O-α-L-arabinoside
千层纸素A-7-0-Β-D-葡萄糖醛酸苷,Cimicifugoside M
Cimigenol-3-O-α-L-arabinoside 是总状升麻的活性成分，可激活 AMPK，具有潜在的抗糖尿病活性。
GN10473 Ginkgolide C
银杏内酯C,BN-52022; Ginkgolide-C
A PAF receptor antagonist
GN10592 Platycodin D
桔梗皂苷 D
A saponin isolated from a Chinese medicinal herb
GN10093 6-gingerol
6-姜酚; 6-姜辣素; (S)-(+)-[6]Gingerol; 6-Gingerol
A natural TRP receptor agonist
GC10518 AICAR
阿卡地新; Acadesine; AICA Riboside
AICAR（也称为 acadesine）是一种嘌呤核苷。