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Home >> Signaling Pathways >> PI3K/Akt/mTOR Signaling >> DNA-PK

DNA-PK(DNA依赖蛋白激酶)

DNA-PK is a serine/threonine kinase and acts a molecular sensor for DNA damage. It is involved in NHEJ (non-homologous end joining) for DSB (DNA double strand break) repair and V(D)J recombination.

Products for  DNA-PK

  1. Cat.No. 产品名称 Information
  2. GC65249 STL127705 STL127705 (Compound L) 是一种有效的 Ku 70/80 异二聚体蛋白 Ku 70/80 heterodimer protein 抑制剂，IC50 为 3.5 μM。STL127705 通过抑制 DNA-PKCS 激酶的激活干扰 Ku70/80 与 DNA 的结合。STL127705 显示出抗增殖和抗肿瘤活性。 STL127705 诱导细胞凋亡 (apoptosis) 。
  3. GC64938 AZD-7648 An inhibitor of DNA-PK
  4. GC64818 AMA-37 AMA-37 是Arylmorpholine 的类似物，是ATP 竞争性的DNA-PK 抑制剂，其IC50 值分别为0.27 μM (DNA-PK)、32 μM (p110α)、3.7 μM (p110β)、and 22 μM (p110γ)。
  5. GC63763 BAY-8400 BAY-8400是一种口服活性、有效和选择性 DNA 依赖蛋白激酶 (DNA-PK) 抑制剂(IC50=81 nM)。BAY-8400 可用于癌症研究。
  6. GC50009 LY 294002 hydrochloride Prototypical PI 3-kinase inhibitor; also inhibits other kinases
  7. GC34749 Rac-Nedisertib Rac-Nedisertib(Rac-M3814)是Nedisertib的外消旋体，为有效的DNA-PK抑制剂，IC50值小于3nM。
  8. GC34444 (R)-Nedisertib (R)-Nedisertib((R)-M3814)是一种活性较弱的Nedisertib的R型异构体，对DNA-PK的IC50值为7-30nM。
  9. GC34121 CC-115 hydrochloride A dual inhibitor of mTOR and DNA-PK
  10. GC33325 VX-984 (M9831)

    M9831

     VX-984 (M9831) (M9831) 是一种具有口服活性、强效、选择性和 BBB 穿透的 DNA-PK 抑制剂。 VX-984 (M9831) 有效抑制 NHEJ（非同源末端连接）并增加 DSB（DNA 双链断裂）。 VX-984 (M9831) 可用于胶质母细胞瘤 (GBM) 和非小细胞肺癌 (NSCLC) 研究。
  11. GC32718 M3814 (nedisertib)

    M3814

     Nedisertib (M3814, Peposertib, MSC2490484A) is an orally bioavailable, highly potent and selective inhibitor of DNA activated protein kinase (DNA-PK) with IC50 of < 3 nM.
  12. GC19390 YU238259 An inhibitor of homology-dependent DNA repair
  13. GC19328 SF2523 A dual inhibitor of PI3K and BRD4
  14. GC19227 LTURM34 An inhibitor of DNA-PK
  15. GC16654 CC-115 A dual inhibitor of mTOR and DNA-PK
  16. GC14371 LY3023414

    LY3023414

     LY3023414 (LY3023414) potently and selectively inhibits class I PI3K isoforms, DNA-PK, and mTORC1/2 with IC50s of 6.07 nM, 77.6 nM, 38 nM, 23.8 nM, 4.24 nM and 165 nM for PI3Kα, PI3Kβ, PI3Kδ , PI3Kγ, DNA-PK 和 mTOR, 分别。 LY3023414 在低纳摩尔浓度下有效抑制 mTORC1/2。
  17. GC10812 Compound 401 A dual inhibitor of mTOR and DNA-PK
  18. GC13858 Torin 2

    9-(6-氨基-3-吡啶基)-1-[3-(三氟甲基)苯基]苯并[H]-1,6-萘啶-2(1H)-酮

     Selective inhibitor of mTOR
  19. GC12332 NU 7026

    2-(4-吗啉基)-4H-萘并[1,2-B]吡喃-4-酮,LY293646

     Inhibitor of DNA-dependent protein kinase
  20. GC10196 ETP-46464

    ATM Inhibitor III, ATR Inhibitor III

     An ATR inhibitor
  21. GC11251 NU7441 (KU-57788)

    8-(4-二苯并噻吩基)-2-(4-吗啉基)-4H-1-苯并吡喃-4-酮,KU 57788; NU-7441;KU57788;NU7441;NU 7441

     NU7441 (KU-57788)是一种高效的选择性DNA依赖性蛋白激酶（DNA-PK）抑制剂，IC50为13nM。NU7441还抑制磷脂酰肌醇3-激酶（PI3K）和哺乳动物雷帕霉素靶蛋白（mTOR），IC50分别为5.0和1.7μM。
  22. GC14346 KU-0060648 A dual inhibitor of DNA-PK and PI3K
  23. GC16904 PIK-75

    2-甲基-5-硝基苯磺酸[(6-溴咪唑并[1,2-A]吡啶-3-基)亚甲基]甲基肼盐酸盐

     A selective p110α inhibitor
  24. GC17199 PIK-90

    N-(2,3-二氢-7,8-二甲氧基咪唑并[1,2-C]喹唑啉-5-基)-3-吡啶甲酰胺

     Potent, cell permeable PI3K inhibitor
  25. GC11165 PI-103 A potent, cell-permeable PI3-kinase inhibitor
  26. GC15485 LY 294002

    LY294002/PI3K抑制剂

    LY294002是第一个合成的PI3Kα、δ和β抑制剂。
  27. GC16379 PI-103 Hydrochloride

    PI 103 hydrochloride;PI103 hydrochloride

     A potent, cell-permeable PI3K inhibitor
  28. GC11175 Daun02

    (8S,10S)-8-乙酰基-7,8,9,10-四氢-6,8,11-三羟基-1-甲氧基-10-[[2,3,6-三脱氧-3-[[[[4-(BETA-D-吡喃半乳糖基氧基)-3-硝基苯基]甲氧基]羰基]氨基]-ALPHA-L-来苏-己糖吡喃糖苷]氧基]-5,12-并四苯醌,Daun 02; Daun-02

     Daun02 是拓扑异构酶抑制剂柔红霉素的前药。

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