Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

Products for Proteases

Cat.No. 产品名称 Information
GC43251 Cholesterol Sulfate (sodium salt)
胆固醇硫酸酯钠盐

硫酸胆固醇（Cholesterol Sulfate (sodium salt)) 于 1965 年首次从人体血浆中分离出来，浓度为 300 μg/100 ml 。
GC43248 Chlorzoxazone N-Glucuronide A phase II metabolite of chlorzoxazone
GC43225 Celecoxib Carboxylic Acid Acyl-β-D-Glucuronide
塞来昔布羧酸酰基-Β-D-葡糖苷酸
A metabolite of celecoxib
GC43195 CAY10703 A stable dichloroacetate derivative
GC43194 CAY10698 A selective inhibitor of 12-LO
GC43192 CAY10685 A “clickable” analog of CPTH2
GC43188 CAY10680 A dual inhibitor of monoamine oxidase B and adenosine A_2A receptors
GC43154 CAY10443
(S)Indan1yl 3,4dichlorobenzylcarbamate
A cytochrome c-dependent inducer of apoptosis
GC43153 CAY10416 A dual COX-2/5-LO inhibitor
GC43146 Caspase-9 Inhibitor III (trifluoroacetate salt)
Ac-LEHD-CMK
A caspase-9 inhibitor
GC43144 Carfilzomib Impurity 13 (hydrochloride) A potential impurity found in commercial carfilzomib preparations
GC43141 Carboxyatractyloside (potassium salt)
羧基苍术苷
An inhibitor of ADP/ATP translocases
GC43140 Captopril Disulfide
卡托普利二硫化物,SQ 14551
A metabolite and degradation product of captopril
GC43114 Caffeic Acid-13C3 An internal standard for the quantification of caffeic acid
GC43069 C22 Ceramide (d18:1/22:0)
C22 Ceramide；Cer(d18:1/22:0)；Ceramide (d18:1/22:0)
C22 Ceramide (d18:1/22:0)是一种从海绵Haliclona koremella中分离的含有山萮酸的长链神经酰胺，是一种内源性生物活性鞘脂。
GC43052 C18 Phytoceramide (t18:0/18:0)
N-硬脂酰植物鞘胺醇
A bioactive sphingolipid
GC43051 C18 L-threo Ceramide (d18:1/18:0)
N-octadecanoyl-L-threo-Sphingosine, L-threo Cer(d18:1/18:0), L-threo Ceramide (d18:1/18:0)
A synthetic ceramide
GC43050 C18 L-erythro Ceramide (d18:1/18:0)
L-erythro Cer(d18:1/18:0), L-erythro Ceramide (d18:1/18:0), N-octadecanoyl-L-erythro-Sphingosine
A naturally occurring ceramide
GC43030 C16 dihydro Ceramide (d18:0/16:0)
Cer(d18:0/16:0) ; Ceramide (d18:0/16:0); N-hexadecanoyl-D-erythro-Dihydrosphingosine; N-Palmitoyl Sphinganine
A bioactive sphingolipid
GC43000 Butyryl-L-carnitine (chloride)
R-丁酰基肉碱
A butyrate ester of carnitine
GC42978 Bromamphenicol A dibrominated derivative of chloramphenicol
GC42915 Benzamidine (hydrochloride)
苄脒盐酸盐
A serine protease inhibitor
GC42913 Benazeprilat
苯那普利拉,CGS 14831
An ACE inhibitor
GC42887 Axitinib Sulfoxide
阿西替尼杂质A
A major inactive metabolite of axitinib
GC42879 Avanafil metabolite M4 An active metabolite of avanafil
GC42878 Avanafil metabolite M16 A major inactive metabolite of avanafil
GC42874 Aureothin
金链菌素
A polyketide antibiotic that inhibits oxidoreductase
GC42873 Auraptene
橙皮油素
A coumarin derivative with anti-inflammatory and chemopreventative activity
GC42846 Arachidonoyl-L-carnitine (chloride)
C20:4 Carnitine

A C20:4 acylcarnitine
GC42824 APC 366 (trifluoroacetate salt) A mast cell tryptase inhibitor
GC42823 AP39 A mitochondrial H₂S donor
GC42821 AP219 A control compound for AP39
GC42820 Antimycin A4
抗霉素A4
An active component of the antimycin A antibiotic complex
GC42818 Antimycin A1
抗黴素A1
An active component of the antimycin A antibiotic complex
GC42806 Andrastin A
NSC 697452
A meroterpenoid farnesyltransferase inhibitor
GC42788 Aminopeptidase N Inhibitor Aminopeptidase N (AP-N) inhibitor is a reversible inhibitor of AP-N/CD13 (IC50 = 25 μM).
GC42777 Amastatin (hydrochloride)
氨肽酶抑制剂盐酸盐
An aminopeptidase inhibitor
GC42769 all-trans Retinoyl β-D-Glucuronide
(E-视黄酰基)-Β-葡糖苷酸
A metabolite of all-trans retinoic acid
GC42742 ADT-OH
5-(4-羟基苯基)-3H-1,2-二硫杂环戊烯-3-硫酮,5-(4-Hydroxyphenyl)-3H-1,2-dithiole-3-thione; ACS 1
A synthetic H₂S donor used in making chimeras
GC42718 Ac-VEID-CHO (trifluoroacetate salt)
Ac-Val-Glu-Ile-Asp-CHO
A caspase-6 inhibitor
GC42715 Ac-VDVAD-CHO (trifluoroacetate salt)
Ac-Val-Asp-Val-Ala-Asp-CHO
A caspase-2, caspase-3, and caspase-7 inhibitor
GC42709 Ac-LEVD-CHO (trifluoroacetate salt)
Ac-Leu-Glu-Val-Asp-CHO, Caspase-4 Inhibitor I
A caspase-4 inhibitor
GC42697 Acetyl Coenzyme A (sodium salt)
乙酰辅酶A钠盐; Acetyl-CoA trisodium
乙酰辅酶A钠盐（Acetyl Coenzyme A (sodium salt)）是酶促乙酰基转移反应中必需的辅因子和酰基载体。Acetyl Coenzyme A 可作为组蛋白乙酰酶（HAT）的乙酰基供体，用于组蛋白和非组蛋白的翻译后乙酰化反应。
GC42695 Acetoacetyl Coenzyme A (sodium salt hydrate)
Acetoacetyl-CoA
A precursor to HMG-CoA
GC42694 Acetaminophen sulfate (potassium salt)
4-乙酰氨基酚硫酸钾盐
An inactive metabolite of acetaminophen
GC42693 Acetaminophen Glucuronide (sodium salt)
P-乙酰氨基苯-B-D-葡萄糖酸钠盐
An inactive metabolite of acetaminophen
GC42690 Acecainide (hydrochloride)
N-盐酸乙酰普鲁卡胺
An active metabolite of procainamide
GC42688 Ac-DMQD-CHO (trifluoroacetate salt)
Ac-Asp-Met-Gln-Asp-CHO, Caspase-3 Inhibitor
An inhibitor of caspase-3
GC42667 Abacavir Carboxylate
阿巴卡韦羧酸盐
An inactive metabolite of abacavir
GC42665 AAF-CMK (trifluoroacetate salt)
NAlaAlaPheCMK, Tripeptidyl Peptidase Inhibitor II
An inhibitor of TPPII