Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

Products for Proteases

Cat.No. 产品名称 Information
GC44635 Phosphoenolpyruvic Acid (potassium salt)
磷酸烯醇式丙酮酸钾; Potassium 1-carboxyvinyl hydrogenphosphate
An enzyme substrate for glycolysis and gluconeogenesis pathways
GC44628 Phenylephrine-3-O-Sulfate A metabolite of phenylephrine
GC44627 Phenylephrine Glucuronide
苯福林葡糖苷酸
A metabolite of phenylephrine
GC44599 Perindoprilat
培哚普利,S-9780
An active ACE inhibitor
GC44592 Pentacosanoic Acid
二十五烷酸
A saturated long-chain fatty acid
GC44581 PCTR3
Protein Conjugates in Tissue Regeneration 3
A specialized pro-resolving mediator
GC44580 PCTR2
Protein Conjugates in Tissue Regeneration 2
A specialized pro-resolving mediator
GC44579 PCTR1
Protein Conjugates in Tissue Regeneration 1
A specialized pro-resolving mediator
GC44555 Pantoprazole sulfone
泮托拉唑杂质A
A pantoprazole metabolite
GC44554 Pantoprazole Sulfide
泮托拉唑硫醚
A pantoprazole metabolite
GC44551 Palmitoyl-L-carnitine (chloride)
L-氯化棕榈酰肉碱
A long-chain acylcarnitine
GC44550 Palmitoyl-D-carnitine (chloride)
CAR 16:0, C16:0 Carnitine, D-Carnitine hexadecanoyl ester, D-Carnitine palmitoyl ester, D-Hexadecanoylcarnitine, Hexadecanoyl-D-carnitine, D-Palmitoylcarnitine
A long-chain acylcarnitine
GC44527 p,p'-DDE
2，2-双（4-氯苯基）-1，1-二氯乙烯,4,4'-DDE; p,p'-Dichlorodiphenyldichloroethylene
A metabolite and degradation product of the pesticide DDT
GC44509 Omeprazole sulfide
奥美拉唑硫醚,Ufiprazole
An intermediate for omeprazole synthesis
GC44506 Oligomycin D
芦他霉素,26-Demethyloligomycin A
An inhibitor of mitochondrial F₁F_O-ATPase
GC44492 O-Desmethyl Metoprolol
O-去甲基美托洛尔
A major active metabolite of metoprolol
GC44490 Octanoyl-L-carnitine (chloride)
C8 Carnitine
A medium-chain acylcarnitine
GC44488 Octanoyl Coenzyme A (sodium salt)
Octanoyl-CoA
A medium-chain acyl CoA
GC44464 NSC 109555
DDUG, NCI C04808
An inhibitor of Chk2
GC44451 Norfluoxetine (hydrochloride)
去甲氟西汀,Desmethylfluoxetine
An active metabolite of fluoxetine
GC44444 N-Oleoyl Valine A TRPV3 antagonist
GC44441 N-Oleoyl Leucine An N-acyl amide involved in mitochondrial uncoupling
GC44431 nNOS Inhibitor I
Neuronal Nitric Oxide Synthase, NOS I, ncNOS
A selective inhibitor of nNOS
GC44416 N-methyl Mesoporphyrin IX
N-甲基中卟啉IX
N-methyl Mesoporphyrin IX（NMM）是卟啉的过渡态类似物，是亚铁螯合酶的有效抑制剂，K_d值为7 nM。N-methyl Mesoporphyrin IX是G-四链体的特异性染色剂，激发/发射最大值分别为399/610 nm。
GC44415 N-methyl Leukotriene C4
Nmethyl LTC4

A stable LTC₄ mimetic
GC44409 Nivalenol
雪腐镰刀菌烯醇
A trichothecene mycotoxin
GC44358 Nebivolol O-β-D-Glucuronide An active metabolite of nebivolol
GC44353 NDMC101 A salicylanilide derivative
GC44352 N-Desmethylclomipramine (hydrochloride)
去甲氯丙咪嗪盐酸,Desmethylclomipramine hydrochloride
An Analytical Reference Material
GC44351 N-Desmethyl Sildenafil (citrate) A major metabolite of sildenafil
GC44350 N-Desmethyl Sildenafil
N-去甲基西地那非,Desmethylsildenafil; UK-103,320
A major metabolite of sildenafil
GC44349 N-desmethyl Levofloxacin
左氧氟沙星相关物质A
An active metabolite of levofloxacin
GC44348 N-desmethyl Bendamustine
盐酸苯达莫司汀乙酯水解杂质
An active metabolite of bendamustine
GC44345 N-Desethyl Vardenafil
N-去乙基伐地那非
A vardenafil metabolite
GC44341 ND-336 A selective inhibitor of MMP-2, -9, and -14
GC44338 NCT-501 (hydrochloride) A reversible inhibitor of ALDH1A1
GC44308 NADP+ (sodium salt hydrate)
Β-烟酰胺腺嘌呤二核苷酸磷酸钠盐水合物
The oxidized form of NADPH
GC44307 NADP+
烟酰胺腺嘌呤双核苷酸磷酸盐,Coenzyme II, β-NADP, Nicotinamide adenine dinucleotide phosphate, TPN
NADP+ 是电子供体烟酰胺腺嘌呤二核苷酸磷酸的氧化形式。
GC44306 N-acetyl-S-geranylgeranyl-L-Cysteine
N-乙酰基-S-香叶基香叶基-L-半胱氨酸
A synthetic substrate for the SAM-dependent methyltransferase
GC44304 N-Acetyl-S-allyl-L-cysteine A primary metabolite of L-deoxyalliin
GC44299 N-Acetyl-4-benzoquinone imine
N-乙酰基-4-苯醌亚胺
A reactive CYP450 metabolite of acetaminophen
GC44295 N-acetyl Leukotriene E4
Nacetyl LTE4
The major inactive metabolite of LTE₄ found in bile
GC44294 N-acetyl Dapsone
N-乙酰氨苯砜
A metabolite of dapsone
GC44284 N1,N8-Diacetylspermidine (hydrochloride)
NSC 685959
An acetyl derivative of spermidine
GC44262 Myristoyl-L-carnitine (chloride)
L-Myristoylcarnitine
A long-chain acylcarnitine
GC44246 Moxifloxacin N-Sulfate (sodium salt) A metabolite of moxifloxacin
GC44237 MMP-9 Inhibitor I
Matrix Metalloproteinase-9 Inhibitor I
An inhibitor of MMP-9
GC44236 MMP-2/MMP-9 Inhibitor III (trifluoroacetate salt)
Matrix Metalloproteinase-2/Matrix Metalloproteinase-9 Inhibitor III
An inhibitor of MMP-2 and MMP-9
GC44225 ML-345 An inhibitor of the insulin-degrading enzyme
GC44214 ML-162 A GPX4 inhibitor