Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

Products for Proteases

Cat.No. 产品名称 Information
GC40620 Heneicosanoic Acid
二十一碳酸
A very long-chain saturated fatty acid
GC40616 Des-4-fluorobenzyl Mosapride
莫沙必利脱氟苄基杂质
A metabolite of mosapride
GC40612 Resolvin E1
RvE1

A specialized pro-resolving mediator
GC40609 Lipoxin A5
LXA5
An EPA-derived bronchoconstrictor
GC40555 Tiopronin
BRN 1859822, (±)-Tiopronin
Tiopronin is an antioxidant that has diverse biological activities.
GC40542 9(R)-HODE
9(R)-Hydroxyoctadecadienoic Acid
A linoleic acid metabolite
GC40539 (±)12(13)-EpOME
(±)12,13-EODE, Isoleukotoxin, (±)-Vernolic Acid
The 12,13-cis epoxide form of linoleic acid
GC40538 Decylubiquinone
癸基泛醌
An analog of ubiquinone (coenzyme Q₁₀)
GC40529 7-hydroxy Warfarin
7-羟基华法林
A phase I metabolite of (-)-warfarin
GC40495 DL-Mevalonolactone
甲瓦龙酸内酯,(±)-Mevalonolactone; Mevalolactone
A precursor in the mevalonate pathway
GC40491 Meconin
袂康宁
An Analytical Reference Standard
GC40480 α-Phenyl-α-(2-pyridyl)acetonitrile
alpha-(2-吡啶基)-苯乙腈
The major metabolite of α-phenyl-α-(2-pyridyl)thioacetamide
GC40463 8(S)-HETE
8(S)-Hydroxyeicosatetraenoic Acid
A PKC and PPARα activator
GC40462 8(R)-HETE
8(R)-Hydroxyeicosatetraenoic Acid
A product of lipoxygenation of arachidonic acid in marine invertebrates
GC40460 5(S)-HETE
5(S)-Hydroxyeicosatetraenoic Acid
A 5-LO metabolite of arachidonic acid
GC40459 5(R)-HETE
5(R)-Hydroxyeicosatetraenoic Acid
A rare lipoxygenase product of arachidonic acid
GC40451 15(S)-HETE
15(S)-Hydroxyeicosatetraenoic Acid
An active metabolite of arachidonic acid
GC40448 12(S)-HETE
12(S)-Hydroxyeicosatetraenoic Acid
The predominant lipoxygenase product of mammalian platelets
GC40447 12(R)-HETE
12(R)-Hydroxyeicosatetraenoic Acid
An active metabolite of arachidonic acid
GC40445 11(R)-HETE
11(R)-Hydroxyeicosatetraenoic Acid
An oxylipin
GC40442 (±)8-HETE
(±)8-Hydroxyeicosatetraenoic Acid
A monohydroxy fatty acid produced by the non-enzymatic oxidation of arachidonic acid
GC40427 15(S)-HEDE Isolated by the chromatographic resolution of (±)15-HEDE
GC40399 Linoelaidic Acid
亚麻酸; Linoelaidic acid
An all-trans fatty acid homolog of linoleic acid
GC40394 11-deoxy Corticosterone
去氧皮质酮
An endogenous mineralocorticoid
GC40383 9(S)-HEPE A monohydroxy fatty acid derived from EPA
GC40382 8(S)-HEPE A monohydroxy fatty acid produced by lipoxygenase oxidation of EPA
GC40380 5-OxoETE
5-KETE
A polyunsaturated keto acid?that stimulates neutrophil migration
GC40378 5(S)-HEPE A fatty acid produced by 5-LO oxidation of EPA
GC40376 15-OxoETE
15KETE
An oxylipin produced by oxidation of the 15-hydroxyl of 15-HETE
GC40373 15(S)-HEPE
15S-hydroxy-Eicosapentaenoic Acid
A monohydroxy fatty acid derived from EPA
GC40372 12-OxoETE
12-KETE
A 12-oxo derivative of arachidonic acid
GC40371 12(S)-HEPE An anti-inflammatory monohydroxy fatty acid derived from EPA
GC40368 11(R)-HEPE Produced by the oxidation of EPA by 11(R)-LO
GC40357 9(S)-HpODE A 5-LO product derived from linoleic acid
GC40349 12(S)-HETE-19,20-alkyne
Click Tag 12(S)-HETE-19,20-alkyne, Click Tag 12(S)-Hydroxyeicosatetraenoic Acid-19,20-alkyne
A probe for 12(S)-HETE activity
GC40339 Hepoxilin A3 methyl ester
HxA3 methyl ester
A metabolite of arachidonic acid
GC40301 Tamoxifen N-oxide
他莫昔芬N-氧化物
A metabolite of tamoxifen
GC40298 N-acetyl-5-Aminosalicylic Acid
5-乙酰氨基水杨酸
A metabolite of 5-ASA and sulfasalazine
GC40286 (E,Z)-2-propyl-2-Pentenoic Acid
2-丙基-2-戊烯酸
A valproic acid metabolite
GC40278 Leukotriene B3
LTB3
The LTA hydrolase metabolite of LTA₃
GC40265 Pheleuin A pyrazinone
GC40260 (±)-γ-Tocopherol
3,4-二氢-2,7,8-三甲基-2-(4,8,12-三甲基十三烷)-2H-1-苯并吡喃-6-醇
A form of vitamin E
GC40259 (±)-β-Tocopherol
β-生育酚
A lipid-soluble form of vitamin E
GC10559 Erythrodiol
高根二醇,Oleanolic alcohol; olean-12-ene-3,28-diol; ERYTHODIOL; Erythrodiol; 12-OLEANENE-3,28-DIOL; HOMOOLESTRANOL;
A triterpene with diverse biological activities
GC10456 Fucosterol
岩皂甾醇,24-ethylidene Cholesterol
A natural phytosterol with diverse biological activities
GC19523 Sivelestat sodium tetrahydrate
EI546 sodium tetrahydrate; LY544349 sodium tetrahydrate; ONO5046 sodium tetrahydrate
An inhibitor of neutrophil elastase
GC34924 NSC 185058 An inhibitor of ATG4B
GC34914 LysoPC(14:0/0:0)
1-十四酰-2-羟基卵磷脂
A lysophospholipid
GC34881 5-Methyltetrahydrofolic acid
甲基叶酸盐,5-Methyl THF
5-Methyltetrahydrofolicacid是一种具有生物活性的叶酸形式。5-Methyltetrahydrofolicacid是四氢叶酸的甲基化衍生物。5-Methyltetrahydrofolicacid是主要的天然膳食叶酸，是血浆和脑脊液中叶酸的主要形式。
GC34831 Tauroursodeoxycholate dihydrate
牛磺熊去氧胆酸二水合物; Tauroursodeoxycholic acid dihydrate; TUDCA dihydrate; UR 906 dihydrate
Tauroursodeoxycholatedihydrate(TUDCAdihydrate;UR906dihydrate;Taurolitedihydrate)是一种内质网应激抑制剂。Tauroursodeoxycholate显著降低凋亡分子如caspase-3和caspase-12表达。Tauroursodeoxycholate也抑制ERK。