Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

Products for Proteases

Cat.No. 产品名称 Information
GC43709 Fumonisin B2
伏马菌素B2
A mycotoxin
GC43697 Formoterol O-β-D-Glucuronide
福莫特罗杂质14
A metabolite of formoterol
GC43675 Florfenicol amine (hydrochloride)
氟苯尼考胺盐酸盐
A veterinary antibiotic metabolite
GC43664 Filipin II An active component of the filipin complex
GC43649 Falcarinol
人参炔醇; Panaxynol; Carotatoxin
A plant defense polyacetylene
GC43646 Ezetimibe Hydroxy Glucuronide
依泽替米贝羟基-b-D-葡萄糖醛酸
A minor phase II metabolite of ezetimibe
GC43616 EOS (d18:1/32:1/18:2)
C52:3 EOS (18:1/32:1(22 Z)w18:2(9Z,12Z), Esterified ω-hydroxyacyl Sphingosine
An essential ceramide for prevention of epidermal water loss
GC43611 Enniatin B1
恩镰孢菌素 B1
An antibiotic ionophore
GC43609 Enniatin A
镰孢菌素 A
A component of the enniatin complex
GC43582 Dynorphin B (1-9) (trifluoroacetate salt) A neuropeptide
GC43565 Doxorubicinol (hydrochloride)
13-Dihydroadriamycin hydrochloride
A doxorubicin metabolite
GC43543 DNP-INT An electron transport inhibitor in plants
GC43498 DL-α-Lipoic Acid
α-硫辛酸; Thioctic acid; (±)-α-Lipoic acid; DL-α-Lipoic acid
An important decarboxylation cofactor and antioxidant
GC43493 DL-Sulforaphane N-acetyl-L-cysteine
SFNNAC
An anticancer agent
GC43490 DL-Glyceraldehyde-3-phosphate
DL-甘油醛3-磷酸
DL-甘油醛-3-磷酸是冬氨酸氨基转移酶阳离子和阴离子同工酶的一种时间依赖性抑制剂。
GC43466 Dimethyl sulfone
二甲基砜
An Analytical Reference Standard
GC43463 DiIC1(5)
1,1',3,3,3',3'-六甲基吲哚双碳菁碘
A signal-off fluorescent probe
GC43459 Dihydro Montelukast
孟鲁司特钠二氢杂质
A potential impurity found in commercial montelukast preparations
GC43453 Diflapolin
双黄素
A dual FLAP/sEH inhibitor
GC43444 Diclofenac Acyl-β-D-Glucuronide
双氯芬酸酰基-Β-D-葡糖苷酸
An active metabolite of diclofenac
GC43434 D-Glucose-6-phosphate (sodium salt)
D-葡萄糖-6-磷酸
D-Glucose-6-phosphate (sodium salt)是葡萄糖代谢的基本组成部分，是葡萄糖被己糖激酶（或葡萄糖激酶）磷酸化或葡萄糖-1-磷酸被磷酸葡糖变位酶转化时在细胞中形成的，这是糖原合成的第一步。
GC43432 D-Glucosamine-2-sulfate (sodium salt)
氨基葡萄糖硫酸钠盐
D-Glucosamine-2-sulfate（钠盐）是一种内源性代谢物。
GC43431 D-Fructose-6-phosphate (sodium salt)
D-果糖-6-磷酸二钠
D-Fructose-6-phosphate（钠盐）是一种内源性代谢物。
GC43423 Desmethylene Paroxetine (hydrochloride)
帕罗西汀杂质5
A major metabolite of the SSRI paroxetine
GC43422 Desmethyldoxepin (hydrochloride)
N-去甲盐酸多塞平,Desmethyldoxepin hydrochloride
The primary metabolite of doxepin
GC43419 Desmethyl Erlotinib
2-[[4-[(3-乙炔基苯基)氨基]-7-(2-甲氧基乙氧基)-6-喹唑啉基]氧基]乙醇,OSI-420 free base; CP-373420
A metabolite of erlotinib
GC43418 Desethylene Ciprofloxacin (hydrochloride)
脱乙烯环丙沙星盐酸盐
A major metabolite and degradation product of ciprofloxacin
GC43412 Desacetyl Bisacodyl
苉可硫酸钠杂质B
An active metabolite of the laxatives bisacodyl and sodium picosulfate
GC43403 Dehydroepiandrosterone Sulfate (sodium salt)
去氢表雄酮硫酸钠,Sodium prasterone sulfate
A steroid precursor
GC43401 Dehydro Nifedipine
4-(2硝基苯基)-2,6-二甲基吡啶-3,5二羧酸二甲酯
An active metabolite of nifedipine
GC43400 Dehydro Aripiprazole (hydrochloride)
脱氢阿立哌唑盐酸盐
The primary, active metabolite of aripiprazole
GC43393 Decanoyl-L-carnitine (chloride)
L-癸酰氯化肉碱
A derivative of L-carnitine
GC43376 Dapagliflozin-3-O-β-D-Glucuronide A metabolite of dapagliflozin
GC43371 Dabigatran Acyl-β-D-Glucuronide
达比加群酰基Β维葡糖苷酸
A major active metabolite of dabigatran
GC43367 D-(+)-Glucose-13C6
13C6-葡萄糖,Glucose-13C6; D-(+)-Glucose-13C6; Dextrose-13C6
D-(+)-Glucose-13C6是D-(+)-Glucose的稳定同位素标记对应物，主要用作定量 D-(+)-Glucose的内标，通过GC-或LC-MS测量。
GC43358 Cytochalasin A
细胞松弛素A
Inhibitor of actin polymerization
GC43355 Cytidine 5'-triphosphate (sodium salt)
三磷酸胞苷二钠,NSC 20261
Cytidine 5͇-三磷酸（钠盐）是一种内源性代谢物。
GC43345 Cyclohexanoyl Coenzyme A
CHCoA, Cyclohexanecarboxyl-CoA
An acyl CoA that contains a cyclohexane group
GC43343 Cyclo(L-Tyr-L-Val)
环(酪氨酸-缬氨酸)二肽,Cyclo(L-Tyr-L-Val)
A diketopiperazine fungal metabolite
GC43323 Creatine Phosphate (potassium salt)
Phosphocreatine
磷酸肌酸（钾盐）主要存在于脊椎动物的骨骼肌中，是一种称为 α 氨基酸和衍生物的有机化合物，是测定肌酸激酶的底物，用于在骨骼肌收缩过程中再生 ATP。
GC43297 Coenzyme Q2
辅酶Q2
A biosynthetic precursor to CoQ₁₀ and an inhibitor of mitochondrial complex I
GC43296 Coenzyme B12
腺苷钴胺; Coenzyme B12; Cobamamide; AdoCbl

A biologically active form of vitamin B12
GC43295 Coenzyme A (sodium salt hydrate)
CoA
An essential cofactor in enzymatic acetyl transfer reactions
GC43289 Cochlioquinone B A fungal metabolite
GC43285 CM037
A37
A selective inhibitor of ALDH1A1
GC43284 Clozapine N-oxide (hydrochloride)
CNO

A metabolite of clozapine and muscarinic DREADD agonist
GC43281 Clopidogrel Carboxylic Acid (hydrochloride)
(S)-(O-氯苯基)-6,7-二羟噻吩[3,2-C]吡啶-5(4H)-醋酸盐酸盐
A major inactive metabolite of clopidogrel
GC43278 Clindamycin Sulfoxide
克林霉素亚砜
An active metabolite of clindamycin
GC43261 Cholesteryl Myristate
胆固醇肉豆蔻酸; Cholesteryl myristate; Cholesteryl tetradecanoate
A cholesterol ester
GC43257 Cholesteryl Eicosapentaenoate
20:5 Cholesteryl ester
A cholesterol ester