Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

Products for Proteases

Cat.No. 产品名称 Information
GC34682 N-Ethylmaleimide
N-乙基马来酰亚胺; NEM
N-乙基马来酰亚胺（N-Ethylmaleimide；NEM）衍生于马来酸，能烷基化游离巯基，是一种蛋白质巯基修饰剂，可用于修饰蛋白质和多肽中的半胱氨酸残基。N-Ethylmaleimid对脯氨酰内肽酶有抑制作用，IC₅₀值为6.3μM。
GC34634 JG-98
3-苄基-2-((Z)-((E)-5-(6-氯-3-甲基苯并[D]噻唑-2(3H)-亚基)-3-乙基-4-氧代噻唑啉-2-亚基)甲基)噻唑-3-鎓氯化物
JG-98 is an allosteric inhibitor of Hsp70 that binds tightly to a deep pocket that is conserved in members of the Hsp70 family. JG-98 induces classical apoptosis features, including morphological changes consistent with programmed cell death and positive annexin staining. JG-98 exhibits anticancer activity.
GC34613 HFI-142 HFI-142是胰岛素调节性氨基肽酶(IRAP)抑制剂，ki值为2.01μM。
GC34609 Guanosine 5'-diphosphate disodium salt
鸟苷-5'-二磷酸二钠盐,GDP disodium salt
Guanosine5'-diphosphatedisodiumsalt是一种核苷二磷酸。Guanosine5'-diphosphate是一种潜在的铁动员剂，可阻断铁调素-铁转运蛋白相互作用并调节白细胞介素-6(IL-6)/stat-3途径。
GC34569 Elamipretide TFA
ElamipretideTFA(MTP-131TFA;RX-31TFA;SS-31TFA)是一种靶向作用于线粒体内膜的多肽，是心磷脂过氧化物酶(cardiolipinperoxidase)抑制剂。
GC34539 Col003
Col003是一种有效的Hsp47抑制剂，竞争性地与Hsp47上的胶原结蛋白合位点结合(IC50，1.8μM)，通过破坏胶原蛋白的三重螺旋结构抑制胶原蛋白的分泌。
GC34513 C25-140 C25-140 is a small-molecule inhibitor of TRAF6-Ubc13 interaction. C25-140 directly binds to TRAF6, thereby blocking the interaction of TRAF6 with Ubc13, and as a consequence lowers TRAF6 activity. C25-140 impedes NF-κB activation in various immune and inflammatory signaling pathways also in primary human and murine cells.
GC34442 (R)-(+)-Citronellal
(R)-(+)-香茅醛; (+)-Citronellal
(R)-(+)-Citronellal可从柑橘、薰衣草和桉树油中分离得到，是一种单萜化合物，是香茅醛的主要成分，具有独特的柠檬香味。是一种调味剂。可用于驱虫和抗真菌。
GC19520 Cysteine Protease inhibitor
半胱氨酸蛋白酶抑制剂
半胱氨酸蛋白酶抑制剂是半胱氨酸蛋白酶的抑制剂。
GP24824 Thrombin 人类凝血酶
GP24734 Streptolysin-O 链球菌溶血素-O 化脓性链球菌重组体
GC19495 DL-Folinic Acid (calcium salt)
亚叶酸钙; Leucovorin calcium; Calcium folinate
A reduced folic acid
GC40256 p-APMSF (hydrochloride)
(4-脒苯基)甲磺酰氟盐酸盐
An irreversible inhibitor of serine proteases
GC40252 Phosphatidic Acids (egg) (ammonium salt) A mixture of phosphatidic acids
GC40250 9(S)-HODE-d4 MaxSpec® Standard An internal standard for the quantification of 9-HODE
GC40234 Ramipril-d5
雷米普利 d5
An internal standard for the quantification of ramipril
GC40229 (±)-Warfarin-d5
4-羟基-3-[3-氧代-1-(苯基-D5)丁基]-2H-1-苯并吡喃-2-酮,WARF-42-d5; Athrombine-K-d5
An internal standard for the quantification of warfarin
GC40221 Ritonavir-d6
利托那韦 d6
An internal standard for the quantification of ritonavir
GC40220 Pravastatin-d3 (sodium salt) An internal standard for the quantification of pravastatin
GC40218 (-)-Epigallocatechin Gallate-d3/d4
EGCG-d3/d4
An internal standard for the quantification of (–)-epigallocatechin gallate
GC40191 Ibuprofen Carboxylic Acid
羧基布洛芬
A major metabolite of ibuprofen
GC40190 Febuxostat Acyl Glucuronide
非布司他杂质
A metabolite of febuxostat
GC40183 1-Oleoyl Glycerol
甘油单油酸酯
A monoacylglycerol
GC40164 Ac-IETD-CHO (trifluoroacetate salt)
Caspase-8 Inhibitor
A caspase-8 inhibitor
GC40149 Boc-AEVD-CHO (trifluoroacetate salt)
Boc-Ala-Glu-Val-Asp-CHO
An inhibitor of caspase-8
GC40145 (S)-Laudanosine
(+)-Laudanosine, L-Laudanosine, L-(+)-Laudanosine, NSC 35045
The (S) enantiomer of laudanosine
GC40144 Levofloxacin N-oxide
左氧氟沙星EP杂质C (Levofloxacin N-Oxide)
An inactive metabolite of levofloxacin
GC40143 Dihydrotetrabenazine
反式(2,3)-二氢丁苯那嗪
An active metabolite of tetrabenazine
GC40141 C18 Phytoceramide-d3 (t18:0/18:0-d3)
Cer(t18:0/18:0) - d3, Ceramide (t18:0/18:0)- d3, N-Octadecanoyl Phytosphingosine- d3, C18:0 Phytoceramide- d3, N-Stearoyl Phytosphingosine- d3
An internal standard for the quantification of C18 phytoceramide
GC40125 Z-VA-DL-D(OMe)-FMK (trifluoroacetate salt)
Caspase-1 Inhibitor V, Z-VAD-FMK, Z-VAD(OMe)-FMK, Z-Val-Ala-DL-Asp(OMe)-Fluoromethyl Ketone
A pan-caspase inhibitor
GC40123 Ac-AAVALLPAVLLALLAP-VAD-CHO (trifluoroacetate salt)
Caspase Inhibitor II, Ac-AAVALLPAVLLALLAP-VAD-aldehyde, Ac-AAVALLPAVLLALLAPVAD-CHO
A non-selective caspase inhibitor
GC40122 Ac-AAVALLPAVLLALLAP-DEVD-CHO (trifluoroacetate salt)
Ac-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Asp-Glu-Val-Asp-CHO, Ac-AAVALLPAVLLALLAP-DEVD-aldehyde, Ac-AAVALLPAVLLALLAPDEVD-CHO, Caspase-3 Inhibitor I, DEVD-CHO-CPP 32
A caspase-3 inhibitor
GC40118 Ac-AAVALLPAVLLALLAP-IETD-CHO (trifluoroacetate salt)
Ac-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Ile-Glu-Thr-Asp-CHO, Caspase-8 Inhibitor I
An inhibitor of caspase-8 and granzyme B
GC40101 IMP-1088
An inhibitor of N-myristoyltransferase
GC40099 Leukotriene D4 MaxSpec® Standard
LTD4
An active metabolite of LTC₄ and a constituent of SRS-A
GC40097 4-HOBA
4-羟基苄胺
An isomer of 2-HOBA
GC40087 7α-hydroxy-4-Cholesten-3-one
7-羟基-4-胆甾烯-3-酮
A metabolite of 7α-hydroxy cholesterol
GC40038 Heptanoyl-L-carnitine (chloride)
C7:0 Carnitine, CAR 7:0, L-Carnitine heptanoyl ester, L-Heptanoylcarnitine
A medium-chain acylcarnitine
GC40037 Linoleoyl-L-carnitine (chloride)
CAR 18:2, C18:2 Carnitine, L-Carnitine linoleoyl ester, L-Linoleoylcarnitine
A long-chain acylcarnitine
GC40033 Phenazolam
Clobromazolam
An Analytical Reference Standard
GC40032 Antipain (hydrochloride)
抗痛素二盐酸盐
A protease inhibitor
GC40029 9(S),10(S),13(S)-TriHOME An oxylipin
GC40018 Donepezil N-oxide
多奈哌齐N氧化物
An active metabolite of donepezil
GC40008 Fuscin
暗褐菌素
A fungal metabolite with diverse biological activities
GC40007 Malformin A
Malformin A1
A cyclopentapeptide fungal metabolite with diverse biological activities
GC34417 (R,S)-Ivosidenib ((R,S)-AG-120) (R,S)-Ivosidenib是一种异柠檬酸脱氢酶(IDH1)抑制剂。
GC34414 AZ7550 Mesylate (AZ7550 trimesylate salt) An active metabolite of AZ 9291
GC34413 Lurasidone Metabolite 14283 D8 LurasidoneMetabolite14283D8是LurasidoneMetabolite14283的氘代化合物标准品。
GC34412 Lurasidone metabolite 14326 hydrochloride Lurasidonemetabolite14326(hydrochloride)是一种非典型抗精神病药物Lurasidone的活性代谢物。
GC34411 Lurasidone Metabolite 14326 D8 LurasidoneMetabolite14326D8是LurasidoneMetabolite14326的氘代化合物标准品。