Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

Products for Proteases

Cat.No. 产品名称 Information
GC35320 Aminoadipic acid
2-氨基己二酸水合物
DL-2-Aminoadipic acid is an excitatory amino acid analogue, which functions as a glutamine synthetase inhibitor.
GC35300 Aloin(mixture of A&B)
芦荟苷
An anthroquinone with diverse biological activities
GC35295 Allopurinol riboside
别嘌呤醇核糖苷
A ribonucleoside
GC35262 Afzelin
阿福豆苷,Kaempferol-3-O-rhamnoside
A polyphenolic glycoside flavone with diverse biological activities
GC35261 Aflatoxin B1
黄曲霉毒素B1
黄曲霉毒素B1作为一类由曲霉属真菌产生的致癌真菌毒素，常导致人和动物发生肝细胞癌。
GC35228 Aceglutamide
乙酰谷酰胺; α-N-Acetyl-L-glutamine; N2-Acetylglutamine
An acetylated form of L-glutamine
GC35221 ABT-046
反式-4-[4-(7-氨基吡唑并[1,5-A]嘧啶-6-基)苯基]环己烷乙酸
ABT-046 是一种具有口服活性的选择性二酰基甘油酰基转移酶 1 (DGAT-1) 抑制剂，IC50 为 8 nM。
GC35219 Abiraterone metabolite 1
3β-OH-5α-Abi
Abiraterone metabolite 1 是 abiraterone 的 5β-还原代谢物。Abiraterone 是一种甾体药物，可抑制 CYP17A1，阻断雄激素的合成，延长前列腺癌的生存期。
GC35204 8-Hydroxyguanine
2-氨基-6,8-二羟基嘌呤
8-Hydroxyguanine是由活性氧物质产生的主要诱变前损伤。它导致G-T和A-C置换。
GC35168 5-O-Demethylnobiletin
去甲基川陈皮素,5-Demethylnobiletin
A flavonoid with diverse biological activities
GC35166 5-Methylcytosine
5-甲基胞嘧啶
5-Methylcytosine, a methylated form of the DNA base cytosine, is a major epigenetic mark in the nuclear DNA in mammals and may be involved in the regulation of gene transcription.
GC35159 5'-Guanylic acid disodium salt
5'-鸟苷酸二钠
A nucleotide
GC35157 5'-GTP trisodium salt
鸟苷-5'-三磷酸三钠盐

Guanosine 5'-triphosphate (5'-GTP, Guanosine triphosphate, H4GTP) trisodium salt is an enhancer of myogenic cell differentiation in a murine cells.
GC35156 5-Amino-3H-imidazole-4-Carboxamide
4-氨基-5-咪唑甲酰胺,5-Aminoimidazole-4-carboxamide; AICA
4-Amino-5-imidazolecarboxamide is an imidazole derivative which is a metabolite of the antineoplastic agents BIC and DIC. By itself, or as the ribonucleotide, it is used as a condensation agent in the preparation of nucleosides and nucleotides.
GC35152 5,6-Dihydro-5-methyluracil
二氢胸腺嘧啶,Dihydrothymine
Dihydrothymine is an intermediate breakdown product of thymine.
GC35150 5,7,4'-Trimethoxyflavone
5,7,4'-三甲氧基黄酮
4',5,7-Trimethoxyflavone (5,7,4'-Trimethoxyflavone, TMF) is a flavonoid isolated from Kaempferia parviflora (KP) that induces apoptosis. 4',5,7-Trimethoxyflavone increases sub-G1 phase, DNA fragmentation, annexin-V/PI staining and Bax/Bcl-xL ratio, activates caspase-3 and degrades poly (ADP-ribose) polymerase (PARP) protein.
GC35139 4-Methylesculetin
4-甲基七叶亭
4-methylesculetin is one of the coumarin derivatives with great anti-oxidant and anti-inflammatory activities. 4-Methylesculetin inhibits myeloperoxidase (MPO) activity and reduces IL-6 level.
GC35135 4-Methoxycinnamic acid
4-甲氧基肉桂酸
4-Methoxycinnamic acid 是一种天然苯丙烷类化合物。
GC35134 4-Methoxybenzaldehyde
4-甲氧基苯甲醛
p-Anisaldehyde (4-Methoxybenzaldehyde, Anisaldehyde, Anisic aldehyde, P-Methoxybenzaldehyde, 4-Anisaldehyde), an extract from Pimpinella anisum seeds, exhibits antifungal activity against a number of yeast and mold strains in laboratory media, fruit purees and fruit juices.
GC35131 4-Hydroxycoumarin
4-羟基香豆素
A coumarin
GC35126 4-Hydroxyphenylpyruvic acid
4-羟苯基丙酮酸
4-Hydroxyphenylpyruvic acid (4-HPPA), an abundant colon metabolite of polyphenols, is a potent scavenger that suppresses levels of free radicals and cyclooxygenase-2 (COX-2) and contributes to reduced risk of colon cancer development.
GC35111 3-Epiursolic Acid
3-表熊果酸
A pentacyclic triterpenoid with diverse biological activities
GC35106 3-Dehydrotrametenolic acid
3-氢化去氢松苓酸
3-?Dehydrotrametenolic acid，分离于茯苓菌核，是一种乳酸脱氢酶 (LDH) 抑制剂。3-?Dehydrotrametenolic acid 促进体外脂肪细胞分化，在体内起胰岛素增敏剂的作用。3-?Dehydrotrametenolic acid 诱导细胞凋亡，具有抗癌活性。
GC35095 2-Phospho-L-ascorbic acid trisodium salt
L-抗坏血酸-2-磷酸三钠盐; 2-Phospho-L-ascorbic acid trisodium

Sodium L-ascorbyl-2-phosphate (Sodium ascorbyl monophosphate, Sodium ascorbyl phosphate, SAP) is specifically produced for use as a stabilized source of vitamin C in cosmetic products.
GC35090 2-Hydroxy atorvastatin calcium salt
2-羟基阿托伐他汀钙盐
An active metabolite of atorvastatin
GC35081 25,26-Dihydroxyvitamin D3
25,26-二羟基维生素D3,25,26-Dihydroxycholecalciferol
25,26-Dihydroxyvitamin D3是维生素D3代谢物。
GC35079 24, 25-Dihydroxy VD2
24,25-二羟基维他命 D2; 24,25-Dihydroxy vitamin D2

24, 25-Dihydroxy VD2是维生素D2的羟基化代谢产物，是合成的维生素D类似物。
GC35075 20-HETE
20-羟基二十碳-5Z,8Z,11Z,14Z-四烯酸

A cytochrome P450 (CYP450) metabolite of arachidonic acid
GC35068 1-Monomyristin
1-肉豆蔻酸单甘油酯
A monoacylglycerol
GC35067 1-Methylguanosine
1-甲基鸟酐
A methylated purine nucleoside
GC35061 18α-Glycyrrhetinic acid
18-α-甘草次酸
Glycyrrhetinic acid is a triterpenoid aglycone component of the natural product glycyrrhizinic acid and possesses remarkable anti-proliferative and apoptosis-inducing activity in various cancer cell lines.
GC35058 16-Dehydroprogesterone
16-去氢黄体酮
16-Dehydroprogesterone is a chemical derived from a progesterone.
GC35039 1,4-Diaminobutane dihydrochloride
1,4-丁二胺二盐酸盐,Putrescine dihydrochloride
1,4-Diaminobutane (Putrescine, Tetramethylenediamine, 1,4-Butanediamine) is used as a precursor in many biological systems and synthon for amido-ureas.
GC35029 1-Arachidoyl-sn-glycero-3-phosphocholine 1-Arachidoyl-sn-glycero-3-phosphocholine是一种溶血磷脂 (LyP)。
GC35003 (S)-Nornicotine
3-(吡咯烷-2-基)吡啶
(S)-Nornicotine 是尼古丁的代谢物。
GC34961 (±)-BI-D
人BH3结构域凋亡诱导蛋白(BID)ELISA试剂盒
(_plusmn_)-BI-D是HIV整合酶（integrase）变构抑制剂，作用于整合酶与LEDGF/p75结合部位。
GC34951 (-)-Menthol
L-薄荷醇
A monoterpene with diverse biological activities
GC45252 (-)-Sitagliptin Carbamoyl Glucuronide
BETA-D-吡喃葡萄糖醛酸1-[N-[(1R)-3-[5,6-二氢-3-(三氟甲基)-1,2,4-三唑并[4,3-A]吡嗪-7(8H)-基]-3-氧代-1-[(2,4,5-三氟苯基)甲基]丙基]氨基甲酸酯]
A minor phase II metabolite of (–)-sitagliptin
GC45245 (-)-Caryophyllene oxide
石竹素,(-)-Caryophyllene oxide
A bicyclic sesquiterpene
GC45226 β-BHC
β-HCH, β-Hexachlorocyclohexane, β-Lindane
β-BHC is an isomer of the organochlorine pesticide γ-lindane that is a potential impurity found in commercial preparations of lindane.
GC45208 α-hydroxy Metoprolol
Α-羟基美托洛尔
An active metabolite of metoprolol
GC45204 α-Ecdysone
蜕皮激素; α-Ecdysone

蜕皮激素（α-蜕皮激素）是一种存在于昆虫和植物中的类固醇蜕皮激素，可激活盐皮质激素受体（MR），从而导致肾小球疾病。
GC45193 Z-YVAD-CMK (trifluoroacetate salt)
Benxyloxycarbonyl-Tyr-Val-Ala-Asp-Chloromethylketone, Caspase-1 Inhibitor IV
An inhibitor of caspase-1 and caspase-3
GC45192 Z-VRPR-FMK (trifluoroacetate salt)
Z-Val-Arg-Pro-DL-Arg-FMK
An irreversible inhibitor of MALT1
GC45189 Z-VAD(OH)-FMK
Z-VAD(OH)-FMK
Z-VAD(OH)-FMK是所有半胱天冬酶的不可逆三肽抑制剂。
GC45179 Zeaxanthin
玉米黄素
Zeaxanthin是一种具有多种生物活性的类胡萝卜素色素，存在于多种水果和蔬菜中，可以帮助治疗或预防与年龄相关的黄斑变性、青光眼和白内障。
GC45178 Z-DEVD-CMK (trifluoroacetate salt)
Z-Asp-Glu-Val-Asp-CMK
An irreversible protease inhibitor
GC45177 Z-AEVD-FMK
Z-Ala-Glu-Val-Asp-Fluoromethyl Ketone
A caspase-10 inhibitor
GC45175 YVAD-CHO (trifluoroacetate salt)
H-Tyr-Val-Ala-Asp-CHO
A caspase-1/ICE inhibitor
GC45151 Voriconazole N-oxide
伏立康唑N-氧化物
A major metabolite of voriconazole