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Home >> Signaling Pathways >> PI3K/Akt/mTOR Signaling >> PI3K

PI3K

PI3K (phosphatidylinositol-4,5-bisphosphate 3-kinase) is a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer.

Products for  PI3K

  1. Cat.No. 产品名称 Information
  2. GC35580 CAL-130 Racemate

    2-[1-[(2-氨基-9H-嘌呤-6-基)氨基]乙基]-5-甲基-3-(2-甲基苯基)-4(3H)-喹唑啉酮

     CAL-130 Racemate 是 CAL-130 的外消旋体。CAL-130 Racemate 是一种 PI3Kδ 抑制剂。
  3. GC35579 CAL-130 CAL-130 是一种 PI3Kδ 和 PI3Kγ 抑制剂，IC50 分别为 1.3 和 6.1 nM。
  4. GC35509 BGT226

    NVP-BGT226

     BGT226 (NVP-BGT226) maleate is a novel class I PI3K/mTOR inhibitor for PI3Kα/β/γ with IC50 of 4 nM/63 nM/38 nM. Phase 1/2.
  5. GC35395 Arnicolide D

    山金车内酯 D

     A sesquiterpene lactone with anticancer activity
  6. GC35037 1,3-Dicaffeoylquinic acid

    1,3-二咖啡酰奎宁酸; 1,3-O-Dicaffeoylquinic acid; 1,5-Dicaffeoylquinic acid

     An HIV-1 integrase inhibitor and free radical scavenger
  7. GC44475 NVP-BEZ235 (hydrochloride)

    Dactolisib

     Dual inhibitor of PI3K and mTOR
  8. GC42856 AS-605240 (potassium salt) A potent inhibitor of PI3Kγ
  9. GC41992 1-Deoxynojirimycin (hydrochloride)

    去氧野艽霉素盐酸盐,Duvoglustat hydrochloride

     An iminosugar with diverse biological activities
  10. GC19540 α-Linolenic Acid

    α-亚麻酸

    An essential ω-3 polyunsaturated fatty acid
  11. GC33385 PQR-530 A dual inhibitor of PI3Kα and mTOR
  12. GC33162 Duvelisib R enantiomer (IPI-145 R enantiomer)

    IPI-145 R enantiomer; INK1197 R enantiomer

     Duvelisib R 对映异构体是一种 PI3K 抑制剂，是 Duvelisib 活性较低的对映异构体。
  13. GC33145 BEBT-908 (PI3Kα inhibitor 1)

    PI3Kα抑制剂1,PI3Kα inhibitor 1

     BEBT-908 (PI3Kα inhibitor 1) (PI3Kα inhibitor 1) 是一种选择性 PI3Kα从专利US/20120088764A1中提取的抑制剂化合物243，IC50<0.1 μM, PI3Kα抑制剂 1 还抑制 HDAC (0.1 μM≤IC50≤1 μM)。
  14. GC33130 Recilisib (Ex-RAD)

    ON 01210

     Recilisib (Ex-RAD) (ON 01210) 是一种辐射防护剂，可激活细胞中的 AKT、PI3K 活性。
  15. GC33014 NSC781406 A dual inhibitor of PI3K and mTOR
  16. GC32932 Vps34-IN-2 Vps34-IN-2是一种新型的，有效且有选择性的Vps34抑制剂，在Vps34酶促测定和GFP-FYVE细胞测定中的IC50值分别为2和82nM。
  17. GC32916 Parsaclisib (INCB050465)

    INCB050465

     Parsaclisib (INCB050465, INCB-50465, IBI376) is a potent and highly selective PI3Kδ(PI3K delta) inhibitor with an IC50 of 1 nM at 1 mM ATP in biochemical assay and approximately 20,000-fold selectivity for PI3Kα, PI3Kβ, PI3Kγ and 57 other kinases.
  18. GC32847 PI4KIIIbeta-IN-9 PI4KIIIbeta-IN-9是一种有效的PI4KIIIβ抑制剂，IC50为7nM。PI4KIIIbeta-IN-9也抑制PI3Kδ和PI3Kγ，IC50分别为152nM和1046nM。
  19. GC32828 Tenalisib (RP6530)

    RP6530

     Tenalisib (RP6530) is a potent and selective dual PI3Kδ/γ inhibitor with IC50 values of 24.5 nM and 33.2 nM for PI3Kδ and PI3Kγ, respectively. Its selectivity over α and β isoforms are more than 300-fold and 100-fold, respectively.
  20. GC32710 GDC-0077 (RG6114)

    GDC-0077; RG6114

     Inavolisib (GDC-0077, RG6114, RO-7113755) is a potent selective inhibitor of PI3K alpha (PI3Kα) with an IC50 of 0.038 nM. GDC-0077 is >300-fold more selective for PI3K alpha over the other class I PI3K isoforms (beta, delta, and gamma) and >2000-fold more selective over PIK family members. GDC-0077 binds to the ATP binding site of PI3K and inhibits the phosphorylation of PIP2 to PIP3.
  21. GC31756 IPI-3063 IPI-3063 is a potent and selective p110δ inhibitor with biochemical IC50 of 2.5?±?1.2 nM and IC50 values for the other class I PI3K isoforms (p110α, p110β, p110γ) are at least 400-fold higher.
  22. GC31751 PI3Kδ-IN-2

    YY-20394

    PI3Kδ-IN-2 (YY-20394) 是 PI3K&#948 的强效、口服生物利用度和选择性抑制剂；提取自专利WO 2015055071 A1，化合物10； IC50 为 6.4 nM。
  23. GC31666 Seletalisib (UCB5857)

    UCB5857

     Seletalisib (UCB-5857) is a novel small-molecule inhibitor of PI3Kδ with an IC50 value of 12 nM and shows significant selectivity to PI3Kδ with respect to the other class I PI3K isoforms (between 24- and 303-fold).
  24. GC30884 LX2343 An inhibitor of BACE1 and PI3K
  25. GC30156 Brevianamide F (Cyclo(L-Pro-L-Trp))

    Cyclo(L-Pro-L-Trp)

     An alkaloid with diverse biological activities
  26. GC19471 Leniolisib

    CDZ173

     An inhibitor of PI3Kδ
  27. GC19411 IITZ-01 IITZ-01 是一种有效的溶酶体自噬抑制剂，具有单剂抗肿瘤活性，对 PI3Kγ 的 IC50 为 2.62 μM。
  28. GC19355 Umbralisib

    TGR-1202; RP5264

     A PI3K p110δ inhibitor
  29. GC19328 SF2523 A dual inhibitor of PI3K and BRD4
  30. GC19300 PQR309

    PQR309

     PQR309 是一种有效的脑渗透性口服生物利用度泛 I 类 PI3K/mTOR 抑制剂，对 PI3Kα、PI3Kδ、PI3Kβ、PI3Kγ 和 mTOR 的 IC50 分别为 33nM、451nM、661nM、708nM 和 89nM .PQR309 在人脑胶质瘤细胞中通过抑制增殖、诱导细胞凋亡、诱导 G1 细胞周期停滞、抑制侵袭和迁移等方式发挥抗肿瘤作用。
  31. GC19283 PF-04979064 PF-04979064 是一种有效的选择性 PI3K/mTOR 双激酶抑制剂，对 PI3Kα 和 mTOR 的 Kis 分别为 0.13 nM 和 1.42 nM。
  32. GC19256 MTX-211

    Mol 211

     MTX-211 (Mol 211) 是 EGFR 和 PI3K 的双重抑制剂，IC50 值 <100 nM。 MTX-211可用于癌症和其他疾病的研究。
  33. GC19202 IPI549

    IPI-549

     An inhibitor of PI3Kγ
  34. GC19161 GDC-0326 A selective inhibitor of PI3Kα
  35. GC19145 ETP-46321 ETP-46321 是一种有效且具有口服生物利用度的 PI3Kα 和 PI3Kδ 抑制剂，Kiapps 分别为 2.3 和 14.2 nM。
  36. GC19109 CNX-1351 A PI3Kα inhibitor
  37. GC18479 SAR260301

    (S)-2-(2-(2-甲基吲哚啉-1-基)-2-氧代乙基)-6-吗啉嘧啶-4(3H)-酮

     A selective PI3Kβ inhibitor
  38. GC18164 UCB9608

    (S)-4-(6-氨基-1-甲基-1H-吡唑并[3,4-D]嘧啶-4-基)-N-(4-甲氧基-2-甲基苯基)-3-甲基哌嗪-1-甲酰胺

     UCB9608 是一种有效、选择性和口服活性的 PI4KIIIβ 抑制剂，IC50 为 11 nM，对 PI3KC2 α、β 和 γ 脂质激酶具有选择性。
  39. GC10228 GDC-0084 PI3K and mTOR inhibitor, brain-permeable
  40. GC15595 GSK2269557 A selective inhibitor of PI3Kδ
  41. GC11910 AS-041164 Selective inhibitor of PI3Kγ
  42. GC12416 INK1117

    [6-(2-氨基-5-苯并恶唑基)咪唑并[1,2-A]吡啶-3-基]-4-吗啉基甲酮,MLN1117,TAK-117;Serabelisib

    A selective inhibitor of PI3Kα
  43. GC12889 PX 866

    PX-866

     An inhibitor of PI3K
  44. GC10436 VPS34-IN1

    Vacuolar Protein Sorting 34 Inhibitor 1, Vps34 Inhibitor 1

     A potent and selective inhibitor of Vps34
  45. GC11248 AZD8835 An inhibitor of PI3Kα and PI3Kδ
  46. GC15679 GSK2292767 A potent and selective inhibitor of PI3Kδ
  47. GC14679 PIK-III

    Vacuolar Protein Sorting 34 Inhibitor 2, Vps34-IN2, Vps34 Inhibitor 2

     A selective inhibitor of Vps34
  48. GC14371 LY3023414

    LY3023414

     LY3023414 (LY3023414) potently and selectively inhibits class I PI3K isoforms, DNA-PK, and mTORC1/2 with IC50s of 6.07 nM, 77.6 nM, 38 nM, 23.8 nM, 4.24 nM and 165 nM for PI3Kα, PI3Kβ, PI3Kδ , PI3Kγ, DNA-PK 和 mTOR, 分别。 LY3023414 在低纳摩尔浓度下有效抑制 mTORC1/2。
  49. GC13913 AMG319 Potent, selective PI3Kδ inhibitor
  50. GC12576 AZD8186

    8-[(1R)-1-[(3,5-二氟苯基)氨基]乙基]-N,N-二甲基-2-(4-吗啉基)-4-氧代-4H-1-苯并吡喃-6-甲酰胺

     A PI3Kβ/δ inhibitor
  51. GC12375 PF-4989216

    4-(4-氰基-2-氟苯基)-2-吗啉-5-(1H-1,2,4-三唑-5-基)噻吩-3-腈

     An orally bioavailable PI3K inhibitor

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