Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

Products for Proteases

Cat.No. 产品名称 Information
GC42653 9-OxoOTrE
9KOTE, 9KOTrE
An antimicrobial oxidized fatty acid
GC42651 9-oxo-10(E),12(E)-Octadecadienoic Acid
9-oxo ODA
A natural agonist of PPARα
GC42637 9(S)-HpOTrE A 5-LO product derived from α-linolenic acid
GC42636 9(S)-HOTrE
9S-羟基-10E，12Z，15Z-十八碳三烯酸
A product of the action of 5-LO on α-linolenic acid
GC42633 9(E)-Erythromycin A oxime
红霉素肟A
A metabolite of roxithromycin
GC42626 8-hydroxy Efavirenz
8-羟基依法韦伦
A major metabolite of efavirenz
GC42619 8(S)-HETrE A monohydroxy PUFA derivative of DGLA
GC42608 7-hydroxy Methotrexate (sodium salt)
7-hydroxy MTX
A metabolite of methotrexate
GC42607 7-hydroxy Coumarin sulfate (potassium salt)
7-HC, 7HCS
An internal standard for the quantification of 7-hydroxy coumarin
GC42606 7-hydroxy Coumarin Glucuronide (sodium salt) A 7-hydroxy coumarin phase II metabolite
GC42586 6α-hydroxy Paclitaxel
6-羟基泰素
A metabolite of paclitaxel
GC42584 6-O-desmethyl Donepezil
6-O-去甲基多奈哌齐
An active metabolite of donepezil
GC42580 6-hydroxy Chlorzoxazone
6-.羟基氯唑沙宗,NSC 24955
A metabolite of chlorzoxazone
GC42578 6-Formylpterin
2-氨基-4-氧代-3,4-二氢蝶啶-6-甲醛
An intracellular generator of hydrogen peroxide
GC42562 5-Methyl-2'-deoxycytidine
5-甲基-2'-脱氧胞苷,5-Methyldeoxycytidine
A pyrimidine nucleoside
GC42551 5-hydroxymethyl Tolterodine (formate)
5-羟甲基托特罗定
An active metabolite of tolterodine and fesoterodine
GC42550 5-hydroxy-6-methoxy (S)-Duloxetine
度洛西汀杂质
A metabolite of (S)-duloxetine
GC42549 5-hydroxy Thiabendazole
噻苯咪唑-5-羟基
A major metabolite of thiabendazole
GC42548 5-hydroxy Saxagliptin (hydrochloride) A major active metabolite of saxagliptin
GC42546 5-hydroxy Diclofenac
5-羟基双氯芬酸
An active metabolite of diclofenac
GC42484 5,6-dihydroxy Indole
5,6-二羟基吲哚
An intermediate in melanogenesis
GC42479 5(S)-HETrE A monohydroxy fatty acid synthesized by 5-LO from mead acid
GC42415 4-hydroxy Valsartan
4-羟基缬沙坦
A major metabolite of valsartan
GC42410 4-hydroxy Nonenal
4-羟基壬烯醛,4-HNE
4-羟基壬烯醛（4-hydroxy Nonenal，4-HNE）是一种脂质过氧化（LPO）产物，是一种α，β不饱和羟基烯醛，由ω-6多不饱和脂肪酸氧化形成，它是一种无色油。
GC42409 4-hydroxy Nebivolol (hydrochloride) A major metabolite of nebivolol
GC42407 4-hydroxy Diclofenac
4′-羟基双氯芬酸
A CYP2C9 metabolite of the NSAID diclofenac
GC42405 4-hydroxy Atorvastatin (calcium salt)
4-羟基阿托伐他汀（钙盐）
A metabolite of atorvastatin
GC42402 4-hydroxy (S)-Duloxetine β-D-Glucuronide (sodium salt)
LY550408
An inactive metabolite of (S)-duloxetine
GC42401 4-hydroperoxy Cyclophosphamide
培磷酰胺,4-OOH-CY
4-hydroperoxy Cyclophosphamide（4-羟基过氧化环磷酰胺），环磷酰胺的活性代谢产物，能够交联DNA并独立于caspase受体激活诱导T细胞凋亡，通过产生活性氧（ROS）激活线粒体死亡途径。
GC42370 4-desmethoxy Omeprazole
埃索美拉唑杂质B
A potential impurity found in commercial omeprazole and esomeprazole magnesium preparations
GC42351 4-carboxy TEMPO
4-羧基-2,2,6,6-四甲基氮杂环己烷-1-氧基自由基
A spin label
GC42307 3-O-methyl-L-DOPA (hydrate)
3-O-甲基-L-多巴一水合物
A metabolite of L-DOPA
GC42275 3-hydroxy Desloratidine
3-羟基去氯雷他定盐酸盐
A major metabolite of desloratadine
GC42274 3-hydroxy Darifenacin
UK 148993
A metabolite of darifenacin
GC42201 3,3'-Diiodo-L-thyronine
3,3'-二碘甲腺原氨酸,3,3'-T2
A metabolite of thyroid hormone
GC42198 3-(4-Chlorophenyl)-4-hydroxybutyric Acid (sodium salt)
γ-Hydroxybaclofen
An inactive metabolite of baclofen
GC42193 2-Thenoyltrifluoroacetone
2-噻吩甲酰三氟丙酮,HTTA; TTA; TTFA
An inhibitor of respiration
GC42189 2-oxo Clopidogrel
甲基(2-氯苯基)(2-氧代-2,6,7,7ALPHA-四氢噻吩并[3,2-C]吡啶-5(4H)-基)乙酸酯
An intermediary metabolite of clopidogrel
GC42150 2'-Deoxycytidine 5'-diphosphate (sodium salt hydrate)
2'-脱氧胞苷-5'-二磷酸三钠盐,dCDP trisodium
A nucleotide diphosphate
GC42082 20-carboxy Leukotriene B4
20-羧基白三烯B4
A LTB₄ metabolite
GC42042 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE
1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-phosphoethanolamine, 15(S)-HpETE-SAPE, 15(S)-hydroperoxyeicostetraenoic acid-SAPE

An oxidized phospholipid
GC42041 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PC
15(S)-HpETE-SAPC, 15(S)-Hydroperoxyeicostetraenoic Acid-SAPC, 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-Phosphatidylcholine

An oxidized phospholipid
GC42040 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE
15(S)-HETE-SAPE, 15(S)-Hydroxyeicosatetraenoic Acid-SAPE, 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-Phosphatidylethanolamine

An oxidized phospholipid
GC42039 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PC
15(S)-HETE-SAPC, 15(S)-Hydroxyeicostetraenoic Acid-SAPC, 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-Phosphatidylcholine
An oxidized phospholipid
GC42000 1-Methylnicotinamide (chloride)
3-氨基甲酰-1-甲基氯化吡啶,1-Methylnicotinamide chloride; N-methylnicotinamide chloride
A metabolite of nicotinamide
GC41999 1-Methylhistamine (hydrochloride)
1-甲基组胺二对甲苯磺酸盐
A major metabolite of histamine
GC41995 1'-hydroxy Midazolam
1-羟基咪达唑仑
A CYP3A metabolite of midazolam
GC41980 18-carboxy dinor Leukotriene B4
18carboxy dinor LTB4
β-oxidation metabolite of LTB₄
GC41955 17-DMAG
阿螺旋霉素; 17-DMAG; NSC 707545
Water-soluble inhibitor of Hsp90
GC41952 17(R)-Resolvin D4
4(S),5(R),17(R)-trihydroxy-DHA, 17(R)-RvD4
An aspirin-triggered epimer of RvD4