Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

Products for Proteases

Cat.No. 产品名称 Information
GC44212 MK-886 (sodium salt) A potent, selective inhibitor of 5-lipoxygenase-activating protein (FLAP)
GC44207 MitoTEMPOL A mitochondrial-targeting SOD mimetic
GC44206 MitoTEMPO (hydrate) A mitochondria-targeted antioxidant
GC44205 Mitoquinol
A mitochondria-targeted antioxidant
GC44204 MitoPQ
MitoParaquat
A mitochondria-targeted redox cycler
GC44203 MitoPerOx A ratiometric fluorescent probe for mitochondrial lipid peroxidation
GC44202 MitoPBN A mitochondria-targeted antioxidant
GC44201 MitoP
MitoPhenol
The end product of a mitochondrial matrix H₂O₂ probe reaction
GC44199 MitoB
MitoBoronic Acid
A probe to detect H₂O₂ in mitochondria
GC44198 MitoA A probe to detect H₂S in mitochondria
GC44186 Metoclopramide (hydrochloride)
盐酸甲氧氯普胺
An orally bioavailable 5-HT₃ and D₂ receptor antagonist
GC44140 MCTR3
13-cysteinyl14-hydroxyDocosahexaenoic Acid, Maresin Conjugates in Tissue Regeneration 3, Maresin Sulfido Conjugate 3
A specialized pro-resolving mediator
GC44139 MCTR2
13-cysteinylglycinyl-14-hydroxy Docosahexaenoic Acid, Maresin Conjugates in Tissue Regeneration 2, Maresin Sulfido Conjugate 2
A specialized pro-resolving mediator
GC44138 MCTR1
13-glutathionyl-14-hydroxy Docosahexaenoic Acid, Maresin Conjugates in Tissue Regeneration 1, Maresin Sulfido Conjugate 1
A specialized pro-resolving mediator
GC44093 Lutein
叶黄素
A carotenoid with diverse biological activities
GC44083 LP-533401
L-苯丙氨酸,4[2-AMINO-6-(3-[2,2,2-三氟-1-氟[1,1'-联苯-4-乙氧基])]-4-PYRIMIDINYL]—
An inhibitor of gut-derived serotonin biosynthesis
GC44079 L-Leucyl-L-Leucine methyl ester (hydrochloride)
LLOMe hydrochloride; Leu-Leu methyl ester hydrochloride; H-Leu-Leu-OMe hydrochloride
An immunosuppressant
GC44061 L-Homoarginine (hydrochloride)
L-高精氨酸盐酸盐
An uncompetitive inhibitor of alkaline phosphatases
GC44056 Leukotriene E4 methyl ester
LTE4 methyl ester
A more lipid soluble formulation of LTE₄
GC44055 Leukotriene D4 methyl ester A more lipid soluble formulation of LTD₄
GC44054 Leukotriene C4 methyl ester
LTC4 methyl ester
A more lipid soluble formulation of LTE₄
GC44053 Leukotriene B4 Ethanolamide
LTB4EA
A theoretical 5-LO metabolite of arachidonoyl ethanolamide
GC44052 Leukotriene B4 dimethyl amide
LTB4 dimethyl amide
A LTB₄ receptor antagonist
GC44044 Lauroyl-L-carnitine (chloride)
L-氯化月桂酰肉碱
月桂基-l-肉碱是一种天然存在的化合物，属于酰基肉碱家族。
GC44033 Lansoprazole sulfone
兰索拉唑磺酸盐
A metabolite of lansoprazole
GC44029 L-Alanyl-L-Glutamine
L-丙氨酸-L-谷氨酰胺
A synthetic glutamine dipeptide
GC44019 L-(+)-Ergothioneine
麦角硫因; L-(+)-Ergothioneine
A natural antioxidant
GC43922 Isovaleryl-L-carnitine (chloride)
L-异戊酰基肉碱
An acylcarnitine
GC43912 Isoapoptolidin Isoapoptolidin is a stable derivative of apoptolidin that demonstrates 10-fold reduced F1FO-ATP synthase inhibitory activity compared to apoptolidin (IC50s = 17 and 0.7 μM, respectively).
GC43909 Iromycin A
6-[(2E,5E)-3,7-二甲基-2,5-辛二烯基]-4-羟基-3-甲基-5-丙基-2(1H)-吡啶酮
A natural eNOS inhibitor
GC43904 Inosine 5'-triphosphate (sodium salt)
三磷酸肌苷三钠盐
A nucleoside triphosphate
GC43903 Indoxyl Sulfate (potassium salt)
硫酸吲哚钾盐
硫酸吲哚酚(Indoxyl sulfate (IS)),又称3-吲哚酚硫酸和3-吲哚酚硫酸,是膳食l -色氨酸的代谢物,具有心脏毒素和尿毒症毒素的作用。
GC43901 Indole-3-Acetic Acid (sodium salt)
1H-吲哚-3-羧酸（吲哚乙酸）,Indole-3-acetic acid sodium; 3-IAA sodium
A plant growth regulator
GC43896 Iloperidone metabolite P95
伊潘立酮代谢物P95
A metabolite of iloperidone
GC43895 Iloperidone metabolite P88
伊潘立酮代谢物; P88; Hydroxy Iloperidone
An active metabolite of iloperidone
GC43887 IBTP (iodide) A mitochondria-targeting thiol reactive probe
GC43881 Hydroxy Varenicline
伐伦克林杂质
A metabolite of varenicline
GC43879 Hydroxy Ebastine An ebastine metabolite
GC43878 Hydroxy Dimetridazole
1-甲基-5-硝基-2-羟甲基咪唑,Hydroxy Dimetridazole
A metabolite of dimetridazole
GC43876 Hydroxy Bosentan
波生坦羟甲基杂质,Ro 48-5033
A metabolite of bosentan
GC43820 Hexadecanal
十六醛,Palmitaldehyde
A free fatty aldehyde analog of palmitic acid
GC43786 GS-143
4-(3-苄基-4-((5-(2-氟苯基)呋喃-2-基)亚甲基)-5-氧代-4,5-二氢-1H-吡唑-1-基)苯甲酸
An inhibitor of IκBα ubiquitylation
GC43780 GM 1489 An MMP inhibitor
GC43776 Glycochenodeoxycholic Acid (sodium salt)
甘氨鹅脱氧胆酸钠; Chenodeoxycholylglycine sodium salt; Sodium glycochenodeoxycholate
A primary bile acid
GC43743 Gemfibrozil 1-O-β-Glucuronide
吉非罗齐酰基β-D-葡萄糖醛酸
A major metabolite of gemfibrozil
GC43729 Ganglioside GD3 Mixture (sodium salt)
双唾液酸神经节苷脂GD3; Disialosyllactosylceramide
A mixture of ganglioside G_D3
GC43725 Gallocyanine
花菁
A Dkk1 inhibitor
GC43723 Galactosylsphingosine (d18:1)
神经鞘氨醇半乳糖苷,Galactosylsphingosine
A bioactive sphingolipid
GC43714 Fura-FF AM
钙离子荧光探针FURA-FF,AM
A cell-permeable, low affinity fluorescent calcium indicator
GC43713 Fura-FF (potassium salt)
钙离子荧光探针FURA-FF,五钾盐
A low affinity fluorescent calcium indicator