Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

Products for Proteases

Cat.No. 产品名称 Information
GC41399 5α-dihydro Levonorgestrel
5-Α-二氢左炔诺孕酮
A metabolite of levonorgestrel
GC41390 Aldosterone
醛固酮

醛固酮是由肾上腺皮质分泌的一种类固醇激素，是控制钠和钾平衡的主要矿物质皮质激素
GC41380 N-desmethyl Rosiglitazone
N-去甲罗格列酮
A major metabolite of rosiglitazone
GC41362 OMDM-1
(S)Noleoyl Tyrosinol
An inhibitor of AEA uptake
GC41339 Pioglitazone Ketone
吡格列酮
An active metabolite of pioglitazone
GC41325 Mycophenolic Acid β-D-Glucuronide
霉酸Β-D-葡萄糖醛酸,MPAG，Mycophenolic Acid Glucosiduronate
A metabolite of mycophenolic acid
GC41322 5-OxoETE methyl ester
5-KETE methyl ester
An esterified form of 5-oxoETE
GC41315 (±)-Ketoprofen Glucuronide
(酮洛芬酰基)-Β-D-葡糖苷酸
A metabolite of ketoprofen
GC41312 5-hydroxy Omeprazole
5-羟基奥美拉唑
A major metabolite of omeprazole
GC41310 5-Octyl-α-ketoglutarate
αKG octyl ester
A cell-permeable form of α-ketoglutarate
GC41309 16α-hydroxy Prednisolone
16alpha-羟基泼尼松龙,OH-PRED
A stereoselective metabolite of 22(R)-budesonide
GC41300 17β-hydroxy Exemestane
亚甲基宝丹酮
An active metabolite of exemestane
GC41289 U-75302 A BLT₁ receptor antagonist
GC41283 N-acetyl-D-Glucosamine
N-乙酰-D-氨基葡萄糖; N-Acetyl-2-amino-2-deoxy-D-glucose
Monosaccharide derivative of glucose
GC41282 2'-O-Methyladenosine
2'-O-甲基腺苷
An adenosine analog
GC41270 N-desmethyl Zolmitriptan
N-去甲佐米曲坦-D3
An active metabolite of zolmitriptan
GC41266 Pregnanediol-3-Glucuronide
Pregnanediol-3α-Glucuronide
A metabolite of progesterone
GC41258 Spiroxamine
螺噁茂胺
A fungicide
GC41252 BI-6C9 An inhibitor of tBid-mediated apoptosis
GC41251 Pirlindole
坡尔吲哚
A selective and reversible MAO-A inhibitor
GC41249 p,p'-DDD
4,4-滴滴滴,4,4'-DDD; p,p'-Dichlorodiphenyl dichloroethane
A metabolite of DDT
GC41232 Resolvin D3 methyl ester
RvD3 methyl ester
A methyl ester form of resolvin D3
GC41231 Resolvin D2 methyl ester
7(S),16(R),17(S)Resolvin D2 methyl ester, RvD2 methyl ester
Methyl ester form of RvD2
GC41230 Resolvin D1 methyl ester
RvD1 methyl ester
Derivative of resolvin D1
GC41227 17(R)-Resolvin D1 methyl ester
AspirintriggeredResolvin D1 methyl ester, ATRvD1 methyl ester, 17epiResolvin D1 methyl ester, 17(R)RvD1 methyl ester
Methyl ester of an aspirin-triggered resolvin
GC41224 6-diazo-5-oxo-L-nor-Leucine
6-重氮-5-氧代-L-正亮氨酸; L-6-Diazo-5-oxonorleucine; DON
6-Diazo-5-oxo-L-nor-Leucine (DON)是一种抑制谷氨酰胺酶的谷氨酰胺类似物,是一种选择性的、基于机制的谷氨酰胺酶失活剂。
GC41220 13(S)-HODE methyl ester Hydroxy fatty acid methyl ester
GC41211 Anacardic Acid Diene
Anacardic Acid 15:2
A polyunsaturated for of anacardic acid
GC41209 17-oxo-7(Z),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic Acid
EFOX, 17-oxo-DPA, 17oxo7(Z),10(Z),13(Z),15(E),19(Z)DPA
A metabolite of DPA with anti-inflammatory properties
GC41208 17(S)-HDHA
17(S)hydroxy Docosahexaenoic Acid, 17(S)HDoHE
An oxidation product of DHA
GC41206 14(S)-HDHA
14(S)-HDoHE
An anti-inflammatory lipid produced by macrophages
GC41189 Ricinelaidic Acid An LTB₄ antagonist
GC41183 α-Carotene
α-胡萝卜素

A precursor of vitamin A
GC41177 Lurasidone metabolite 14283 An active metabolite of lurasidone
GC41151 Decursinol angelate Decursinol angelate is a pyranocoumarin that has been found in the Korean medicinal herb A.
GC41150 14,15-Leukotriene E4
Eoxin E4, EXE4, 14,15LTE4
A metabolite of 14,15-LTC₄ with pro-inflammatory activity
GC41149 11-trans Leukotriene E4
11trans LTE4
The C-11 double bond isomer of LTE₄
GC41148 14,15-Leukotriene D4
Eoxin D4, EXD4, 14,15-LTD4
A pro-inflammatory arachidonic acid metabolite
GC41147 11-trans Leukotriene D4
11trans LTD4
A C-11 double bond isomer of LTD₄
GC41145 14,15-Leukotriene C4
Eoxin C4, EXC4, 14,15LTC4
A pro-inflammatory arachidonic acid metabolite
GC41144 11-trans Leukotriene C4
11trans LTC4
A C-11 double bond isomer of LTC₄
GC41136 8(S),15(S)-DiHETE A dihydroxy fatty acid synthesized by 15-LO from 15(S)-HETE
GC41131 5(S),6(S)-DiHETE A hydrolysis product of LTA₄
GC41129 5(S),6(R)-DiHETE A dihydroxy hydrolysis product of LTA₄
GC41128 5(S),6(R)-11-trans DiHETE A metabolite of LTA₄
GC41127 5(S),15(S)-DiHETE A dihydroxy fatty acid synthesized by 15-LO from 5(S)-HETE
GC41126 5(S),12(S)-DiHETE A natural bioactive lipid
GC41124 15(S)-HpETE
15-羟基二十碳-5Z,8Z,11Z,13E-四烯酸
A product of 15-LO metabolism of arachidonic acid
GC41123 12-epi Leukotriene B4
12epi LTB4
LTB₄ isomer with weak agonist activity at BLT₁ and BLT₂ receptors
GC41122 12(S)-HpETE
A 12-LO metabolite of arachidonic acid