Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

Products for Proteases

Cat.No. 产品名称 Information
GC41107 Leukotriene B5
LTB5
A leukotriene
GC41105 5(S)-HpEPE Produced by the action of 5-LO on EPA; LTA₅ precursor
GC41101 15(S)-HpEPE Produced by the action of 15-lipoxygenase on EPA
GC41100 14,15-dehydro Leukotriene B4
14,15dehydro LTB4
A LTB₄ receptor antagonist
GC41096 12-oxo Leukotriene B4
12keto LTB4, 12oxo LTB4
A natural metabolite of LTB₄
GC41095 12(S)-HpEPE A 12-LO product derived from EPA
GC41044 CAY10583 A selective BLT₂ agonist
GC41003 4'-O-methyl Quercetin
柽柳黄素,4'-O-Methyl Quercetin
A flavonoid with anticancer and antiplasmodial activity
GC40998 Pinostrobin
球松素
A flavonoid with diverse biological activities
GC40994 N-Methylnicotinamide
N-甲基烟酰胺
An isomer of nicotinamide
GC40982 Resolvin D5
7(S),17(S)-diHDHA
A potent anti-inflammatory, pro-resolving lipid mediator
GC40981 Protectin D1
保护素D1,Neuroprotectin D1; NPD1

A specialized pro-resolving mediator
GC40980 Maresin 2
3R,14S-diHDHA
A 13R,14S-dihydroxy DHA produced by macrophages
GC40978 7-epi Maresin 1
7(S)MaR1, 7(S)Maresin 1
An inactive Maresin 1 epimer
GC40975 17(S)-HpDHA
17(S)hydroperoxy Docosahexaenoic Acid, 17(S)HpDoHE
A mono-oxygenation product of DHA
GC40971 10(S),17(S)-DiHDHA
10(S),17(S)-DiHDoHE; PDX
A DHA derivative with anti-inflammatory and anti-platelet activity
GC40968 21-hydroxy Eplerenone
21-羟基依普利酮
A major metabolite of eplerenone
GC40928 Trimethylamine N-oxide
三甲胺N-氧化物

A metabolite of choline, phosphatidylcholine, and L-carnitine
GC40926 8-Hydroxy-2'-deoxyguanosine
8-OH-脱氧鸟嘌呤,8-OHdG
Product of oxidative damage to DNA
GC40913 Glycohyodeoxycholic Acid
甘氨猪去氧胆酸
A metabolite of hyodeoxycholic acid
GC40879 4-hydroxy Solifenacin N-oxide An N-oxide form of 4-hydroxy solifenacin
GC40852 N-Demethylerythromycin A
N-去甲基红霉素A
A metabolite of erythromycin
GC40851 Pseudoerythromycin A enol ether
伪赤藓霉素A烯醇醚,LY267108
An erythromycin impurity used as an analytical standard
GC40840 Leukotriene A3 methyl ester
LTA3 methyl ester
A metabolically stable form of LTA₃
GC40839 15(S)-HETE methyl ester
15(S)-Hydroxyeicosatetraenoic Acid methyl ester
A synthetic derivative of 15(S)-HETE
GC40834 cis-Entacapone
(2Z)-2-氰基-3-(3,4-二羟基-5-硝基苯基)-N,N-二乙基-2-丙烯酰胺
A metabolite of entacapone
GC40830 5,6-dehydro Arachidonic Acid
5,6dehydro AA
An analog of arachidonic acid with acetylene in the 5,6 position
GC40829 5(S)-HETE lactone
5(S)-Hydroxyeicosatetraenoic Acid lactone
A potential 5-LO inhibitor
GC40828 (±)5-HETE lactone
(±)5-Hydroxyeicosatetraenoic Acid lactone
A 5-LO inhibitor
GC40801 (±)9(10)-DiHOME
(±)-苏式-9,10-二羟基-12(Z)-十八碳烯酸
A diol form of (±)9(10)-EpOME
GC40794 Sphinganine (d18:0)
D-赤式-C18-二氢-D-神经鞘氨醇
Sphinganine (d18:0)是一种鞘脂代谢途径的中间体。
GC40784 5(Z),8(Z),14(Z)-Eicosatrienoic Acid A polyunsaturated fatty acid
GC40777 β-D-Glucose
D-无水葡萄糖
A cyclic monosaccharide
GC40769 Asperphenamate
Anabellamide, Auranamide, NSC 306231
A fungal secondary metabolite
GC40758 Gly-Phe-β-naphthylamide
(S)-2-(2-氨基乙酰氨基)-N-(萘-2-基)-3-苯基丙酰胺
A cathepsin C substrate
GC40743 3-deoxy Galactosone
3-脱氧-山梨糖酮
A galactose degradation product
GC40730 11-cis Vaccenyl Acetate Male mating pheromone of D. melanogaster
GC40724 Heat Shock Protein Inhibitor II
Hsp Inhibitor II, KNK 423
Prevents the synthesis of inducible heat shock proteins
GC40719 β-Muricholic Acid
Β-鼠胆酸,5β-Cholanic Acid-3α,6β,7β-triol, β-MCA
β-胆酸β-muricholic acid是一种天然存在的三羟基亲水性胆汁酸，作为胆道胆固醇去饱和剂，促进胆固醇胆结石的溶解。
GC40718 α-Muricholic Acid
5β-Cholanic Acid-3α,6β,7α-triol
A murine-specific primary bile acid
GC40697 DDA
(2E,4E)-癸-2,4-二烯醛
A lipid decomposition product with cancer inhibiting activity
GC40694 Calpain Inhibitor II
Calpain inhibitor II
A non-selective cysteine protease inhibitor
GC40677 Avenaciolide
(±)-Avenaciolide
A fungal metabolite
GC40675 2-deoxy-Artemisinin
脱氧青蒿素
An inactive metabolite of artemisinin
GC40669 Nerol
橙花醇
A monoterpene
GC40665 Harzianopyridone
(-)-Harzianopyridone
An inhibitor of mitochondrial complex II
GC40661 D-Carnitine
右旋肉碱
An isomer of L-carnitine
GC40631 Leukotriene B4-3-aminopropylamide
LTB4-3aminopropylamide
A potent BLT₁ receptor ligand
GC40627 tetranor-Misoprostol A metabolite of misoprostol
GC40624 MMP-3 Inhibitor VIII
Matrix Metalloproteinase-3 Inhibitor VIII, Stromelysin-1 Inhibitor VIII
A selective inhibitor of MMP-3